Bronchodilator responsiveness in wheezy infants predicts continued early childhood respiratory morbidity

References

• Pedersen SE, Hurd SS, Lemanske RF, Becker A, Zar HJ, Sly PD, et al. Global strategy for the diagnosis and management of asthma in children 5 years and younger. Pediatr Pulmonol 2011;46(1):1-17.
   PubMed Web of Science ®Google Scholar
• Martinez FDF, Wright AAL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995;332(3):133-138.
   PubMed Web of Science ®Google Scholar
• Savenije OEM, Kerkhof M, Koppelman GH, Postma DS. Predicting who will have asthma at school age among preschool children. J Allergy Clin Immunol 2012;130(2):325-331.
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma (GINA). The Global Strategy for Asthma Management and Prevention. 2015 Update. Available from: http://ginasthma.org/wp-content/uploads/2016/01/GINA_Report_2015_Aug11-1.pdf [last accessed 13 September 2015].
   Google Scholar
• Galant SP, Morphew T, Newcomb RL, Hioe K, Guijon O, Liao O. The relationship of the bronchodilator response phenotype to poor asthma control in children with normal spirometry. J Pediatr 2011;158(6):953-939.e1.
   PubMed Web of Science ®Google Scholar
• Sharma S, Litonjua A a, Tantisira KG, Fuhlbrigge AL, Szefler SJ, Strunk RC, et al. Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management program. J Allergy Clin Immunol 2008;122(5):921-928.e4.
   PubMed Web of Science ®Google Scholar
• Lesnick BL, Davis SD. Infant pulmonary function testing: overview of technology and practical considerations–new current procedural terminology codes effective 2010. Chest 2011 May;139(5):1197-1202.
   PubMed Web of Science ®Google Scholar
• ATS/ERS statement: raised volume forced expirations in infants: guidelines for current practice. Am J Respir Crit Care Med 2005;172(11):1463-1471.
   PubMed Web of Science ®Google Scholar
• Turner SW, Palmer LJ, Rye PJ, Gibson NA, Judge PK, Cox M, et al. The relationship between infant airway function, childhood airway responsiveness, and asthma. Am J Respir Crit Care Med 2004;169(8):921-927.
   PubMed Web of Science ®Google Scholar
• Pike KC, Rose-Zerilli MJ, Osvald EC, Inskip HM, Godfrey KM, Crozier SR, et al. The relationship between infant lung function and the risk of wheeze in the preschool years. Pediatr Pulmonol 2011;46(1):75-82.
   PubMed Web of Science ®Google Scholar
• Frey U, Stocks J, Coates A, Sly P, Bates J. Specifications for equipment used for infant pulmonary function testing. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Society. Eur Respir J 2000;16(4):731-740.
   PubMed Web of Science ®Google Scholar
• Sly PD, Tepper R, Henschen M, Gappa M, Stocks J. Tidal forced expirations. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Society. Eur Respir J 2000;16(4):741-748.
   PubMed Web of Science ®Google Scholar
• Stocks J, Godfrey S, Beardsmore C, Bar-Yishay E, Castile R. Plethysmographic measurements of lung volume and airway resistance. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/ American Thoracic Society. Eur Respir J 2001;17(2):302-312.
   PubMed Web of Science ®Google Scholar
• McCoy KS, Castile RG, Allen ED, Filbrun DA, Flucke RL, Bar-Yishay E. Functional residual capacity (FRC) measurements by plethysmography and helium dilution in normal infants. Pediatr Pulmonol 1995;19(5):282-290.
   PubMed Web of Science ®Google Scholar
• Hoo A-F, Dezateux C, Hanrahan JP, Cole TJ, Tepper RS, Stocks J. Sex-specific prediction equations for Vmax(FRC) in infancy: a multicenter collaborative study. Am J Respir Crit Care Med 2002;165(8):1084-1092.
   PubMed Web of Science ®Google Scholar
• Hayden MJ, Wildhaber JH, LeSouëf PN. Bronchodilator responsiveness testing using raised volume forced expiration in recurrently wheezing infants. Pediatr Pulmonol 1998;26(1):35-41.
   PubMed Web of Science ®Google Scholar
• Prendiville A, Green S, Silverman M. Paradoxical response to nebulised salbutamol in wheezy infants, assessed by partial expiratory flow-volume curves. Thorax 1987;42(2):86-91.
   PubMed Web of Science ®Google Scholar
• Beardsmore CS, Page C, Silverman M. The response to beta-agonists in wheezy infants: three methods compared. Respir Med 2004;98(11):1138-45.
   PubMed Web of Science ®Google Scholar
• Sheikh S, Castile R, Hayes J, McCoy K, Eid N. Assessing bronchodilator responsiveness in infants using partial expiratory flow-volume curves. Pediatr Pulmonol 2003;36(3):196-201.
   PubMed Web of Science ®Google Scholar
• Modl M, Eber E, Weinhandl E, Gruber W, Zach MS. Assessment of bronchodilator responsiveness in infants with bronchiolitis. A comparison of the tidal and the raised volume rapid thoracoabdominal compression technique. Am J Respir Crit Care Med 2000;161(3 Pt 1):763-768.
   PubMed Web of Science ®Google Scholar
• Lenney W, Milner AD. At what age do bronchodilator drugs work? Arch Dis Child 1978;53(7):532-535.
   PubMed Web of Science ®Google Scholar
• Tepper RS, Rosenberg D, Eigen H, Reister T. Bronchodilator responsiveness in infants with bronchiolitis. Pediatr Pulmonol 1994;17(2):81-85.
   PubMed Web of Science ®Google Scholar
• Bar-Yishay E, Avital A, Springer C, Amirav I. Lung function response to bronchodilator nebulization via hood in wheezy infants: a pilot study. Am J Respir Crit Care Med 2011;13(1):39-43.
   Google Scholar
• Debley J, Stanojevic S. Bronchodilator responsiveness in wheezy infants and toddlers is not associated with asthma risk factors. Pediatr Pulmonol 2012;428:421-428.
   Web of Science ®Google Scholar
• Saito J, Harris WT, Gelfond J, Noah TL, Leigh MW, Johnson R, et al. Physiologic, bronchoscopic, and bronchoalveolar lavage fluid findings in young children with recurrent wheeze and cough. Pediatr Pulmonol 2006;41(8):709-719.
   PubMed Web of Science ®Google Scholar
• Chavasse RJ, Bastian-Lee Y, Richter H, Hilliard T, Seddon P. Inhaled salbutamol for wheezy infants: a randomised controlled trial. Arch Dis Child 2000;82(5):370-375.
   PubMed Web of Science ®Google Scholar
• Hofhuis W, van der Wiel EC, Tiddens H, Brinkhorst G, Holland W, de Jongste JC, et al. Bronchodilation in infants with malacia or recurrent wheeze. Arch Dis Child 2003;88(3):246-249.
   PubMed Web of Science ®Google Scholar
• Johnson C, Ownby D. Environmental epidemiology of pediatric asthma and allergy. Epidemiol Rev 2002;24(2):154-175.
   PubMed Web of Science ®Google Scholar
• Strachan DP. The epidemiology of childhood asthma. Allergy 1999;54(Suppl 4):7-11.
   PubMed Web of Science ®Google Scholar
• Wechsler ME, Kelley JM, Boyd IOE, Dutile S, Marigowda G, Kirsch I, et al. Active albuterol or placebo, sham acupuncture, or no intervention in asthma. N Engl J Med 2011;365(2):119-126.
   PubMed Web of Science ®Google Scholar
• Ranganathan SC, Hoo AF, Lum SY, Goetz I, Castle RA, Stocks J. Exploring the relationship between forced maximal flow at functional residual capacity and parameters of forced expiration from raised lung volume in healthy infants. Pediatr Pulmonol 2002;33(6):419-428.
   PubMed Web of Science ®Google Scholar
• Bar-Yishay E, Springer C, Hevroni A, Godfrey S. Relation between partial and raised volume forced expiratory flows in sick infants. Pediatr Pulmonol 2011;46:458-463.
   PubMed Web of Science ®Google Scholar
• Lagerstrand L, Ingemansson M, Bergström SE, Lidberg K, Hedlin G. Tidal volume forced expiration in asthmatic infants: reproducibility and reversibility tests. Respiration 2002;69(5):389-396.
   PubMed Web of Science ®Google Scholar
• van Grunsven PM, van Schayck CP, Molema J, Akkermans RP, van Weel C. Effect of inhaled corticosteroids on bronchial responsiveness in patients with “corticosteroid naive” mild asthma: a meta-analysis. Thorax 1999;54(4):316-322.
   PubMed Web of Science ®Google Scholar
• Hancox RJ. Interactions between corticosteroids and beta2-agonists. Clin Rev Allergy Immunol 2006;31(2–3):231-246.
   PubMed Web of Science ®Google Scholar
• Cohen S, Avital A, Hevroni A, Avenshtein A, Hadi R, Springer C. Predictive value of adenosine 5′-monophosphate challenge in preschool children for the diagnosis of asthma 5 years later. J Pediatr 2012;161(1):156-159.
   PubMed Web of Science ®Google Scholar