Irreversible airway obstruction in asthma: A risk factor for severe exacerbations in spite of proper treatment

References

• Kim ES, Kim SH, Kim KW, Park JW, Kim YS, Sohn MH, et al. Basement membrane thickening and clinical features of children with asthma. Allergy 2007;62:635–640.
   PubMed Web of Science ®Google Scholar
• Bumbacea D, Campbell D, Nguyen L, Carr D, Barnes PJ, Robinson D, et al. Parameters associated with persistent airflow obstruction in chronic severe asthma. Eur Respir J 2004;24:122–128.
   PubMed Web of Science ®Google Scholar
• ten Brinke A, Zwinderman AH, Sterk PJ, Rabe KF, Bel EH. Factors associated with persistent airflow limitation in severe asthma. Am J Respir Crit Care Med 2001;164:744–748.
   PubMed Web of Science ®Google Scholar
• Lee JH, Haselkorn T, Borish L, Rasouliyan L, Chipps BE, Wenzel SE. Risk factors associated with persistent airflow limitation in severe or difficult-to-treat asthma: insights from the TENOR study. Chest 2007;132:1882–1889.
   PubMed Web of Science ®Google Scholar
• Jang AS, Lee JH, Park SW, Park JS, Kim DJ, Park CS. Risk factors related to fixed airway obstruction in patients with asthma after antiasthma treatment. Ann Allergy Asthma Immunol 2007;99:408–412.
   PubMed Web of Science ®Google Scholar
• Ten Brinke A, Zwinderman AH, Sterk PJ, Rabe KF, Bel EH. Factors associated with persistent airflow limitation in severe asthma. Am J Resp Crit Care Med 2001;164:744–748.
   PubMed Web of Science ®Google Scholar
• Sexton P, Black P, Wu L, Sommerville F, Hamed M, Metcalf P, et al. Fixed airflow obstruction among nonsmokers with asthma:a case-comparison study. J Asthma 2013;50:606–612.
   PubMed Web of Science ®Google Scholar
• Mascia K, Haselkorn T, Deniz YM, Miller DP, Bleecker ER, Borish L, et al. Aspirin sensitivity and severity of asthma: evidence for irreversible airway obstruction in patients with severe or difficult-to-treat asthma.J Allergy Clin Immunol 2005;116:970–975.
   PubMed Web of Science ®Google Scholar
• Boulet L, Bélanger M, Carrier G. Airway responsiveness and bronchial-wall thickness in asthma with or without fixed airflow obstruction. Am J Respir Crit Care Med 1995;152:865–871.
   PubMed Web of Science ®Google Scholar
• Jang AS, Park JS, Lee JH, Park SW, Kim DJ, Uh ST, et al. Asthmatics without rhinitis have more fixed airway obstruction than those with concurrent rhinitis. Allergy Asthma Immunol Res 2010;2:108–113.
   PubMed Web of Science ®Google Scholar
• Grol MH, Gerritsen J, Vonk JM, Schouten JP, Koëter GH, Rijcken B, et al. Risk factors for growth and decline of lung function in asthmatic individuals up to age 42 years. A 30-year follow-up study. Am J Respir Crit Care Med 1999;160:1830–1837.
   PubMed Web of Science ®Google Scholar
• Vonk JM, Jongepier H, Panhuynsen CIM, Schouten JP, Bleecker ER, Postma DS. Risk factors associated with the presence of irreversible airflow limitation and reduced transfer coefficient in patients with asthma after 26 years of follow up. Thorax 2003;58:322–327.
   PubMed Web of Science ®Google Scholar
• Lee T, Lee YS, Bae YJ, Kim TB, Kim SO, Cho SH, et al. Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: findings from the COREA study. Respir Res 2011;3:12.
   Google Scholar
• Ulrik CS, Backer V. Nonreversible airflow obstruction in life-long nonsmokers with moderate to severe asthma. Eur Respir J 1999;14:892–896.
   PubMed Web of Science ®Google Scholar
• Hansen EF, Phanareth K, Laursen LC, Kok-Jensen A, Dirksen A. Reversible and irreversible airflow obstruction as predictor of overall mortality in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999;159:1267–1271.
   PubMed Web of Science ®Google Scholar
• Limb SL, Brown KC, Wood RA, Wise RA, Eggleston PA, Tonascia J, et al. Irreversible lung function deficits in young adults with a history of childhood asthma. J Allergy Clin Immunol 2005;116:1213–1219.
   PubMed Web of Science ®Google Scholar
• Diretrizes da Sociedade Brasileira de Pneumologia e Tisiologica para. Asma J Brasil Pneumol 2012;38:S1–S46.
   Google Scholar
• American Thoracic Society (ATS) Standardization of Spirometry 1994 Update. Am J Respir Crit Care Med 1995;152:1107–1136.
   PubMed Web of Science ®Google Scholar
• Pereira CAC, Barreto SP, Simões JG. Valores de referência para espirometria em uma amostra da população brasileira adulta. J Pneumol 1992;18:10–22.
   Google Scholar
• Cerveri I, Corsico AG, Accordini S, Niniano R, Ansaldo E, Antó JM, et al. Underestimation of airflow obstruction among young adults using FEV1/FVC <70% as a fixed cut-off: a longitudinal evaluation of clinical and functional outcomes. Thorax 2008;63:1040–1045.
   PubMed Web of Science ®Google Scholar
• Leite M, Ponte EV, Petroni J, D'Oliveira Júnior A, Pizzichini E, Cruz AA. Evaluation of the Asthma Control Questionnaire validated for use in Brazil. J Bras Pneumol 2008;34:756–763.
   PubMedGoogle Scholar
• Juniper EF, Guyatt GH, Cox FM, Ferrie PJ, King DR. Development validation of the Mini Asthma Quality of Life Questionnaire. Eur Respir J 1999;14:32–38.
   PubMed Web of Science ®Google Scholar
• Teeter JG, Bleecker ER. Relationship between airway obstruction and respiratory symptoms in adult asthmatics. Chest 1998;113:272–277.
   PubMed Web of Science ®Google Scholar
• Burdon JG, Juniper EF, Killian KJ, Hargreave FE, Campbell EJ. The perception of breathlessness in asthma. Am Rev Respir Dis 1982;126:825–828.
   PubMed Web of Science ®Google Scholar
• Ponte EV, Petroni J, Ramos DC, Pimentel L, Freitas DN, Cruz AA. Perception of asthma control in asthma patients. J Bras Pneumol 2007;33:635–640.
   PubMedGoogle Scholar
• Hasaneen NA1, Zucker S, Cao J, Chiarelli C, Panettieri RA, Foda HD. Cyclic mechanical strain-induced proliferation and migration of human airway smooth muscle cells: role of EMMPRIN and MMPs. FASEB J 2005;19:1507–1509.
   PubMed Web of Science ®Google Scholar
• Grainge CL, Lau LC, Ward JA, Dulay V, Lahiff G, Wilson S, et al. Effect of bronchoconstriction on airway remodeling in asthma. N Engl J Med 2011;364:2006–2015.
   PubMed Web of Science ®Google Scholar
• Ponte EV, Souza-Machado A, Souza-Machado C, Franco R, Cruz AA. Atopy is not associated with poor control of asthma. J Asthma 2012;49:1021–1026.
   PubMed Web of Science ®Google Scholar
• Ponte EV, Franco R, Nascimento HF, Souza-Machado A, Cunha S, Barreto ML, et al. Lack of control of severe asthma is associated with co-existence of moderate-to-severe rhinitis. Allergy 2008;63:564–569.
   PubMed Web of Science ®Google Scholar
• Almqvist C, Worm M, Leynaert B. Impact of gender on asthma in childhood and adolescence: a GA2LEN review. Allergy 2008;63:47–57.
   PubMed Web of Science ®Google Scholar
• Abadoglu O, Berk S. Tiotropium may improve asthma symptoms and lung function in asthmatic patients with irreversible airway obstruction: the real-life data. Clin Respir J 2014 doi: 10.1111/crj.12230. Available from http://onlinelibrary.wiley.com/doi/10.1111/crj.12230/pdf
   PubMed Web of Science ®Google Scholar