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Journal of Asthma Volume 32, 1995 - Issue 2
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Original Article

Duration of Action of a Single Dose of Azelastine in Patients with Chronic Asthma

Paul Chervinsky Allergy and Asthma Center North Dartmouth, Massachusetts,
,
Jay Grossman Albany Medical College Allergy Division Albany, New York,
&
Jeffrey J. Freitag Wallace Laboratories Princeton, New Jersey,
Pages 141-145 | Published online: 02 Jul 2009

References

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  • Chand N, Nolan K, Diamantis W, Perhach J L, Sofia R D. Inhibition of leukotriene (SRS-A) mediated allergic bronchospasm by azelastine, a novel, orally effective antiasthmatic drug. J Allergy Clin Immunol 1983; 71: 149
  • Chand N, Nolan K, Diamantis W. Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs. Allergy 1986; 41: 473
  • Chand N, Pillar J, Diamantis W. Inhibition of allergic histamine release from rat peritoneal mast cells by azelastine. Int Arch Allergy Appl Immunol 1988; 86: 256
  • Fischer B, Schmutzler W. Inhibition by azelastine of the immunologically induced histamine release from isolated guinea pig mast cells. Arzneim Forsch 1981; 31: 1193
  • Chand N, Pillar J, Nolan K. Inhibition of 5-HETE, LTB4 and LTC4 synthesis by azelastine and its d-and -isomers in rat mixed peritoneal cells. Am Rev Respir Dis 1987; 135: 381, abstract
  • Kemp J P, Meltzer E O, Orgel H A, Welch M J, Bucholtz G A, Middleton E, Spector S L, Newton J J, Perhach J L. A dose-response study of the bronchodilator action of azelastine in asthma. J Allergy Clin Immunol 1987; 79: 893
  • Holgate S T, Hardy C C, Robinson C, Agius R M, Howarth P H. The mast cell as a primary effector cell in the pathogenesis of asthma. J Allergy Clin Immunol 1986; 77: 274
  • Holgate S T, Finnerty J P. Antihistamines in asthma. J Allergy Clin Immunol 1989; 83(Pt 2)537
  • Cockcroft D W, Ruffin R M, Dolovich J, Hargreave F E. Allergen-induced increase in non-allergic bronchial reactivity. Clin Allergy 1977; 7: 503
  • Perhach J L, Freitag J J, Rosenberg A. Azelastine: A review in light of current concepts and therapies. J Respir Dis October, 1989; S75
  • Todoroke I, Yoshizawa I, Kawano Y, Noma T. Suppressive effect of azelastine on the induction of Df antigen specific IL-2 responsiveness in lymphocytes from patients with bronchial asthma. Jpn J Allergol 1990; 39: 1509
  • Little M, Casale T. Azelastine inhibits both human lung and basophil degranulation. J Allergy Clin Immunol 1987; 79: 204

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