19
Views
16
CrossRef citations to date
0
Altmetric
Original Article

Gastroesophageal Reflux and Asthma: Are They Related?

Pages 631-644 | Published online: 02 Jul 2009

References

  • Centers for Disease Control. Asthma—United States, 1982–1992. MMWR 1995; 43: 952
  • Woolcock A J, Peat J K. Evidence for the increase in asthma worldwide. Ciba Found Symp 1997; 206: 122
  • Stedman J R, Anderson H R, Atkinson R W, Maynard R L. Emergency hospital admissions for respiratory disorders attributable to summer time ozone episodes in Great Britain. Thorax 1997; 52: 958
  • Strachan D P, Cook D G. Health effects of passive smoking. 6. Parental smoking and childhood asthmalongitudinal and case-control studies. Thorax 1998; 53: 204
  • Black P N, Sharpe S. Dietary fat and asthma: is there a connection. Eur Respir J 1997; 10: 6
  • Shirakawa T, Enomoto T, Shimazu S-I, Hopkin J M. The inverse association between tuberculin responses and atopic disorder. Science 1997; 275: 77
  • Ernst P, Fitzgerald J M, Spier S. Canadian asthma consensus conference summary of recommendations. Can Respir J 1996; 3: 89
  • Harding S M, Richter J E. The role of gastroesophageal reflux in chronic cough and asthma. Chest 1997; 111: 1389
  • Sontag S J. Gastroesophageal reflux and asthma. Am J Med 1997; 203: 84S
  • Urschel H C, Paulson D I. Gastroesophageal reflux and hiatal hernia. Complications and therapy. J Thorac Cardiovasc Surg 1967; 63: 21
  • Overholt R H, Voorhees R J. Esophageal reflux as a trigger in asthma. Dis Chest 1966; 49: 464
  • Irwin R S, Curley F J, French C L. Difficult-to-control asthma. Contributing factors and outcome of a systematic management protocol. Chest 1993; 103: 1662
  • Ekstrom T, Tibbling L. Gastro-oesophageal reflux and triggering of bronchial asthma: a negative report. Eur J Respir Dis 1987; 71: 177
  • Ekstrom T, Tibbling L. Esophageal acid perfusion, airway function and symptoms in asthmatic patients with marked bronchial reactivity. Chest 1989; 96: 995
  • Wesseling G, Brummer R J, Wouters E F, Ten Velde G P. Gastric asthma: no change in respiratory impedance during intraesophageal acidification in adult asthmatics. Chest 1993; 104: 1733
  • National Institutes of Health. Expert panel report. Guidelines for the diagnosis and management of asthma. Pediatr Asthma Allergy Immunol 1991; 5: 57
  • National Institutes of Health. Global initiative for asthma. Publication No. 95–3659. National Institutes of Health, Bethesda, MD January, 1995
  • Castell D O, Schnatz P F. Gastroesophageal reflux disease and asthma. Reflux or reflex. Chest 1995; 108: 1186
  • Mansfield L E, Hameister H H, Spaulding H S, Smith N J, Glab N. The role of the vagus nerve in airway narrowing caused by intraesophageal hydrochloric acid provocation and esophageal distention. Ann Allergy 1981; 47: 431
  • Tuchman D N, Boyle J T, Pack A I, Scwartz J, Kokonos M, Spitzer A R, Cohen S. Comparisons of airway responses following tracheal or esophageal acidification in the cat. Gastroenterology 1984; 87: 872
  • Wynne J W, Ramphal R, Hood C I. Tracheal mucosal damage after aspiration. A scanning electron microscope study. Am Rev Respir Dis 1981; 124: 728
  • Mansfield L E, Stein M R. Gastroesophageal reflux and asthma: a possible reflex mechanism. Ann Allergy 1978; 41: 224
  • Spaulding H S, Mansfield L E, Stein M R, Sellner J C, Gremillion D E. Further investigation of the association between gastroesophageal reflux and broncho-constriction. /. Allergy Clin Immunol 1982; 69: 516
  • Perpina M, Pellicer C, Marco V, Maldonado J, Ponce J. The significance of the reflex bronchoconstriction provoked by gastroesophageal reflux in bronchial asthma. Eur J Respir Dis 1985; 66: 91
  • Harding S M, Schan C A, Guzzo M R, Alexander R W, Bradley L A, Richter J E. Gastroesophageal reflux-induced bronchoconstriction. Is microaspiration a factor. Chest 1995; 108: 1220
  • Kjellen G, Tibbling L, Wranne B. Bronchial obstruction after oesophageal acid perfusion in asthmatics. Clin Physiol 1981; 1: 285
  • Herve P, Denjean A, Jian R, Simonneau G, Duroux P. Intraesophageal perfusion of acid increases the bronchomotor response to methacholine and iso-capnic hyperventilation in asthmatic subjects. Am Rev Respir Dis 1986; 134: 986
  • Andersen L I, Schmidt A, Bundgaard A. Pulmonary function and acid application in the esophagus. Chest 1986; 90: 358
  • Ducolone A, Vandevenne A, Jouin H, Glob J-C, Coumaros D, Meyer C, Burghard G, Methlin G, Hollender L. Gastroesophageal reflux in patients with asthma and chronic bronchitis. Am Rev Respir Dis 1987; 135: 327
  • Harper P C, Bergner A, Kaye D M. Antireflux treatment for asthma. Improvement with associated gastroesophageal reflux. Arch Intern Med 1987; 147: 56
  • Rauscher H, Popp W, Ritschka L. Effect of short esophageal acidification on airway hyperreactivity. Respiration 1989; 55: 11
  • Wright R A, Miller S A, Corsello B F. Acid-induced esophagobronchial-cardiac reflexes in humans. Gastroenterology 1990; 99: 71
  • Tan W C, Martin R J, Pandey R, Ballard R D. Effects of spontaneous and simulated gastroesophageal reflux on sleeping asthmatics. Am Rev Respir Dis 1990; 141: 1394
  • Schan C A, Harding S M, Haile J M, Bradley L A, Richter J E. Gastroesophageal reflux-induced bronchoconstriction. An intraesophageal acid infusion study using state-of-the-art technology. Chest 1994; 106: 731
  • Jack C IA, Calverley P MA, Donnelly R J, Tran J, Russell G, Hind C RK, Evans C C. Simultaneous tracheal and oesophageal pH measurements in asthmatic patients with gastro-oesophageal reflux. Thorax 1995; 50: 201
  • Jakes M E, Agran P, Ong K S. Does gastroesophageal reflux (GER) or low pH in the lower esophagus (LE) cause bronchoconstriction. Chest 1982; 82: 246
  • Harding S M, Richter J E, Guzzo M, Schan C A, Alexander R W, Richter J E. Asthma and gastroesophageal reflux: acid suppressive therapy improves asthma outcome. Am J Med 1996; 100: 395
  • Choy D, Leung R. Gastro-oesophageal reflux disease and asthma. Respirology 1997; 2: 163
  • Perrin-Fayolle M, Gormand F, Braillon G, Lombard-Platet R, Vignal J, Azzar D, Forichon J, Adeleine P. Long-term results of surgical treatment in asthmatic patients. Chest 1989; 96: 40
  • Ford G A, Oliver P S, Prior J S, Butland R JA, Wilkinson S P. Omeprazole in the treatment of asthmatics with nocturnal symptoms and gastro-oesophageal reflux: a placebo-controlled cross-over study. Postgrad. Med J 1994; 70: 350
  • Vincent D, Cohen-Jonathan A M, Leport J, Mer-rouche M, Geronimi A, Pradalier A, Soule J C. Gastro-oesophageal reflux prevalence and relationship with bronchial reactivity in asthma. Eur Respir J 1997; 10: 2255
  • Boeree M J, Peters F TM, Postma D S, Kleibeuker J H. No effects of high-dose omeprazole in patients with severe airway hyperresponsiveness and (asymptomatic gastro-oesophageal reflux. Eur Respir J 1998; 11: 1070
  • Levin T R, Sperling R M, McQuaid R. Omeprazole improves peak expiratory flow rate and quality of life in asthmatics with gastroesophageal reflux. Am J Gastroenterol 1998; 93: 1060
  • Rothenberg S S, Bratton D, Larsen G, Deterding R, Milgrom H, Brugman S, Boguniewicz M, Copen-haver S, White C, Wagener J, Fan L, Chang J, Stathos T. Laparoscopic fundoplication to enhance pulmonary function in children with severe reactive airway disease and gastroesophageal reflux disease. Surg Endoscopy 1997; 11: 1088
  • Field S K, Underwood M, Brant R, Cowie R L. Prevalence of gastroesophageal reflux symptoms in asthma. Chest 1996; 109: 316
  • Sontag S J, O'Connell S, Khandelwal S, Miller T, Nemchausky B, Schnell T G, Serlovsky R. Most asthmatics have GER with or without bronchodilator therapy. Gastroenterology 1990; 99: 613
  • Sontag S J, Schnell T G, Miller T Q, Khandelwal S, O'Connell S, Chejfec G, Greenlee H, Seidel U J, Brand L. Prevalence of oesophagitis in asthmatics. Gut 1992; 33: 872
  • Shapiro G G, Christie D C. Gastroesophageal reflux in steroid dependent asthmatic youths. Pediatrics 1979; 63: 207
  • Balston B M, Kravitz E KS, McGeady S J. Diagnosis and treatment of gastroesophageal reflux in children and adolescents with severe asthma. Ann Allergy Asthma Immunol 1998; 81: 159
  • Berquist W E, Rachelefsky G S, Kadden M, Siegel S C, Katz R M, Fonkalsrud E W, Ament M E. Gastroesophageal reflux-associated recurrent pneumonia and chronic asthma in children. Pediatrics 1981; 68: 29
  • Iverson L IG, May I A, Samson P C. Pulmonary complications in benign esophageal disease. Am J Surg 1973; 126: 223
  • Lomasney T L. Hiatus hernia and the respiratory tract. Ann Thome Surg 1977; 24: 448
  • Henderson R D, Woolfe C R. Aspiration and gastroesophageal reflux. Can J Surg 1978; 21: 352
  • Pellegrini C A, DeMeester T R, Johnson L F, Skinner D B. Gastroesophageal reflux and pulmonary aspiration: incidence, functional abnormality and results of surgical therapy. Surgery 1979; 86: 110
  • Johnson D G, Syme W C, Matlak M E, Black R E, Herbst S J. Gastro-oesophageal reflux and respiratory disease: the place of the surgeon. Aust NZ J Surg 1984; 54: 405
  • Boyle J T, Altschuler S M, Nixon T E, Tuchman D N, Pack A I, Cohen S. Role of the diaphragm in the genesis of the lower esophageal pressure in the cat. Gastroenterology 1985; 88: 723
  • Welch R W, Gray J E. Influence of respiration on recordings of lower esophageal sphincter pressure in humans. Gastroenterology 1982; 83: 590
  • Mays E E, DuBois J J, Hamilton G B. Pulmonary fibrosis associated with tracheobronchial aspiration. A study of the frequency of hiatal hernia and gastroesophageal reflux in interstitial pulmonary fibrosis of obscure etiology. Chest 1976; 69: 512
  • Pearson J EG, Wilson R SE. Diffuse pulmonary fibrosis and hiatus hernia. Thorax 1971; 26: 300
  • Scott R B, O'Loughlin E V, Gall D G. Gastroesophageal reflux in patients with cystic fibrosis. J Pediatr 1985; 106: 223
  • Kennedy J H. ‘Silent’ gastroesophageal reflux: an important but little known cause of pulmonary complications. Dis Chest 1962; 42: 42
  • Singh V, Jain N K. Asthma as a cause for, rather than a result of gastroesophageal reflux. J Asthma 1983; 20: 241
  • Moote D W, Lloyd D A, McCourtie D R, Wells G A. Increase in gastroesophageal reflux during metha-choline-induced bronchospasm. J Allergy Clin Immunol 1986; 78: 619
  • Ekstrom TK-A, Tibbling L IE. Can mild bronchospasm reduce gastroesophageal reflux. Am Rev Respir Dis 1989; 139: 52
  • Zfass A M, Prince R, Allen F N, Farrar J T. Inhibitory beta adrenergic receptors in the human distal esophagus. Am J Dig Dis 1970; 15: 303
  • Goyal R K, Rattan S. Mechanism of the lower esophageal sphincter relaxation: action of Prostaglandin El and theophylline. J Clin Invest 1973; 52: 337
  • Schindlbeck N E, Heinrich C, Huber R M, Muller-Lissner S A. Effects of albuterol (salbutamol) on esophageal motility and gastroesophageal reflux in patients with asthma. JAMA 1988; 260: 3156
  • Michoud M C, Leduc T, Proulx F, Perreault S, Du Souich P, Duranceau A, Amyot R. Effect of salbutamol on gastroesophageal reflux in healthy volunteers and patients with asthma. J Allergy Clin Immunol 1991; 87: 762
  • Berquist W E, Rachelefsky G S, Rowshan N, Siegel S, Katz R, Welch M. Quantitative gastroesophageal reflux and pulmonary function in asthmatic children and normal adults receiving placebo, theophylline, and metaproterenol sulfate therapy. J. Allergy Clin Immunol 1984; 73: 253
  • Stein M R, Towner T G, Weber R W, Mansfield L E, Jacobson K W, McDonnell J T, Nelson H S. The effect of theophylline on lower esophageal sphincter pressure. Ann Allergy 1980; 45: 238
  • Foster L J, Trudeau W L, Goldman A L. Bronchodila-tor effects on gastric acid secretion. JAMA 1979; 241: 2613
  • Berquist W E, Rachelefsky G S, Kadden M, Siegel S C, Katz R M, Mickey M R, Ament M E. Effect of theophylline on gastroesophageal reflux in normal adults. J Allergy Clin Immunol 1981; 67: 407
  • Ekstrom T, Tibbling L. Influence of theophylline on gastro-oesophageal reflux and asthma. Eur J Clin Pharmacol 1988; 35: 353
  • Hubert D, Gaudric M, Guerre J. Effect of theophylline on gastroesophageal reflux in patients with asthma. J Allergy Clin Immunol 1988; 81: 1168
  • Ruzkowski C J, Sanowski R A, Austin J R, Thowedder J J, Waring J P. The effects of inhaled albuterol and oral theophylline on gastroesophageal reflux in patients with gastroesophageal reflux disease and obstructive lung disease. Arch Intern Med 1992; 152: 783
  • Ekstrom T, Lindgren B R, Tibbling L. Effects of ranitidine treatment on patients with asthma and a history of gastro-oesophageal reflux: a double blind crossover study. Thorax 1989; 44: 19
  • Monges H, Salducci J, Naudy B. Dissociation between the electrical activity of the diaphragmic dome and crura muscular fibres during esophageal distension, vomiting and eructation. J Physiol (Paris) 1978; 74: 547
  • Harding R, Titchen D A. Chemosensitive vagal endings in the oesophagus of the cat. J Physiol 1975; 247: 52P
  • Bray G W. Recent advances in the treatment of asthma and hay fever. Practitioner 1934; 34: 368
  • Greyson N D, Reid R H, Liu Y C, Thomas P. Radionuclide assessment in nocturnal asthma. Clin Nucl Med 1982; 7: 318
  • Ghaed N, Stein M R. Assessment of a technique for scintigraphic monitoring of pulmonary aspiration of gastric contents in asthmatics with gastroesophageal reflux. Ann Allergy 1979; 42: 306
  • Gastal O L, Castell J A, Castell D O. Frequency and site of gastroesophageal reflux in patients with chest symptoms. Studies using proximal and distal pH monitoring. Chest 1994; 106: 1793
  • Field S K. A critical review of the studies of the effects of simulated or real gastroesophageal reflux on pulmonary function in adult asthmatics. Chest 1999; 115: 848
  • Irwin R S, Zawacki J K, Curley F J, French C L, Hoffman P J. Chronic cough as the sole manifestation of gastroesophageal reflux. Am Rev Respir Dis 1989; 140: 1294
  • Fitzgerald J M, Allen C J, Craven M A, Newhouse M T. Chronic cough and gastroesophageal reflux. Can Med Assoc J 1989; 140: 520
  • Ing A J, Ngu M C, Breslin A BX. Chronic persistent cough and gastro-oesophageal reflux. Thorax 1991; 46: 479
  • Ing A J, Ngu M C, Breslin A B. Pathogenesis of chronic persistent cough associated with gastroeso-paheal reflux. Am J Respir Crit Care Med 1994; 149: 160
  • Ferrari M, Olivieri M, Sembenini C, Benini L, Zuc-cali V, Bardelli E, Bovo P, Cavallini G, Vantini I, LoClasco V. Tussive effect of capsaicin in patients with gastroesophageal reflux without cough. Am J Respir Crit Care Med 1995; 151: 557
  • Hamamoto J, Kohrogi H, Kawano O, Iwagoe H, Fujii K, Hirata N, Ando M. Esophageal stimulation by hydrochloric acid causes neurogenic inflammation in the airways in guinea pigs. J Appl Physiol 1997; 82: 738
  • Larrain A, Carrasco E, Galleguillos F, Sepulveda R, Pope C E. Medical and surgical treatment of nonallelic asthma associated with gastroesophageal reflux. Chest 1991; 99: 1330
  • Kjellen G, Tibbling L, Wranne B. Effect of conservative treatment of oesophageal dysfunction on bronchial asthma. Eur J Resp Dis 1981; 62: 190
  • Goodall R JR, Earis J E, Cooper D N, Bernstein A, Temple J G. Relationship between asthma and gastro-oesophageal reflux. Thorax 1981; 36: 116
  • Nagel R A, Brown P, Perks W H, Wilson R, Kerr G D. Ambulatory pH monitoring of gastro-oesophageal reflux in morning dipper asthma. Br Med J 1988; 297: 1371
  • Gustafsson P M, Kjellman N-I M, Tibbling L. A trial of ranitidine in asthmatic children and adolescents with or without pathological gastro-oesophageal reflux. Eur Respir J 1992; 5: 201
  • Tucci F, Resti M, Fontana R, Novembre E, Lami C A, Vierucci A. Gastroesophageal reflux and bronchial asthma prevalence and effect of cisapride therapy. Pediatr Gastroenterol Nutr 1993; 27: 265
  • Meier J H, McNally P R, Punja M, Freeman S R, Sud-duth R H, Stacker N, Perry M, Spaulding H S. Does omeprazole (Prilosec) improve respiratory function in asthmatics with gastroesophageal reflux? A double-blind placebo-controlled crossover study. Dig Dis Sci 1994; 39: 2127
  • Teichtahl H, Yeomans N D, Kronborg I J, Robinson P. Adult asthma and gastro-oesophageal reflux: the effects of omeprazole therapy on asthma. Aust NZ J Med 1996; 26: 671
  • Field S K, Sutherland L R. Does medical antireflux therapy improve asthma in asthmatics with gastroesophageal reflux? A critical review of the literature. Chest 1998; 114: 275
  • DeMeester T R, Bonavina L, Iascone C, Courtney J V, Skinner D B. Chronic respiratory symptoms and occult gastroesophageal reflux. Prospective clinical study and results of surgical therapy. Ann Surg 1990; 211: 337
  • Vaezi M F, Richter J E. Role of acid and duodenogas-troesophageal reflux in gastroesophageal reflux disease. Gastroenterology 1996; 222: 1192
  • Juniper E F, Kline P A, Vanzieleghem M A, Ramsdale E H, O'Byrne P M, Hargreave F E. Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in nonsteroid-dependent asthmatics. Am Rev Respir Dis 1990; 242: 832
  • Foglia R P, Fonkalsrud E W, Ament M E, Byrne W J, Berquist W, Siegel S C, Katz R M, Rachelefsky G S. Gastroesophageal fundoplication for the management of chronic pulmonary disease in children. Am J Surg 1980; 140: 72
  • Mays E E. Intrinsic asthma in adults. Association with gastroesophageal reflux. JAMA 1976; 236: 2626
  • Sontag S, O'Connell S, Greenlee H, Schnell T, Chintam R, Nemchausky B, Chejfec G, van Drunan M, Wanner J. Is gastroesophageal reflux a factor in some asthmatics. Am J Gastroenterol 1987; 82: 119
  • Ribet M, Pruvot F R, Mensier E, Ghoch K, Rousseau B. Gastro-oesophageal reflux and respiratory disorders treated by Hill's procedure. Eur J Cardio-thorac Surg 1989; 3: 414
  • Bittner H B, Meyers W C, Brazer S R, Pappas T N. La-parascopic Nissen fundoplication: operative results and short-term follow-up. Am J Surg 1994; 267: 193
  • Davis M V. Evolving concepts regarding hiatus hernia and gastroesophageal reflux. Ann Thorac Surg 1969; 7: 120
  • Klotz S D, Moeller R K. Hiatal hernia and intractable bronchial asthma. Ann Allergy 1971; 29: 325
  • Babb R R, Notarangelo J, Smith V C. Wheezing: a clue to gastroesophageal reflux. Am J Gastroenterol 1970; 53: 230
  • Christie D L, O'Grady L R, Mack D V. Incompetent lower esophageal sphincter and gastroesophageal reflux in recurrent acute pulmonary disease of infancy and childhood. J Pediatr 1978; 93: 23
  • Tardif C, Nouvet G, Denis P, Tombelaine R, Pasquis P. Surgical treatment of gastroesophageal reflux in ten patients with severe asthma. Respiration 1989; 56: 110
  • Buts J P, Barudi C, Moulin D, Claus D, Cornu G, Otte J B. Prevalence and treatment of silent gastro-oesophageal reflux in children with recurrent respiratory disorders. Eur J Pediatr 1986; 245: 396
  • Sontag S J, O'Connell S, Khandelwal S, Greenlee H, Chejfec G, Nemchausky B, Schnell T, Miller T, Brand L. Antireflux surgery in asthmatics with reflux (GER) improves pulmonary symptoms and function. Gastroenterology 1990; 98: A128
  • Alexander R, Kopita J, Kussin I, Pappas T, Brazer S, Kussin P. Outcome of laparoscopic Nissen fundoplication for asthma associated with refractory gastroesophageal reflux: evidence for clinical benefit at one year follow-up. Am J Respir Crit Care Med 1994; 149: A202
  • Pratter M R, Curley F J, Dubois J, Irwin R S. Cause and evaluation of chronic dyspnea in a pulmonary disease clinic. Arch Mem Med 1989; 149: 2277
  • DePaso W J, Winterbauer R H, Lusk J A, Dresi D F, Springmeyer S C. Chronic dyspnea unexplained by history, chest roentgenogram, and spirometry. Analysis of a seven year experience. Chest 1991; 200: 1293
  • Killian K J, Campbell E JM. Dyspnea. The Thorax, 2nd ed. Lung Biology in Health and Disease, C Roussos. Marcel Dekker, New York 1995; 1709–1741
  • Higgs C MB, Laszlo G. Perception of asthma. Respiratory Sensation Lung Biology in Health and Disease, L Adams, A Guz. Marcel Dekker, New York 1996; 285–309
  • Field S K, Bell S G, Cenaiko D F, Whitelaw W A. Relationship between respiratory effort and breath-lessness in pregnancy. J Appl Physiol 1991; 72: 1897
  • Sarton E, Dahan A, Teppema L, Van den Eisen E, Olofsen E, Berkenbosch A, Van Kleef J. Acute pain and central nervous system arousal do not restore impaired hypoxic ventilatory response during se-voflurane sedation. Anesthesiology 1996; 85: 295
  • Bourke D L. Respiratory effects of regional anesthesia during acute pain. Reg Anesth 1993; 18: 361
  • Borgbjerg F M, Nielsen K, Franks K J. Experimental pain stimulates respiration and attenuates morphine-induced respiratory depression: a controlled study in human volunteers. Pain 1996; 64: 123
  • Field S K, Evans J A, Price L M. The effects of acid perfusion of the esophagus on ventilation and respiratory sensation. Am J Respir Crit Care Med 1998; 157: 1058
  • Shaker R, Dodds W J, Ren J, Hogan W J, Arndorfer R C. Esophagoglottal closure reflex: a mechanism of airway protection. Gastroenterology 1992; 102: 857
  • Kienle G S, Kiene H. Placebo effect and placebo concept: a critical methodological and conceptual analysis of reports on the magnitude of the placebo effect. Alt Ther Health Med 1996; 2: 39
  • Juniper E F, Guyatt G H, Ferrie P J. Measuring quality of life in asthma QOL. Am Rev Respir Dis 1993; 247: 832

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.