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Acta Radiologica Volume 32, 1991 - Issue 2
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Original Article

Muscle Toxicity of Diatrizoate and Iohexol in Rabbits

A model for local tissue damage

H. S. Thomsen Department of Diagnostic Radiology, Köbenhavns Amts Sygehus, Herlev, Denmark; Department of Diagnostic Radiology, University of Copenhagen, Denmark; Department of Diagnostic Radiology, Experimental Research, Malmö Allmänna Sjukhus, University of Lund, Sweden; Department of/Diagnostic Radiology, Scantox A/S, Lille Skensved, Denmark
,
Klaes Golman Department of Diagnostic Radiology, Köbenhavns Amts Sygehus, Herlev, Denmark; Department of Diagnostic Radiology, University of Copenhagen, Denmark; Department of Diagnostic Radiology, Experimental Research, Malmö Allmänna Sjukhus, University of Lund, Sweden; Department of/Diagnostic Radiology, Scantox A/S, Lille Skensved, Denmark
&
O. Svendsen Department of Diagnostic Radiology, Köbenhavns Amts Sygehus, Herlev, Denmark; Department of Diagnostic Radiology, University of Copenhagen, Denmark; Department of Diagnostic Radiology, Experimental Research, Malmö Allmänna Sjukhus, University of Lund, Sweden; Department of/Diagnostic Radiology, Scantox A/S, Lille Skensved, Denmark
Pages 182-183 | Accepted 20 Nov 1990, Published online: 07 Jan 2010

References

  • Cohan R. H., Leder R. A., Bolick D., et al. Extravascular extravasation of radiographic contrast media. Effects of conventional and low-osmolar agents in the rat thigh. Invest. Radiol 1990; 25: 504
  • Kim S. H., Park J. H., Kim Y. J., Kim C. W., Han M. C. Experimental tissue damage after subcutaneous injection of water soluble contrast media. Invest. Radiol 1990; 25: 678
  • Svendsen O. Local muscle damage and oily vehicles. A study on local reactions in rabbits after intramuscular injection of neuroleptic drugs in aqueous or oily vehicles. Acta Pharmacol. Toxicol 1983; 52: 298
  • Svendsen O. Intramuscular injections and local muscle damage. An experimental study of the effect on injection speed. Acta Pharmacol. Toxicol 1983; 52: 305
  • Svendsen O., Hojelse F., Bagdon R. Tests for local toxicity of intramuscular drug preparations. Comparison of in vivo and in vitro methods. Acta Pharmacol. Toxicol 1985; 56: 183
  • Svendsen O., Rasmussen F., Nielsen P., Steiness E. The loss of creatine Phosphokinase (CK) from intramuscular injection sites in rabbits. A predictive tool for local muscle damage. Acta Pharmacol. Toxicol 1979; 44: 324

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