The number of identified lymph node metastases increases continuously with increased total lymph node recovery in pT3 colon cancer

References

• Chau I, Cunningham D. Adjuvant therapy in colon cancer–what, when and how?. Ann Oncol 2006; 17: 1347–59
   PubMed Web of Science ®Google Scholar
• Caplin S, Cerottini JP, Bosman FT, Constanda MT, Givel JC. For patients with Dukes' B (TNM Stage II) colorectal carcinoma, examination of six or fewer lymph nodes is related to poor prognosis. Cancer 1998; 83: 666–72
   PubMed Web of Science ®Google Scholar
• Cianchi F, Palomba A, Boddi V, Messerini L, Pucciani F, Perigli G, et al. Lymph node recovery from colorectal tumor specimens: Recommendation for a minimum number of lymph nodes to be examined. World J Surg 2002; 26: 384–9
   PubMed Web of Science ®Google Scholar
• Johnson PM, Porter GA, Ricciardi R, Baxter NN. Increasing negative lymph node count is independently associated with improved long-term survival in stage IIIB and IIIC colon cancer. J Clin Oncol 2006; 24: 3570–5
   PubMed Web of Science ®Google Scholar
• Sarli L, Bader G, Iusco D, Salvemini C, Mauro DD, Mazzeo A, et al. Number of lymph nodes examined and prognosis of TNM stage II colorectal cancer. Eur J Cancer 2005; 41: 272–9
   PubMed Web of Science ®Google Scholar
• Swanson RS, Compton CC, Stewart AK, Bland KI. The prognosis of T3N0 colon cancer is dependent on the number of lymph nodes examined. Ann Surg Oncol 2003; 10: 65–71
   PubMed Web of Science ®Google Scholar
• Tsai HL, Lu CY, Hsieh JS, Wu DC, Jan CM, Chai CY, et al. The prognostic significance of total lymph node harvest in patients with T2-4N0M0 colorectal cancer. J Gastrointest Surg 2007; 11: 660–5
   PubMedGoogle Scholar
• Vather, R, Sammour, T, Zargar-Shoshtari, K, Metcalf, P, Connolly, A, Hill, A. Lymph node examination as a predictor of long-term outcome in Dukes B colon cancer. Int J Colorectal Dis 2008, [Epub ahead of print].
   PubMedGoogle Scholar
• Jestin P, Pahlman L, Glimelius B, Gunnarsson U. Cancer staging and survival in colon cancer is dependent on the quality of the pathologists' specimen examination. Eur J Cancer 2005; 41: 2071–8
   PubMed Web of Science ®Google Scholar
• Luna-Perez P, Rodriguez-Ramirez S, Alvarado I, Gutierrez de la Barrera M, Labastida S. Prognostic significance of retrieved lymph nodes per specimen in resected rectal adenocarcinoma after preoperative chemoradiation therapy. Arch Med Res 2003; 34: 281–6
   PubMedGoogle Scholar
• Iddings D, Ahmad A, Elashoff D, Bilchik A. The prognostic effect of micrometastases in previously staged lymph node negative (N0) colorectal carcinoma: A meta-analysis. Ann Surg Oncol 2006; 13: 1386–92
   PubMedGoogle Scholar
• Pheby DF, Levine DF, Pitcher RW, Shepherd NA. Lymph node harvests directly influence the staging of colorectal cancer: Evidence from a regional audit. J Clin Pathol 2004; 57: 43–7
   PubMed Web of Science ®Google Scholar
• Goldstein NS. Lymph node recoveries from 2427 pT3 colorectal resection specimens spanning 45 years: Recommendations for a minimum number of recovered lymph nodes based on predictive probabilities. Am J Surg Pathol 2002; 26: 179–89
   PubMed Web of Science ®Google Scholar
• Kim J, Huynh R, Abraham I, Kim E, Kumar RR. Number of lymph nodes examined and its impact on colorectal cancer staging. Am Surg 2006; 72: 902–5
   PubMedGoogle Scholar
• Wittekind, C, Greene, F, Hutter, R, M Klimpfinger, L Sobin. TNM Atlas: Illustrated guide to the TNM classification of malignant tumours, 5th ed. Germany: Springer; 2005. p 101–113.
   Google Scholar
• Moertel CG, Fleming TR, Macdonald JS, Haller DG, Laurie JA, Goodman PJ, et al. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med 1990; 322: 352–8
   PubMed Web of Science ®Google Scholar
• Monig SP, Baldus SE, Zirbes TK, Schroder W, Lindemann DG, Dienes HP, et al. Lymph node size and metastatic infiltration in colon cancer. Ann Surg Oncol 1999; 6: 579–81
   PubMedGoogle Scholar
• Richter D, Lorenz D, Isemer FE, Braun S, Fisseler-Eckhoff A. [Acetone treatment of lymph node preparations in staging colorectal specimens]. Pathologe 2007; 28: 269–72
   PubMedGoogle Scholar
• Tepper JE, O'Connell MJ, Niedzwiecki D, Hollis D, Compton C, Benson AB, 3rd, et al. Impact of number of nodes retrieved on outcome in patients with rectal cancer. J Clin Oncol 2001; 19: 157–63
   PubMed Web of Science ®Google Scholar
• Wong JH, Severino R, Honnebier MB, Tom P, Namiki TS. Number of nodes examined and staging accuracy in colorectal carcinoma. J Clin Oncol 1999; 17: 2896–900
   PubMed Web of Science ®Google Scholar
• Cserni G, Vinh-Hung V, Burzykowski T. Is there a minimum number of lymph nodes that should be histologically assessed for a reliable nodal staging of T3N0M0 colorectal carcinomas?. J Surg Oncol 2002; 81: 63–9
   PubMed Web of Science ®Google Scholar
• Iversen LH, Laurberg S, Hagemann-Madsen R, Dybdahl H. Increased lymph node harvest from colorectal cancer resections using GEWF solution: A randomized study. J Clin Pathol 2008; 61: 1203–8
   PubMed Web of Science ®Google Scholar
• Markl B, Kerwel TG, Jahnig HG, Oruzio D, Arnholdt HM, Scholer C, et al. Methylene blue-assisted lymph node dissection in colon specimens: A prospective, randomized study. Am J Clin Pathol 2008; 130: 913–9
   PubMedGoogle Scholar
• Newell KJ, Sawaka BW, Rudrick BF, Driman DK. GEWF solution: An inexpensive, simple, and effective aid for the retrieval of lymph nodes from colorectal cancer resections. Arch Pathol Lab Med 2001; 125: 642–5
   PubMed Web of Science ®Google Scholar