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Original Article

Preoperative radiotherapy and extracellular matrix remodeling in rectal mucosa and tumour matrix metalloproteinases and plasminogen components

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Pages 1144-1151 | Received 03 Apr 2009, Published online: 28 Oct 2009

References

  • Folkesson J, Birgisson H, Pahlman L, Cedermark B, Glimelius B, Gunnarsson U. Swedish Rectal Cancer Trial: Long lasting benefits from radiotherapy on survival and local recurrence rate. J Clin Oncol 2005; 23: 5644–50
  • Birgisson H, Pahlman L, Gunnarsson U, Glimelius B. Late adverse effects of radiation therapy for rectal cancer – a systematic overview. Acta Oncol 2007; 46: 504–16
  • Baker EA, Bergin FG, Leaper DJ. Matrix metalloproteinases, their tissue inhibitors and colorectal cancer staging. Br J Surg 2000; 87: 1215–21
  • Hovdenak N, Wang J, Sung CC, Kelly T, Fajardo LF, Hauer-Jensen M. Clinical significance of increased gelatinolytic activity in the rectal mucosa during external beam radiation therapy of prostate cancer. Int J Radiat Oncol Biol Phys 2002; 53: 919–27
  • Kumar A, Collins HM, Scholefield JH, Watson SA. Increased type-IV collagenase (MMP-2 and MMP-9) activity following preoperative radiotherapy in rectal cancer. Br J Cancer 2000; 82: 960–5
  • Angenete E, Langenskiold M, Falk P, Ivarsson ML. Matrix metalloproteinases in rectal mucosa, tumour and plasma: Response after preoperative irradiation. Int J Colorectal Dis 2007; 22: 667–74
  • Unsal Kilic D, Uner A, Akyurek N, Erpolat P, Dursun A, Pak Y. Matrix metalloproteinase-9 expression correlated with tumor response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy. Int J Radiat Oncol Biol Phys 2007; 67: 196–203
  • Bentzen SM. Preventing or reducing late side effects of radiation therapy: Radiobiology meets molecular pathology. Nat Rev Cancer 2006; 6: 702–13
  • Johnson LB, Adawi D, Agren MS, Jorgensen LN, Wittgren L, Mattsson S, et al. Combination of pre-operative radiotherapy and surgery suppresses local accumulation of collagen and TGF-beta1 in rats. J Surg Res 2006; 133: 136–42
  • Richter KK, Fink LM, Hughes BM, Shmaysani HM, Sung CC, Hauer-Jensen M. Differential effect of radiation on endothelial cell function in rectal cancer and normal rectum. Am J Surg 1998; 176: 642–7
  • Angenete E, Langenskiold M, Palmgren I, Falk P, Oresland T, Ivarsson ML. Transforming growth factor beta-1 in rectal tumour, mucosa and plasma in relation to radiotherapy and clinical outcome in rectal cancer patients. Int J Colorectal Dis 2007; 22: 1331–8
  • Loskutoff DJ, Quigley JP. PAI-1, fibrosis, and the elusive provisional fibrin matrix. J Clin Invest 2000; 106: 1441–3
  • Zhao W, Spitz DR, Oberley LW, Robbins ME. Redox modulation of the pro-fibrogenic mediator plasminogen activator inhibitor-1 following ionizing radiation. Cancer Res 2001; 61: 5537–43
  • Angenete, E, Langenskiold, M, Palmgren, I, Falk, P, Oresland, T, Ivarsson, ML. uPA and PAI-1 in rectal cancer-relationship to radiotherapy and clinical outcome. J Surg Res 2008.
  • Strup-Perrot C, Vozenin-Brotons MC, Vandamme M, Benderitter M, Mathe D. Expression and activation of MMP-2, -3, -9, -14 are induced in rat colon after abdominal X-irradiation. Scand J Gastroenterol 2006; 41: 60–70
  • Ivarsson ML, Bergstrom M, Eriksson E, Risberg B, Holmdahl L. Tissue markers as predictors of postoperative adhesions. Br J Surg 1998; 85: 1549–54
  • Gebhardt C, Nemeth J, Angel P, Hess J. S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol 2006; 72: 1622–31
  • Isaksen B, Fagerhol MK. Calprotectin inhibits matrix metalloproteinases by sequestration of zinc. Mol Pathol 2001; 54: 289–92
  • Larsen A, Bjorge B, Klementsen B, Helgeland L, Wentzel-Larsen T, Fagerhol MK, et al. Time patterns of changes in biomarkers, symptoms and histopathology during pelvic radiotherapy. Acta Oncol 2007; 46: 639–50
  • Hille, A, Schmidt-Giese, E, Hermann, RM, Herrmann, MK, Rave-Frank, M, Schirmer, M, , et al. A prospective study of faecal calprotectin and lactoferrin in the monitoring of acute radiation proctitis in prostate cancer treatment. Scand J Gastroenterol 2007:1–7.
  • Lowry O, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265–75
  • Speake WJ, Dean RA, Kumar A, Morris TM, Scholefield JH, Watson SA. Radiation induced MMP expression from rectal cancer is short lived but contributes to in vitro invasion. Eur J Surg Oncol 2005; 31: 869–74
  • Stumpf M, Klinge U, Wilms A, Zabrocki R, Rosch R, Junge K, et al. Changes of the extracellular matrix as a risk factor for anastomotic leakage after large bowel surgery. Surgery 2005; 137: 229–34
  • Matthiessen P, Hallbook O, Andersson M, Rutegard J, Sjodahl R. Risk factors for anastomotic leakage after anterior resection of the rectum. Colorectal Dis 2004; 6: 462–9
  • Hartley A, Giridharan S, Gray L, Billingham L, Ismail T, Geh JI. Retrospective study of acute toxicity following short-course preoperative radiotherapy. Br J Surg 2002; 89: 889–95
  • Zou, Y, Qi, Y, Roztocil, E, Davies, MG. Patterns of gelatinase activation induced by injury in the murine femoral artery. J Surg Res 2008.

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