668
Views
22
CrossRef citations to date
0
Altmetric
Original Article

Synaptophysin A widespread constituent of small neuroendocrine vesicles and a new tool in tumor diagnosis

Pages 435-440 | Accepted 11 Dec 1990, Published online: 08 Jul 2009

References

  • Wiedenmann B, Huttner WB. Synaptophysin and chromogranins/secretogranins—widespread constituents of distinct types of neuroendocrine vesicles and new tools in tumor diagnosis. Virchows Arch (B) 1989; 58: 95–121
  • Wiedenmann B, Franke WW. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38 000 characteristic of presynaptic vesicles. Cell 1985; 41: 1017–28
  • Whittaker VP. Cholinergic synaptic vesicles from the electromotor nerve terminals of torpedo—Composition and life cycle. Ann NY Acad Sci 1987; 493: 77–91
  • Naito S, Ueda T. Adenosine triphosphate-dependent uptake of glutamate into protein I-associated synaptic vesicles. J Biol Chem 1983; 258: 696–9
  • Naito S, Ueda T. Characterization of glutamate uptake into synaptic vessels. J Neurochem 1985; 44: 99–109
  • Maycox P R, Deckwerth Th., Hell J W, Jahn R. Glutamate uptake by brain synaptic vesicles—Energy dependence of transport and functional reconstitution in proteoliposomes. J Biol Chcm 1988; 263: 1523–8
  • Fykse E M, Fonnum F. Uptake of γ-aminobutyric acid by a synaptic vesicle fraction isolated from rat brain. J Neurochem 1988; 50: 1237–42
  • Hell J W, Maycox P R, Stadler H, Jahn R. Uptake of GABA by rat brain synaptic vesicles isolated by a new procedure. EMBO J 1988; 7: 3023–9
  • Kish P E, Fischer-Bovenkerk C, Ueda T. Active transport of γ-aminobutyric acid and glycine into synaptic vesicles. Proc Natl Acad Sci USA 1989; 86: 3877–81
  • Maycox P R, Hell J W, Jahn R. Amino acid neurotransmission: spotlight on synaptic vesicles. Trends Neurosci 1990; 13: 83–7
  • Lundberg J M, Hökfelt T. Coexistence of peptides and classical neurotransmitters. Trends Neurosci 1983; 6: 325–33
  • Orci L, Ravazzola M, Amherdt M, et al. The trans-most cisternae of the Golgi complex: A compartment for sorting of secretory and plasma membrane proteins. Cell 1987; 51: 1039–51
  • Tooze J, Tooze S A, Fuller SD. Sorting of progency coronavirus from condensed secretory proteins at the exit from the trans-Golgi network of AtT20 cells. J Cell Biol 1987; 105: 1215–26
  • Rosa P, Fumagalli G, Zanini A, Huttner WB. The major tyrosine-sulfated protein of the bovine anterior pituitary is a secretory protein present in the gonadotrophs, thyrotrophs, mammotrophs and corticotrophs. J Cell Biol 1985; 100: 928–37
  • Rosa P, Hille A, Lee R W, Zanini A, De Camilli P, Huttner WB. Secretogranins I and II: two tyrosine-sulfated secretory proteins common to a variety of cells secreting peptides by the regulated pathway. J Cell Biol 1985; 101: 1999–2011
  • Eiden L E, Huttner W B, Mallet J, O'Connor D T, Winkler H, Zanini A. A Nonenclature proposed for the chromogranin/ secretogranin proteins. Neuroscience 1987; 21: 1019–21
  • Fischer-Colbrie R, Hagen C, Schober M. Chromogranins A, B, and C: widespread constituents of secretory vesicles. Ann NY Acad Sci 1987; 493: 120–34
  • Jahn R, Schiebler W, Ouimet C, Greengard P. A 38 000-dalton membrane protein (p38) present in synaptic vesicles. Proc Natl Acad Sci USA 1985; 82: 4137–41
  • Huttner W B, Schiebler W, Greengard P, De Camilli P. Synapsin I (protein I), a nerve terminal-specific phosphor-protein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation. J Cell Biol 1983; 96: 1374–88
  • Navone F, Jahn R, Di Gioia G, Stukenbrok H, Greengard P, De Camilli P. Protein 38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells. J Cell Biol 1986; 103: 2511–27
  • Rehm H, Wiedenmann B, Betz H. Molecular characterization of synaptophysin, a major calcium binding protein of the synaptic vesicle membrane. EMBO J 1986; 5: 535–41
  • Wiedenmann B, Franke W W, Kuhn C, Moll R, Gould VE. Synaptophys In: a marker protein for neuroendocrine cells and neoplasms. Proc Natl Acad Sci USA 1986; 83: 3500–4
  • Lee I, Gould V E, Moll R, Wiedenmann B, Franke WW. Synaptophysin expressed in the bronchopulmonary tract: neuroendocrine cells, neuroepithelial bodies, and neuroendocrine neoplasms. Differentiation 1987; 34: 115–25
  • Thomas L, Hartung K, Langosch D, et al. Identification of synaptophysin as a hexameric channel protein of the synaptic vesicle membrane. Science 1988; 242: 1050–3
  • Johnston P A, Siidhof TC. The multisubunit structure of synaptophysin—Relationship between disulfide bonding and homo-oligomerization. J Biol Chem 1990; 265: 8869–73
  • Buckley K M, Floor E, Kelly RB. Cloning and sequence analysis of cDNA encoding p38, a major synaptic vesicle protein. J Cell Biol 1987; 105: 2447–56
  • Leube R E, Kaiser P, Seiter A, et al. Synaptophys In: molecular organization and raRNA expression as determined from cloned cDNA. EMBO J 1987; 6: 3261–8
  • Siidhof T C, Lottspeich F, Greengard P, Mehl E, Jahn R. A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions. Science 1987; 238: 1142–4
  • Pang D T, Wang J K, Valtorta F, Benfenati F, Greengard P. Protein tyrosine phosphorylation in synaptic vesicles. Proc Natl Acad Sci USA 1988; 85: 762–6
  • Johnston P A, Jahn R, Siidhoff TC. Transmembrane topography and evolutionary conservation of synaptophysin. J Biol Chem 1989; 264: 1268–73
  • Knaus P, Betz H. Mapping of a dominant immunogenic region of synaptophysin, a major membrane protein of synaptic vesicles. FEBS Lett 1990; 261: 358–60
  • Franke W W, Grund C, Achtstatter T. Co-expression of cy-tokeratins and neurofilament proteins in a permanent cell line: cultured rat PC 12 cells combine neuronal and epithelial features. J Cell Biol 1986; 103: 1933–43
  • Wiedenmann B, Rehm H, Franke WW. Synaptophysin, an integral membrane protein of vesicles present in normal and neoplastic neuroendocrine cells. Ann NY Acad Sci 1987; 493: 500–3
  • Tixier-Vidal A, Faivre-Bauman A, Picart R, Wiedenmann B. Immunoelectron microscopic localization of synaptophysin in a Golgi subcompartment of developing hypothalamic neurons. Neuroscience 1988; 26: 847–61
  • Lowe A W, Madeddu L, Kelly RB. Endocrine secretory granules and neuronal synaptic vesicles have three integral membrane proteins in common. J Cell Biol 1988; 106: 51–9
  • Obendorf D, Schwarzenbrunner U, Fischer-Colbrie R, Laslop A, Winkler H. In adrenal medulla synaptophysin (protein p38) is present in chromaffin granules in a special vesicle population. J Neurochem 1988; 51: 1573–80
  • Schilling K, Gratzl M. Quantification of p38/synaptophysin in highly purified adrenal medullary chromaffin vesicles. FEBS Lett 1988; 233: 22–4
  • Wiedenmann B, Rehm H, Knierim M, Becker C-M. Fractionation of synaptophysin-containing vesicles from rat brain and cultured PC 12 preochromocytoma cells. FEBS Lett 1988; 240: 71–7
  • Leube R E, Wiedenmann B, Franke WW. Topogenesis and sorting of synaptophys In: synthesis of a synaptic vesicle protein from a gene transfected into non-neuroendocrine cells. Cell 1989; 59: 433–46
  • Clift-O'Grady L, Linstedt A D, Lowe A W, Grote E, Kelly RB. Biogenesis of synaptic vesicle-like structures in a pheochromocytoma cell line PC-12. J Cell Biol 1990; 110: 1693–703
  • Johnston P A, Cameron P L, Stukenbrok H, Jahn R, De Camilli P, Siidhof ThC. Synaptophysin is targeted to similar microvesicles in CHO and PC 12 cells. EMBO J 1989; 8: 2863–72
  • Knaus P, Betz H, Rehm H. Expression of synaptophysin during postnatal development of the mouse brain. J Neurochem 1986; 47: 1302–4
  • Hoog A, Gould V E, Grimelius L, Franke W W, Fakmer S, Chejfec G. Tissue fixation methods alter the immunohisto-chemical demonstrability of synaptophysin. Ultrastruct Pathol 1988; 12: 673–8
  • Kayser K, Schmidt W, Ebert W, Wiedenmann B. Expression of neuroendocrine markers (neuron-specific enolase, synaptophysin and bombesin) in carcinoma of the lung. Pathol Res Pract 1988; 183: 412–7
  • Miettinen M. Synaptophysin and neurofilament proteins as markers for neuroendocrine tumors. Arch Pathol Lab Med 1987; 111: 813–8
  • Turbat-Herrera E A, Herrera G A, Gore I, Lott R L, Grizzle W E, Bonnin JM. Neuroendocrine differentiation in prostatic carcinomas. Arch Pathol Lab Med 1988; 112: 1100–5
  • Blomjous C EM, Thunnissen G BJM, Vos W, De Boogt H J, Meijer C JL M. Small cell neuroendocrine carcinoma of the urinary bladder. Virchows Arch A 1988; 413: 505–12
  • Buffa R, Rindi G, Sessa F, et al. Synaptophysin immunoreactivity and small clear vesicles in neuroendocrine cells and related tumours. Mol Cell Probes 1988; 1: 367–81
  • Wiedenmann B, Kuhn C, Schwechheimer K, et al. Synaptophysin identified in metastases of neuroendocrine tumors by immunocytochemistry and immunoblotting. Am J Clin Pathol 1987; 88: 560–69
  • Wiedenmann B, Waldherr R, Buhr H, Hille A, Rosa P, Huttner WB. Identification of gastroenteropancreatic neuroendocrine cells in normal and neoplastic human tissue with antibodies against synaptophysin, chromogranin A, secretogranin I (chromogranin B), and secretogranin II. Gastroenterology 1988; 95: 1364–74
  • Chejfec G, Falkmer S, Grimelius L, et al. Synaptophysin. A new marker for pancreatic neurondocrine tumors. Am J Surg Pathol 1987; 11: 241–7
  • Gould V E, Wiedenmann B, Lee I, et al. Synaptophysin expression in neuroendocrine neoplasms as determined by immunocytochemistry. Am J Pathol 1987; 126: 243–57

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.