221
Views
5
CrossRef citations to date
0
Altmetric
Original Article

Antiemetic Regimens in Outpatients Receiving Cisplatin and Non-Cisplatin Chemotherapy: A Randomized Trial Comparing High-Dose Metoclopramide Plus Methylprednisolone with and Without Lorazepam

, , , , , , , , & show all
Pages 623-627 | Received 08 Jun 1990, Accepted 08 Dec 1990, Published online: 08 Jul 2009

References

  • Ignoffo RJ. Adverse reactions to anticancer drugs. Manual of oncology therapeutics, K Lasley, R J Ignoffo. CV Mosby, St. Louis 1981; 249
  • Diaz-Rubio E. Tratamiento de los vomitos inducidos por ciostaticos. Med Clin (Barc) 1989; 93: 54–7
  • Penta J, Poster D, Bruno S. The pharmacologic treatment of nausea and vomiting caused by cancer chemotherapy: a review. Antiemetics and cancer chemotherapy, J Lazlo. Williams & Wilkins, Baltimore 1983; 53–92
  • Gralla R J, Itri I M, Pisko S E, et al. Antiemetic efficacy of high-dose metoclopramide: Randomized trials with placebo and prochloroperazine in patients with chemotherapy nausea and vomiting. N Engl J Med 1981; 305: 905–9
  • Kris M G, Gralla R J, Clark R A, et al. Incidence, course and severity of delayed nausea and vomiting following the administration of high-dose cisplatin. J Clin Oncol 1985; 3: 1379–84
  • Alavi J B, Torri S, Glover D, et al. High-dose oral metoclopramide: an effective antiemetic agent. Am J Clin Oncol 1985; 8: 260–5
  • Kris M G, Gralla R J, Tyson L B, et al. Improved control of cisplatin-induced emesis with high-dose metoclopramide and with combinations of metoclopramide, dexamethasone and diphenhydramine. Cancer 1985; 55: 527–34
  • Bruera E D, Roca E, Cedaro L, et al. Improved control of chemotherapy-induced emesis by the addition of dexamethasone to metoclopramide in patients resistant to metoclopramide. Cancer Treat Rep 1983; 67: 381–3
  • Roila F, Tonato M, Basurto C, et al. Antiemetic activity of high-doses of metoclopramide combined with methylpred-nisolone versus metoclopramide alone in cisplatin treated cancer patients: randomized double-blind trial of the Italian Oncology Group for Clinical Research. J Clin Oncol 1987; 5: 141–9
  • Kris M G, Gralla R J, Clark R A, et al. Consecutive dose-finding trial adding lorazepam to the combination of metoclopramide plus dexamethasone: improved subjective effectiveness over the combination of diphenhydramine plus metoclopramide plus dexamethasone. Cancer Treat Rep 1985; 69: 1257–62
  • Gordon C J, Pazdur R, Ziccarelli A, et al. Metoclopramide versus metoclopramide and lorazepam. Superiority of combined therapy in the control of cisplatin-induced vomiting. Cancer 1989; 63: 578–82
  • Maher J. Intravenous lorazepam to prevent nausea and vomiting associated with cancer chemotherapy. Lancet 1981; 1: 91–2
  • Gagen M, Gochnour D, Young D, et al. A randomized trial of metoclopramide and a combination of dexamethasone and lorazepam for prevention of chemotherapy-induced vomiting. J Clin Oncol 1984; 2: 2696–701
  • Laszlo J, Clark R A, Hanson D C, et al. Lorazepam in cancer patients treated with cisplatin: a drug having antiemetic amnesia and anxiolytic effects. J Clin Oncol 1985; 3: 864–9
  • Kris M G, Tyson L B, Gralla R J, Clark R A, Allen J C, Reilly LK. Extrapyramidal reactions with high-dose metoclopramide. N Engl J Med 1983; 309: 433
  • Peroutka S J, Snyder SH. Antiemesis: Neurotransmitter receptor binding predicts therapeutic actions. Lancet 1982; 1: 658–9
  • Eyre H J, Ward JH. Control of cancer chemotherapy-induced nausea and vomiting. Cancer 1984; 54: 2642–8
  • Bishop J F, Wolf M, Matthews J P, et al. Randomized, double-blind, cross-over study comparing prochlorperazine and lorazepam with high-dose metoclopramide and lorazepam for the control of emesis in patients receiving cytotoxic therapy. Cancer Treat Rep 1987; 71: 1007–11
  • Strum S B, McDermed J E, Streng B R, McDermott NM. Combination metoclopramide and dexamethasone: an effective antiemetic regimen in outpatients receiving non-cisplatin chemotherapy. J Clin Oncol 1984; 2: 1057–63

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.