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Original Article

Hepatic Intra-Arterial Administration of Doxorubicin and Degradable Starch Microspheres: A pharmacokinetic study in the rat

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Pages 39-42 | Received 10 Mar 1993, Accepted 10 Sep 1993, Published online: 08 Jul 2009

References

  • Kemeny N. Liver cancer: A review of current treatment options. An update on regional treatment of liver cancer. The role of vascular occlusion, L. Monger, et al. Wells Medical Ltd, Kent 1992; 7–16
  • Lindberg B, Lote K, Teder H. Biogradable microspheres—a new medical tool. Microspheres and drug therapy, S Davis, L Ilium, J McVie, E Tomlinson. Elsevier, Amsterdam 1984; 153–87
  • Taguchi T, Ogawa N, Bunke B, Nilsson B. DSM Study Group (Japan). The use of degradable starch microspheres (Spherex) with intra-arterial chemotherapy for the treatment of primary and secondary liver tumours—results of a phase III clinical trial. Reg Cancer 1992; 4: 161–5
  • Eksborg S, Ehrsson H, Andersson I. Reversed-phase liquid chromatographic determination of plasma levels of adri-amycin and adriamycinol. J. Chromatogr 1979; 164: 479–86
  • Speth P AJ, van Hoesel Q GCM, Haanen C. Clinical pharma-cokinetics of doxorubicin. Clin Pharmacokinet 1988; 15: 15–31
  • Oosterbaan M JM, Dirks R JM, Vree T B, Van der Kleijn E. Pharmacokinetics of anthracyclines in dogs: evidence for structure related body distribution and reduction to their hydroxy metabolites. Pharm Res 1984; 1: 33–8
  • Jakobsson B, Teder H, Roos G, Stenram U. Reduction by norepinephrine of the side-effects induced by combined hepatic arterial adminstration of degradable starch microspheres and adriamycin in rats with a liver adenocarcinoma. Sel Cancer Ther 1991; 7: 93–7
  • Teder H, Nilsson B, Jonsson K, Hellekant C, Aspegren K, Aronsen K F. Hepatic arterial administration of doxorubicin (adriamycin) with or without degradable starch microspheres: a pharmacokinetic study in man. Anthracyclines and cancer therapy, H Hansen. Excerpta Medica, Amsterdam 1983
  • Domellöf L, Andersson M, Eksborg S. Hepatic arterial chemotherapy and embolization with degradable starch microspheres. Cancer chemotherapy: challenge for the future: proceedings of the Fourth Nagoya International Symposium on cancer treatment ICS904, K Kimura, K Ota, S K Carter, H M Pinedo. Elsevier Science Publishers BV, 1989; 11–22
  • Gyves J W, Ensminger W D, Van Harken D, Niederhuber J, Stetson P, Walker S. Improved regional selectivity of hepatic arterial mitomycin by starch microspheres. Clin Pharmacol Ther 1983; 34: 259–65
  • Czejka M J, Jäger W, Schüller J S. Pharmacokinetics of mitomycin C in patients after bolus injection and chemobolisation of the hepatic artery with Spherex starch particles. Eur J Drug Metab Pharmacokinet 1992; 17: 85–7

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