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Original Article

Spin-Lattice Relaxation Time of Inorganic Phosphate in Human Tumor Xenografts Measured in Vivo by 31P-Magnetic Resonance Spectroscopy Influence of oxygen tension

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Pages 339-343 | Received 10 Oct 1994, Accepted 07 Dec 1994, Published online: 08 Jul 2009

References

  • Tozer G M, Griffiths J R. The contribution made by cell death and oxygenation to 31P MRS observations of tumour energy metabolism. NMR Biomed 1992; 5: 279–89
  • Vaupel P, Okunieff P, Kallinowski F, Neuringer L J. Correlations between 31P-NMR spectroscopy and tissue O2 tension measurements in a murine fibrosarcoma. Radiat Res 1989; 120: 477–93
  • Rofstad E K, DeMuth P, Fenton B M, Sutherland R M. 31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracapillary oxyhemoglobin saturation status and tumor hypoxia. Cancer Res 1988; 48: 5440–6
  • Lyng H, Olsen D R, Southon T E, Rofstad E K. 31P-nuclear magnetic resonance spectroscopy in vivo of six human melanoma xenograft lines: tumour bioenergetic status and blood supply. Br J Cancer 1993; 68: 1061–70
  • Rofstad E K, Howell R L, DeMuth P, Ceckler T L, Sutherland R M. 31P NMR spectroscopy in vivo of two murine tumour lines with widely different fractions of radiobiologically hypoxic cells. Int J Radiat Biol 1988; 54: 635–49
  • Okunieff P, Ramsay J, Tokuhiro T, et al. Estimation of tumor oxygenation and metabolic rate using 31P MRS: correlation of longitudinal relaxation with tumor growth rate and DNA synthesis. Int J Radiat Oncol Biol Phys 1988; 14: 1185–95
  • Rofstad E K, Wahl A, Stokke T, Nesland J M. Establishment and characterization of six human melanoma xenograft lines. Acta Pathol Microbiol Immunol Scand 1990; 98: 945–53
  • Lyng H, Skretting A, Rofstad E K. Blood flow in six human melanoma xenograft lines with different growth characteristics. Cancer Res 1992; 52: 584–92
  • Brammer I, Jung H. Morphometry of irradiated tumors. Rodent tumor models in experimental cancer therapy, R F Kallman. Pergamon Press, New York 1987; 97–100
  • Olsen D R, Lyng H, Southon T E, Rofstad E K. 31P-nuclear magnetic resonance spectroscopy in vivo of four human melanoma xenograft lines: spin-lattice relaxation times. Radiother Oncol 1994; 32: 54–62
  • Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989; 49: 6449–65
  • Sutherland R M, Rasey J S, Hill R P. Tumor biology. Am J Clin Oncol 1988; 11: 253–74
  • Negendank W, Corbett T, Crowley M, Kellogg C. Evidence for a contribution of paramagnetic ions to water proton spin-lattice relaxation in normal and malignant mouse tissues. Magn Reson Med 1991; 18: 280–93
  • McCain D C. 31P nuclear spin relaxation. Phosphorus NMR in biology, C Tyler Burt. CRC Press, Boca Raton 1987; 25–61

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