703
Views
50
CrossRef citations to date
0
Altmetric
Original Article

The Effect of Tumor Size on Necrosis and Polarographically Measured pO2

, , , , &
Pages 183-189 | Received 20 May 1996, Accepted 22 Oct 1996, Published online: 08 Jul 2009

References

  • Crabtree H G, Cramer W. The action of radium on cancer cells. II. Some factors determining the susceptibility of cancer cells to radium. Proc Soc Lond 1933; 113: 238–50
  • Mottram J C. On the alteration in the sensitivity of cells towards radiation produced by cold and by anaerobiosis. Br J Radiol 1935; 8: 32–9
  • Powers W E, Tolmach L J. A multicomponent X-ray survival curve for mouse lymphosarcoma cells irradiated in vivo. Nature 1963; 197: 710–1
  • Moulder J E, Rockwell S. Tumor hypoxia: its impact on cancer therapy. Cancer Metastasis Rev 1987; 5: 313–41
  • Dische S. Hyperbaric oxygen: the Medical Research Council trials and their clinical significance. Br J Radiol 1979; 51: 888–94
  • Dische S. Chemical sensitizers for hypoxic cells: A decade of experience in clinical radiotherapy. Radiother Oncol 1985; 3: 97–115
  • Overgaard J, Hansen H S, Anderson A P, et al. Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: Report from the DHANCA 2 study. Int J Radiat Oncol Biol Phys 1989; 16: 1065–8
  • Denekamp J, Fowler J F, Dische S. The proportion of hypoxic cells in a human tumor. Int J Radiat Oncol Biol Phys 1977; 2: 1227–8
  • Hill R P, Stanley J A. The response of hypoxic B16 melanoma cells to in vivo treatment with chemotherapeutic agents. Cancer Res 1975; 35: 1147–53
  • Tannock I. Response of aerobic and hypoxic cells in a solid tumor to adriamycin and cyclophosphamide and interaction of the drugs with radiation. Cancer Res 1982; 42: 4921–6
  • Teicher B A, Holden S A, Al-Achi A, Herman T S. Classification of antineoplastic treatments by their differential toxicity toward putative oxygenated and hypoxic tumor subpopula-tions in vivo in the FSa-II murine fibrosarcoma. Cancer Res 1990; 50: 3339–44
  • Siemann D W. Tumor size: A factor influencing the isoeffect analysis of tumor response to combined modalities. Br J Cancer 1980; 41(Suppl IV)294–8
  • Suit H, Maeda M. Oxygen effect factor and tumor volume in the C3H mouse mammary carcinoma. Am J Roentgen 1966; 96: 1177–82
  • Vaupel P, Okunieff P, Kallinowski F, Neuringer L J. Correlations between 31P-NMR spectroscopy and tissue 02 tension measurements in a murine fibrosarcoma. Radiat Res 1989; 120: 477–93
  • Rofstad E K, Howell R L, DeMuth P, Ceckler T L, Sutherland R M. 31P spectroscopy in vivo of two murine tumor lines with widely different fractions of radiobiologically hypoxic cells. Int J Radiat Biol 1988; 54: 635–49
  • Baker G M, Goddard H L, Clarke M B, Whimster W F. Proportion of necrosis in transplanted murine adenocarcinomas and its relationship to tumor growth. Growth Dev Aging 1990; 54: 85–93
  • Khalil A A, Horsman M R, Overgaard J. The importance of determining necrotic fraction when studying the effect of tumour volume on tissue oxygenation. Acta Oncol 1995; 34: 297–300
  • Camplejohn R S, Penhaligon M. The tumor bed effect: a cell kinetic and histological investigation of tumors growing in irradiated mouse skin. Br J Radiol 1985; 58: 443–51
  • Stephens L C, Ang K K, Schultheiss T E, Milas L, Meyn R E. Apoptosis in irradiated murine tumors. Radiat Res 1991; 127: 308–16
  • Thomlinson R H, Gray L H. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 1955; 9: 539–49
  • Tannock I F. Relationship between cell proliferation and the vascular system in a transplantable mouse mammary tumor. Br J Cancer 1968; 22: 258–73
  • Fryer J P, Sutherland R M. Regulation of growth saturation and development of necrosis in EMT6/R0 multicellular spheroids by the glucose and oxygen supply. Cancer Res 1986; 46: 3504–12
  • Tannock I F. Population kinetics of carcinoma cells, capillary endothelial cells, and fibroblasts in a transplanted mouse mammary tumor. Cancer Res 1970; 30: 2470–6
  • Cater D B, Silver I A. Quantitative measurements of oxygen tension in normal tissues and in the tumors of patients before and after radiotherapy. Acta Radiol 1960; 53: 233–56
  • Badib A O, Webster J H. Changes in tumor oxygen tension during radiation therapy. Acta Radiol Ther Phys Biol 1969; 8: 247–57
  • Vaupel P. Oxygenation of human tumors. Strahlenther Onkol 1990; 166: 377–86
  • Stone H B, Brown J M, Phillips T L, Sutherland R M. Oxygen in human tumors: Correlations between methods of measurement and response to therapy. Radiat Res 1993; 136: 422–34
  • Hockel M, Knoop C, Schlenger K, et al. Intratumor pO2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol 1993; 26: 45–50
  • Okunieff P, Hockel M, Dunphy E P, Schlenger K, Knoop C, Vaupel P. Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone. Int J Radiat Oncol Biol Phys 1993; 26: 631–6
  • Gatenby R A, Kessler H B, Rosenblum J S, et al. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys 1988; 14: 831–8
  • Milas L, Hunter N R, Mason K A, Milross C G, Saito Y, Peters L J. Role of reoxygenation in induction of enhancement of tumor radioresponse by paclitaxel. Cancer Res 1995; 55: 3564–8
  • Teicher B A, Holden S A, Gulshan A, Dupuis N P, Goff D. Restoration of tumor oxygenation after cytotoxic therapy by a perflubron emulsion/carbogen breathing. Cancer J Sci Am 1995; 1: 43–8
  • Teicher B A, Dupuis N, Holden S A, Schwartz G N, Lester S, Frei E. Definition and manipulation of tumor oxygenation. Radiat Oncol Invest 1994; 2: 66–76
  • Horsman M R, Nordsmark M, Khalil A A, et al. Reducing acute and chronic hypoxia in tumors by combining nicotinamide with carbogen breathing. Acta Oncol 1994; 4: 371–6
  • Thomas C D, Prade M, Guichard M. Tumor oxygenation, radiosensitivity, and necrosis before and/or after nicotinamide, carbogen, and perflubron emulsion administration. Int J Radiat Biol 1995; 67: 597–605
  • Horsman M A, Khalil A A, Nordsmark M, Grau C, Overgaard J. Relationship between radiobiological hypoxia and direct estimates of tumor oxygenation in a mouse tumor model. Radiother Oncol 1993; 28: 69–71
  • Nordsmark M, Bentzen S M, Overgaard J. Measurement of human tumor oxygenation status by a polarographic needle electrode. Acta Oncol 1994; 33: 383–9
  • Brizel D M, Rosner G L, Proznitz L R, Dewhirst M W. Patterns and variability of tumor oxygenation in soft tissue sarcomas, cervical carcinomas, and lymph node metastases. Int J Radiat Oncol Biol Phys 1995; 32: 1121–5
  • Milross C G, Peters L J, Mason K A, Hunter N R, Tucker S L, Milas L. Polarographic p02 measurement in mice: The effect of tumor type, site of implantation, and anesthesia. Radiat Oncol Invest 1996; 4: 108–14
  • Milas L, Wike J, Hunter N, Volpe J, Basic I. Macrophage content of murine sarcomas and carcinomas: Associations with tumor growth parameters and tumor radiocurability. Cancer Res 1987; 47: 1069–75

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.