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Review Article

Current treatments for radiation retinopathy

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Pages 6-13 | Received 19 Mar 2010, Accepted 07 Jun 2010, Published online: 20 Aug 2010

References

  • Finger PT, Chin KJ, Duvall G, Palladium-103 for Choroidal Melanoma Study Group. Palladium-103 ophthalmic plaque radiation therapy for choroidal melanoma: 400 treated patients. Ophthalmology 2009;116:790–6, 796.e1.
  • Krema H, Somani S, Sahgal A, Xu W, Heydarian M, Payne D, . Stereotactic radiotherapy for treatment of juxtapapillary choroidal melanoma: 3-year follow-up. Br J Ophthalmol 2009;93:1172–6.
  • Gragoudas ES, Seddon JM, Egan K, Glynn R, Munzenrider J, Austin-Seymour M, . Long-term results of proton beam irradiated uveal melanomas. Ophthalmology 1987; 94:349–53.
  • Haas A, Pinter O, Papaefthymiou G, Weger M, Berghold A, Schrottner O, . Incidence of radiation retinopathy after high-dosage single-fraction gamma knife radiosurgery for choroidal melanoma. Ophthalmology 2002;109:909–13.
  • Levy RP, Fabrikant JI, Frankel KA, Phillips MH, Lyman JT, Lawrence JH, . Heavy-charged-particle radiosurgery of the pituitary gland: Clinical results of 840 patients. Stereotact Funct Neurosurg 1991;57:22–35.
  • Bianciotto C, Shields CL, Pirondini C, Mashayekhi A, Furuta M, Shields JA. Proliferative radiation retinopathy after plaque radiotherapy for uveal melanoma. Ophthalmology 2010.
  • Egbert PR, Donaldson SS, Moazed K, Rosenthal AR. Visual results and ocular complications following radiotherapy for retinoblastoma. Arch Ophthalmol 1978;96:1826–30.
  • Amoaku WM, Archer DB. Cephalic radiation and retinal vasculopathy. Eye (Lond) 1990;4(Pt 1):195–203.
  • Shields CL, Shields JA, Milite J, De Potter P, Sabbagh R, Menduke H. Uveal melanoma in teenagers and children. A report of 40 cases. Ophthalmology 1991;98:1662–6.
  • Phillpotts BA, Sanders RJ, Shields JA, Griffiths JD, Augsburger JA, Shields CL. Uveal melanomas in black patients: A case series and comparative review. J Natl Med Assoc 1995;87:709–14.
  • Shields CL, Naseripour M, Cater J, Shields JA, Demirci H, Youseff A, . Plaque radiotherapy for large posterior uveal melanomas (> or =8 mm thick) in 354 consecutive patients. Ophthalmology 2002;109:1838–49.
  • Gunduz K, Shields CL, Shields JA, Cater J, Freire JE, Brady LW. Radiation retinopathy following plaque radiotherapy for posterior uveal melanoma. Arch Ophthalmol 1999;117:609–14.
  • Gunduz K, Shields CL, Shields JA, Cater J, Freire JE, Brady LW. Radiation complications and tumor control after plaque radiotherapy of choroidal melanoma with macular involvement. Am J Ophthalmol 1999;127:579–89.
  • Brown GC, Shields JA, Sanborn G, Augsburger JJ, Savino PJ, Schatz NJ. Radiation retinopathy. Ophthalmology 1982; 89:1494–501.
  • Chacko DC. Considerations in the diagnosis of radiation injury. JAMA 1981;245:1255–8.
  • Elsas T, Thorud E, Jetne V, Conradi IS. Retinopathy after low dose irradiation for an intracranial tumor of the frontal lobe. A case report. Acta Ophthalmol (Copenh) 1988;66:65–8.
  • Lopez PF, Sternberg P, Jr, Dabbs CK, Vogler WR, Crocker I, Kalin NS. Bone marrow transplant retinopathy. Am J Ophthalmol 1991;112:635–46.
  • Moore RF. Choroidal sarcoma treated by the intraocular insertion of radon seeds. Br J Ophthalmol 1930;14:145–52.
  • Saconn PA, Gee CJ, Greven CM, McCoy TP, Ekstrand KE, Greven KM. Alternative dose for choroidal melanoma treated with an iodine-125 radioactive plaque: A single-institution retrospective study. Int J Radiat Oncol Biol Phys 2010.
  • Gragoudas ES, Li W, Lane AM, Munzenrider J, Egan KM. Risk factors for radiation maculopathy and papillopathy after intraocular irradiation. Ophthalmology 1999;106:1571–7; Discussion 1577–8.
  • Archer DB. Doyne Lecture. Responses of retinal and choroidal vessels to ionising radiation. Eye (Lond) 1993;7(Pt 1):1–13.
  • Archer DB, Gardiner TA. Ionizing radiation and the retina. Curr Opin Ophthalmol 1994;5:59–65.
  • Archer DB, Amoaku WM, Gardiner TA. Radiation retinopathy–clinical, histopathological, ultrastructural and experimental correlations. Eye (Lond) 1991;5(Pt 2):239–51.
  • Irvine AR, Alvarado JA, Wara WM, Morris BW, Wood IS. Radiation retinopathy: An experimental model for the ischemic–proliferative retinopathies. Trans Am Ophthalmol Soc 1981;79:103–22.
  • Midena E, Segato T, Valenti M, Degli Angeli C, Bertoja E, Piermarocchi S. The effect of external eye irradiation on choroidal circulation. Ophthalmology 1996;103:1651–60.
  • Kinyoun JL. Long-term visual acuity results of treated and untreated radiation retinopathy (an AOS thesis). Trans Am Ophthalmol Soc 2008;106:325–35.
  • Leuenberger PM, Englert U, Schepens JM. Biological effect of laser-photo-coagulation on the retina (author's transl). Klin Monbl Augenheilkd 1977;170:228–37.
  • Diddie KR, Ernest JT. The effect of photocoagulation on the choroidal vasculature and retinal oxygen tension. Am J Ophthalmol 1977;84:62–6.
  • Augustin AJ, Scholl S, Kirchhof J. Treatment of neovascular age-related macular degeneration: Current therapies. Clin Ophthalmol 2009;3:175–82.
  • Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Early Treatment Diabetic Retinopathy Study research group. Arch Ophthalmol 1985;103:1796–806.
  • Muqit MM, Sanghvi C, McLauchlan R, Delgado C, Young LB, Charles SJ, . Study of clinical applications and safety for Pascal(®) laser photocoagulation in retinal vascular disorders. Acta Ophthalmol 2010.
  • Arnarsson A, Stefansson E. Laser treatment and the mechanism of edema reduction in branch retinal vein occlusion. Invest Ophthalmol Vis Sci 2000;41:877–9.
  • Wen JC, McCannel TA. Treatment of radiation retinopathy following plaque brachytherapy for choroidal melanoma. Curr Opin Ophthalmol 2009;20:200–4.
  • Kinyoun JL, Chittum ME, Wells CG. Photocoagulation treatment of radiation retinopathy. Am J Ophthalmol 1988; 105:470–8.
  • Kinyoun JL, Zamber RW, Lawrence BS, Barlow WE, Arnold AM. Photocoagulation treatment for clinically significant radiation macular oedema. Br J Ophthalmol 1995;79: 144–9.
  • Finger PT, Kurli M. Laser photocoagulation for radiation retinopathy after ophthalmic plaque radiation therapy. Br J Ophthalmol 2005;89:730–8.
  • Hykin PG, Shields CL, Shields JA, Arevalo JF. The efficacy of focal laser therapy in radiation-induced macular edema. Ophthalmology 1998;105:1425–9.
  • Kinyoun JL, Lawrence BS, Barlow WE. Proliferative radiation retinopathy. Arch Ophthalmol 1996;114:1097–100.
  • Miller JW, Walsh AW, Kramer M, Hasan T, Michaud N, Flotte TJ, . Photodynamic therapy of experimental choroidal neovascularization using lipoprotein-delivered benzoporphyrin. Arch Ophthalmol 1995;113:810–8.
  • Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: One-year results of 2 randomized clinical trials–TAP report. Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group. Arch Ophthalmol 1999;117:1329–45.
  • Bakri SJ, Beer PM. Photodynamic therapy for maculopathy due to radiation retinopathy. Eye (Lond) 2005;19:795–9.
  • Lee SC, Song JH, Chung EJ, Kwon OW. Photodynamic therapy of subretinal neovascularization in radiation retinopathy. Eye (Lond) 2004;18:745–6.
  • Nakano T, Ohara O, Teraoka H, Arita H. Glucocorticoids suppress group II phospholipase A2 production by blocking mRNA synthesis and post-transcriptional expression. J Biol Chem 1990;265:12745–8.
  • Tano Y, Chandler D, Machemer R. Treatment of intraocular proliferation with intravitreal injection of triamcinolone acetonide. Am J Ophthalmol 1980;90:810–6.
  • Matsuda S, Gomi F, Oshima Y, Tohyama M, Tano Y. Vascular endothelial growth factor reduced and connective tissue growth factor induced by triamcinolone in ARPE19 cells under oxidative stress. Invest Ophthalmol Vis Sci 2005;46: 1062–8.
  • Shields CL, Demirci H, Dai V, Marr BP, Mashayekhi A, Materin MA, . Intravitreal triamcinolone acetonide for radiation maculopathy after plaque radiotherapy for choroidal melanoma. Retina 2005;25:868–74.
  • Sutter FK, Gillies MC. Intravitreal triamcinolone for radiation-induced macular edema. Arch Ophthalmol 2003;121: 1491–3.
  • Gillies MC, Sutter FK, Simpson JM, Larsson J, Ali H, Zhu M. Intravitreal triamcinolone for refractory diabetic macular edema: Two-year results of a double-masked, placebo-controlled, randomized clinical trial. Ophthalmology 2006;113:1533–8.
  • Conti SM, Kertes PJ. The use of intravitreal corticosteroids, evidence-based and otherwise. Curr Opin Ophthalmol 2006; 17:235–44.
  • Horgan N, Shields CL, Mashayekhi A, Teixeira LF, Materin MA, O'Regan M, . Periocular triamcinolone for prevention of macular edema after iodine 125 plaque radiotherapy of uveal melanoma. Retina 2008;28:987–95.
  • Horgan N, Shields CL, Mashayekhi A, Salazar PF, Materin MA, O'Regan M, . Periocular triamcinolone for prevention of macular edema after plaque radiotherapy of uveal melanoma: A randomized controlled trial. Ophthalmology 2009;116:1383–90.
  • Ferrara N. Vascular endothelial growth factor and the regulation of angiogenesis. Recent Prog Horm Res 2000;55:15–35; Discussion 35–6.
  • Tolentino MJ, Miller JW, Gragoudas ES, Chatzistefanou K, Ferrara N, Adamis AP. Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate. Arch Ophthalmol 1996;114:964–70.
  • Tolentino MJ, McLeod DS, Taomoto M, Otsuji T, Adamis AP, Lutty GA. Pathologic features of vascular endothelial growth factor-induced retinopathy in the nonhuman primate. Am J Ophthalmol 2002;133:373–85.
  • Yang JC, Haworth L, Sherry RM, Hwu P, Schwartzentruber DJ, Topalian SL, . A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003;349:427–34.
  • Michels S, Rosenfeld PJ, Puliafito CA, Marcus EN, Venkatraman AS. Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration twelve-week results of an uncontrolled open-label clinical study. Ophthalmology 2005;112:1035–47.
  • Chan WM, Lai TY, Liu DT, Lam DS. Intravitreal bevacizumab (Avastin) for myopic choroidal neovascularization: Six-month results of a prospective pilot study. Ophthalmology 2007;114:2190–6.
  • Kondo M, Kondo N, Ito Y, Kachi S, Kikuchi M, Yasuma TR, . Intravitreal injection of bevacizumab for macular edema secondary to branch retinal vein occlusion: Results after 12 months and multiple regression analysis. Retina 2009;29: 1242–8.
  • Jorge R, Costa RA, Calucci D, Cintra LP, Scott IU. Intravitreal bevacizumab (Avastin) for persistent new vessels in diabetic retinopathy (IBEPE study). Retina 2006;26:1006–13.
  • Mason JO, 3rd, Albert MA, Jr, Persaud TO, Vail RS. Intravitreal bevacizumab treatment for radiation macular edema after plaque radiotherapy for choroidal melanoma. Retina 2007;27:903–7.
  • Gupta A, Muecke JS. Treatment of radiation maculopathy with intravitreal injection of bevacizumab (Avastin). Retina 2008;28:964–8.
  • Finger PT, Chin K. Anti-vascular endothelial growth factor bevacizumab (avastin) for radiation retinopathy. Arch Ophthalmol 2007;125:751–6.
  • Finger PT. Radiation retinopathy is treatable with anti-vascular endothelial growth factor bevacizumab (Avastin). Int J Radiat Oncol Biol Phys 2008;70:974–7.
  • Vasquez LM, Somani S, Altomare F, Simpson ER. Intracameral bevacizumab in the treatment of neovascular glaucoma and exudative retinal detachment after brachytherapy in choroidal melanoma. Can J Ophthalmol 2009;44:106–7.
  • Ziemssen F, Voelker M, Altpeter E, Bartz-Schmidt KU, Gelisken F. Intravitreal bevacizumab treatment of radiation maculopathy due to brachytherapy in choroidal melanoma. Acta Ophthalmol Scand 2007;85:579–80.
  • Solano JM, Bakri SJ, Pulido JS. Regression of radiation-induced macular edema after systemic bevacizumab. Can J Ophthalmol 2007;42:748–9.
  • Arriola-Villalobos P, Donate-Lopez J, Calvo-Gonzalez C, Reche-Frutos J, Alejandre-Alba N, Diaz-Valle D. Intravitreal bevacizumab (Avastin) for radiation retinopathy neovascularization. Acta Ophthalmol 2008;86:115–6.
  • Krzystolik MG, Afshari MA, Adamis AP, Gaudreault J, Gragoudas ES, Michaud NA, . Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch Ophthalmol 2002;120:338–46.
  • Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, . Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006;355:1419–31.
  • Dunavoelgyi R, Zehetmayer M, Simader C, Schmidt-Erfurth U. Rapid improvement of radiation-induced neovascular glaucoma and exudative retinal detachment after a single intravitreal ranibizumab injection. Clin Experiment Ophthalmol 2007;35:878–80.
  • Finger PT, Chin KJ. Intravitreous ranibizumab (lucentis) for radiation maculopathy. Arch Ophthalmol 2010;128:249–52.
  • Ng EW, Shima DT, Calias P, Cunningham ET, Jr, Guyer DR, Adamis AP. Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat Rev Drug Discov 2006;5: 123–32.
  • VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group, Chakravarthy U, Adamis AP, Cunningham ET, Jr, Goldbaum M, Guyer DR, . Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration. Ophthalmology 2006;113:1508.e1–1508.25.
  • Gonzalez VH, Giuliari GP, Banda RM, Guel DA. Intravitreal injection of pegaptanib sodium for proliferative diabetic retinopathy. Br J Ophthalmol 2009;93:1474–8.
  • Querques G, Prascina F, Iaculli C, Delle Noci N. Intravitreal pegaptanib sodium (Macugen) for radiation retinopathy following episcleral plaque radiotherapy. Acta Ophthalmol 2008;86:700–1.
  • Oguz H, Sobaci G. The use of hyperbaric oxygen therapy in ophthalmology. Surv Ophthalmol 2008;53:112–20.
  • Gall N, Leiba H, Handzel R, Pe'er J. Severe radiation retinopathy and optic neuropathy after brachytherapy for choroidal melanoma, treated by hyperbaric oxygen. Eye (Lond) 2007;21:1010–2.
  • Stanford MR. Retinopathy after irradiation and hyperbaric oxygen. J R Soc Med 1984;77:1041–3.
  • Chiao TB, Lee AJ. Role of pentoxifylline and vitamin E in attenuation of radiation-induced fibrosis. Ann Pharmacother 2005;39:516–22.
  • Gupta P, Meisenberg B, Amin P, Pomeranz HD. Radiation retinopathy: The role of pentoxifylline. Retina 2001;21: 545–7.

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