Proton therapy in adjuvant treatment of gastric cancer: Planning comparison with advanced x-ray therapy and feasibility report

References

• Ferlay J, Shin H-R, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127: 2893–917.
   PubMed Web of Science ®Google Scholar
• Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001;345:725–30.
   PubMed Web of Science ®Google Scholar
• Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJH, Nicolson M, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 2006;355:11–20.
   PubMed Web of Science ®Google Scholar
• Smalley SR, Benedetti JK, Haller DG, Hundahl SA, Estes NC, Ajani JA, et al. Updated analysis of SWOG- directed intergroup study 0116: a phase III trial of adjuvant radiochemotherapy versus observation after curative gastric cancer resection. J Clin Oncol 2012;30:2327–33.
   PubMed Web of Science ®Google Scholar
• Jansen EPM, Saunders MP, Boot H, Oppedijk V, Dubbelman R, Porritt B, et al. Prospective study on late renal toxicity following postoperative chemoradiotherapy in gastric cancer. Int J Radiat Oncol Biol Phys 2007;67:781–5.
   PubMed Web of Science ®Google Scholar
• Wysocka B, Kassam Z, Lockwood G, Brierley J, Dawson L, Ringash J. Late toxicity after adjuvant radiochemotherapy for gastric adenocarcinoma. J Clin Oncol 2006;24:s14042.
   Google Scholar
• Tepper JE, Gunderson LL. Radiation treatment parameters in the adjuvant postoperative therapy of gastric cancer. Semin Radiat Oncol 2002;12:187–95.
   PubMed Web of Science ®Google Scholar
• Smalley SR, Gunderson L, Tepper J, Martenson JA Jr, Minsky B, Willett C, et al. Gastric surgical adjuvant radiotherapy consensus report: Rationale and treatment implementation. Int J Radiat Oncol Biol Phys 2002;52:283–93.
   PubMed Web of Science ®Google Scholar
• Leong T, Willis D, Joon DL, Condron S, Hui A, Ngan SYK. 3D conformal radiotherapy for gastric cancer – results of a comparative planning study. Radiother Oncol 2005;74: 301–6.
   PubMed Web of Science ®Google Scholar
• Milano MT, Garofalo MC, Chmura SJ, Farrey K, Rash C, Heimann R, et al. Intensity-modulated radiation therapy in the treatment of gastric cancer: Early clinical outcome and dosimetric comparison with conventional techniques. Br J Radiol 2006;79:497–503.
   PubMed Web of Science ®Google Scholar
• Dahele M, Skinner M, Schultz B, Cardoso M, Bell C, Ung YC. Adjuvant radiotherapy for gastric cancer: A dosimetric comparison of 3-dimensional conformal radiotherapy, tomotherapy and conventional intensity modulated radiotherapy treatment plans. Med Dosim 2010;35:115–21.
   PubMed Web of Science ®Google Scholar
• Shibuya S, Takase Y, Aoyagi H, Orii K, Sharma N, Tsujii H, et al. Definitive proton beam radiation therapy for inoperable gastric cancer: A report of two cases. Radiat Med 1991;9: 35–40.
   PubMedGoogle Scholar
• Koyama S, Kawanishi N, Fukutomi H, Osuga T, Iijima T, Tsujii H, et al. Advanced carcinoma of the stomach treated with definitive proton therapy. Am J Gastroenterol 1990; 85:443–7.
   PubMed Web of Science ®Google Scholar
• Lin SH, Komaki R, Liao Z, Wei C, Myles B, Guo X, et al. Proton beam therapy and concurrent chemotherapy for esophageal cancer. Int J Radiat Oncol Biol Phys 2012;83: e345–51.
   PubMed Web of Science ®Google Scholar
• Nichols RC Jr, George TJ, Zaiden RA Jr, Awad ZT, Asbun HJ, Huh S, et al. Proton therapy with concomitant capecitabine for pancreatic and ampullary cancers is associated with a low incidence of gastrointestinal toxicity. Acta Oncol 2013;52: 498–505.
   PubMed Web of Science ®Google Scholar
• Moyers MF, Miller DW, Bush DA, Slater JD. Methodologies and tools for proton beam design for lung tumors. Int J Radiat Oncol Biol Phys 2001;49:1429–38.
   PubMed Web of Science ®Google Scholar
• Eldebawy E, Parker W, Abdel Rahman W, Freeman CR. Dosimetric study of current treatment options for radiotherapy in retinoblastoma. Int J Radiat Oncol Biol Phys 2012; 82:e501–5.
   Web of Science ®Google Scholar
• Lee J, Lim DH, Kim S, Park SH, Park JO, Park YS, et al. Phase III trial comparing capecitabine plus cisplatin versus capecitabine plus cisplatin with concurrent capecitabine radiotherapy in completely resected gastric cancer with D2 lymph node dissection: The ARTIST trial. J Clin Oncol 2012;30:268–73.
   PubMed Web of Science ®Google Scholar
• Valentini V, Cellini F, Minsky BD, Mattiucci GC, Balducci M, D’Agostino G, et al. Survival after radiotherapy in gastric cancer: Systematic review and meta-analysis. Radiother Oncol 2009;92:176–83.
   PubMed Web of Science ®Google Scholar
• Ohri N, Garg MK, Aparo S, Kaubisch A, Tome W, Kennedy TJ, et al. Who benefits from adjuvant radiation therapy for gastric cancer?A meta-analysis. Int J Radiat Oncol Biol Phys 2013;86:330–5.
   PubMed Web of Science ®Google Scholar
• Coburn NG, Govindarajan A, Law CHL, Guller U, Kiss A, Ringash J, et al. Stage-specific effect of adjuvant therapy following gastric cancer resection: A population-based analysis of 4,041 patients. Ann Surg Oncol 2008;15:500–7.
   PubMed Web of Science ®Google Scholar
• ICRU Report No. 78. Treatment planning. J ICRU 2007;7:95–122.
   PubMedGoogle Scholar
• Glimelius B, Ask A, Bjelkengren G, Björk-Eriksson T, Blomquist E, Johansson B, et al. Number of patients potentially eligible for proton therapy. Acta Oncol 2005; 44:836–49.
   PubMed Web of Science ®Google Scholar
• Ask A, Johansson B, Glimelius B. The potential of proton beam radiation therapy in gastrointestinal cancer. Acta Oncol 2005;44:896–903.
   PubMed Web of Science ®Google Scholar
• Kassam Z, Lockwood G, O’Brien C, Brierley J, Swallow C, Oza A, et al. Conformal radiotherapy in the adjuvant treatment of gastric cancer: Review of 82 cases. Int J Radiat Oncol Biol Phys 2006;65:713–9.
   PubMed Web of Science ®Google Scholar
• Kundel Y, Purim O, Idelevich E, Lavrenkov K, Man S, Kovel S, et al. Postoperative chemoradiation for resected gastric cancer – is the Macdonald Regimen Tolerable? A retrospective multi-institutional study.Radiat Oncol 2011; 6:127.
   PubMed Web of Science ®Google Scholar
• Boda-Heggemann J, Weiss C, Schneider V, Hofheinz R-D, Haneder S, Michaely H, et al. Adjuvant IMRT/XELOX radiochemotherapy improves long-term overall- and disease-free survival in advanced gastric cancer. Strahlenther Onkol 2013;189:417–23.
   PubMed Web of Science ®Google Scholar
• Kavanagh BD, Pan CC, Dawson LA, Das SK, Li XA, Ten Haken RK, et al. Radiation dose-volume effects in the stomach and small bowel. Int J Radiat Oncol Biol Phys 2010;76:S101–7.
   PubMed Web of Science ®Google Scholar
• Dawson LA, Kavanagh BD, Paulino AC, Das SK, Miften M, Li XA, et al. Radiation-associated kidney injury. Int J Radiat Oncol Biol Phys 2010;76:S108–15.
   PubMed Web of Science ®Google Scholar
• Wieland P, Dobler B, Mai S, Hermann B, Tiefenbacher U, Steil V, et al. IMRT for postoperative treatment of gastric cancer: Covering large target volumes in the upper abdomen: A comparison of a step-and-shoot and an arc therapy approach. Int J Radiat Oncol Biol Phys 2004;59:1236–44.
   PubMed Web of Science ®Google Scholar
• Pan CC, Kavanagh BD, Dawson LA, Li XA, Das SK, Miften M, et al. Radiation-associated liver injury. Int J Radiat Oncol Biol Phys 2010;76:S94–100.
   PubMed Web of Science ®Google Scholar
• Darby SC, Ewertz M, McGale P, Bennet AM, Blom- Goldman U, Brønnum D, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med 2013;368:987–98.
   PubMed Web of Science ®Google Scholar
• Hall EJ. Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int J Radiat Oncol Biol Phys 2006;65:1–7.
   PubMed Web of Science ®Google Scholar
• Paganetti H, Bortfeld T, Delaney TF. Neutron dose in proton radiation therapy: In regard to Eric J. Hall (Int J Radiat Oncol Biol Phys 2006;65:1–7). Int J Radiat Oncol Biol Phys 2006;66:1594–5.
   PubMed Web of Science ®Google Scholar
• Gottschalk B. Neutron dose in scattered and scanned proton beams: In regard to Eric J. Hall (Int J Radiat Oncol Biol Phys 2006;65:1–7). Int J Radiat Oncol Biol Phys 2006;66:1594.
   PubMed Web of Science ®Google Scholar
• Chung CS, Yock TI, Nelson K, Xu Y, Keating NL, Tarbell NJ. Incidence of second malignancies among patients treated with proton versus photon radiation. Int J Radiat Oncol Biol Phys 2013;87:46–52.
   PubMed Web of Science ®Google Scholar
• Engelsman M, Schwarz M, Dong L. Physics controversies in proton therapy. Semin Radiat Oncol 2013;23:88–96.
   PubMed Web of Science ®Google Scholar
• Unkelbach J, Chan TCY, Bortfeld T. Accounting for range uncertainties in the optimization of intensity modulated proton therapy. Phys Med Biol 2007;52:2755–73.
   PubMed Web of Science ®Google Scholar
• Knopf A-C, Hong TS, Lomax A. Scanned proton radiotherapy for mobile targets – the effectiveness of re-scanning in the context of different treatment planning approaches and for different motion characteristics. Phys Med Biol 2011;56:7257–71.
   PubMed Web of Science ®Google Scholar
• Ajani JA, Mansfield PF, Janjan N, Morris J, Pisters PW, Lynch PM, et al. Multi-institutional trial of preoperative chemoradiotherapy in patients with potentially resectable gastric carcinoma. J Clin Oncol 2004;22:2774–80.
   PubMed Web of Science ®Google Scholar
• Wang J, Wei C, Tucker SL, Myles B, Palmer M, Hofstetter WL, et al. Predictors of postoperative complications after trimodality therapy for esophageal cancer. Int J Radiat Oncol Biol Phys 2013;86:885–91.
   PubMed Web of Science ®Google Scholar