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Prostate cancer

Pathophysiology of late anorectal dysfunction following external beam radiotherapy for prostate cancer

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Pages 1398-1404 | Received 01 May 2014, Accepted 14 May 2014, Published online: 24 Jun 2014

References

  • Potosky AL, Davis WW, Hoffman RM, Stanford JL, Stephenson RA, Penson DF, et al. Five-year outcomes after prostatectomy or radiotherapy for prostate cancer: The prostate cancer outcomes study. J Natl Cancer Inst 2004;96: 1358–67.
  • Korfage IJ, Essink-Bot ML, Borsboom GJ, Madalinska JB, Kirkels WJ, Habbema JD, et al. Five-year follow-up of health-related quality of life after primary treatment of localized prostate cancer. Int J Cancer 2005;116:291–6.
  • Litwin MS, Gore JL, Kwan L, Brandeis JM, Lee SP, Withers HR, et al. Quality of life after surgery, external beam irradiation, or brachytherapy for early-stage prostate cancer. Cancer 2007;109:2239–47.
  • Schaake W, Wiegman EM, de GM, van der Laan HP, van der Schans CP, van den Bergh AC, et al. The impact of gastrointestinal and genitourinary toxicity on health related quality of life among irradiated prostate cancer patients. Radiother Oncol 2014;110:284–90.
  • Yeoh EK, Holloway RH, Fraser RJ, Botten RJ, Di Matteo AC, Butters J. Pathophysiology and natural history of anorectal sequelae following radiation therapy for carcinoma of the prostate. Int J Radiat Oncol Biol Phys 2012;84:e593–9.
  • Krol R, Hopman WP, Smeenk RJ, Van Lin EN. Increased rectal wall stiffness after prostate radiotherapy: Relation with fecal urgency. Neurogastroenterol Motil 2012;24:339–e166.
  • Ippolito E, Deodato F, Macchia G, Massaccesi M, Digesu C, Pirozzi GA, et al. Early radiation-induced mucosal changes evaluated by proctoscopy: Predictive role of dosimetric parameters. Radiother Oncol 2012;104:103–8.
  • Alevronta E, Lind H, Al-Abany M, Waldenstrom AC, Olsson C, Dunberger G, et al. Dose-response relationships for an atomized symptom of fecal incontinence after gynecological radiotherapy. Acta Oncol 2013;52:719–26.
  • Al-Abany M, Helgason AR, Cronqvist AK, Lind B, Mavroidis P, Wersall P, et al. Dose to the anal sphincter region and risk of fecal leakage. Acta Oncol 2004;43:117–8.
  • Syndikus I, Morgan RC, Sydes MR, Graham JD, Dearnaley DP. Late gastrointestinal toxicity after dose-escalated conformal radiotherapy for early prostate cancer: Results from the UK Medical Research Council RT01 trial (ISRCTN47772397). Int J Radiat Oncol Biol Phys 2010; 77:773–83.
  • Yeoh EE, Holloway RH, Fraser RJ, Botten RJ, Di Matteo AC, Moore JW, et al. Anorectal dysfunction increases with time following radiation therapy for carcinoma of the prostate. Am J Gastroenterol 2004;99:361–9.
  • Maeda Y, Hoyer M, Lundby L, Norton C. Faecal incontinence following radiotherapy for prostate cancer: A systematic review. Radiother Oncol 2011;98:145–53.
  • Petersen SE, Bentzen L, Emmertsen KJ, Laurberg S, Lundby L, Hoyer M. Development and validation of a scoring system for late anorectal side-effects in patients treated with radiotherapy for prostate cancer. Radiother Oncol 2014;111:94–9.
  • Goldner G, Tomicek B, Becker G, Geinitz H, Wachter S, Zimmermann F, et al. Proctitis after external-beam radiotherapy for prostate cancer classified by Vienna Rectoscopy Score and correlated with EORTC/RTOG score for late rectal toxicity: Results of a prospective multicenter study of 166 patients. Int J Radiat Oncol Biol Phys 2007;67:78–83.
  • Brock C, Nissen TD, Gravesen FH, Frokjaer JB, Omar H, Gale J, et al. Multimodal sensory testing of the rectum and rectosigmoid: Development and reproducibility of a new method. Neurogastroenterol Motil 2008;20: 908–18.
  • Bregendahl S, Emmertsen KJ, Fassov J, Krogh K, Zhao J, Gregersen H, et al. Neorectal hyposensitivity after neoadjuvant therapy for rectal cancer. Radiother Oncol 2013;108: 331–6.
  • Abrahamsson H, Antov S, Bosaeus I. Gastrointestinal and colonic segmental transit time evaluated by a single abdominal x-ray in healthy subjects and constipated patients. Scand J Gastroenterol Suppl 1988;152:72–80.
  • Wachter S, Gerstner N, Goldner G, Potzi R, Wambersie A, Potter R. Endoscopic scoring of late rectal mucosal damage after conformal radiotherapy for prostatic carcinoma. Radiother Oncol 2000;54:11–9.
  • Ippolito E, Massaccesi M, Digesu C, Deodato F, Macchia G, Pirozzi GA, et al. Early proctoscopy is a surrogate endpoint of late rectal toxicity in prostate cancer treated with radiotherapy. Int J Radiat Oncol Biol Phys 2012; 83:e191–5.
  • O’Brien PC, Hamilton CS, Denham JW, Gourlay R, Franklin CI. Spontaneous improvement in late rectal mucosal changes after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 2004;58:75–80.
  • Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995;31: 1341–6.
  • Krol R, Smeenk RJ, Van Lin EN, Yeoh EE, Hopman WP. Systematic review: Anal and rectal changes after radiotherapy for prostate cancer. Int J Colorectal Dis 2013;29:273–83.
  • Kushwaha RS, Hayne D, Vaizey CJ, Wrightham E, Payne H, Boulos PB. Physiologic changes of the anorectum after pelvic radiotherapy for the treatment of prostate and bladder cancer. Dis Colon Rectum 2003;46:1182–8.
  • Smeenk RJ, Hopman WP, Hoffmann AL, Van Lin EN, Kaanders JH. Differences in radiation dosimetry and anorectal function testing imply that anorectal symptoms may arise from different anatomic substrates. Int J Radiat Oncol Biol Phys 2012;82:145–52.
  • Speakman CT, Hoyle CH, Kamm MA, Swash M, Henry MM, Nicholls RJ, et al. Abnormal internal anal sphincter fibrosis and elasticity in fecal incontinence. Dis Colon Rectum 1995;38:407–10.
  • Da Silva GM, Berho M, Wexner SD, Efron J, Weiss EG, Nogueras JJ, et al. Histologic analysis of the irradiated anal sphincter. Dis Colon Rectum 2003;46:1492–7.
  • Suckow SK, Anderson EM, Caudle RM. Lesioning of TRPV1 expressing primary afferent neurons prevents PAR-2 induced motility, but not mechanical hypersensitivity in the rat colon. Neurogastroenterol Motil 2012;24:e125–35.
  • Nilius B, Appendino G, Owsianik G. The transient receptor potential channel TRPA1: From gene to pathophysiology. Pflugers Arch 2012;464:425–58.

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