A metastatic relapse associated with hippocampal dose sparing after whole-brain radiotherapy

References

• Slotman BJ, Mauer ME, Bottomley A, Faivre-Finn C, Kramer GW, Rankin EM, et al. Prophylactic cranial irradiation in extensive disease small-cell lung cancer: Short-term health-related quality of life and patient reported symptoms: Results of an international phase III randomized controlled trial by the EORTC Radiation Oncology and Lung Cancer Groups. J Clin Oncol 2009;27:78–84.
   PubMed Web of Science ®Google Scholar
• Gondi V, Hermann BP, Mehta MP, Tome WA. Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors. Int J Radiat Oncol Biol Phys 2013; 85:348–54.
   PubMed Web of Science ®Google Scholar
• Chargari C, Campana F, Pierga JY, Vedrine L, Ricard D, Le Moulec S, et al. Whole-brain radiation therapy in breast cancer patients with brain metastases. Nat Rev Clin Oncol 2010;7:632–40.
   PubMed Web of Science ®Google Scholar
• Gondi V, Tome WA, Mehta MP. Why avoid the hippocampus? A comprehensive review. Radiother Oncol 2010;97:370–6.
   PubMed Web of Science ®Google Scholar
• Welzel G, Fleckenstein K, Schaefer J, Hermann B, Kraus-Tiefenbacher U, Mai SK, et al. Memory function before and after whole brain radiotherapy in patients with and without brain metastases. Int J Radiat Oncol Biol Phys 2008;72:1311–8.
   PubMed Web of Science ®Google Scholar
• Hattiangady B, Shetty AK. Neural stem cell grafting counteracts hippocampal injury-mediated impairments in mood, memory, and neurogenesis. Stem Cell Translat Med 2012; 1:696–708.
   PubMed Web of Science ®Google Scholar
• Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, et al. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: A randomised controlled trial. Lancet Oncol 2009;10:1037–44.
   PubMed Web of Science ®Google Scholar
• Chow E, Davis L, Holden L, Tsao M, Danjoux C. Prospective assessment of patient-rated symptoms following whole brain radiotherapy for brain metastases. J Pain Symptom Manage 2005;30:18–23.
   PubMed Web of Science ®Google Scholar
• Marsh JC, Ziel GE, Diaz AZ, Wendt JA, Gobole R, Turian JV. Integral dose delivered to normal brain with conventional intensity-modulated radiotherapy (IMRT) and helical tomotherapy IMRT during partial brain radiotherapy for high-grade gliomas with and without selective sparing of the hippocampus, limbic circuit and neural stem cell compartment. J Med Imaging Radiat Oncol 2013;57:378–83.
   PubMed Web of Science ®Google Scholar
• Marsh JC, Godbole RH, Herskovic AM, Gielda BT, Turian JV. Sparing of the neural stem cell compartment during whole-brain radiation therapy: A dosimetric study using helical tomotherapy. Int J Radiat Oncol Biol Phys 2010;78:946–54.
   PubMed Web of Science ®Google Scholar
• Gondi V, Tome WA, Marsh J, Struck A, Ghia A, Turian JV, et al. Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: Safety profile for RTOG 0933. Radiother Oncol 2010; 95:327–31.
   PubMed Web of Science ®Google Scholar
• Wan JF, Zhang SJ, Wang L, Zhao KL. Implications for preserving neural stem cells in whole brain radiotherapy and prophylactic cranial irradiation: A review of 2270 metastases in 488 patients. J Radiat Res 2013;54:285–91.
   PubMed Web of Science ®Google Scholar
• Ghia A, Tome WA, Thomas S, Cannon G, Khuntia D, Kuo JS, et al. Distribution of brain metastases in relation to the hippocampus: Implications for neurocognitive functional preservation. Int J Radiat Oncol Biol Phys 2007;68: 971–7.
   PubMed Web of Science ®Google Scholar
• Marsh JC, Herskovic AM, Gielda BT, Hughes FF, Hoeppner T, Turian J, et al. Intracranial metastatic disease spares the limbic circuit: A review of 697 metastatic lesions in 107 patients. Int J Radiat Oncol Biol Phys 2010;76: 504–12.
   PubMed Web of Science ®Google Scholar
• Tome WA, Bender ET, Gondi V, Mehta MP. In response to “The distribution of brain metastases in the perihippocampal region (regarding Gondi et al., Radiother Oncol 2010; 95:327–31) by van Kesteren et al Radiother Oncol 2011; 98:284.
   Google Scholar
• Prokic V, Wiedenmann N, Fels F, Schmucker M, Nieder C, Grosu AL. Whole brain irradiation with hippocampal sparing and dose escalation on multiple brain metastases: A planning study on treatment concepts. Int J Radiat Oncol Biol Phys 2013;85:264–70.
   PubMed Web of Science ®Google Scholar
• Hopf L, Quraan MA, Cheung MJ, Taylor MJ, Ryan JD, Moses SN. Hippocampal lateralization and memory in children and adults. J Int Neuropsychol Soc 2013:1–11.
   Google Scholar