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Original Article

Proton therapy and helical tomotherapy result in reduced dose deposition to the pancreas in the setting of cranio-spinal irradiation for medulloblastoma: Implications for reduced risk of diabetes mellitus in long-term survivors

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Pages 522-526 | Received 07 Sep 2014, Accepted 13 Oct 2014, Published online: 22 Mar 2015

References

  • Smoll NR. Relative survival of childhood and adult medulloblastomas and primitive neuroectodermal tumors (PNETs). Cancer 2012;118:1313–22.
  • von Hoff K, Hinkes B, Gerber NU, Deinlein F, Mittler U, Urban C, et al. Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT’91. Eur J Cancer 2009;45:1209–17.
  • Miralbell R, Lomax A, Russo M. Potential role of proton therapy in the treatment of pediatric medulloblastoma/ primitive neuro-ectodermal tumors: Spinal theca irradiation. Int J Radiat Oncol Biol Phys 1997;38:805–11.
  • Morris EB, Gajjar A, Okuma JO, Yasui Y, Wallace D, Kun LE, et al. Survival and late mortality in long-term survivors of pediatric CNS tumors. J Clin Oncol 2007;25:1532–8.
  • Yock TI, Caruso PA. Risk of second cancers after photon and proton radiotherapy: A review of the data. Health Phys 2012; 103:577–85.
  • Merchant TE. Proton beam therapy in pediatric oncology. Cancer J 2009;15:298–305.
  • Mertens AC, Liu Q, Neglia JP, Wasilewski K, Leisenring W, Armstrong GT, et al. Cause-specific late mortality among 5-year survivors of childhood cancer: The Childhood Cancer Survivor Study. J Natl Cancer Inst 2008;100:1368–79.
  • Meacham LR, Sklar CA, Li S, Liu Q, Gimpel N, Yasui Y, et al. Diabetes mellitus in long-term survivors of childhood cancer. Increased risk associated with radiation therapy: A report for the childhood cancer survivor study. Arch Intern Med 2009;169:1381–8.
  • de Vathaire F, El-Fayech C, Ben Ayed FF, Haddy N, Guibout C, Winter D, et al. Radiation dose to the pancreas and risk of diabetes mellitus in childhood cancer survivors: A retrospective cohort study. Lancet Oncol 2012;13: 1002–10.
  • van Nimwegen FA, Schaapveld M, Janus CP, Krol AD, Raemaekers JM, Kremer LC, et al. Risk of diabetes mellitus in long-term survivors of Hodgkin lymphoma. J Clin Oncol 2014;32:3257–63.
  • Wittingen J, Frey CF. Islet concentration in the head, body, tail and uncinate process of the pancreas. Ann Surg 1974; 179:412–4.
  • Teinturier C, Tournade MF, Caillat-Zucman S, Boitard C, Amoura Z, Bougneres PF, et al. Diabetes mellitus after abdominal radiation therapy. Lancet 1995;346: 633–4.
  • Cicognani A, Cacciari E, Mancini AF, Pasini A, Salardi S, Salmi S, et al. Abnormal insulin response to glucose following treatment for Wilms’ tumor in childhood. Eur J Pediatr 1997;156:371–5.
  • Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, Caicedo A. The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci 2006;103:2334–9.
  • Bosco D, Armanet M, Morel P, Niclauss N, Sgroi A, Muller YD, et al. Unique arrangement of alpha- and beta-cells in human islets of Langerhans. Diabetes 2010;59:1202–10.
  • Kilimnik G, Kim A, Jo J, Miller K, Hara M. Quantification of pancreatic islet distribution in situ in mice. Am J Physiol Endocrinol Metab 2009;297:E1331–8.

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