1,275
Views
7
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE: Lung Cancer

Keratin 34betaE12/keratin7 expression is a prognostic factor of cancer-specific and overall survival in patients with early stage non-small cell lung cancer

, , , , , , , , , & show all
Pages 167-177 | Received 15 Jan 2015, Accepted 29 Apr 2015, Published online: 09 Jun 2015

References

  • Goldstraw P, Crowley J, Chansky K, Giroux DJ, Groome PA, Rami-Porta R, et al. The IASLC Lung Cancer Staging Project: Proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol 2007;2:706–14.
  • Novello S, Asamura H, Bazan J, Carbone D, Goldstraw P, Grunenwald D, et al. Early-stage lung cancer: 40s anniversary. J Thorac Oncol 2014;9:1434–42.
  • Arriagada R, Auperin A, Burdett S, Higgins JP, Johnson DH, Le CT, et al. Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: Two meta-analyses of individual patient data. Lancet 2010;375:1267–77.
  • Moll R, Divo M, Langbein L. The human keratins: Biology and pathology. Histochem Cell Biol 2008;129:705–33.
  • Broers JL, de LL, Rot MK, ter HA, Lane EB, Leigh IM, et al. Expression of intermediate filament proteins in fetal and adult human lung tissues. Differentiation 1989;40:119–28.
  • Karantza V. Keratins in health and cancer: More than mere epithelial cell markers. Oncogene 2011;30:127–38.
  • Boers JE, Ambergen AW, Thunnissen FB. Number and proliferation of basal and parabasal cells in normal human airway epithelium. Am J Respir Crit Care Med 1998;157:2000–6.
  • Mackinder MA, Evans CA, Chowdry J, Staton CA, Corfe BM. Alteration in composition of keratin intermediate filaments in a model of breast cancer progression and the potential to reverse hallmarks of metastasis. Cancer Biomark 2012;12:49–64.
  • Seltmann K, Fritsch AW, Kas JA, Magin TM. Keratins significantly contribute to cell stiffness and impact invasive behavior. Proc Natl Acad Sci U S A 2013;110:18507–12.
  • Hendrix MJ, Seftor EA, Chu YW, Trevor KT, Seftor RE. Role of intermediate filaments in migration, invasion and metastasis. Cancer Metastasis Rev 1996;15:507–25.
  • Donnem T, Al-Shibli K, Andersen S, Al-Saad S, Busund LT, Bremnes RM. Combination of low vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 expression and high lymphocyte infiltration is a strong and independent favorable prognostic factor in patients with nonsmall cell lung cancer. Cancer 2010;116:4318–25.
  • Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. International association for the study of lung cancer/American thoracic society/ European respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011; 6:244–85.
  • Pohl M, Olsen KE, Holst R, Ditzel HJ, Hansen O. Tissue microarrays in non-small-cell lung cancer: Reliability of immunohistochemically-determined biomarkers. Clin Lung Cancer 2014;15:222–30.e3.
  • Donnem T, Al-Saad S, Al-Shibli K, Delghandi MP, Persson M, et al. Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer. Clin Cancer Res 2007;13:6649–57.
  • Camilo R, Capelozzi VL, Siqueira SA, Del Carlo BF. Expression of p63, keratin 5/6, keratin 7, and surfactant-A in non-small cell lung carcinomas. Hum Pathol 2006;37:542–6.
  • McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM. Reporting recommendations for tumor marker prognostic studies (REMARK). J Natl Cancer Inst 2005;97: 1180–4.
  • Moll R, Franke WW, Schiller DL, Geiger B, Krepler R. The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells. Cell 1982;31:11–24.
  • Yamada A, Sasaki H, Aoyagi K, Sano M, Fujii S, Daiko H, et al. Expression of cytokeratin 7 predicts survival in stage I/IIA/IIB squamous cell carcinoma of the esophagus. Oncol Rep 2008;20:1021–7.
  • Gharib TG, Chen G, Wang H, Huang CC, Prescott MS, Shedden K, et al. Proteomic analysis of cytokeratin isoforms uncovers association with survival in lung adenocarcinoma. Neoplasia 2002;4:440–8.
  • Mehta R, Jain RK, Sneige N, Badve S, Resetkova E. Expression of high-molecular-weight cytokeratin (34betaE12) is an independent predictor of disease-free survival in patients with triple-negative tumours of the breast. J Clin Pathol 2010;63:744–7.
  • Davis TL, Goldman AJ, Cress AE. Cell adhesion and cytoskeletal molecules in metastasis. In Cress AE, Nagle, RB, editors. Cancer metasis biology and treatment. The Netherlands: Springer Link; 2006.
  • Bennouna J, Senellart H, Hiret S, Vaissiere N, Douillard JY. Impact of histology on survival of resected non-small cell lung cancer (NSCLC) receiving adjuvant chemotherapy: Subgroup analysis of the adjuvant vinorelbine (NVB) cisplatin (CDDP) versus observation in the ANITA trial. Lung Cancer 2011;74:30–4.
  • Viberti L, Bongiovanni M, Croce S, Bussolati G. 34betaE12 cytokeratin immunodetection in the differential diagnosis of small cell tumors of lung. Int J Surg Pathol 2000;8: 317–22.
  • Sturm N, Rossi G, Lantuejoul S, Laverriere MH, Papotti M, Brichon PY, et al. 34BetaE12 expression along the whole spectrum of neuroendocrine proliferations of the lung, from neuroendocrine cell hyperplasia to small cell carcinoma. Histopathology 2003;42:156–66.
  • Donnem TP, Hald SM, Paulsen EE, Richardsen E, Al-Saad S, Kilvaer TK, et al. Stromal CD8 + T cell density – a promising supplement to TNM staging in non-small cell lung cancer. Clin Cancer Res Epub 2015 Feb 13.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.