1,011
Views
3
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLES: Breast cancer

Pak1, adjuvant tamoxifen therapy, and breast cancer recurrence risk in a Danish population-based study

, , , , , & show all
Pages 734-741 | Received 15 Oct 2015, Accepted 30 Jan 2016, Published online: 08 Apr 2016

References

  • Moy B, Lee RJ, Smith M. Natural Products in Cancer Chemotherapy: Hormones and Related Agents. In: Brunton LL, editor. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 12 ed. New York: McGraw-Hill; 2011.
  • Davies C, Godwin J, Gray R, Clarke M, Cutter D. Early Breast Cancer Trialists' Collaborative G. Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet 2011;378:771–84.
  • Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, Thurlimann B, et al. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann Oncol 2013;24:2206–23.
  • Kichina J, Goc A, Al-Husein B, Somanath P, Kandel E. PAK1 as a therapeutic target. Expert Opin Therapeutic Target 2010;14:703–25.
  • Wang RA, Vadlamudi RK, Bagheri-Yarmand R, Beuvink I, Hynes NE, Kumar R. Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands. J Cell Biol 2003;161:583–92.
  • Wang RA, Zhang H, Balasenthil S, Medina D, Kumar R. PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene 2006;25:2931–6.
  • Rayala SK, Talukder AH, Balasenthil S, Tharakan R, Barnes CJ, Wang RA, et al. P21-Activated Kinase 1 Regulation of Estrogen Receptor-alpha Activation Involves Serine 305 Activation Linked with Serine 118 Phosphorylation. Cancer Res 2006;66:1694–701.
  • Balasenthil S, Barnes C, Rayala S, Kumar R. Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells. FEBS Lett 2004;567:243–7.
  • Bostner J, Ahnstrom Waltersson M, Fornander T, Skoog L, Nordenskjold B, Stal O. Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer. Oncogene 2007;26:6997–7005.
  • Holm C, Rayala S, Jirström K, Stål O, Kumar R, Landberg G. Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients. J Natl Cancer Inst 2006;98:671–80.
  • Holm C, Kok M, Michalides R, Fles R, Koornstra R, Wesseling J, et al. Phosphorylation of the oestrogen receptor alpha at serine 305 and prediction of tamoxifen resistance in breast cancer. J Pathol 2009;217:372–9.
  • Bostner J, Skoog L, Fornander T, Nordenskjöld B, Stål O. Estrogen receptor-alpha phosphorylation at serine 305, nuclear p21-activated kinase 1 expression, and response to tamoxifen in postmenopausal breast cancer. Clinical Cancer Res. 2010;16:1624–33.
  • Kok M, Zwart W, Holm C, Fles R, Hauptmann M, Van't Veer L, et al. PKA-induced phosphorylation of ERα at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer. Breast Cancer Res Treat 2011;125:1–12.
  • Jordan V. Pak up your breast tumor–and grow!. J Nat Cancer Inst 2006;98:657–9.
  • Lash T, Cronin-Fenton D, Ahern T, Rosenberg C, Lunetta K, Silliman R, et al. CYP2D6 inhibition and breast cancer recurrence in a population-based study in Denmark. J Natl Cancer Inst 2011;103:489–500.
  • Blichert-Toft M, Christiansen P, Mouridsen H. Danish Breast Cancer Cooperative Group–DBCG: History, organization, and status of scientific achievements at 30-year anniversary. Acta Oncol 2008;47:497–505. (Stockholm, Sweden).
  • Møller S, Jensen M, Ejlertsen B, Bjerre K, Larsen M, Hansen H, et al. The clinical database and the treatment guidelines of the Danish Breast Cancer Cooperative Group (DBCG); its 30-years experience and future promise. Acta Oncol 2008;47:506–24.
  • Charlson M, Pompei P, Ales K, MacKenzie C. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373–83.
  • Thygesen SK, Christiansen CF, Christensen S, Lash TL, Sorensen HT. The predictive value of ICD-10 diagnostic coding used to assess Charlson comorbidity index conditions in the population-based Danish National Registry of Patients. BMC Med Res Methodol 2011;11:83
  • Lynge E, Sandegaard JL, Rebolj M. The Danish National Patient Register. Scand J Public Health 2011;39:30–3.
  • Andersen K, Mouridsen H. Danish Breast Cancer Cooperative Group (DBCG). A description of the register of the nation-wide programme for primary breast cancer. Acta Oncol 1988;27:627–47.
  • Trikalinos T, Salanti G, Khoury M, Ioannidis J. Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations. Am J Epidemiol2006;163:300–9.
  • Rothman KJ, Greenland S, Lash TL. Case-Control Studies. In: Rothman KJ, Greenland S, Lash TL, editors. Modern Epidemiology. 3rd ed. Philadelphia: Wolters Kluwer; 2008. p. 111–27.
  • Buuren S. Multiple imputation of discrete and continuous data by fully conditional specification. Stat Method Med Res 2007;16:219–42.
  • The MIANALYZE Procedure. SAS/STAT User's Guide: The SAS Institute; 2014.
  • Jensena A, Ewertz M, Cold S, Storm H, Overgaard J. Time trends and regional differences in registration, stage distribution, surgical management and survival of breast cancer in Denmark. Eur J Cancer 2003;39:1783–93.
  • Cronin-Fenton DP, Hellberg Y, Lauridsen KL, Ahern TP, Garne JP, Rosenberg C, et al. Factors associated with concordant estrogen receptor expression at diagnosis and centralized re-assay in a Danish population-based breast cancer study. Acta Oncol 2012;51:254–61.
  • Aaltonen K, Ahlin C, Amini R, Salonen L, Fjallskog M, Heikkila P, et al. Reliability of cyclin A assessment on tissue microarrays in breast cancer compared to conventional histological slides. Br J Cancer 2006;94:1697–702.
  • Camp R, Charette L, Rimm D. Validation of tissue microarray technology in breast carcinoma. Lab Invest 2000;80:1943–9.
  • Desai M, Kubo J, Esserman D, Terry MB. The handling of missing data in molecular epidemiology studies. Cancer Epidemiol Biomarkers Prev 2011;20:1571–9.
  • Ryden L, Jonsson PE, Chebil G, Dufmats M, Ferno M, Jirstrom K, et al. Two years of adjuvant tamoxifen in premenopausal patients with breast cancer: a randomised, controlled trial with long-term follow-up. Eur J Cancer 2005;41:256–64.
  • Rutqvist LE, Johansson H, Stockholm Breast Cancer Study G. Long-term follow-up of the randomized Stockholm trial on adjuvant tamoxifen among postmenopausal patients with early stage breast cancer. Acta Oncol 2007;46:133–45.
  • Kok M, Linn SC, Van Laar RK, Jansen MP, van den Berg TM, Delahaye LJ, et al. Comparison of gene expression profiles predicting progression in breast cancer patients treated with tamoxifen. Breast Cancer Res Treat 2009;113:275–83.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.