229
Views
33
CrossRef citations to date
0
Altmetric
Research Article

RANKL Inhibition Improves Bone Properties in a Mouse Model of Osteogenesis Imperfecta

, , , &
Pages 123-131 | Received 02 Apr 2009, Accepted 10 Jun 2009, Published online: 06 Jan 2010

REFERENCES

  • Rauch, F., and Glorieux, F.H. (2004). Osteogenesis imperfecta. Lancet, 363:1377–1385.
  • Gatti, D., Antoniazzi, F., Prizzi, R., (2005). Intravenous neridronate in children with osteogenesis imperfecta: a randomized controlled study. J. Bone. Miner. Res. 20:758–763.
  • Glorieux, F.H., Bishop, N.J., Plotkin, H., (1998). Cyclic administration of pamidronate in children with severe osteogenesis imperfecta. N. Engl. J. Med., 339:947–952.
  • Letocha, A.D., Cintas, H.L., Troendle, J.F., (2005). Controlled trial of pamidronate in children with types III and IV osteogenesis imperfecta confirms vertebral gains but not short-term functional improvement. J. Bone Miner. Res., 20:977–986.
  • Madenci, E., Yilmaz, K., Yilmaz, M., (2006). Alendronate treatment in osteogenesis imperfecta. J. Clin. Rheumatol., 12:53–56.
  • Sakkers, R., Kok, D., and Engelbert, R., (2004). Skeletal effects and functional outcome with olpadronate in children with osteogenesis imperfecta: a 2-year randomised placebo-controlled study. Lancet, 363:1427–1431.
  • Glorieux, F.H. (2007). Experience with bisphosphonates in osteogenesis imperfecta. Pediatrics, 119(suppl 2):S163–S165.
  • Vallo, A., Rodriguez-Leyva, F., and Rodriguez Soriano, J. (2006). Osteogenesis imperfecta: anthropometric, skeletal and mineral metabolic effects of long-term intravenous pamidronate therapy. Acta Paediatr., 95:332–339.
  • Munns, C.F., Rauch, F., Mier, R.J., (2004). Respiratory distress with pamidronate treatment in infants with severe osteogenesis imperfecta. Bone, 35:231–234.
  • Rauch, F., Munns, C., Land, C., (2006). Pamidronate in children and adolescents with osteogenesis imperfecta: effect of treatment discontinuation. J. Clin. Endocrinol. Metab., 91:1268–1274.
  • Land, C., Rauch, F., and Glorieux, F.H. (2006). Cyclical intravenous pamidronate treatment affects metaphyseal modeling in growing patients with osteogenesis imperfecta. J. Bone Miner. Res., 21:374–379.
  • Pizones, J., Plotkin, H., Parra-Garcia, J.I., (2005). Bone healing in children with osteogenesis imperfecta treated with bisphosphonates. J. Pediatr. Orthop., 25:332–335.
  • Chan, B., and Zacharin, M. (2006). Maternal and infant outcome after pamidronate treatment of polyostotic fibrous dysplasia and osteogenesis imperfecta before conception: a report of four cases. J. Clin. Endocrinol. Metab., 91:2017–2020.
  • Teitelbaum, S.L. (2007). Osteoclasts: what do they do and how do they do it?. Am. J. Pathol., 170:427–435.
  • de Vernejoul, M.C. (2008). Sclerosing bone disorders. Best Prac. Res. Clin. Rheumatol., 22:71–83.
  • Tanaka, S., Nakamura, K., Takahasi, N., (2005). Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system. Immunol. Rev., 208:30–49.
  • Bone, H.G., Bolognese, M.A., Yuen, C.K., (2008). Effects of denosumab on bone mineral density and bone turnover in postmenopausal women. J. Clin. Endocrinol. Metab., 93:2149–2157.
  • Brown, J.P., Prince, R.L., Deal, C., (2009). Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial. J. Bone Miner. Res., 24:153–161.
  • Kostenuik, P.J.N.H., McCabe, J., Warmington, K., Kurahara, C., Sun, N., Chen, C., Li, L., Cattley, R.C., Van, G., Scully, S., Elliott, R., Grisanti, M., Morony, S., Tan, H.L., Asuncion, F., Li, X., Ominsky, M.S., Stolina, M., Dwyer, D., Dougall, W.C., Hawkins, N., Boyle, W.J., Simonet, W.S., and Sullivan, J.K. (2009). Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases bone density in knock-in mice that express chimeric (human/murine) RANKL. J. Bone Miner. Res., 24:182–195.
  • Miller, R.E., Branstetter, D., Armstrong, A., (2007). Receptor activator of NF-kappa B ligand inhibition suppresses bone resorption and hypercalcemia but does not affect host immune responses to influenza infection. J. Immunol., 179:266–274.
  • Chipman, S.D., Sweet, H.O., McBride, D.J., Jr., (1993). Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: a model of human osteogenesis imperfecta. Proc. Natl. Acad. Sci. USA, 90:1701–1705.
  • Camacho, N.P., Raggio, C.L., Doty, S.B., (2001). A controlled study of the effects of alendronate in a growing mouse model of osteogenesis imperfecta. Calcif. Tissue Int., 69:94–101.
  • Evans, K.D., Lau, S.T., Oberbauer, A.M., (2003). Alendronate affects long bone length and growth plate morphology in the oim mouse model for osteogenesis Imperfecta. Bone, 32:268–274.
  • McCarthy, E.A., Raggio, C.L., and Hossack, M.D., (2002). Alendronate treatment for infants with osteogenesis imperfecta: demonstration of efficacy in a mouse model. Pediatr. Res. 52:660–670.
  • Misof, B.M., Roschger, P., Baldini, T., (2005). Differential effects of alendronate treatment on bone from growing osteogenesis imperfecta and wild-type mouse. Bone, 36:150–158.
  • King, D., Jarjoura, D., McEwen, H.A., (2005). Growth hormone injections improve bone quality in a mouse model of osteogenesis imperfecta. J. Bone Miner. Res., 20:987–993.
  • Bonadio, J., Jepsen, K.J., Mansoura, M.K., (1993). A murine skeletal adaptation that significantly increases cortical bone mechanical properties. Implications for human skeletal fragility. J. Clin. Invest., 92:1697–1705.
  • Kamoun-Goldrat, A.S., and Le Merrer, M.F. (2007). Animal models of osteogenesis imperfecta and related syndromes. J. Bone Miner. Metab., 25:211–218.
  • Kozloff, K.M., Carden, A., Bergwitz, C., (2004). Brittle IV mouse model for osteogenesis imperfecta IV demonstrates postpubertal adaptations to improve whole bone strength. J. Bone Miner. Res., 19:614–622.
  • Sillence, D.O., Ritchie, H.E., Dibbayawan, T., (1993). Fragilitas ossium (fro/fro) in the mouse: a model for a recessively inherited type of osteogenesis imperfecta. Am. J. Med. Genet., 45:276–283.
  • Fisher, S., Jagadeeswaran, P., and Halpern, M.E. (2003). Radiographic analysis of zebrafish skeletal defects. Dev. Biol., 264:64–76.
  • Uveges, T.E., Kozloff, K.M., Ty, J.M., Ledgard, F., Raggio, C.L., Gronowicz, G., Goldstein, S.A., and Marini, J.C. (2009). Alendronate ttreatment of Brtl osteogenesis imprefacta mouse improves geometry and load response before fracture but decreases predicted material properties and has detrimental effects on osteoblasts and bone formation. J. Bone Miner. Res., 24(5):849–59.
  • Delos, D., Yang, X., Ricciardi, B.F., (2008). The effects of RANKL inhibition on fracture healing and bone strength in a mouse model of osteogenesis imperfecta. J. Orthop. Res., 26:153–164.
  • Turner, C.H., and Burr, D.B. (1993). Basic biomechanical measurements of bone: a tutorial. Bone, 14:595–608.
  • Huang, A.R.C, Fritton, J., and Camacho, N. (2005). Comparison of radiographic and micro-CT determined parameters in mouse bone specimens. 51st annual meeting of the Orthopaedic Research Society.
  • Van Der Meulen, M.C., Jepsen, K.J., and Miki, B. (2001). Understanding bone strength: size isn't everything. Bone, 29:101–104.
  • Van Slyke, M.A., and Marks, S.C., Jr. (1987). Failure of normal osteoclasts to resorb calcified cartilage from osteosclerotic (oc/oc) mice in vitro. Bone, 8:39–44.
  • Faden, M.A., Krakow, D., Ezgu, F., (2009). The Erlenmeyer flask bone deformity in the skeletal dysplasias. Am. J. Med. Genet., 149A(6):1334–45
  • Cho, T.J., Choi, I.H., Chung, C.Y., (2005). Efficacy of oral alendronate in children with osteogenesis imperfecta. J. Pediatr. Orthop., 25:607–612.
  • Rauch, F., Cornibert, S., Cheung, M., (2007). Long-bone changes after pamidronate discontinuation in children and adolescents with osteogenesis imperfecta. Bone, 40:821–827.
  • Bonnick, S., Saag, K.G., Kiel, D.P., (2006). Comparison of weekly treatment of postmenopausal osteoporosis with alendronate versus risedronate over two years. J. Clin. Endocrinol. Metab., 91:2631–2637.
  • Rosen, C.J., Hochberg, M.C., and Bonnick, S.L., (2005). Treatment with once-weekly alendronate 70 mg compared with once-weekly risedronate 35 mg in women with postmenopausal osteoporosis: a randomized double-blind study. [see comment]. J. Bone Miner. Res., 20:141–151.
  • Delmas, P.D., and Seeman, E. (2004). Changes in bone mineral density explain little of the reduction in vertebral or nonvertebral fracture risk with anti-resorptive therapy. [see comment]. Bone, 34:599–604.
  • Plotkin, L.I., Aguirre, J.I., Kousteni, S., (2005). Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation. J. Biol. Chem., 280:7317–7325.
  • Plotkin, L.I., Weinstein, R.S., Parfitt, A.M., (1999). Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J. Clin. Invest., 104:1363–1374.
  • Samadfam, R., Xia, Q., and Goltzman, D. (2007). Co-treatment of PTH with osteoprotegerin or alendronate increases its anabolic effect on the skeleton of oophorectomized mice. J. Bone Miner. Res., 22:55–63.
  • Albright, J.A., and Grunt, J.A. (1971). Studies of patients with osteogenesis imperfecta. J. Bone Joint Surg. Amer., 53:1415–1425.
  • Flick, L.M., Weaver, J.M., Ulrich-Vinther, M., (2003). Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healing. J. Orthop. Res., 21:676–684.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.