Reduced local blood supply to the tibial metaphysis is associated with ovariectomy-induced osteoporosis in mice

REFERENCES

• Kanis, J.A. (1994). Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: Synopsis of a WHO report. WHO Study Group. Osteoporos. Int. 4:368–381.
   PubMed Web of Science ®Google Scholar
• Nian, H., Qin, L.P., Chen, W.S., Zhang, Q.Y., Zheng, H.C., and Wang, Y. (2006). Protective effect of steroidal saponins from rhizome of Anemarrhena asphodeloides on ovariectomy-induced bone loss in rats. Acta Pharmacol. Sin. 27:728–734.
   PubMed Web of Science ®Google Scholar
• Waarsing, J.H., Day, J.S., Verhaar, J.A., Ederveen, A.G., and Weinans, H. (2006). Bone loss dynamics result in trabecular alignment in aging and ovariectomized rats. J. Orthop. Res. 24:926–935.
   PubMed Web of Science ®Google Scholar
• Egrise, D., Martin, D., Neve, P., Vienne, A., Verhas, M., and Schoutens, A. (1992). Bone blood flow and in vitro proliferation of bone marrow and trabecular bone osteoblast-like cells in ovariectomized rats. Calcif. Tissue Int. 50:336–341.
   PubMed Web of Science ®Google Scholar
• Athanasopoulos, A.N., Schneider, D., Keiper, T., Alt, V., Pendurthi, U.R., Liegibel, U.M., Sommer, U., Nawroth, P.P., Kasperk, C., and Chavakis, T. (2007). Vascular endothelial growth factor (VEGF)-induced up-regulation of CCN1 in osteoblasts mediates proangiogenic activities in endothelial cells and promotes fracture healing. J. Biol. Chem. 282: 26746–26753.
   PubMed Web of Science ®Google Scholar
• Geris, L., Gerisch, A., Sloten, J.V., Weiner, R., and Oosterwyck, H.V. (2008). Angiogenesis in bone fracture healing: A bioregulatory model. J. Theor. Biol. 251:137–158.
   PubMed Web of Science ®Google Scholar
• Towler, D.A. (2007). Vascular biology and bone formation: Hints from HIF. J. Clin. Invest. 117:1477–1480.
   PubMed Web of Science ®Google Scholar
• Bonnarens, F., and Einhorn, T.A. (1984). Production of a standard closed fracture in laboratory animal bone. J. Orthop. Res. 2:97–101.
   PubMedGoogle Scholar
• Duvall, C.L., Taylor, W.R., Weiss, D., Wojtowicz, A.M., and Guldberg, R.E. (2007). Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice. J. Bone Miner. Res. 22:286–297.
   PubMed Web of Science ®Google Scholar
• Seeman, E., Young, N., Szmukler, G., Tsalamandris, C., and Hopper, J.L. (1993). Risk factors for osteoporosis. Osteoporos. Int. 3(Suppl. 1):40–43.
   PubMedGoogle Scholar
• Hunter, J. (2007). A treatise on the blood, inflammation, and gun-shot wounds. 1794. Clin. Orthop. Relat. Res. 458:27–34.
   PubMedGoogle Scholar
• Geiger, F., Bertram, H., Berger, I., Lorenz, H., Wall, O., Eckhardt, C., Simank, H.G., and Richter, W. (2005). Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects. J. Bone Miner. Res. 20:2028–2035.
   PubMed Web of Science ®Google Scholar
• Leach, J.K., Kaigler, D., Wang, Z., Krebsbach, P.H., and Mooney, D.J. (2006). Coating of VEGF-releasing scaffolds with bioactive glass for angiogenesis and bone regeneration. Biomaterials 27:3249–3255.
   PubMed Web of Science ®Google Scholar
• Hausman, M.R., Schaffler, M.B., and Majeska, R.J. (2001). Prevention of fracture healing in rats by an inhibitor of angiogenesis. Bone 29:560–564.
   PubMed Web of Science ®Google Scholar
• Griffith, J.F., Yeung, D.K., Tsang, P.H., Choi, K.C., Kwok, T.C., Ahuja, A.T., Leung, K.S., and Leung, P.C. (2008). Compromised bone marrow perfusion in osteoporosis. J. Bone Miner. Res. 23:1068–1075.
   PubMed Web of Science ®Google Scholar
• Rosen, C.J., Ackert-Bicknell, C., Rodriguez, J.P., and Pino, A.M. (2009). Marrow fat and the bone microenvironment: Developmental, functional, and pathological implications. Crit. Rev. Eukaryot. Gene Expr. 19:109–124.
   PubMed Web of Science ®Google Scholar
• Garcia-Sanz, A., Rodriguez-Barbero, A., Bentley, M.D., Ritman, E.L., and Romero, J.C. (1998). Three-dimensional microcomputed tomography of renal vasculature in rats. Hypertension 31:440–444.
   PubMed Web of Science ®Google Scholar
• Daghini, E., Zhu, X.Y., Versari, D., Bentley, M.D., Napoli, C., Lerman, A., and Lerman, L.O. (2007). Antioxidant vitamins induce angiogenesis in the normal pig kidney. Am. J. Physiol. Renal Physiol. 293:F371–F381.
   PubMed Web of Science ®Google Scholar
• Wietholt, C., Roerig, D.L., Gordon, J.B., Haworth, S.T., Molthen, R.C., and Clough, A.V. (2008). Bronchial circulation angiogenesis in the rat quantified with SPECT and micro-CT. Eur. J. Nucl. Med. Mol. Imaging 35: 1124–1132.
   PubMed Web of Science ®Google Scholar
• Cheung, A.M., Brown, A.S., Cucevic, V., Roy, M., Needles, A., Yang, V., Hicklin, D.J., Kerbel, R.S., and Foster, F.S. (2007). Detecting vascular changes in tumour xenografts using micro-ultrasound and micro-CT following treatment with VEGFR-2 blocking antibodies. Ultrasound Med. Biol. 33:1259–1268.
   PubMed Web of Science ®Google Scholar
• Lu, C., Marcucio, R., and Miclau, T. (2006). Assessing angiogenesis during fracture healing. Iowa Orthop. J. 26:17–26.
   PubMedGoogle Scholar
• Ferguson, C., Alpern, E., Miclau, T., and Helms, J.A. (1999). Does adult fracture repair recapitulate embryonic skeletal formation? Mech. Dev. 87:57–66.
   PubMed Web of Science ®Google Scholar
• Glowacki, J. (1998). Angiogenesis in fracture repair. Clin. Orthop. Relat. Res. 355(Suppl.):S82–S89.
   PubMedGoogle Scholar
• Felsenberg, D., and Boonen, S. (2005). The bone quality framework: Determinants of bone strength and their interrelationships, and implications for osteoporosis management. Clin. Ther. 27:1–11.
   PubMed Web of Science ®Google Scholar
• Guldberg, R.E., Ballock, R.T., Boyan, B.D., Duvall, C.L., Lin, A.S., Nagaraja, S., Oest, M., Phillips, J., Porter, B.D., Robertson, G., and Taylor, W.R. (2003). Analyzing bone, blood vessels, and biomaterials with microcomputed tomography. IEEE Eng. Med. Biol. Mag. 22:77–83.
   PubMed Web of Science ®Google Scholar