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Research Article

Intermittent Traction Stretch Promotes the Osteoblastic Differentiation of Bone Mesenchymal Stem Cells by the ERK1/2-Activated Cbfa1 Pathway

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Pages 451-459 | Received 17 Dec 2011, Accepted 11 Jun 2012, Published online: 24 Jul 2012

References

  • Heinonen, A., Sievanen, H., Kyrolainen, H., Perttunen, J., and Kannus, P. (2001). Mineral mass, size, and estimated mechanical strength of triple jumpers’ lower limb. Bone 29:279–285.
  • Karsten, J., and Hellsing, E. (1997). Effect of phenytoin on periodontal tissues exposed to orthodontic force – An experimental study in rats. Br. J. Orthod. 24:209–215.
  • Smith, R.K., and Roberts, W.E. (1980). Cell kinetics of the initial response to orthodontically induced osteogenesis in rat molar periodontal ligament. Calcif. Tissue Int. 30:51–56.
  • Thi, M.M., Iacobas, D.A., Iacobas, S., and Spray, D.C. (2007). Fluid shear stress upregulates vascular endothelial growth factor gene expression in osteoblasts. Ann. NY Acad. Sci. 1117:73–81.
  • Sakai, K., Mohtai, M., and Iwamoto, Y. (1998). Fluid shear stress increases transforming growth factor beta 1 expression in human osteoblast-like cells: Modulation by cation channel blockades. Calcif. Tissue Int. 63:515–520.
  • Pavalko, F.M., Chen, N.X., Turner, C.H., Burr, D.B., Atkinson, S., Hsieh, Y.F., Qiu, J., and Duncan, R.L. (1998). Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton–integrin interactions. Am. J. Physiol. 275:C1591–C1601.
  • Huang, L., Meng, Y., Ren, A., Han, X., Bai, D., and Bao, L. (2009). Response of cementoblast-like cells to mechanical tensile or compressive stress at physiological levels in vitro. Mol. Biol. Rep. 36:1741–1748.
  • Cancel, M., Grimard, G., Thuillard-Crisinel, D., Moldovan, F., and Villemure, I. (2009). Effects of in vivo static compressive loading on aggrecan and type II and X collagens in the rat growth plate extracellular matrix. Bone 44:306–315.
  • Fermor, B., Gundle, R., Evans, M., Emerton, M., Pocock, A., and Murray, D. (1998). Primary human osteoblast proliferation and prostaglandin E2 release in response to mechanical strain in vitro. Bone 22:637–643.
  • Kaspar, D., Seidl, W., Neidlinger-Wilke, C., Ignatius, A., and Claes, L. (2000). Dynamic cell stretching increases human osteoblast proliferation and CICP synthesis but decreases osteocalcin synthesis and alkaline phosphatase activity. J. Biomech. 33:45–51.
  • Song, G., Ju, Y., Soyama, H., Ohashi, T., and Sato, M. (2007). Regulation of cyclic longitudinal mechanical stretch on proliferation of human bone marrow mesenchymal stem cells. Mol. Cell. Biomech. 4:201–210.
  • Pavlin, D., Dove, S.B., Zadro, R., and Gluhak-Heinrich, J. (2000). Mechanical loading stimulates differentiation of periodontal osteoblasts in a mouse osteoinduction model: Effect on type I collagen and alkaline phosphatase genes. Calcif. Tissue Int. 67:163–172.
  • Mauney, J.R., Sjostorm, S., Blumberg, J., Horan, R., O’Leary, J.P., Vunjak-Novakovic, G., Volloch, V., and Kaplan, D.L. (2004). Mechanical stimulation promotes osteogenic differentiation of human bone marrow stromal cells on 3-D partially demineralized bone scaffolds in vitro. Calcif. Tissue Int. 74:458–468.
  • Kreke, M.R., Sharp, L.A., Lee, Y.W., and Goldstein, A.S. (2008). Effect of intermittent shear stress on mechanotransductive signaling and osteoblastic differentiation of bone marrow stromal cells. Tissue Eng. Part A 14:529–537.
  • Kreke, M.R., Huckle, W.R., and Goldstein, A.S. (2005). Fluid flow stimulates expression of osteopontin and bone sialoprotein by bone marrow stromal cells in a temporally dependent manner. Bone 36:1047–1055.
  • Shi, Y., Li, H., Zhang, X., Fu, Y., Huang, Y., Lui, P.P., Tang, T., and Dai, K. (2011). Continuous cyclic mechanical tension inhibited Runx2 expression in mesenchymal stem cells through RhoA-ERK1/2 pathway. J. Cell. Physiol. 226:2159–2169.
  • Qi, M.C., Zou, S.J., Han, L.C., Zhou, H.X., and Hu, J. (2009). Expression of bone-related genes in bone marrow MSCs after cyclic mechanical strain: Implications for distraction osteogenesis. Int. J. Oral Sci. 00: 143–150.
  • Ducy, P., Zhang, R., Geoffroy, V., Ridall, A.L., and Karsenty, G. (1997). Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell 89:747–754.
  • Otto, F., Thornell, A.P., Crompton, T., Denzel, A., Gilmour, K.C., Rosewell, I.R., Stamp, G.W., Beddington, R.S., Mundlos, S., Olsen, B.R., Selby, P.B., and Owen, M.J. (1997). Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765–771.
  • Simmons, C.A., Matlis, S., Thornton, A.J., Chen, S., Wang, C.Y., and Mooney, D.J. (2003). Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J. Biomech. 36:1087–1096.
  • Arita, N.A., Pelaez, D., and Cheung, H.S. (2011). Activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) is needed for the TGFbeta-induced chondrogenic and osteogenic differentiation of mesenchymal stem cells. Biochem. Biophys. Res. Commun. 405:564–569.
  • Jessop, H.L., Rawlinson, S.C., Pitsillides, A.A., and Lanyon, L.E. (2002). Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. Bone 31:186–194.
  • Turner, C.H. (2006). Bone strength: Current concepts. Ann. NY Acad. Sci. 1068:429–446.
  • Kanno, T., Takahashi, T., Tsujisawa, T., Ariyoshi, W., and Nishihara, T. (2007). Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts. J. Cell. Biochem. 101: 1266–1277.
  • Koike, M., Shimokawa, H., Kanno, Z., Ohya, K., and Soma, K. (2005). Effects of mechanical strain on proliferation and differentiation of bone marrow stromal cell line ST2. J. Bone Miner. Metab. 23:219–225.
  • Burger, E.H., and Klein-Nulend, J. (1999). Mechanotransduction in bone—Role of the lacuno-canalicular network. FASEB J. 13(Suppl.):S101–S112.
  • Pratap, J., Galindo, M., Zaidi, S.K., Vradii, D., Bhat, B.M., Robinson, J.A., Choi, J.Y., Komori, T., Stein, J.L., Lian, J.B., Stein, G.S., and van Wijnen, A.J. (2003). Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts. Cancer Res. 63:5357–5362.
  • Ziros, P.G., Gil, A.P., Georgakopoulos, T., Habeos, I., Kletsas, D., Basdra, E.K., and Papavassiliou, A.G. (2002). The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells. J. Biol. Chem. 277:23934–23941.
  • Turjanski, A.G., Vaque, J.P., and Gutkind, J.S. (2007). MAP kinases and the control of nuclear events. Oncogene 26:3240–3253.

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