390
Views
20
CrossRef citations to date
0
Altmetric
Research Article

Roles of TGF-β/Smad signaling pathway in pathogenesis and development of gluteal muscle contracture

, , , , , & show all
Pages 9-17 | Received 16 May 2014, Accepted 03 Sep 2014, Published online: 30 Sep 2014

References

  • Liu GH, Cao FQ, Yang SH, Zhu JF. Factors influencing the treatment of severe gluteal muscle contracture in children. J Pediatr Orthop B 2011;20:67–9
  • Cai JH, Gan LF, Zheng HL, Li H. Iliac hyperdense line: a new radiographic sign of gluteal muscle contracture. Pediatr Radiol 2005;35:995–7
  • Liu G, Yang S, Du J, Zheng Q, Shao Z, Yang C. Treatment of severe gluteal muscle contracture in children. J Huazhong Univ Sci Technolog Med Sci 2008;28:171–3
  • Chen X, Tang X, Jiang X, Wang D, Peng M, Liu L. Diagnosis and treatment of unilateral gluteal muscle contracture. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2011;25:530–2
  • Zhang XT, Xiao DM, Shi JJ, Zhang WT. Familial osteopoikilosis in the pelvic region combined with bilateral gluteal muscle contracture: a case report. Zhongguo Gu Shang 2013;26:246–7
  • Zhao CG, He XJ, Lu B, Li HP, Kang AJ. Increased expression of collagens, transforming growth factor-beta1, and -beta3 in gluteal muscle contracture. BMC Musculoskelet Disord 2010;11:15
  • Cabello-Verrugio C, Santander C, Cofre C, Acuna MJ, Melo F, Brandan E. The internal region leucine-rich repeat 6 of decorin interacts with low density lipoprotein receptor-related protein-1, modulates transforming growth factor (TGF)-beta-dependent signaling, and inhibits TGF-beta-dependent fibrotic response in skeletal muscles. J Biol Chem 2012;287:6773–87
  • Wang S, Sun A, Li L, Zhao G, Jia J, Wang K, Ge J, Zou Y. Up-regulation of BMP-2 antagonizes TGF-beta1/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1/Smad6 complex. J Cell Mol Med 2012;16:2301–10
  • Choe JY, Jung HJ, Park KY, Kum YS, Song GG, Hyun DS, Park SH, Kim SK. Anti-fibrotic effect of thalidomide through inhibiting TGF-beta-induced ERK1/2 pathways in bleomycin-induced lung fibrosis in mice. Inflamm Res 2010;59:177–88
  • Yang J, Zheng J, Wu L, Shi M, Zhang H, Wang X, Xia N, Wang D, Liu X, Yao L, Li L, Dou K. NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-beta1/Smad pathway and altering the MMP2/TIMP2 ratio in rats. PLoS One 2011;6:e27710
  • Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003;113:685–700
  • Sun ZJ, Kim KS, Wagner G, Reinherz EL. Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer. Cell 2001;105:913–23
  • Phan TT, Lim IJ, Aalami O, Lorget F, Khoo A, Tan EK, Mukhopadhyay A, Longaker MT. Smad3 signalling plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions. J Pathol 2005;207:232–42
  • Gao Z, Wang Z, Shi Y, Lin Z, Jiang H, Hou T, Wang Q, Yuan X, Zhao Y, Wu H, Jin Y. Modulation of collagen synthesis in keloid fibroblasts by silencing Smad2 with siRNA. Plast Reconstr Surg 2006;118:1328–37
  • Yu H, Bock O, Bayat A, Ferguson MW, Mrowietz U. Decreased expression of inhibitory SMAD6 and SMAD7 in keloid scarring. J Plast Reconstr Aesthet Surg 2006;59:221–9
  • Tan AB, Kress S, Castro L, Sheppard A, Raghunath M. Cellular re- and de-programming by microenvironmental memory: why short TGF-beta1 pulses can have long effects. Fibrogenesis Tissue Repair 2013;6:12
  • Chen L, Ge Q, Black JL, Deng L, Burgess JK, Oliver BG. Differential regulation of extracellular matrix and soluble fibulin-1 levels by TGF-beta1 in airway smooth muscle cells. PLoS One 2013;8:e65544
  • Wang P, Nie X, Wang Y, Li Y, Ge C, Zhang L, Wang L, Bai R, Chen Z, Zhao Y, Chen C. Multiwall carbon nanotubes mediate macrophage activation and promote pulmonary fibrosis through TGF-beta/Smad signaling pathway. Small 2013;9:3799–811
  • Xu L, Zheng N, He Q, Li R, Zhang K, Liang T. Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-beta1/Smad signaling pathway, thereby leading to anti-fibrotic effect. Phytomedicine 2013;20:1172–9
  • Gao X, Cao Y, Yang W, Duan C, Aronson JF, Rastellini C, Chao C, Hellmich MR, Ko TC. BMP2 inhibits TGF-beta-induced pancreatic stellate cell activation and extracellular matrix formation. Am J Physiol Gastrointest Liver Physiol 2013;304:G804–13
  • Ye B, Zhou P, Xia Y, Chen Y, Yu J, Xu S. New minimally invasive option for the treatment of gluteal muscle contracture. Orthopedics 2012;35:e1692–8
  • Li Q, Lingyan Z, Yan L, Yulan P. The role of ultrasonography in the diagnosis of gluteal muscle contracture. Skeletal Radiol 2011;40:215–21
  • Samarakoon R, Dobberfuhl AD, Cooley C, Overstreet JM, Patel S, Goldschmeding R, Meldrum KK, Higgins PJ. Induction of renal fibrotic genes by TGF-beta1 requires EGFR activation, p53 and reactive oxygen species. Cell Signal 2013;25:2198–209
  • Zhao C, Qin J, He X, Guan Y, Jia Y, Lei W. Sphingosine-1-phosphate is a possible fibrogenic factor in gluteal muscle fibrosis. Physiol Res 2013;62:691–9
  • Kim DJ, Lee DC, Yang SJ, Lee JJ, Bae EM, Kim DM, Min SH, Kim SJ, Kang DC, Sang BC, Myung PK, Park KC, Yeom YI. Lysyl oxidase like 4, a novel target gene of TGF-beta1 signaling, can negatively regulate TGF-beta1-induced cell motility in PLC/PRF/5 hepatoma cells. Biochem Biophys Res Commun 2008;373:521–7
  • Fuchshofer R, Stephan DA, Russell P, Tamm ER. Gene expression profiling of TGFbeta2- and/or BMP7-treated trabecular meshwork cells: identification of Smad7 as a critical inhibitor of TGF-beta2 signaling. Exp Eye Res 2009;88:1020–32
  • He S, Yang Y, Liu X, Huang W, Zhang X, Yang S, Zhang X. Compound Astragalus and Salvia miltiorrhiza extract inhibits cell proliferation, invasion and collagen synthesis in keloid fibroblasts by mediating transforming growth factor-beta/Smad pathway. Br J Dermatol 2012;166:564–74
  • Xu Q, Tan Y, Zhang K, Li Y. Crosstalk between p38 and Smad3 through TGF-beta1 in JEG-3 choriocarcinoma cells. Int J Oncol 2013;43:1187–93
  • Matsuzaki K. Smad phospho-isoforms direct context-dependent TGF-beta signaling. Cytokine Growth Factor Rev 2013;24:385–99
  • Liu Y, Zheng WK, Gao WS, Shen Y, Ding WY. Function of TGF-beta and p38 MAKP signaling pathway in osteoblast differentiation from rat adipose-derived stem cells. Eur Rev Med Pharmacol Sci 2013;17:1611–19
  • Gao Y, Lui WY. Transforming growth factor-beta1 (TGF-beta1) regulates cell junction restructuring via Smad-mediated repression and Clathrin-mediated endocytosis of nectin-like molecule 2 (Necl-2). PLoS One 2013;8:e64316
  • Zhao L, Yee M, O'Reilly MA. Transdifferentiation of alveolar epithelial type II to type I cells is controlled by opposing TGF-beta and BMP signaling. Am J Physiol Lung Cell Mol Physiol 2013;305:409–18
  • Wharton K, Derynck R. TGFbeta family signaling: novel insights in development and disease. Development 2009;136:3691–7
  • Yumoto K, Thomas PS, Lane J, Matsuzaki K, Inagaki M, Ninomiya-Tsuji J, Scott GJ, Ray MK, Ishii M, Maxson R, Mishina Y, Kaartinen V. TGF-beta-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells. J Biol Chem 2013;288:13467–80
  • Thatcher JD. The TGF-beta signal transduction pathway. Sci Signal 2010;3:tr4
  • He S, Yang Y, Liu X, Huang W, Zhang X, Yang S, Zhang X. Compound Astragalus and Salvia miltiorrhiza extract inhibits cell proliferation, invasion and collagen synthesis in keloid fibroblasts by mediating transforming growth factor-beta/Smad pathway. Br J Dermatol 2012;166:564–74
  • Bellaye PS, Wettstein G, Burgy O, Besnard V, Joannes A, Colas J, Causse S, Marchal-Somme J, Fabre A, Crestani B, Kolb M, Gauldie J, Camus P, Garrido C, Bonniaud P. The small heat shock protein alphaB-crystallin is essential for the nuclear localisation of Smad4: impact on pulmonary fibrosis. J Pathol 2014;232:458–72
  • He Y, Huang C, Sun X, Long XR, Lv XW, Li J. MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4. Cell Signal 2012;24:1923–30
  • Wang J, Zhao J, Chu E, Mok M, Go MY, Man K, Heuchel R, Lan HY, Chang Z, Sung JJ, Yu J. Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro. J Pathol 2013;230:441–52
  • Jiang X, Castelao JE, Vandenberg D, Carracedo A, Redondo CM, Conti DV, Paredes CJ, Potter JD, Newcomb PA, Passarelli MN, Jenkins MA, Hopper JL, Gallinger S, Le Marchand L, Martínez ME, Ahnen DJ, Baron JA, Lindor NM, Haile RW, Gago-Dominguez M. Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry. PLoS One 2013;8:e60464
  • Dong C, Zhu S, Wang T, Yoon W, Li Z, Alvarez RJ, Ten DP, White B, Wigley FM, Goldschmidt-Clermont PJ. Deficient Smad7 expression: a putative molecular defect in scleroderma. Proc Natl Acad Sci USA 2002;99:3908–13
  • Wilkins-Port CE, Ye Q, Mazurkiewicz JE, Higgins PJ. TGF-beta1 + EGF-initiated invasive potential in transformed human keratinocytes is coupled to a plasmin/MMP-10/MMP-1-dependent collagen remodeling axis: role for PAI-1. Cancer Res 2009;69:4081–91
  • Bohm L, Serafin A, Akudugu J, Fernandez P, van der Merwe A, Aziz NA. uPA/PAI-1 ratios distinguish benign prostatic hyperplasia and prostate cancer. J Cancer Res Clin Oncol 2013;139:1221–8
  • Solberg A, Holmdahl L, Falk P, Wolving M, Palmgren I, Ivarsson ML. Local and systemic expressions of MMP-9, TIMP-1 and PAI-1 in patients undergoing surgery for clinically suspected appendicitis. Eur Surg Res 2012;48:99–105
  • Armendariz-Borunda J, Rincon AR, Munoz-Valle JF, Bueno-Topete M, Oregon-Romero E, Islas-Carbajal MC, Medina-Preciado D, Gonzalez-Garcia I, Bautista CA, Garcia-Rocha S, Godoy J, Vázquez-Del Mercado M, Troyo-SanRoman R, Arellano-Olivera I, Lucano S, Alvarez-Rodríguez A, Salazar A. Fibrogenic polymorphisms (TGF-beta, PAI-1, AT) in Mexican patients with established liver fibrosis. Potential correlation with pirfenidone treatment. J Investig Med 2008;56:944–53
  • Wang H, Zhang Y, Heuckeroth RO. PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA. FEBS Lett 2007;581:3098–104

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.