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Review Article

Genetic inactivation of the vesicular glutamate transporter 2 (VGLUT2) in the mouse: What have we learnt about functional glutamatergic neurotransmission?

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Pages 11-20 | Received 19 Oct 2009, Accepted 17 Dec 2009, Published online: 01 Mar 2010

References

  • Fonnum F. Glutamate: a neurotransmitter in mammalian brain. J Neurochem. 1984;42:1–11.
  • Moriyama Y, Yamamoto A. Glutamatergic chemical transmission: look! Here, there, and anywhere. J Biochem. 2004;135:155–63.
  • Chen J, Lipska BK, Weinberger DR. Genetic mouse models of schizophrenia: from hypothesis-based to susceptibility gene-based models. Biol Psychiatry. 2006;59:1180–8.
  • Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of depression. Neuron. 2002;34:13–25.
  • Kashani A, Lepicard E, Poirel O, Videau C, David JP, Fallet-Bianco C, Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease. Neurobiol Aging. 2008;29:1619–30.
  • Bellocchio EE, Reimer RJ, Fremeau RT Jr, Edwards RH. Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Science. 2000;289:957–60.
  • Fremeau RT Jr, Troyer MD, Pahner I, Nygaard GO, Tran CH, Reimer RJ, The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron. 2001;31:247–60.
  • Takamori S, Rhee JS, Rosenmund C, Jahn R. Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. Nature. 2000;407:189–94.
  • Herzog E, Bellenchi GC, Gras C, Bernard V, Ravassard P, Bedet C, The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons. J Neurosci. 2001;21:RC181.
  • Kaneko T, Fujiyama F. Complementary distribution of vesicular glutamate transporters in the central nervous system. Neurosci Res. 2002;42:243–50.
  • Miyazaki T, Fukaya M, Shimizu H, Watanabe M. Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum. Eur J Neurosci. 2003;17:2563–72.
  • Wojcik SM, Rhee JS, Herzog E, Sigler A, Jahn R, Takamori S, An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size. Proc Natl Acad Sci USA. 2004; 101:7158–63.
  • Fremeau RT Jr, Kam K, Qureshi T, Johnson J, Copenhagen DR, Storm-Mathisen J, Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science. 2004;304:1815–9.
  • Schuske K, Jorgensen EM. Neuroscience. Vesicular glutamate transporter—shooting blanks. Science. 2004;304:1750–2.
  • Stornetta RL, Sevigny CP, Schreihofer AM, Rosin DL, Guyenet PG. Vesicular glutamate transporter DNPI/VGLUT2 is expressed by both C1 adrenergic and nonaminergic presympathetic vasomotor neurons of the rat medulla. J Comp Neurol. 2002;444:207–20.
  • Stornetta RL, Rosin DL, Wang H, Sevigny CP, Weston MC, Guyenet PG. A group of glutamatergic interneurons expressing high levels of both neurokinin-1 receptors and somatostatin identifies the region of the pre-Botzinger complex. J Comp Neurol. 2003;455:499–512.
  • Nagy A. Cre recombinase: the universal reagent for genome tailoring. Genesis. 2000;26:99–109.
  • Moechars D, Weston MC, Leo S, Callaerts-Vegh Z, Goris I, Daneels G, Vesicular glutamate transporter VGLUT2 expression levels control quantal size and neuropathic pain. J Neurosci. 2006;26:12055–66.
  • Wallen-Mackenzie A, Gezelius H, Thoby-Brisson M, Nygard A, Enjin A, Fujiyama F, Vesicular glutamate transporter 2 is required for central respiratory rhythm generation but not for locomotor central pattern generation. J Neurosci. 2006;26:12294–307.
  • Lallemand Y, Luria V, Haffner-Krausz R, Lonai P. Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase. Transgenic Res. 1998;7:105–12.
  • Thoby-Brisson M, Trinh JB, Champagnat J, Fortin G. Emergence of the pre-Botzinger respiratory rhythm generator in the mouse embryo. J Neurosci. 2005;25:4307–18.
  • Buchanan JT, Grillner S. Newly identified ‘glutamate interneurons' and their role in locomotion in the lamprey spinal cord. Science. 1987;236:312–4.
  • Grillner S. Ion channels and locomotion. Science. 1997; 278:1087–8.
  • Grillner S. The motor infrastructure: from ion channels to neuronal networks. Nat Rev Neurosci. 2003;4:573–86.
  • Kiehn O. Locomotor circuits in the mammalian spinal cord. Annu Rev Neurosci. 2006;29:279–306.
  • Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab. 2007;5:383–93.
  • Ziegler DR, Cullinan WE, Herman JP. Distribution of vesicular glutamate transporter mRNA in rat hypothalamus. J Comp Neurol. 2002;448:217–29.
  • Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 2006;49:191–203.
  • Wallen-Mackenzie A, Nordenankar K, Fejgin K, Lagerstrom MC, Emilsson L, Fredriksson R, Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function. J Neurosci. 2009;29:2238–51.
  • Sakata-Haga H, Kanemoto M, Maruyama D, Hoshi K, Mogi K, Narita M, Differential localization and colocalization of two neuron-types of sodium-dependent inorganic phosphate cotransporters in rat forebrain. Brain Res. 2001; 902:143–55.
  • Varoqui H, Schafer MK, Zhu H, Weihe E, Erickson JD. Identification of the differentiation-associated Na+/PI transporter as a novel vesicular glutamate transporter expressed in a distinct set of glutamatergic synapses. J Neurosci. 2002;22: 142–55.
  • Oliveira AL, Hydling F, Olsson E, Shi T, Edwards RH, Fujiyama F, Cellular localization of three vesicular glutamate transporter mRNAs and proteins in rat spinal cord and dorsal root ganglia. Synapse. 2003;50:117–29.
  • Minichiello L, Korte M, Wolfer D, Kuhn R, Unsicker K, Cestari V, Essential role for TrkB receptors in hippocampus-mediated learning. Neuron. 1999;24:401–14.
  • Meyerson BJ, Augustsson H, Berg M, Roman E. The concentric square field: a multivariate test arena for analysis of explorative strategies. Behav Brain Res. 2006;168:100–13.
  • Daniels RW, Collins CA, Chen K, Gelfand MV, Featherstone DE, DiAntonio A. A single vesicular glutamate transporter is sufficient to fill a synaptic vesicle. Neuron. 2006;49:11–6.
  • Daniels RW, Collins CA, Gelfand MV, Dant J, Brooks ES, Krantz DE, Increased expression of the Drosophila vesicular glutamate transporter leads to excess glutamate release and a compensatory decrease in quantal content. J Neurosci. 2004;24:10466–74.
  • Kashani A, Betancur C, Giros B, Hirsch E, El Mestikawy S. Altered expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in Parkinson disease. Neurobiol Aging. 2007;28:568–78.
  • Kirvell SL, Esiri M, Francis PT. Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease. J Neurochem. 2006;98:939–50.
  • Smith RE, Haroutunian V, Davis KL, Meador-Woodruff JH. Vesicular glutamate transporter transcript expression in the thalamus in schizophrenia. Neuroreport. 2001;12:2885–7.
  • Wu XS, Xue L, Mohan R, Paradiso K, Gillis KD, Wu LG. The origin of quantal size variation: vesicular glutamate concentration plays a significant role. J Neurosci. 2007;27:3046–56.
  • Leo S, Moechars D, Callaerts-Vegh Z, D'Hooge R, Meert T. Impairment of VGLUT2 but not VGLUT1 signaling reduces neuropathy-induced hypersensitivity. Eur J Pain. 2009;13:1008–17.
  • Kang TC, Kim DS, Kwak SE, Kim JE, Kim DW, Kang JH, Valproic acid reduces enhanced vesicular glutamate transporter immunoreactivities in the dentate gyrus of the seizure prone gerbil. Neuropharmacology. 2005;49:912–21.
  • Schallier A, Massie A, Loyens E, Moechars D, Drinkenburg W, Michotte Y, vGLUT2 heterozygous mice show more susceptibility to clonic seizures induced by pentylenetetrazol. Neurochem Int. 2009;55:41–4.
  • Eells JB, Clough RW, Browning RA, Jobe PC. Comparative fos immunoreactivity in the brain after forebrain, brainstem, or combined seizures induced by electroshock, pentylenetetrazol, focally induced and audiogenic seizures in rats. Neuroscience. 2004;123:279–92.
  • Albo F, Pieri M, Zona C. Modulation of AMPA receptors in spinal motor neurons by the neuroprotective agent riluzole. J Neurosci Res. 2004;78:200–7.
  • Wootz H, Enjin A, Wallen-Mackenzie A, Lindholm D, Kullander K. Reduced VGLUT2 expression increases motor neuron viability in Sod1(G93A) mice. Neurobiol Dis. 2010;37:58–66.