5,704
Views
128
CrossRef citations to date
0
Altmetric
Review Article

Serotonin, genetic variability, behaviour, and psychiatric disorders - a review

&
Pages 2-10 | Received 08 Oct 2009, Accepted 18 Dec 2009, Published online: 01 Mar 2010

References

  • Little KY, McLaughlin DP, Zhang L, Livermore CS, Dalack GW, McFinton PR, Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry. 1998;155:207–13.
  • Sabol SZ, Hu S, Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet. 1998;103:273–9.
  • Deckert J, Catalano M, Syagailo YV, Bosi M, Okladnova O, Di Bella D, Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet. 1999;8:621–4.
  • Denney RM, Koch H, Craig IW. Association between monoamine oxidase A activity in human male skin fibroblasts and genotype of the MAOA promoter-associated variable number tandem repeat. Hum Genet. 1999;105:542–51.
  • Bennett AJ, Lesch KP, Heils A, Long JC, Lorenz JG, Shoaf SE, Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry. 2002;7:118–22.
  • Newman TK, Syagailo YV, Barr CS, Wendland JR, Champoux M, Graessle M, Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys. Biol Psychiatry. 2005;57:167–72.
  • Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet. 2006;78:815–26.
  • Guo G, Ou XM, Roettger M, Shih JC. The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity. Eur J Hum Genet. 2008;16:626–34.
  • Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274:1527–31.
  • Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Role of genotype in the cycle of violence in maltreated children. Science. 2002;297:851–4.
  • Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386–9.
  • Nilsson KW, Sjoberg RL, Damberg M, Leppert J, Ohrvik J, Alm PO, Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity. Biol Psychiatry. 2006;59:121–7.
  • Sjoberg RL, Nilsson KW, Nordquist N, Ohrvik J, Leppert J, Lindstrom L, Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene. Int J Neuropsychopharmacol. 2006;9:443–9.
  • Nilsson KW, Wargelius HL, Sjoberg RL, Leppert J, Oreland L. The MAO-A gene, platelet MAO-B activity and psychosocial environment in adolescent female alcohol-related problem behaviour. Drug Alcohol Depend. 2008;93:51–62.
  • Lau JY, Goldman D, Buzas B, Fromm SJ, Guyer AE, Hodgkinson C, Amygdala function and 5-HTT gene variants in adolescent anxiety and major depressive disorder. Biol Psychiatry. 2009;65:349–55.
  • Nakamura M, Ueno S, Sano A, Tanabe H. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry. 2000;5:32–8.
  • Kraft JB, Slager SL, McGrath PJ, Hamilton SP. Sequence analysis of the serotonin transporter and associations with antidepressant response. Biol Psychiatry. 2005;58:374–81.
  • Lesch KP, Meyer J, Glatz K, Flugge G, Hinney A, Hebebrand J, The 5-HT transporter gene-linked polymorphic region (5-HTTLPR) in evolutionary perspective: alternative biallelic variation in rhesus monkeys. Rapid communication. J Neural Transm. 1997;104:1259–66.
  • Willeit M, Stastny J, Pirker W, Praschak-Rieder N, Neumeister A, Asenbaum S, No evidence for in vivo regulation of midbrain serotonin transporter availability by serotonin transporter promoter gene polymorphism. Biol Psychiatry. 2001;50:8–12.
  • Shioe K, Ichimiya T, Suhara T, Takano A, Sudo Y, Yasuno F, No association between genotype of the promoter region of serotonin transporter gene and serotonin transporter binding in human brain measured by PET. Synapse. 2003;48:184–8.
  • Parsey RV, Hastings RS, Oquendo MA, Hu X, Goldman D, Huang YY, Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry. 2006;163:48–51.
  • Christian BT, Fox AS, Oler JA, Vandehey NT, Murali D, Rogers J, Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET. NeuroImage. 2009;47:1230–6.
  • Jedema HP, Gianaros PJ, Greer PJ, Kerr DD, Liu S, Higley JD, Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmission. Mol Psychiatry. 2009 Sep 1 (Epub ahead of print)
  • Fowler JS, Alia-Klein N, Kriplani A, Logan J, Williams B, Zhu W, Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects. Biol Psychiatry. 2007;62:355–8.
  • Alia-Klein N, Goldstein RZ, Kriplani A, Logan J, Tomasi D, Williams B, Brain monoamine oxidase A activity predicts trait aggression. J Neurosci. 2008;28:5099–104.
  • Alia-Klein N, Kriplani A, Pradhan K, Ma JY, Logan J, Williams B, The MAO-A genotype does not modulate resting brain metabolism in adults. Psychiatry Res. 2008;164:73–6.
  • Balciuniene J, Emilsson L, Oreland L, Pettersson U, Jazin E. Investigation of the functional effect of monoamine oxidase polymorphisms in human brain. Hum Genet. 2002;110:1–7.
  • Cirulli ET, Goldstein DB. In vitro assays fail to predict in vivo effects of regulatory polymorphisms. Hum Mol Genet. 2007;16:1931–9.
  • Soubrié P. Reconciling the role of central serotonin neurons in human and animal behavior. Behav Brain Sci. 1986;9:319–64.
  • Sundstrom E, Kolare S, Souverbie F, Samuelsson EB, Pschera H, Lunell NO, Neurochemical differentiation of human bulbospinal monoaminergic neurons during the first trimester. Brain Res Dev Brain Res. 1993;75:1–12.
  • Moiseiwitsch JR, Lauder JM. Serotonin regulates mouse cranial neural crest migration. Proc Natl Acad Sci U S A. 1995;92:7182–6.
  • Gustafsson BI, Tommeras K, Nordrum I, Loennechen JP, Brunsvik A, Solligard E, Long-term serotonin administration induces heart valve disease in rats. Circulation. 2005;111:1517–22.
  • Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science. 1993;262:578–80.
  • Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science. 1995;268:1763–6.
  • Popova NK, Maslova LN, Morosova EA, Bulygina VV, Seif I. MAO A knockout attenuates adrenocortical response to various kinds of stress. Psychoneuroendocrinology. 2006;31:179–86.
  • Scott AL, Bortolato M, Chen K, Shih JC. Novel monoamine oxidase A knock out mice with human-like spontaneous mutation. Neuroreport. 2008;19:739–43.
  • Holmes A, Lit Q, Murphy DL, Gold E, Crawley JN. Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background. Genes Brain Behav. 2003;2:365–80.
  • Kalueff AV, Olivier JD, Nonkes LJ, Homberg JR. Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes. Neurosci Biobehav Rev. 2009 Aug 19 (Epub ahead of print).
  • Noorlander CW, Ververs FF, Nikkels PG, van Echteld CJ, Visser GH, Smidt MP. Modulation of serotonin transporter function during fetal development causes dilated heart cardiomyopathy and lifelong behavioral abnormalities. PloS One. 2008;3:e2782.
  • Ansorge MS, Morelli E, Gingrich JA. Inhibition of serotonin but not norepinephrine transport during development produces delayed, persistent perturbations of emotional behaviors in mice. J Neurosci. 2008;28:199–207.
  • Clancy B, Kersh B, Hyde J, Darlington RB, Anand KJ, Finlay BL. Web-based method for translating neurodevelopment from laboratory species to humans. Neuroinformatics. 2007;5:79–94.
  • Mejia JM, Ervin FR, Baker GB, Palmour RM. Monoamine oxidase inhibition during brain development induces pathological aggressive behavior in mice. Biol Psychiatry. 2002;52:811–21.
  • Hendricks T, Francis N, Fyodorov D, Deneris ES. The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. J Neurosci. 1999;19:10348–56.
  • Hendricks TJ, Fyodorov DV, Wegman LJ, Lelutiu NB, Pehek EA, Yamamoto B, Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron. 2003;37:233–47.
  • Beaulieu JM, Zhang X, Rodriguiz RM, Sotnikova TD, Cools MJ, Wetsel WC, Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proc Natl Acad Sci U S A. 2008;105:1333–8.
  • Alenina N, Kikic D, Todiras M, Mosienko V, Qadri F, Plehm R, Growth retardation and altered autonomic control in mice lacking brain serotonin. Proc Natl Acad Sci U S A. 2009;106:10332–7.
  • Killackey HP, Rhoades RW, Bennett-Clarke CA. The formation of a cortical somatotopic map. Trends Neurosci. 1995;18:402–7.
  • Cases O, Vitalis T, Seif I, De Maeyer E, Sotelo C, Gaspar P. Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: role of a serotonin excess during the critical period. Neuron. 1996;16:297–307.
  • Vitalis T, Cases O, Callebert J, Launay JM, Price DJ, Seif I, Effects of monoamine oxidase A inhibition on barrel formation in the mouse somatosensory cortex: determination of a sensitive developmental period. J Comp Neurol. 1998;393:169–84.
  • Persico AM, Mengual E, Moessner R, Hall FS, Revay RS, Sora I, Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release. J Neurosci. 2001;21:6862–73.
  • Xu Y, Sari Y, Zhou FC. Selective serotonin reuptake inhibitor disrupts organization of thalamocortical somatosensory barrels during development. Brain Res Dev Brain Res. 2004;150:151–61.
  • Auso E, Cases O, Fouquet C, Camacho M, Garcia-Velasco JV, Gaspar P, Protracted expression of serotonin transporter and altered thalamocortical projections in the barrelfield of hypothyroid rats. Eur J Neurosci. 2001;14:1968–80.
  • Salichon N, Gaspar P, Upton AL, Picaud S, Hanoun N, Hamon M, Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice. J Neurosci. 2001;21:884–96.
  • Rebsam A, Seif I, Gaspar P. Refinement of thalamocortical arbors and emergence of barrel domains in the primary somatosensory cortex: a study of normal and monoamine oxidase a knock-out mice. J Neurosci. 2002;22:8541–52.
  • Laurent A, Goaillard JM, Cases O, Lebrand C, Gaspar P, Ropert N. Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice. J Neurosci. 2002;22:886–900.
  • Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Serotonin transporter genetic variation and the response of the human amygdala. Science. 2002;297:400–3.
  • Hariri AR, Drabant EM, Munoz KE, Kolachana BS, Mattay VS, Egan MF, A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry. 2005;62:146–52.
  • Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci. 2005;8:828–34.
  • Meyer-Lindenberg A, Buckholtz JW, Kolachana B, R Hariri A, Pezawas L, Blasi G, Neural mechanisms of genetic risk for impulsivity and violence in humans. Proc Natl Acad Sci U S A. 2006;103:6269–74.
  • Buckholtz JW, Callicott JH, Kolachana B, Hariri AR, Goldberg TE, Genderson M, Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality. Mol Psychiatry. 2008;13:313–24.
  • Passamonti L, Cerasa A, Gioia MC, Magariello A, Muglia M, Quattrone A, Genetically dependent modulation of serotonergic inactivation in the human prefrontal cortex. NeuroImage. 2008;40:1264–73.
  • Pacheco J, Beevers CG, Benavides C, McGeary J, Stice E, Schnyer DM. Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism. J Neurosci. 2009;29:6229–33.
  • Paton JJ, Belova MA, Morrison SE, Salzman CD. The primate amygdala represents the positive and negative value of visual stimuli during learning. Nature. 2006;439:865–70.
  • Wellman CL, Izquierdo A, Garrett JE, Martin KP, Carroll J, Millstein R, Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. J Neurosci. 2007;27:684–91.
  • Bearer EL, Zhang X, Janvelyan D, Boulat B, Jacobs RE. Reward circuitry is perturbed in the absence of the serotonin transporter. NeuroImage. 2009;46:1091–104.
  • Narboux-Neme N, Pavone LM, Avallone L, Zhuang X, Gaspar P. Serotonin transporter transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs). Neuropharmacology. 2008;55:994–1005.
  • Whitaker-Azmitia PM. Behavioral and cellular consequences of increasing serotonergic activity during brain development: a role in autism? Int J Dev Neurosci. 2005;23:75–83.
  • Young SN, Leyton M. The role of serotonin in human mood and social interaction. Insight from altered tryptophan levels. Pharmacol Biochem Behav. 2002;71:857–65.
  • Fusar-Poli P, Allen P, McGuire P, Placentino A, Cortesi M, Perez J. Neuroimaging and electrophysiological studies of the effects of acute tryptophan depletion: a systematic review of the literature. Psychopharmacology. 2006;188:131–43.
  • Firk C, Markus CR. Differential effects of 5-HTTLPR genotypes on mood, memory, and attention bias following acute tryptophan depletion and stress exposure. Psychopharmacology. 2009;203:805–18.
  • Munafo MR, Brown SM, Hariri AR. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry. 2008;63:852–7.
  • Walderhaug E, Magnusson A, Neumeister A, Lappalainen J, Lunde H, Refsum H, Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people. Biol Psychiatry. 2007;62:593–9.
  • Brummett BH, Muller CL, Collins AL, Boyle SH, Kuhn CM, Siegler IC, 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion. Behav Genet. 2008;38:476–83.
  • Markus CR, Firk C. Differential effects of tri-allelic 5-HTTLPR polymorphisms in healthy subjects on mood and stress performance after tryptophan challenge. Neuropsychopharmacology. 2009;34:2667–74.
  • Sjoberg RL, Nilsson KW, Wargelius HL, Leppert J, Lindstrom L, Oreland L. Adolescent girls and criminal activity: role of MAOA-LPR genotype and psychosocial factors. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:159–64.
  • Nilsson KW, Sjoberg RL, Wargelius HL, Leppert J, Lindstrom L, Oreland L. The monoamine oxidase A (MAO-A) gene, family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumption. Addiction. 2007;102:389–98.
  • Barr CS, Newman TK, Schwandt M, Shannon C, Dvoskin RL, Lindell SG, Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proc Natl Acad Sci U S A. 2004;101:12358–63.
  • Arnold AP. Sex chromosomes and brain gender. Nat Rev Neurosci. 2004;5:701–8.
  • Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Epigenetic programming by maternal behavior. Nat Neurosci. 2004;7:847–54.
  • Holden C. Sex and the suffering brain. Science. 2005;308:1574.
  • Cahill L. Why sex matters for neuroscience. Nat Rev Neurosci. 2006;7:477–84.
  • Spinelli S, Chefer S, Suomi SJ, Higley JD, Barr CS, Stein E. Early-life stress induces long-term morphologic changes in primate brain. Arch Gen Psychiatry. 2009;66:658–65.
  • Cirulli F, Francia N, Branchi I, Antonucci MT, Aloe L, Suomi SJ, Changes in plasma levels of BDNF and NGF reveal a gender-selective vulnerability to early adversity in rhesus macaques. Psychoneuroendocrinology. 2009;34:172–80.
  • Ren-Patterson RF, Cochran LW, Holmes A, Sherrill S, Huang SJ, Tolliver T, Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice. J Neurosci Res. 2005;79:756–71.
  • Pezawas L, Meyer-Lindenberg A, Goldman AL, Verchinski BA, Chen G, Kolachana BS, Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Mol Psychiatry. 2008;13:709–16.
  • Oreland S, Pickering C, Gokturk C, Oreland L, Arborelius L, Nylander I. Two repeated maternal separation procedures differentially affect brain 5-hydroxytryptamine transporter and receptors in young and adult male and female rats. Brain Res. 2009;1305 Suppl:S37–49.
  • Kuramochi M, Nakamura S. Effects of postnatal isolation rearing and antidepressant treatment on the density of serotonergic and noradrenergic axons and depressive behavior in rats. Neuroscience. 2009;163:448–55.