A novel model for studies of blood-mediated long-term responses to cellular transplants

References

• Courtney JM, Lamba NM, Sundaram S, Forbes CD. Biomaterials for blood-contacting applications. Biomaterials. 1994;15:737–44.
   PubMed Web of Science ®Google Scholar
• Nilsson B, Ekdahl KN, Mollnes TE, Lambris JD. The role of complement in biomaterial-induced inflammation. Mol Immunol. 2007;44:82–94.
   PubMed Web of Science ®Google Scholar
• Bennet W, Sundberg B, Groth CG, Brendel MD, Brandhorst D, Brandhorst H, et al. Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation? Diabetes. 1999;48:1907–14.
   PubMed Web of Science ®Google Scholar
• Gong J, Larsson R, Ekdahl KN, Mollnes TE, Nilsson U, Nilsson B. Tubing loops as a model for cardiopulmonary bypass circuits: both the biomaterial and the blood-gas phase interfaces induce complement activation in an in vitro model. J Clin Immunol. 1996;16:222–9.
   PubMed Web of Science ®Google Scholar
• Andersson J, Sanchez J, Ekdahl KN, Elgue G, Nilsson B, Larsson R. Optimal heparin surface concentration and antithrombin binding capacity as evaluated with human non-anticoagulated blood in vitro. J Biomed Mater Res A. 2003;67:458–66.
   PubMedGoogle Scholar
• Hong J, Nilsson Ekdahl K, Reynolds H, Larsson R, Nilsson B. A new in vitro model to study interaction between whole blood and biomaterials. Studies of platelet and coagulation activation and the effect of aspirin. Biomaterials. 1999;20:603–11.
   PubMed Web of Science ®Google Scholar
• Mollnes TE, Brekke OL, Fung M, Fure H, Christiansen D, Bergseth G, et al. Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood. 2002;100:1869–77.
   PubMed Web of Science ®Google Scholar
• Moberg L, Korsgren O, Nilsson B. Neutrophilic granulocytes are the predominant cell type infiltrating pancreatic islets in contact with ABO-compatible blood. Clin Exp Immunol. 2005;142:125–31.
   PubMedGoogle Scholar
• Ekdahl KN, Hong J, Hamad OA, Larsson R, Nilsson B. Evaluation of the blood compatibility of materials, cells, and tissues: basic concepts, test models, and practical guidelines. Adv Exp Med Biol. 2013;735:257–70.
   PubMed Web of Science ®Google Scholar
• Johansson H, Lukinius A, Moberg L, Lundgren T, Berne C, Foss A, et al. Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes. 2005;54:1755–62.
   PubMed Web of Science ®Google Scholar
• Moberg L, Johansson H, Lukinius A, Berne C, Foss A, Kallen R, et al. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet. 2002;360:2039–45.
   PubMed Web of Science ®Google Scholar
• van der Windt DJ, Bottino R, Casu A, Campanile N, Cooper DK. Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies. Xenotransplantation. 2007;14:288–97.
   PubMed Web of Science ®Google Scholar
• Gustafson EK, Elgue G, Hughes RD, Mitry RR, Sanchez J, Haglund U, et al. The instant blood-mediated inflammatory reaction characterized in hepatocyte transplantation. Transplantation. 2011;91:632–8.
   Google Scholar
• Moll G, Rasmusson-Duprez I, von Bahr L, Connolly-Andersen AM, Elgue G, Funke L, et al. Are therapeutic human mesenchymal stromal cells compatible with human blood? Stem Cells. 2012;30:1565–74.
   PubMed Web of Science ®Google Scholar
• Naziruddin B, Iwahashi S, Kanak MA, Takita M, Itoh T, Levy MF. Evidence for instant blood-mediated inflammatory reaction in clinical autologous islet transplantation. Am J Transplant. 2014;14:428–37.
   PubMed Web of Science ®Google Scholar
• Permeability coefficients for peristaltic pump tubings. Saint-Gobain Performance Plastics. Available at http://www.processsystems.saint-gobain.com/uploadedFiles/SGPPL-PS/Documents/Peri_Pump/PS-PeriPumps-Permeability(1).pdf [Last accessed 16 September 2011].
   Google Scholar
• Goto M, Eich TM, Felldin M, Foss A, Kallen R, Salmela K, et al. Refinement of the automated method for human islet isolation and presentation of a closed system for in vitro islet culture. Transplantation. 2004;78:1367–75.
   PubMed Web of Science ®Google Scholar
• Stahle MU, Brandhorst D, Korsgren O, Knutson F. Pathogen inactivation of human serum facilitates its clinical use for islet cell culture and subsequent transplantation. Cell Transplant. 2011;20:775–81.
   PubMed Web of Science ®Google Scholar
• Hammill AK, Uhr JW, Scheuermann RH. Annexin V staining due to loss of membrane asymmetry can be reversible and precede commitment to apoptotic death. Exp Cell Res. 1999;251:16–21.
   PubMed Web of Science ®Google Scholar
• Bartlett GR, Marlow AA. Comparative effects of the different formed elements on normal human blood glycolysis. J Appl Physiol. 1953;6:335–47.
   PubMed Web of Science ®Google Scholar
• van Wijk R, van Solinge WW. The energy-less red blood cell is lost: erythrocyte enzyme abnormalities of glycolysis. Blood. 2005;106:4034–42.
   PubMed Web of Science ®Google Scholar
• Kominsky DJ, Campbell EL, Colgan SP. Metabolic shifts in immunity and inflammation. J Immunol. 2010;184:4062–8.
   PubMed Web of Science ®Google Scholar
• Everts B, Amiel E, van der Windt GJ, Freitas TC, Chott R, Yarasheski KE, et al. Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood. 2012;120:1422–31.
   PubMed Web of Science ®Google Scholar
• van Raam BJ, Sluiter W, de Wit E, Roos D, Verhoeven AJ, Kuijpers TW. Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation. PLoS ONE. 2008;3:e2013.
   PubMedGoogle Scholar
• Borregaard N, Herlin T. Energy metabolism of human neutrophils during phagocytosis. J Clin Invest. 1982;70:550–7.
   PubMed Web of Science ®Google Scholar
• Fox CJ, Hammerman PS, Thompson CB. Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol. 2005;5:844–52.
   PubMed Web of Science ®Google Scholar
• Zharikov S, Shiva S. Platelet mitochondrial function: from regulation of thrombosis to biomarker of disease. Biochem Soc Trans. 2013;41:118–23.
   PubMed Web of Science ®Google Scholar
• Whittam R. Potassium movements and ATP in human red cells. J Physiol. 1958;140:479–97.
   PubMed Web of Science ®Google Scholar
• Post RL, Merritt CR, Kinsolving CR, Albright CD. Membrane adenosine triphosphatase as a participant in the active transport of sodium and potassium in the human erythrocyte. J Biol Chem. 1960;235:1796–802.
   PubMed Web of Science ®Google Scholar
• Schatzmann HJ. ATP-dependent Ca++-extrusion from human red cells. Experientia. 1966;22:364–5.
   PubMedGoogle Scholar
• Brechard S, Tschirhart EJ. Regulation of superoxide production in neutrophils: role of calcium influx. J Leukoc Biol. 2008;84:1223–37.
   PubMed Web of Science ®Google Scholar
• Rink TJ, Sage SO. Calcium signaling in human platelets. Annu Rev Physiol. 1990;52:431–49.
   PubMed Web of Science ®Google Scholar
• Baker JM, Candy DJ, Hawker RJ. Influences of pH on human platelet metabolism. Platelets. 2001;12:333–42.
   PubMed Web of Science ®Google Scholar
• Thistlethwaite AJ, Leeper DB, Moylan DJ3rd, Nerlinger RE. pH distribution in human tumors. Int J Radiat Oncol Biol Phys. 1985;11:1647–52.
   PubMed Web of Science ®Google Scholar
• Lardner A. The effects of extracellular pH on immune function. J Leukoc Biol. 2001;69:522–30.
   PubMed Web of Science ®Google Scholar
• Kellum JA, Song M, Li J. Science review: extracellular acidosis and the immune response: clinical and physiologic implications. Crit Care. 2004;8:331–6.
   PubMed Web of Science ®Google Scholar
• Leblebicioglu B, Lim JS, Cario AC, Beck FM, Walters JD. pH changes observed in the inflamed gingival crevice modulate human polymorphonuclear leukocyte activation in vitro. J Periodontol. 1996;67:472–7.
   PubMed Web of Science ®Google Scholar
• Gabig TG, Bearman SI, Babior BM. Effects of oxygen tension and pH on the respiratory burst of human neutrophils. Blood. 1979;53:1133–9.
   PubMed Web of Science ®Google Scholar
• Heming TA, Dave SK, Tuazon DM, Chopra AK, Peterson JW, Bidani A. Effects of extracellular pH on tumour necrosis factor-alpha production by resident alveolar macrophages. Clin Sci (Lond). 2001;101:267–74.
   PubMed Web of Science ®Google Scholar
• Park SY, Bae DJ, Kim MJ, Piao ML, Kim IS. Extracellular low pH modulates phosphatidylserine-dependent phagocytosis in macrophages by increasing stabilin-1 expression. J Biol Chem. 2012;287:11261–71.
   PubMed Web of Science ®Google Scholar
• Islam A, Li SS, Oykhman P, Timm-McCann M, Huston SM, Stack D, et al. An acidic microenvironment increases NK cell killing of Cryptococcus neoformans and Cryptococcus gattii by enhancing perforin degranulation. PLoS Pathog. 2013;9:e1003439.
   PubMedGoogle Scholar
• Muller B, Fischer B, Kreutz W. An acidic microenvironment impairs the generation of non-major histocompatibility complex-restricted killer cells. Immunology. 2000;99:375–84.
   PubMed Web of Science ®Google Scholar
• Etulain J, Negrotto S, Carestia A, Pozner RG, Romaniuk MA, D’Atri LP, et al. Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets. Thromb Haemost. 2012;107:99–110.
   PubMed Web of Science ®Google Scholar
• Emeis M, Sonntag J, Willam C, Strauss E, Walka MM, Obladen M. Acidosis activates complement system in vitro. Mediators Inflamm. 1998;7:417–20.
   PubMed Web of Science ®Google Scholar
• Trevani AS, Andonegui G, Giordano M, Lopez DH, Gamberale R, Minucci F, et al. Extracellular acidification induces human neutrophil activation. J Immunol. 1999;162:4849–57.
   PubMed Web of Science ®Google Scholar
• Hampton MB, Chambers ST, Vissers MC, Winterbourn CC. Bacterial killing by neutrophils in hypertonic environments. J Infect Dis. 1994;169:839–46.
   PubMed Web of Science ®Google Scholar
• Bryant RE, Sutcliffe MC, McGee ZA. Effect of osmolalities comparable to those of the renal medulla on function of human polymorphonuclear leukocytes. J Infect Dis. 1972;126:1–10.
   PubMed Web of Science ®Google Scholar
• Junger WG, Hoyt DB, Davis RE, Herdon-Remelius C, Namiki S, Junger H, et al. Hypertonicity regulates the function of human neutrophils by modulating chemoattractant receptor signaling and activating mitogen-activated protein kinase p38. J Clin Invest. 1998;101:2768–79.
   PubMed Web of Science ®Google Scholar
• Loomis WH, Namiki S, Hoyt DB, Junger WG. Hypertonicity rescues T cells from suppression by trauma-induced anti-inflammatory mediators. Am J Physiol Cell Physiol. 2001;281:C840–8.
   PubMed Web of Science ®Google Scholar
• Angle N, Cabello-Passini R, Hoyt DB, Loomis WH, Shreve A, Namiki S, et al. Hypertonic saline infusion: can it regulate human neutrophil function? Shock. 2000;14:503–8.
   PubMed Web of Science ®Google Scholar
• Lang KS, Weigert C, Braedel S, Fillon S, Palmada M, Schleicher E, et al. Inhibition of interferon-gamma expression by osmotic shrinkage of peripheral blood lymphocytes. Am J Physiol Cell Physiol. 2003;284:C200–8.
   PubMed Web of Science ®Google Scholar
• Nils S. Hemolysis by hypertonic solutions of neutral salts. Acta Physiol Scand. 1944;7:56–68.
   Google Scholar
• Zade-Oppen AM. Posthypertonic hemolysis in sodium chloride systems. Acta Physiol Scand. 1968;73:341–64.
   PubMedGoogle Scholar
• Korsgren O, Lundgren T, Felldin M, Foss A, Isaksson B, Permert J, et al. Optimising islet engraftment is critical for successful clinical islet transplantation. Diabetologia. 2008;51:227–32.
   PubMed Web of Science ®Google Scholar