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Upsala Journal of Medical Sciences Volume 120, 2015 - Issue 2
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Original Article

Gunnar Blix and his discovery of sialic acids. Fascinating molecules in glycobiology

Arne LundbladG.Kjellbergs väg 5, 75643, Uppsala, SwedenCorrespondence[email protected]
Pages 104-112 | Received 26 Feb 2015, Accepted 28 Feb 2015, Published online: 28 Apr 2015

References

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  • Blix G, Tiselius A, Svensson H. Lipids and polysaccharides in electrophoretically separated blood serum proteins. J Biol Chem. 1941;137:485–94.
  • Blix G. Über die Kohlenhydratgruppen des Submaxillaris mucins. Z Physiol Chem. 1936;240:43–54.
  • Blix G. Sialic acids. Proc Intern Congr Biochem 4th Vienna. 1958;1:94–106.
  • Svennerholm L. On the isolation and characterization of N-acetyl-sialic acid. Acta Soc Med Upsalien. 1956;61:75–85.
  • Blix G. Einige Beobachtungen über eine hexosaminhaltige Substanz in der Protagonfraktion des Gehirns. Scand Arch Physiol. 1938;80:46–51.
  • Klenk E. Über die Natur der Phosphatide und anderer Lipoide des Gehirns und der Leber bei der Niemann-Pickschen Krankheit. Z Physiol Chem. 1935;235:24–36.
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  • Blix G, Lindberg E, Odin L, Werner I. Studies on sialic acids. Acta Soc Med Upsalien. 1956;61:1–25.
  • Gottschalk A. Structural relationship between sialic acid, neuraminic acid and 2-carboxypyrrole. Nature. 1955;176:881–2.
  • Blix G, Gottschalk A, Klenk E. Proposed nomenclature in the field of neuraminic and sialic acids. Nature. 1957;179:1088.
  • Schauer R. Sialic acids: fascinating sugars in higher animals and man. Zoology. 2004;107:49–64.
  • Schauer R. Sialic acids as regulators of molecular and cellular interactions. Curr Opin Struct Biol. 2009;19:507–14.
  • Varki A, Schauer S. Sialic acids. In Varki A, Cummings RD, Esko JD, et al. editors. Essentials of glycobiology. 2nd ed. 2009. Chapter 14 Available at http://www.ncbi.nlm.nih.gov/books/NBK1920/#ch14.s1.
  • Varki A. Sialic acids in human health and disease. Trends Mol Med. 2008;14:351–60.
  • Gamblin SJ, Skehel JJ. Influenza hemagglutinin and neuraminidase glycoproteins. J Biol Chem. 2010;285:28403–9.
  • Wang B. Molecular mechanism underlying sialic acid as an essential nutrient for brain development and cognition. 2012;3:465S–72S.
  • Clark GF. The role of carbohydrate recognition during human sperm-egg binding. Hum Reprod. 2013;28:566–77.

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