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Scandinavian Journal of Rheumatology Volume 42, 2013 - Issue 6
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Research Article

Genetic variants on 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population

R QiuKey Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics, Shandong University School of Medicine, Jinan, Shandong, P. R. China
,
H ZhangInstitute of Basic Medicine, Shandong Academy of Medical Science, Jinan, Shandong, P. R. China
,
H ZhaoKey Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics, Shandong University School of Medicine, Jinan, Shandong, P. R. China
,
J LiKey Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics, Shandong University School of Medicine, Jinan, Shandong, P. R. China
,
C GuoKey Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics, Shandong University School of Medicine, Jinan, Shandong, P. R. China
,
Y GongKey Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics, Shandong University School of Medicine, Jinan, Shandong, P. R. China
&
Q LiuKey Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics, Shandong University School of Medicine, Jinan, Shandong, P. R. ChinaCorrespondence[email protected]
 show all
Pages 469-472 | Accepted 13 Mar 2013, Published online: 12 Nov 2013

References

  • Brown MA. Breakthroughs in genetic studies of ankylosing spondylitis. Rheumatology (Oxford) 2008;47:132–7.
  • Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, . Orm family proteins mediate sphingolipid homeostasis. Nature 2010;463:1048–53.
  • Fang Q, Zhao H, Wang A, Gong Y, Liu Q. Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population. BMC Med Genet 2011;12:133.
  • Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, . Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007;448:470–3.
  • Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, . Genome-wide association defines more than 30 distinct susceptibility loci for Crohn’s disease. Nat Genet 2008;40:955–62.
  • Kurreeman FA, Stahl EA, Okada Y, Liao K, Diogo D, Raychaudhuri S, . Use of a multiethnic approach to identify rheumatoid-arthritis-susceptibility loci, 1p36 and 17q12. Am J Hum Genet 2012;90:524–32.
  • Mielants H, Veys EM, Cuvelier C, De Vos M, Goemaere S, De Clercq L, . The evolution of spondyloarthropathies in relation to gut histology. III. Relation between gut and joint. J Rheumatol 1995;22:2279–84.
  • Leirisalo-Repo M, Turunen U, Stenman S, Helenius P, Seppala K. High frequency of silent inflammatory bowel disease in spondylarthropathy. Arthritis Rheum 1994;37:23–31.
  • van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 1984;27:361–8.
  • Braun J, Golder W, Bollow M, Sieper J, van der Heijde D. Imaging and scoring in ankylosing spondylitis. Clin Exp Rheumatol 2002;20:S178–84.
  • Guo C, Xia Y, Yang Q, Qiu R, Zhao H, Liu Q. Association of the ANTXR2 gene polymorphism and ankylosing spondylitis in Chinese Han. Scand J Rheumatol 2012;41:29–32.
  • Laukens D, Georges M, Libioulle C, Sandor C, Mni M, Vander Cruyssen B, . Evidence for significant overlap between common risk variants for Crohn’s disease and ankylosing spondylitis. PLoS One 2010;5:e13795.
  • Lluis A, Schedel M, Liu J, Illi S, Depner M, von Mutius E, . Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion. J Allergy Clin Immunol 2011;127:1587–94.
  • Cantero-Recasens G, Fandos C, Rubio-Moscardo F, Valverde MA, Vicente R. The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress. Hum Mol Genet 2010;19:111–21.
  • Lessard CJ, Adrianto I, Ice JA, Wiley GB, Kelly JA, Glenn SB, . Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. Am J Hum Genet 2012;90:648–60.

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