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Scandinavian Journal of Rheumatology Volume 10, 1981 - Issue 2
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Original Article

Assessment of Immune Response During Chrysotherapy: Comparison of Gold Sodium Thiomalate vs. Auranofin

Arthur Lorber Division of Rheumatology, Department of Medicine, Memorial Hospital Medical Center of Long Beach, University of California at Irvine, Irvine, California, USA
,
William H. Jackson Division of Rheumatology, Department of Medicine, Memorial Hospital Medical Center of Long Beach, University of California at Irvine, Irvine, California, USA
&
Timothy M. Simon Division of Rheumatology, Department of Medicine, Memorial Hospital Medical Center of Long Beach, University of California at Irvine, Irvine, California, USA
Pages 129-137 | Accepted 04 Feb 1980, Published online: 12 Jul 2009

References

  • Berglof F. E., Berglof K., Walz D. T. Aurano-fin-an oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. J Rheum 1978; 5: 68
  • Catalone W. J., Taylor P. T., Rabson A. S. A method of dinitrochlorobenzene contact sensitization: A clinico-pathologic study. New Engl J Med 1972; 256: 399
  • Denman E. J., Denman A. M. The lymphocyte transformation test and gold hypersensitivity. Ann Rheum Dis 1968; 26: 582
  • Finkelstein A. E., Walz D. T., Batista D. Auranofin-a new oral gold compound for the treatment of rheumatoid arthritis. Ann Rheum Dis 1976; 35: 251
  • Gottlieb N. L., Kiem I. M., Penneys N. S. The influence of chrysotherapy on serum protein and immunoglobulin level, rheumatoid factor, and anti-epithelial antibody titers. J Lab Clin Med 1975; 86: 962
  • Harth M., Stiller N. R., Sinclair C. Effects of a gold salt on lymphocyte response. Clin Exp Immunol 1977; 27: 357
  • Lipsky P. E., Ziff M. Inhibition of antigen and mitogen-induced human lymphocyte proliferation by gold compounds. J Clin Invest 1977; 59: 455
  • Lorber A., Cohen R. L., Chang C. C. Gold determination in biological fluids by atomic absorption spectrophotometry: application to chrysotherapy in rheumatoid arthritis patients. Arthr Rheum 1968; 11: 170
  • Lorber A., Simon T. M. Applications and implications of gold therapy. Gold Bulletin 1979; 12: 149
  • Lorber A., Simon T. M., Harralson A. F. Pharmacokinetics of free serum gold: In vivo and in vitro correlates. J Clin Pharm Therap 1980, (Abstr.) (in press)
  • Lorber A., Simon T. M., Leeb J. Chrysotherapy: Suppression of immunoglobulin synthesis. Arthr Rheum 1978; 21: 785
  • Lorber A., Stebbins B. C., Simon T. M. Immunosuppressive action of gold salts in rheumatoid arthritis. J Rheum 1974; 1: 112, (Suppl. 1, Abstract)
  • Lorber A., Wilcox S., Leeb J. Quantitation of gold lymphocyte binding during chrysotherapy. J Rheum 1979; 6: 270
  • Patel P. J., Lefford M. J. Antigen specific lymphocyte transformation, delayed hypersensitivity, and protective immunity. 1. Kinetics of the response. Cell Immun 1978; 37: 315
  • Sadler P. J. The biological chemistry of gold: A metallo-drug and heavy atom label with variable valency. Bonding & Structure 1976; 29: 171
  • Simon T. M., Kunishima D. H., Vibert G. J. Cellular antiproliferative action exerted by Auranofin. J Rheum 1979; 6: 91, (Suppl. 5)
  • Simon T. M., Kunishima D. H., Vibert G. J. Inhibitory effects of a new oral gold compound on HeLa cells. Cancer 1979; 44: 1965
  • Simon T. M., Lorber A., Holmes H. T. A rapid method for preparing Ficoll-Hypaque step gradients and gradient overlays. J Immunol Methods 1976; 12: 193
  • Stastny P. Immunogenetic factors in rheumatoid arthritis. Clin Rheum Dis 1977; 3: 315
  • Strong J. S., Bartholomew B. A., Smyth C. J. Immunoresponsiveness of patients with rheumatoid arthritis receiving cyclophosphamide or gold salts. Ann Rheum Dis 1973; 32: 233
  • Walz D. T., Griswold D. E. Immunopharmaco-logy of gold sodium thiomalate and Auranofin (SK&F D39162). Effects on cell mediated immunity. Inflammation 1978; 3: 117

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