20 Years' Experience with Ketoprofen

References

• Peyron JG. Epidemiological aspects of osteoarthritis. Scand J Rheumatol 1989; 77: 29–33
   Google Scholar
• Moskowitz RW. Primary osteoarthritis: epidemiology, clinical aspects, and general management. Am J Med 1987; 83(5A)5–10
   PubMedGoogle Scholar
• Huskisson EC. Specifications for an ideal nonsteroidal anti-inflammatory drug. Rheumatol 1985; 85: 431–4
   Google Scholar
• Williams R L., Upton RA. The clinical pharmacology of ketoprofen. J Clin Pharmacol 1988; 28: 13–22
   Google Scholar
• Kantor TG. Ketoprofen: a review of its pharmacologic and clinical properties. Pharmacotherapy 1986; 6: 93–102
   PubMed Web of Science ®Google Scholar
• Hart FD. Rheumatic disorders. Avery's drug treatment3rd edn., T M. Speight. Adis Press Ltd, Auckland 1987; 910–57
   Google Scholar
• Julou L, Guyonnet J C., Ducrot R, Foumel J, Pasquet J. Ketoprofen (19.583 R.P.). Main pharmacological properties — outline of toxicological and pharmacokinetic data. Scand J Rheumatol 1976; 14: 33–44
   Google Scholar
• Guyonnet J C., Julou L. Relationship between the inhibitory activity on 'RCS' and prostaglandins synthesis and the anti-inflammatory activity of ketoprofen and several other non-steroidal anti-inflammatory agents. Rheumatol Rehabil 1976; 11–14, Suppl.
   PubMedGoogle Scholar
• Humes J L., Winter C A., Sadowski S J., Kuehl FA., Jr. Multiple sites on prostaglandin cyclooxygenase are determinants in the action of nonsteroidal antiinflammatory agents. Proc Natl Acad Sci 1981; 78: 2053–6
   PubMed Web of Science ®Google Scholar
• Matsuda K, Ohnishi K, Misaka E, Yamazaki M. Decrease of urinary prostaglandin E2 and prostaglandin F2 α excretion by non-steroidal anti-inflammatory drugs in rats. Biochcm Pharmacol 1983; 32: 1347–52
   PubMedGoogle Scholar
• Ligumsky M, Sestieri M, Karmeli F, Zimmerman J, Okon E, Rachmilewitz D. Rectal administration of nonsteroidal anti-inflammatory drugs. Gastroenterology 1990; 98: 1245–9
   PubMed Web of Science ®Google Scholar
• Julou L, Guyonnet J-C, Ducrot R, et al. Iitude des proprietes pharmacologiques dun nouvel anti-inflammatoire, l'acide (Benzoyl-3 phenyl)-2 propionique (19 583 R.P.). J Pharmacol 1971; 2: 259–86
   Google Scholar
• Julou L, Guyonnet J C., Ducrot R, Pasquet J. Some pharmacological and toxicological studies on ketoprofen. Rheumatol Rehabil 1976; 5–10, Suppl.
   PubMedGoogle Scholar
• Ottemess I G., Gans DJ. Nonsteroidal anti-inflammatory drugs: an analysis of the relationship between laboratory animal and clinical doses, including species scaling. J Pharm Sci 1988; 77: 790–5
   PubMedGoogle Scholar
• Collier S, Ghosh P. Evaluation of the effects of antiarthritic drugs on the secretion of proteoglycans by lapine chondrocytes using a novel assay procedure. Ann Rheum Dis 1989; 48: 372–81
   PubMedGoogle Scholar
• Kalbhen D A., Hoedt-Schmidt S. Pharmakologische Betrachtungen zur medikamenlosen Therapie der Arthrosen. Aktuel Rheumatol 1986; 11: 75–83
   Google Scholar
• Kalbhen DA. The influence of NSAIDs on morphology of articular cartilage. Scand J Rheumatol 1989; 77: 13–22
   Google Scholar
• Australian National Drug Information Service. Profile on ketoprofen. The Eastern Pharmacist 1986; 29: 77–80
   Google Scholar
• Fossgreen J. Ketoprofen: a survey of current publications. Scand J Rheumatol 1976; 14: 7–32
   Google Scholar
• Turek M D., Baird WM. Double-blind parallel comparison of Ketoprofen (Orudis), acetaminophen plus codeine, and placebo in postoperative pain. J Clin Pharmacol 1988; 28: 23–8
   Google Scholar
• Mehlisch DR. Ketoprofen, ibuprofen, and placebo in the treatment of primary dysmenorrhea: a double-blind crossover comparison. J Clin Pharmacol 1988; 28: 29–33
   PubMedGoogle Scholar
• Stambaugh J, Drew J. A double-blind parallel evaluation of the efficacy and safely of a single dose of ketoprofen in cancer pain. J Clin Pharmacol 1988; 28: 34–9
   Google Scholar
• Hébert J-G, Le Morvan P, Bourgouin J. Double-blind comparison of ketoprofen and mefenamic acid in the treatment of dysmenorrhea. Clin Ther 1986; 8: 329–35
   PubMedGoogle Scholar
• Sunshine A, Olson NZ. Analgesic efficacy of ketoprofen in postpartum, general surgery, and chronic cancer pain. J Clin Pharmacol 1988; S47–S54
   Google Scholar
• Goulton J, Baker P G., Wilkinson MA. A multicentre hospital study of Orudis in osteoarthritis of the hip and knee. Br J Clin Pract 1979; 33: 26–8
   PubMedGoogle Scholar
• Fellet A J., Cury CE. Ketoprofen “slow release” long term treatment of osteoarthritis. Clin Exp Rheumatol 1987; 5(2)48
   Google Scholar
• Ring E FJ, Dieppe P A., Bacon PA. The thermographic assessment of inflammation and anti-inflammatory drugs in osteoarthritis. Br J Clin Pract 1981; 35: 263–4
   PubMedGoogle Scholar
• Mathieu P, Benzoni D, Fonunges E, Vignon E. Étude de l'action du Ketoprofene sur les pros tag landines primaires du lipid synovial dans la polyarthrile rhumatoide. Rhumalologie 1988; 40: 223–8
   Google Scholar
• Baccino E, Harrewyn J M., Jouquan J, et al. Ketoprofen-induced reduction of polymorphonuclear cell activation in rheumatoid arthritis. Clin Exp Rheumatol 1987; 5: 53–7
   PubMedGoogle Scholar
• Baker P G., Goulton K. Ketoprofen (Orudis) twice daily dosage in arthritis and tissue injuries: a general practice study. J Int Med Res 1979; 7: 344–50
   PubMed Web of Science ®Google Scholar
• Goulton J, Baker PG. Ketoprofen ('Orudis') in the treatment of inflammatory arthritic conditions: a multi-centre study in general practice. Curr Med Res Opin 1980; 6: 423–30
   PubMed Web of Science ®Google Scholar
• Fine IT. Clinical experience with ketoprofen in the management of osteoarthritis and rheumatoid arthritis. Md Med J 1989; 38: 485–8
   PubMedGoogle Scholar
• Arramon J Y., Cayla P, Clément A, et al. Étude comparative en double aveugle de l'activité du kétoprofène à libération prolongée seul ou associé à un antalgique dans l' arthrose. Sem Høp 1989; 65: 1949–54
   Google Scholar
• van der Meij T, van Harten R PW. Evaluation of the efficacy and tolerance of Orudis 100 mg in osleo-arthritis in general practice. Clin Exp Rheumatol 1987; 5: 88
   Google Scholar
• Serry MM. A low-dosage Ketoprofen preparation in the management of osteoarthrosis of the knee joint. J Int Med Res 1980; 8: 388–90
   PubMedGoogle Scholar
• Scheller AD. The management of orthopedic pain with Ketoprofen. Adv Ther 1989; 6: 1–10
   Google Scholar
• Gleeson S, Sorbie J. Efficacy of Ketoprofen in treating primary dysmenorrhea. Can Med Assoc J 1983; 129: 842–4
   PubMedGoogle Scholar
• Akerlund M, Strömberg P. Comparison of Ketoprofen and naproxen in the treatment of dysmenorrhoea, with special regard to the time of onset of pain relief. Curr Med Res Opin 1989; 11: 485–90
   PubMed Web of Science ®Google Scholar
• D'Arienzo M, Pennisi M, Zanolo G, Borsa M. Ketoprofen lysine: Ketoprofen serum levels and analgesic activity. Drags Exp Clin Res 1984; 10: 863–6
   Google Scholar
• Cooper SA. Ketoprofen in oral surgery pain: a review. J Clin Pharmacol 1988; 28: 40–6
   Google Scholar
• Chlud K, Pangerl S. Ketoprofen in the treatment of soft tissue injury. Rheumatol Rehabil 1979; 18(1)114
   PubMedGoogle Scholar
• Huber-Bruning O, Wilbrinck B, van der Meij T. No adverse effect of Ketoprofen on proteoglycans of healthy human articular cartilage in vitro. Clin Exp Rheumatol 1987; 5(2)F514
   Google Scholar
• Huber-Bruning O, Willbrinck B, Vanroy J LA M, Vanderveen MJ. Potential influences of Ketoprofen on human healthy and osteoarthrilic cartilage in vitro. Scand J Rheumatol 1989; 18(83)29–32
   PubMedGoogle Scholar
• Rondier J, Cayla J, Menkes CJ. A controlled trial of Ketoprofen (administered rectally) in arthritis of the hip and knee. Rheumatol Rehabil 1976; 71–4, Suppl.
   PubMedGoogle Scholar
• Howard D LG. A double-blind crossover evaluation of Ketoprofen (Orudis) and placebo in rheumatoid arthritis with assessment of long-term tolerance. J Int Med Res 1978; 6: 300–5
   PubMedGoogle Scholar
• Peltola P. A double-blind cross-over study of Ketoprofen and phenylbutazone in rheumatoid arthritis. Scand J Rheumatol 1976; 14: 111–3
   Google Scholar
• Fava G, Galli L, Pollini C, Liverta C, Vicari A, Pontiroli AE. Single nightly administration of Ketoprofen (Orudis) and indomethacin suppositories in the management of osteoarthritis: a double-blind trial. J Int Med Res 1977; 5: 301–7
   PubMed Web of Science ®Google Scholar
• El-Ghobarey A F., Rennie J AN, Hadidi T, Abdcl Hamid H, Mavrikakis M. A comparative trial of large doses of Ketoprofen and indomethacin in the treatment of rheumatoid arthritis. Curr Med Res Opin 1976; 4: 432–5
   PubMedGoogle Scholar
• Caldwell J R., Germain B F., Lourie S H., McLaughlin G E., Poiley J E., Vreede P D., Wilson CH., Jr. Ketoprofen versus indomethacin in patients with rheumatoid arthritis: a multicentre double blind comparative study. J Rheumatol 1988; 15: 1476–9
   PubMedGoogle Scholar
• Franchi R, Liverta C, Pollini C, Pontiroli AE. Parenteral administration of Ketoprofen in osteoarthritis: a double-blind trial versus the N-methyl-d-glucamine salt of indomethacin. Scand J Rheumatol 1979; 26: 1–7
   Google Scholar
• Saxena R P., Saxena U. A comparative trial of Ketoprofen and ibuprofen in patients with rheumatic disease. Curr Med Res Opin 1978; 5: 484–8
   PubMed Web of Science ®Google Scholar
• Lang E, Steger W. A comparative study of efficacy and tolerability of Ketoprofen and piroxicam. Br J Clin Pract 1981; 35: 267
   PubMedGoogle Scholar
• Jalava S, Junnila S YT. Double-blind cross-over comparison of piroxicam (Felden) and Ketoprofen (Orudis) in rheumatoid arthritis. Scand J Rheumatol 1986; 16: 68–9
   Google Scholar
• Wollheim F A., Lindroth Y, Sjöblom KG. A comparison of Ketoprofen and naproxen in rheumatoid arthritis. Rheumatol Rehabil 1978; 78–83, Suppl.
   PubMedGoogle Scholar
• Leopold M. A double-blind cross-over comparative study of Ketoprofen versus naproxen in the treatment of osteoarthritis of the knee. Scand J Rheumatol 1980; 33: 45
   Google Scholar
• Bendix T, Schmidt I, Rasmussen K-JE, Ibfelt HH. Diclofenac (Voltaren) and Ketoprofen (Orudis) in rheumatoid arthritis: a randomised double-blind multicentre trial. Curr Ther Res 1983; 33: 192–9
   Web of Science ®Google Scholar
• Boey M L., Rae S, Feng PH. Comparison of efficacy of and tolerance to Ketoprofen and diclofenac sodium in the treatment of rheumatoid arthritis. Singapore Med J 1988; 29: 240–5
   PubMedGoogle Scholar
• Matsumo S, Kaneda K, Nohara Y. Clinical evaluation of Ketoprofen (Orudis) in lumbago — a double-blind comparison with diclofenac sodium. Br J Clin Pract 1981; 35: 266
   PubMedGoogle Scholar
• Kantor T, Cavaliere M B., Hopper M, Roepke S. A double-blind parallel comparison of Ketoprofen, codeine, and placebo in patients with moderate to severe postpartum pain. J Clin Pharmacol 1984; 24: 228–34
   PubMed Web of Science ®Google Scholar
• Roaas A. A double-blind between patient dose range trial of 2 doses of Ketoprofen (Orudis) 75 mg and 150 mg, and 2 doses of morphine 7.5 mg and 15 mg in patients with postoperative pain following articular surgery. Clin Exp Rheumatol 1987; 5: 148
   Google Scholar
• Simon L. Low back pain. Eur J Rheumatol Inflamm 1985; 8: 65–70
   Google Scholar
• Ishizaki T, Sasaki T, Suganuma T, et al. Pharmacokinetics of Ketoprofen following single oral, intramuscular and rectal doses and after repeated oral administration. Eur J Clin Pharmacol 1980; 18: 407–14
   PubMed Web of Science ®Google Scholar
• Ollagnier M, Decousus H, Cherrah Y, et al. Circadian changes in the pharmacokinetics of oral Ketoprofen. Clin Pharmacokinet 1987; 12: 367–78
   PubMed Web of Science ®Google Scholar
• Bannwarth B, Lapique F, Netter P, et al. The effect of food on the systemic availability of Ketoprofen. Eur J Clin Pharmacol 1988; 33: 643–5
   PubMedGoogle Scholar
• Clinical Pharmacokinetics Drug Data Handbook 1990. Adis Press Ltd, Auckland 1990
   Google Scholar
• Jamali F, Brocks DR. Clinical pharmacokinetics of Ketoprofen and its enantiomers. Clin Pharmacokinet 1990; 19: 197–217
   PubMed Web of Science ®Google Scholar
• Foster R T., Jamali F, Russell A S., Alballa SR. Pharmacokinetics of Ketoprofen enantiomers in young and elderly arthritic patients following single and multiple doses. J Pharm Sci 1988; 77: 191–5
   PubMed Web of Science ®Google Scholar
• Jamali F, Russell A S., Foster R T., Lemko C. Ketoprofen pharmacokinetics in humans: evidence of enantiomeric inversion and lack of interaction. J Pharm Sci 1990; 79: 460–1
   PubMed Web of Science ®Google Scholar
• Foster R T., Jamali F, Russell A S., Alballa SR. Pharmacokinetics of ketoprofen enantiomers in healthy subjects following single and multiple doses. J Pharm Sci 1988; 77: 70–3
   PubMed Web of Science ®Google Scholar
• Meffin P J., Ahem M J., Purdie YJ. Enantioselective disposition of ketoprofen in man. Clin Exp Pharmacol Physiol 1987; 11: 149
   Google Scholar
• Netter P, Bannwarth B, Lapicque F, et al. Total and free ketoprofen in serum and synovial fluid after intramuscular injection. Clin Pharmacol Ther 1987; 42: 555–61
   PubMed Web of Science ®Google Scholar
• Brater DC. Clinical pharmacology of NSAIDs. J Clin Pharmacol 1988; 28: 518–23
   PubMedGoogle Scholar
• Wallis W J., Simkin PA. Antirheumatic drug concentrations in human synovial fluid and synovial tissue. Observations on extravascular pharmacokinetics. Clin Pharmacokinet 1983; 8: 496–522
   PubMed Web of Science ®Google Scholar
• Köhler G, Mohing W, Lutz D, Morand J. Teneur en principe actif du sang, du liquide synovial, de la membrane synoviale el des tissus osseux, musculaires et adipeux avoisinants chez des malades atteints de polyarthrite rhumatoïde et ayant reĉu une injection intramusculaire unique de kétoprofène ou d'acide acétylsalicylique (3 heures après l'injection). Rev Rhum 1983; 13: 79–83
   Google Scholar
• Netter P, Bannwarth B, Royer-Morrot M-J. Recent findings on the pharmacokinetics of nonsteroidal anti-inflammatory drugs in synovial fluid. Clin Pharmacokinet 1989; 17: 145–62
   PubMed Web of Science ®Google Scholar
• Graham G G., Day R O., Champion D G., Lee E, Newton K. Aspects of the clinical pharmacology of nonsteroidal anti-inflammatory drugs. Clin Rheum Dis 1984; 190: 229–49
   Google Scholar
• Houghton G W., Dennis M J., Rigler E D., Parsons RL. Urinary pharmacokinetics of orally administered Ketoprofen in man. Eur J Drug Metab Pharmacokinet 1984; 9: 201–4
   PubMedGoogle Scholar
• Debruyne D, de Ligny B H., Ryckelynck J P., Albessard F, Moulin M. Clinical pharmacokinetics of ketoprofen after a single intravenous administration as a bolus or infusion. Clin Pharmacokinet 1987; 12: 214–21
   PubMed Web of Science ®Google Scholar
• Day R O., Graham G G., Williams K M., Champion G D., de Jager J. Clinical pharmacology of nonsteroidal antiinflammatory drugs. Pharmacol Ther 1987; 33: 383–433
   PubMed Web of Science ®Google Scholar
• McCrea J D., Telford A M., Kaye C M., Boyd M WJ. A comparison of plasma and synovial fluid profiles of standard and controtled-release formulations of ketoprofen in patients with rheumatoid arthritis. Curr Med Res Opin 1986; 10: 73–81
   PubMed Web of Science ®Google Scholar
• Kennedy AC. Synovial-fluid pharmacokinetics of ketoprofen. Rheumatol Rehabil 1976; ??: 20–1
   PubMedGoogle Scholar
• Lima D, Santos R, Fellet A, Andrade G N., Maraes R, Pierangelo S. Comparison of ketoprofen levels in synovial fluid, plasma and saliva after a single oral dose in patients with rheumatic disease. Clin Exp Rheumatol 1987; 5: 538
   Google Scholar
• Brooks P M., Beller E, Dawson M, Smith M, Arnold M, Dunagan F. Orudis-SR — plasma and synovial fluid concentration and response in rheumatoid arthritis. Clin Exp Pharmacol Physiol 1989; 14: 139
   Google Scholar
• Peyron JG. Osteoarthritis: the epidemiological viewpoint. Clin Orthop 1986; 213: 13–9
   PubMed Web of Science ®Google Scholar
• Advenier C, Roux A, Gobert C, Massias P, Varoquaux O, Flouvat B. Pharmacokinetics of ketoprofen in the elderly. Br J Clin Pharmacol 1983; 16: 65–70
   PubMed Web of Science ®Google Scholar
• Dennis M J., French P C., Crome P, Babiker M, Shillingford J, Hopkins R. Pharmacokinetic profile of controlled release ketoprofen in elderly patients. Br J Clin Pharmacol 1985; 20: 567–73
   PubMed Web of Science ®Google Scholar
• Le Loet X. Safety of ketoprofen in the elderly: a prospective study on 20 000 patients. Scand J Rheumatol 1989; 83: 21–7
   Google Scholar
• Allred J, Wong W, Kafelz K. Elderly people taking nonsteroidal anti-inflammatory drugs are unlikely to have excess renal impairment. Postgrad Med J 1989; 65: 735–7
   PubMedGoogle Scholar
• Famaey J P., Colinet E. A double-blind trial of ketoprofen in the treatment of osteoarthritis of the hip. Scand J Rheumatol 1976; 14: 129–32
   Google Scholar
• Muller-Fassbender H, Reiter W, Eveld H. Open multicentre long-term trial (3 years) on efficacy and tolerance of ketoprofen (Orudis capsules) in rheumatology: final assessment. Curr Ther Res 1984; 36: 1221–7
   Google Scholar
• Willans M J., Labelle J-L, Forget J-P. A double blind crossover study of ketoprofen enteric- and non-enteric-coaled tablets in rheumatoid arthritis. Curr Ther Res 1982; 31: 913–21
   Google Scholar
• Russell A S., Labelle J-L. A double-blind crossover study of ketoprofen enteric-coaled and Ketoprofen non-enteric-coated tablets in patients with ankylosing spondylitis, osteoarthritis and rheumatoid arthritis. Curr Ther Res 1983; 33: 185–91
   Web of Science ®Google Scholar
• Russell A S., Le Morvan P. Double-blind comparison between ketoprofen capsules four times daily and enteric-coated tablets twice daily in patients with osteoarthritis. Curr Ther Res 1985; 38: 599–605
   Google Scholar
• Morley K D., Bernstein R M., Hughes G RV, Black C M., Rajapakse C NA, Wilson L. A comparative trial of a controlled-release formulation of ketoprofen ('Oruvail') and a conventional capsule formulation of ketoprofen ('Orudis') inpatients with osteoarthritis of the hip. Curr Med Res Opin 1984; 9: 28–34
   PubMed Web of Science ®Google Scholar
• Toft B, Christophersen J, Christensen N, et al. A double-blind, crossover study of a sustained-release tablet of ketoprofen and normal ketoprofen capsules in the treatment of patients with osteoarthritis. Curr Med Res Opin 1985; 9: 708–12
   PubMed Web of Science ®Google Scholar
• Teule M. Double-blind comparative multicenter study of the efficacy and safety of a slow-release tablet of 200 mg ketoprofen once daily and a 50 mg ketoprofen capsule four limes daily. Curr Ther Res 1986; 40: 1129–46
   Google Scholar
• Christophidis N, Rotstein A, Louis WJ. Acute and chronic pharmacokinetic studies of slow release ketoprofen (Oruvail) in rheumatoid arthritis. Clin Exp Pharmacol Physiol 1986; 13: 555–61
   PubMedGoogle Scholar
• Fourtillan J B., Harrewyn JM. Étude pharmacocinétique du kétoprofène à libération prolongée chez les sujels âgés. Sem Hôp 1988; 64: 2241–5
   Google Scholar
• Roux A, Klein C, Ducreuset C, et al. Pharmacokinetics of sustained-release ketoprofen after daily administration in elderly subjects. Curr Ther Res 1989; 45: 435–46; 100
   Google Scholar
• , Data on file, Rhône-Poulenc
   Google Scholar
• , Data on file, Rhône-Poulenc
   Google Scholar
• Adnan HM. Ketoprofen O.D. and piroxicam in the treatment of osteoarthritis. Inl J Clin Pracl 1986; 1, Symposia Suppl.
   Google Scholar
• Chahade W, Lederman R, Seda M, Cury CE. A comparative study of sustained release ketoprofen, diclofenac and piroxicam in the symptomatic treatment of osteoarthritis. 16th International Congress of Rheumatology, Symposium Satellite Ketoprofen. SydneyAustralia May, 1985; 19–25
   Google Scholar
• Fournie A, Ayrolles C. A clinical study of ketoprofen capsules. Rheumatol Rehabil 1976; 59–60, Suppl.
   PubMedGoogle Scholar
• Caillé G, Besner J G., Lacasse Y, Vézina M. Pharmacokinetic characteristics of ketoprofen suppositories. Biopharm Drug Dispos 1980; 1: 195–201
   PubMed Web of Science ®Google Scholar
• Roux A, Fodor F, Flouvat B. Biodisponibilite chez l'homme dune nouvelle presentation de kétoprofène injectable. 2nd Eur Congress Biopharm Pharmacokinet 1984; 474–83
   Google Scholar
• Levernieux J, Beaslay N, Seze S. Étude comparative du kétoprofène el de l'indométacine injectables dans le traitment de la lombosciatique. Rev Int Rhumatol 1986; 16: 171–5
   Google Scholar
• , et al. Lanzer Actuelle Rheumatologie 1978; 4: 203–9
   Google Scholar
• Noret A, Roly V, Allington N, Haulers P, Zuinen C, Poels R. Ketoprofen gel as topical treatment for sports injuries. Acta Ther 1987; 13: 367–78
   Google Scholar
• Flouvat B, Roux A, Delhotal-Landes B. Pharmacokinetics of ketoprofen in man after repealed percutaneous administration. Arzneimittelforschung 1989; 39: 812–15
   PubMed Web of Science ®Google Scholar
• De Bono G G., Pearlgood M. General practice trials: a reappraisal in the light of the findings of a general practice study of Oruvail. Br J Clin Pract 1986; 40: 421–8
   PubMedGoogle Scholar
• Adams SS. Nonsteroidal anti-inflammatory drugs, plasma half-lives, and adverse reactions. Lancet 1987; 2: 1204–5
   PubMed Web of Science ®Google Scholar
• Fowler PD. Aspirin, paracetamol and nonsteroidal anti-inflammatory drugs A comparative review of side effects. Med Toxicol 1987; 2: 338–66
   Google Scholar
• CSM Update. Nonsteroidal anti-inflammatory drugs and serious gastrointestinal adverse reactions — 2. Br Med J 1986; 292: 1190–1
   PubMed Web of Science ®Google Scholar
• Reynolds J EF. Martindale: The Extra Pharmacopoeia29th edn. The Pharmaceutical Press, London 1989; 21
   Google Scholar
• Carson J L., Strom BL. The gastrointestinal side effects of the nonsteroidal anti-inflammatory drugs. J Clin Pharmacol 1988; 28: 554–9
   PubMedGoogle Scholar
• Magnusson B, Sölvell L, Arvidsson B. A comparative study of gastrointestinal bleeding during administration of ketoprofen and naproxen. Scand J Rheumatol 1977; 6: 62–4
   PubMed Web of Science ®Google Scholar
• Mann N S., Mann S K., Borkar BB. Comparative effects of fenoprofen, ketoprofen, ibuprofen and naproxen on gastric mucosa. Clin Res 1977; 25: 572A
   Google Scholar
• Ranlov P J., Nielsen S P., Bärenholdt O. Faecal blood loss during administration of acetylsalicylic acid, ketoprofen and two new ketoprofen sustained-release compounds. Scand J Rheumatol 1983; 12: 280–4
   PubMed Web of Science ®Google Scholar
• Unsworth J, Sturman S, Lunec J, Blake DR. Renal impairment associated with nonsteroidal anti-inflammatory drugs. Ann Rheum Dis 1987; 46: 233–6
   PubMedGoogle Scholar
• Ryckelynck J P., de Ligny B H., Levallier B, Scanu P. Insuffisance rénale aiguë et anti-inflammatoires non stéroïdens. Rev Rhum 1988; 55: 625–8
   PubMedGoogle Scholar
• Donker A JM, Frydman A, van Leerdam F JM, de Vries P MJ M. The influence of ketoprofen on effective renal plasma flow and glomerular filtration rale (ERPF/GFR) in healthy male volunteers. Clin Exp Rheumatol 1987; 5: 537
   Google Scholar
• Toto R D., Anderson S A., Brown-Cartwright D, Kokko J P., Brater DC. Effects of acute and chronic dosing of NSAIDs in patients with renal insufficiency. Kidney Int 1986; 30: 760–8
   PubMedGoogle Scholar
• Llorea G, Larbre J P., Collet P, Ravaull A, Lejcune E. Changing the class of NSAID in cases of hepatotoxicity. Ann Rheum Dis 1988; 47: 791
   PubMedGoogle Scholar
• Fowler PD. Major toxic reactions associated with NSAIDs. Choosing NSAID therapy: an international reappraisal, F D. Hart, J R. Klinenberg. Adis Press Limited, Auckland 1985; 41–57
   Google Scholar
• Lewis JH. Hepatic toxicity of nonsteroidal anti-inflammatory drugs. Clin Pharm 1984; 3: 128–38
   PubMedGoogle Scholar
• Mills P R., Sturrock RD. Clinical associations between arthritis and liver disease. Ann Rheum Dis 1982; 41: 295–307
   PubMedGoogle Scholar
• Kaidbey K H., Mitchell FN. Photosensitizing potential of certain nonsteroidal anti-inflammatory agents. Arch Dermatol 1989; 125: 783–6
   PubMedGoogle Scholar
• Cusano F, Rafenelli A, Bacchiléga R, Errico G. Photo-contact dermatitis from ketoprofen. Contact Dermatitis 1987; 17: 108–26
   PubMedGoogle Scholar
• Mozzanica N, Pucci M, Pigatto P. Contact allergy from ketoprofen. Contact Dermatitis 1987; 17: 325–6
   PubMedGoogle Scholar
• MacLennan WL. Side-effects of NSAIDs: not so hard on the elderly. Geriatr Med 1986; 16: 48–50
   Google Scholar
• Hosie G, Hosie J. Sex differences in the pharmacokinetics of ketoprofen in the elderly. Br J Rheumatol 1988; 27: 51
   Google Scholar
• Arone S. Long term study of ketoprofen SR in elderly patients. Scand J Rheumatol 1989; 83: 15–9
   Google Scholar
• Menkes CJ. Renal and hepatic effects of NSAIDs in the elderly. Scand J Rheumatol 1989; 83: 11–3
   Google Scholar
• Furst DE. Clinically important interactions of nonsteroidal anti-inflammatory drugs with other medications. J Rheumatol 1988; 15: 58–62
   Google Scholar
• Graham G. Gastrointestinal interactions of nonsteroidal anti-inflammatory drugs. Rheumatology 1985; 85: 441–5
   Google Scholar
• Weinblatt ME. Drug interactions with nonsteroidal anti-inflammatory drugs (NSAIDs). Scand J Rheumatol 1989; 83: 7–10
   Google Scholar
• Caillé G, Du Souich P, Gervais P, Besner J-G. Single dose pharmacokinetics of ketoprofen, indomethacin, and naproxen taken alone or with sucralfate. Biopharm Drug Dispos 1987; 8: 173–83
   PubMedGoogle Scholar
• Orme ML'E. Drug interactions with nonsteroidal anti-inflammatory drugs. Metabolic interactions. Rheumatology 1985; 85: 447–50
   Google Scholar
• Rabourdin J P., Ribeyre J P., Pichon J. Étude clinique du Profénid LP. 200 mg au cours de la rééducation postopératoire chez le sujet âgé. Recherche d' interactions avec les anticoagulants. Rev Geriatr 1988; 13: 312–5
   Google Scholar
• Day R. Pharmacodynamic interactions of NSAID. Rheumatology 1985; 85(43)5-10
   Google Scholar
• Li Kam Wa T C., Lawson M, Jackson S HD, Hitoglou-Makedou A, Turner P. Interaction of ketoprofen and frusemide in man. Br J Clin Pract, submitted
   Google Scholar
• Williams R L., Upton R A., Buskin J N., Jones RM. Ketoprofen-aspirin interactions. Clin Pharmacol 1981; 30: 226–30
   Google Scholar
• Singer L, Imbs J L., Danion JM, et al. Risk of lithium poisoning during combination with nonsteroidal antiinflammatory drugs. Therapie 1981; 36: 323–6
   PubMedGoogle Scholar
• Thyss A, Milano G, Kubar J, Namer M, Schneider M. Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen. Lancet 1986; 1: 256–8
   PubMed Web of Science ®Google Scholar
• Ahern M, Booth J, Loxton A, McCarthy P, Meffin P, Kevat S. Methotrexate kinetics in rheumatoid arthritis: is there an interaction with nonsteroidal anti-inflammatory drugs?. J Rheumatol 1988; 15: 1356–60
   PubMedGoogle Scholar
• Upton R A., Williams R L., Buskin J N., Jones RM. Effects of probenecid on ketoprofen kinetics. Clin Pharmacol 1982; 31: 705–11
   Google Scholar