17
Views
11
CrossRef citations to date
0
Altmetric
Original Article

Comparative Effects of Nabumetone, Naproxen, Piroxicam, and Diclofenac on Rat Gastric lrritancy Following Acute Exposure to OTC Non-steroidal Anti-inflammatory Agents and Other Gastric Irritants

&
Pages 336-341 | Received 10 Oct 1994, Accepted 26 Jun 1995, Published online: 12 Jul 2009

References

  • Brooks P M, Day R O. Non-steroidal anti-inflammatory drugs - differences and similarities. N Engl J Med 1991; 324: 1716–25
  • Fries J F, Williams C A, Bloch D A, et al. Non-steroidal anti-inflammatory drug-associated gastropathy: incidence and risk factor models. Am J Med 1991; 91: 213–22
  • Roth S H, Bennett R E. Non-steroidal anti-inflammatory drug gastropathy. Arch Intern Med 1987; 147: 2093–100
  • Armstrong C P, Blower A L. Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration. Gut 1987; 28: 527–32
  • Konturek S J. Gastric cytoprotection. Scand J Gastroenterol 1985; 20: 543–53
  • Robert A. Cytoprotection of the gastrointestinal mucosa. Adv Intern Med 1983; 28: 325–37
  • Melarange R, Rashbrook L C. Comparison of the effects of nabumetone with indomethacin on rat gastric mucosal 6-keto-PGF1 production and on bile salt induced changes in gastric mucosal function. J Pharm Pharmacol 1987; 39: 717–20
  • Boyle E A, Freeman P C, Mangan F R, et al. Nabumetone (BRL 14777, 4–(6-methoxy-2-naphthyl)-butan-2-one): a new anti-inflammatory agent. J Pharm Pharmacol 1982; 34: 662–9
  • Jeremy J Y, Mikhailidis D P, Barradas M A, et al. The effect of nabumetone and its principle active metabolite on in vitro human gastric mucosal prostanoid synthesis and platelet function. Br J Rheumatol 1990; 29: 116–9
  • Mangan F R, Flack F D, Jackson D. Preclinical overview of nabumetone. Pharmacology, bioavailability, metabolism and toxicology. Am J Med 1987; 83((Suppl 4B))6–10
  • Boyle E A, Mangan F R. The effect of a novel, non-steroidal compound, nabumetone (BRL 14777), on cellular infiltration into 24 h polyvinyl sponge implants in the rat, compared with some steroidal and non-steroidal anti-inflammatory drugs. J Pharm Pharmacol 1982; 34: 570–5
  • Haddock R E, Jeffery D J, Lloyd J A, et al. Metabolism of nabumetone. Pharmacology, bioavailavility, metabolism and toxicology. Am J Med 1987; 83(Suppl 4B)6–10
  • Goudie A C, Gaster L M, Lake A W, et al. 4-(6-Metabolism of nabumetone (BRL 14777) by various species including man. Xenobiotica 1984; 14: 327–37
  • Melarange R, Blower P R, Gentry C, et al. Nabumetone, an effective anti-inflammatory agent lacks the gastric irritancy potential of piroxicam or ibuprofen. Br J Pharmacol 1990; 99: 172P
  • Roth S H. New understandings of NSAID gastropathy. Scand J Rheumatol 1989; 18((Suppl 78))24–9
  • Eversmeyer W, Poland M, DeLapp R E, Jensen C P. Safety experience with nabumetone versus diclofenac, naproxen ibuprofen and piroxicam in osteoarthritis and rheumatoid arthritis. Am J Med 1993; 95((Suppl 2A))10S–8S
  • Greb W H, Von Schrader H W, Cerlek S, et al. Endoscopic studies of nabumetone in patients with rheumatoid arthritis. Am J Med 1987; 83(Suppl 4B)19–24
  • Mangan F R. A reveiw of the pharmacology of nabumetone. Royal Soc. of Med. Intern. Cong. and Sympos 1984; Series 69: 5–14
  • Aase S. Disturbances in the balance between aggressive and protective factors in the gastric and duodenal mucosa. Scand J Gastroenterol 1989; 24(Suppl 163)17–23
  • Shorrock C J, Rees W DW. Mechanisms of gastric damage by non-steroidal anti-inflammatory drugs. Scand J Rheumatol 1989; 18(Suppl 78)5–11
  • Sun D CH, Roth S R, Mitchell C S, et al. Upper gastrointestinal disease in Rheumatoid Arthritis. Am J Dig Dis 1974; 19: 405–10
  • Cooke A R. Drugs and Gastric Damage. Drugs 1976; 11: 3644
  • Jeremy J Y, Mikhailidis D P. Non-steroidal anti-inflammatory drug-induced gastropathy: are non-acidic prodrugs the answer?. Prostaglandins Leukot Essent Fatty Acids 1989; 37: 215–8
  • Schoen R T, Vender R J. Mechanisms of non-steroidal anti-inflammatory drug-induced gastric damage. Am J Med 1989; 86: 449–58
  • Vane J R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol 1971; 231: 232–5
  • Meade E A, Smith W L, DeWitt D L. Differential inhibition of prostaglandin endoperoxide synthase (cyclo-oxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem 1993; 268: 6610–4
  • Ligumsky M, Golanska E A, Hansen D G, Kaufman G L. Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat. Gastroenterology 1983; 84: 756–61
  • Xie W, Robertson D L, Simmons D L. Mitogen-inducible prostaglandin G/H synthase: A new target for non-steroidal anti-inflammatory drugs. Drug Development Reseach 1992; 25: 249–65

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.