241
Views
3
CrossRef citations to date
0
Altmetric
Review Article

Takashi Iyanagi: UGT1 gene complex: from Gunn rat to human

Pages 14-22 | Published online: 21 Oct 2009

References

  • Albert, C., Vallee, M., Beaudry, A., Belanger, A., Hum, D. W. (1999). The monkey and human uridine diphosphate-glucuronosyltransferase UGT1A9, expressed in steroid target tissues, are estrogen-conjugating enzymes. Endocrinology 140:3292–3302.
  • Aono, S., Yamada, Y., Keino, H., Sasaoka, Y., Nakagawa, T., Onishi, S., et al. (1994). A new type of defect in the gene for bilirubin uridine 5’-diphosphate-glucuronosyltransferase in a patient with Crigler-Najjar syndrome type I. Pediatr Res 35:629–632.
  • Aono, S., Adachi, Y., Uyama, E., Yamada, Y., Keino, K., Nanno, T., et al. (1995). Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert’s syndrome. Lancet 345:958–959.
  • Blanckaert, N., Fevery, J., Heirwegh, K. P. M., Compernolle, F. (1977). Characterization of the major diazo-positive pigments in bile of homozygous Gunn rats. Biochem J 164:237–249.
  • Bock, K. W., Josting, D., Lilienblum, W., Pfeil, H. (1979). Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital. Eur J Biochm 98:19–26.
  • Bock, K. W. (2003). Vertebrate UDP-glucuronosyltransferases: functional and evolutionary aspects. Biochem Pharmacol 66:691–696.
  • Bosma, P. J., Seppen, J., Goldhoorn, B., Bakker, C., Oude Elferink, R. P., Chowdhury, J. R., et al. (1994). Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. J Biol Chem 269:17960–17964.
  • Burchell, B. (1977). Studies on the purification of rat liver uridine diphosphate glucuronyltransferase. Biochem J 161:543–549.
  • Cohen, A. N., Kapitulnik, J., Ostrow, J. D., Zenone, E. A., Cochrane, C., Celic, L., et al. (1985). Effects of phenobarbital on bilirubin metabolism and its response to phototherapy in the jaundiced Gunn rat. Hepatology 5:310–316.
  • Coughtrie, M. W., Burchell, B., Shepherd, I. M., Bend, J. R. (1987). Defective induction of phenol glucuronidation by 3-methylcholanthrene in Gunn rats is due to the absence of a specific UDP-glucuronosyltransferase isoenzyme. Mol Pharmacol 31:585–591.
  • Crigler, J. F., Najjar, V. A. (1952). Congenital familial nonhemalytic jaundice with kernicterus. Pediatrics 10:169–180.
  • El Awady, M., Roy Chowdhury, J. R, Kesari, K., van Es, H, Jansen, P. L., Lederstein, M., et al. (1990). Mechanism of the lack of induction of UDP-glucuronosyltransferase activity in Gunn rats by 3-methylcholanthrene. Identification of a truncated enzyme. J Biol Chem 265:10752–10758.
  • Emi, Y., Ikushiro, S., Iyanagi, T. (1995). Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex. J Biochem (Tokyo) 117:392–399.
  • Emi, Y., Ikushiro, S., Iyanagi, T. (1996). Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex. J Biol Chem 271:3952–3958.
  • Emi, Y., Ohnishi, A., Kajimoto, T., Ikushiro, S., Iyanagi, T. (2000). A 66-base-pair enhancer module activates the expression of a distinct isoform of UDP-glucuronosyltransferase family 1 (UGT1A2) in primary hepatocytes. Arch Biochem Biophys 378:384–392.
  • Emi, Y., Omura, S., Ikushiro, S., Iyanagi, T. (2002). Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes. Arch Biochem Biophys 405:163–169.
  • Emi, Y., Ueda, K., Ohnishi, A., Ikushiro, S., Iyanagi, T. (2005). Transcriptional enhancement of UDP-glucuronosyltransferase form 1A2 (UGT1A2) by nuclear factor I-A (NFI-A) in rat hepatocytes. J Biochem (Tokyo) 138:313–325.
  • Falany, C. N., Tephly, T. R. (1983). Separation, purification, and characterization of three isoenzymes of UDP-glucuronyltransferase from rat liver microsomes. Arch Biochem Biophys 227:248–258.
  • Fujiwara, R., Nakajima, M., Oda, S., Yamanaka, H., Ikushiro, S. I., Sakaki, T., et al. (2009). Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes. J Pharm Sci In press.
  • Gong, Q. H., Cho, J. W., Huang, T., Potter, C., Gholami, N., Basu, N. K., et al. (2001). Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. Pharmacogenetics 11:357–368.
  • Gunn, C. H. (1938). Hereditary acholuric jaundice in a new mutant strain of rats. J Hered 29:137–139.
  • Harding, D., Fournel-Gigleux, S., Jackson, M. R., Burchell, B. (1988). Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells. Proc Natl Acad Sci U S A 85:8381–8385.
  • Hirayama, T., Yagi, T. (2006). The role and expression of the protocadherin-alpha clusters in the CNS. Curr Opin Neurobiol 16:1–7.
  • Ikushiro, S., Emi, Y., Iyanagi, T. (1995). Identification and analysis of drug-responsive expression of UDP-glucuronosyltransferase family 1 (UGT1) isozymes in rat hepatic microsomes using antipeptide antibodies. Arch Biochem Biophys 324:267–272.
  • Ikushiro, S., Emi, Y., Iyanagi, T. (1997). Protein-protein interactions between UDP-glucuronosyltransferase isozymes in rat hepatic microsomes. Biochemistry 36:7154–7161.
  • Ikushiro, S., Emi, Y., Kimura, S., Iyanagi, T. (1999). Chemical modification of rat hepatic microsomes with N-ethylmaleimide results in inactivation of both UDP-N-acetylglucosamine-dependent stimulation of glucuronidation and UDP-glucuronic acid uptake. Biochim Biophys Acta 1428:388–396.
  • Ikushiro, S., Emi, Y., Iyanagi, T. (2002). Activation of glucuronidation through reduction of a disulfide bond in rat UDP-glucuronosyltransferase 1A6. Biochemistry 41:12813–12820
  • Ikushiro, S., Sahara, M., Emi, Y., Yabusaki, Y., Iyanagi, T. (2004). Functional coexpression of xenobiotic metabolizing enzymes, rat cytochrome P450 1A1, and UDP-glucuronosyltransferase 1A6 in yeast microsomes. Biochim Biophys Acta 1672:86–92.
  • Ikushiro, S., Emi, Y., Kato, Y., Yamada, S., Sakaki, T. (2006). Monospecific antipeptide antibodies against human hepatic UDP- glucuronosyltransferase 1A subfamily (UGT1A) isoforms. Drug Metab Pharmacokinet 21:70–75.
  • Ishii, Y., Oguri, K., Yoshimura, H. (1993). Purification and characterization of a morphine UDP-glucuronyltransferase isoform from untreated rat liver. Biol Pharm Bull 16:754–758.
  • Ishii, Y., Miyoshi, A., Watanabe, R., Tsuruda, K. Tsuda, M. Yamaguchi-Nagamatsu, Y, et al. (2001). Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21-catalyzed morphine-6-glucuronide formation. Mol Pharmacol 60:1040–1048.
  • Isselbacher, K. J., Chrabas, M. F., Quinn, R. C. (1962). The solubilization and partial purification of a glucuronyl transferase from rabbit liver microsomes. J Biol Chem 237:3033–3036.
  • Iyanagi, T., Haniu, M., Sogawa, K., Fujii-Kuriyama, Y., Watanabe, S., Shively, J. E., et al. (1986). Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase. J Biol Chem 261:15607–15614.
  • Iyanagi, T., Watanabe, T., Uchiyama, Y. (1989). The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a −1 frameshift mutation. J Biol Chem 264:21302–21307.
  • Iyanagi, T. (1991). Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat). J Biol Chem 266:24048–24052.
  • Iyanagi, T., Emi, Y., Ikushiro, S. (1998). Biochemical and molecular aspects of genetic disorders of bilirubin metabolism. Biochim Biophys Acta 1407:173–184.
  • Iyanagi, T. (2007). Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification. Int Rev Cytol 260:35–112.
  • Jackson, M. R., McCarthy, L. R., Corser, R. B., Barr, G. C., Burchell, B. (1985). Cloning of cDNAs coding for rat hepatic microsomal UDP-glucuronyltransferases. Gene 34:147–153.
  • Jackson, M. R., Burchell, B. (1986). The full-length coding sequence of rat liver androsterone UDP-glucuronyltransferase cDNA and comparison with other members of this gene family. Nucl Acids Res 14:779–795.
  • Kaplan, M., Renbaum, P., Levy-Lahad, E., Hammerman, C., Lahad, A., Beutler, E. (1997). Gilbert’s syndrome and glucose-6-phosphate dehydrogenase deficiency: a dosedependent genetic interaction crucial to neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A 94:12128–12132.
  • Kato, Y., Ikushiro, S., Haraguchi, K., Yamazaki, T.., Ito, Y., Suzuki, H., et al. (2004). A possible mechanism for decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats. Toxicol Sci81:309–315.
  • Kato, Y., Suzuki, H., Ikushiro, S., Ema, M., Kanno, J., Yamada, S., et al. (2005). Decrease in serum thyroxine level by phenobarbital in rats is not dependent on increase in hepatic UDP-glucuronosyltransferase. Drug Metab Dispos 33:1608–1612.
  • Kato, Y., Ikushiro, S., Takiguchi, R., Haraguchi, K,, Koga, N., Sakaki, T. et, al. (2007). An exact mechanism for the decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats. Drug Metab Dispos 35:1949–1955.
  • Kessler, F. K., Kessler, M. R., Auyeung, D. J., Ritter, J. K. (2002). Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases. Drug Metab Dispos30:324–330.
  • Kishi, M., Emi, Y., Sakaguchi, M., Ikushiro, S., Iyanagi, T (2008). Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver. Biochem Biophys Res Commun 377:815–819.
  • Krishnaswamy, S., Hao, Q., Von Moltke, L. L., Greenblatt, D.J., Court, M. H. (2004). Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6. Drug Metab Dispos 32:862–869.
  • Kurkela, M., Patana, A. S., Mackenzie, P. I., Court, M. H., Tate, C. G., Hirvonen, J., et al. (2007). Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6. Pharmacogenet Genom 17:115–126.
  • Lamb, J. G., Straub, P., Tukey, R. H. (1994). Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochemistry 33:10513–10520.
  • Lathe, G. H., Walker, M. (1957). An enzyme defect in human neonatal jaundice and in Gunn’s strain of jaundiced rats. Biochem J, 67:9.
  • Mackenzie, P. I., Owens, I. S. (1983). Differences in UDP-glucuronosyltransferase activities in congenic inbred rats homozygous and heterozygous for the jaundice locus. Biochem Pharmacol 32:3777–3781.
  • Mackenzie, P. I., Gonzalez, F. J., Owens, I. S. (1984). Cloning and characterization of DNA complementary to rat liver UDP-glucuronosyltransferase mRNA. J Biol Chem 259:12153–12160.
  • Mackenzie, P. I., Joffe, M. M., Munson, P. J., Owens, I. S. (1985). Separation of different UDP-glucuronosyltransferase activities according to charge heterogeneity by chromatofocusing using mouse liver microsomes. Three major types of aglycones. Biochem Pharmacol 34:737–746.
  • Mackenzie, P. I. (1986a). Rat liver UDP-glucuronosyltransferase. Sequence and expression of a cDNA encoding a phenobarbital-inducible form. J Biol Chem 261:6119–6125.
  • Mackenzie, P. I. (1986b). Rat liver UDP-glucuronosyltransferase. cDNA sequence and expression of a form glucuronidating 3-hydroxyandrogens. J Biol Chem 261:14112–14117.
  • Maniatis, T., Reed, R. (2002). An extensive network of coupling among gene expression machines. Nature 416:499–506.
  • Narayanan, R., LeDuc, B., Williams, D. A. (2004). Glucuronidation of haloperidol by rat liver microsomes: involvement of family 2 UDP-glucuronosyltransferases. Life Sci 74:2527–2539.
  • Ohnishi, A., Emi, Y. (2003). Rapid proteasomal degradation of translocation-deficient UDP-glucuronosyltransferase 1A1 proteins in patients with Crigler-Najjar type II. Biochem Biophys Res Commun 310:735–741.
  • Ritter, J. K., Crawford, J. M., Owens, I. S. (1991). Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells. J Biol Chem 266:1043–1047.
  • Ritter, J. K., Chen, F., Sheen, Y. Y., Tran, H. M., Kimura, S., Yeatman, M. T, et al. (1992). A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. J Biol Chem 267:3257–3261.
  • Sinaasappel, M., Jansen, P. L. M. (1991). The differential diagnosis of Crigler-Najjar disease, types 1 and 2, by bile pigment analysis. Gasteroenterology 100:783–789.
  • Seppen, J., Bosma, P. J., Goldhoorn, B. G., Bakker, C. T., Chowdhury, J. R., Chowdhury, N. R., et al. (1994). Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase. J Clin Invest 94:2385–2391.
  • Seppen, J., Steenken, E., Lindhout, D., Bosma, P. J., Elferink, R. P. (1996). A mutation which disrupts the hydrophobic core of the signal peptide of bilirubin UDP-glucuronosyltransferase, an endoplasmic reticulum membrane protein, causes Crigler-Najjar type II. FEBS Lett 390:294–298.
  • Weatherill, P. J., Burchell, B. (1980). The separation and purification of rat liver UDP-glucuronyltransferase activities towards testosterone and oestrone. Biochem J 189:377–380.
  • Wu, Q., Maniatis, T. (1999). A striking organization of a large family of human neural Cadherin-like cell adhesion genes. Cell 97:779–790.
  • Wu, Q. (2005). Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes. Genetics 169:2179–2188.
  • Yokota, H., Yuasa, A., Sato, R. (1988). Purification and properties of a form of UDP-glucuronyltransferase from liver microsomes of 3-methylcholanthrene-treated rats. J Biochem. (Tokyo) 104:531–536.
  • Zhang, T., Haws, P., Wu, Q. (2004). Multiple variable first exons: a mechanism for cell and tissue-specific gene regulation. Genome Res 14:79–89.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.