The regulation of UDP-glucuronosyltransferase genes by tissue-specific and ligand-activated transcription factors

Rererences

• Albert, C., Vallee, M., Beaudry, G., Belanger, A., Hum, D. W. (1999). The monkey and human uridine diphosphate-glucuronosyltransferase, UGT1A9, expressed in steroid target tissues, are estrogen-conjugating enzymes. Endocrinology 140:3292–3302.
   PubMed Web of Science ®Google Scholar
• Aueviriyavit, S., Furihata, T., Morimoto, K., Kobayashi, K., Chiba, K. (2007). Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3, and UGT1A4 mRNA in human livers. Drug Metab Pharmacokinet 22:391–398.
   PubMed Web of Science ®Google Scholar
• Barbier, O., Belanger, A. (2008). Inactivation of androgens by UDP-glucuronosyltransferases in the human prostate. Best Pract Res Clin Endocrinol Metab 22:259–270.
   PubMed Web of Science ®Google Scholar
• Barbier, O., Duran-Sandoval, D., Pineda-Torra, I., Kosykh, V., Fruchart, J-C., Staels, B. (2003a). Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme. J Biol Chem 278:32852–32860.
   PubMed Web of Science ®Google Scholar
• Barbier, O., Girard, H., Inoue, Y., Duez, H., Villeneuve, L., Kamiya, A., et al. (2005). Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4 alpha. Mol Pharmacol 67:241–249.
   PubMed Web of Science ®Google Scholar
• Barbier, O., Torra, I. P., Sirvent, A., Claudel, T., Blanquart, C., Duran-Sandoval, D., et al. (2003b). FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. Gastroenterology 124:1926–1940.
   PubMed Web of Science ®Google Scholar
• Barbier, O., Villeneuve, L., Bocher, V., Fontaine, C., Torra, I. P., Duhem, C., et al. (2003c). The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene. J Biol Chem 278:13975–13983.
   PubMed Web of Science ®Google Scholar
• Beischlag, T. V., Luis Morales, J., Hollingshead, B. D., Perdew, G. H. (2008). The aryl hydrocarbon receptor complex and the control of gene expression. Crit Rev Eukaryotic Gene Expression 18:207–250.
   PubMed Web of Science ®Google Scholar
• Bernard, P., Goudonnet, H., Artur, Y., Desvergne, B., Wahli, W. (1999). Activation of the mouse TATA-less and human TATA-containing UDP-glucuronosyltransferase 1A1 promoters by hepatocyte nuclear factor 1. Mol Pharmacol 56:526–536.
   PubMed Web of Science ®Google Scholar
• Bock, K. W., Gschaidmeier, H., Heel, H., Lehmkoster, T., Munzel, P. A., Raschko, F., et al. (1998). AH receptor–controlled transcriptional regulation and function of rat and human UDP-glucuronosyltransferase isoforms. Adv Enzyme Regul 38:207–222.
   PubMedGoogle Scholar
• Bock, K. W., Kohle, C. (2005). UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. Meth Enzymol 400:57–75.
   PubMed Web of Science ®Google Scholar
• Bowalgaha, K., Elliot, D. J., Mackenzie, P. I., Knights, K. M., Miners, J. O. (2007). The glucuronidation of Delta4-3-Keto C19- and C21-hydroxysteroids by human liver microsomal and recombinant UDP-glucuronosyltransferases (UGTs): 6alpha- and 21-hydroxyprogesterone are selective substrates for UGT2B7. Drug Metab Dispos 35:363–370.
   PubMed Web of Science ®Google Scholar
• Chouinard, S., Barbier, O., Belanger, A. (2007). UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells. J Biol Chem 282:33466–33474.
   PubMed Web of Science ®Google Scholar
• Chouinard, S., Pelletier, G., Belanger, A., Barbier, O. (2006). Isoform-specific regulation of uridine diphosphate-glucuronosyltransferase 2B enzymes in the human prostate: differential consequences for androgen and bioactive lipid inactivation. Endocrinology 147:5431–5442.
   PubMed Web of Science ®Google Scholar
• Congiu, M., Mashford, M. L., Slavin, J. L., Desmond, P. V. (2002). UDP-glucuronosyltransferase mRNA levels in human liver disease. Drug Metab Dispos 30:129–134.
   PubMed Web of Science ®Google Scholar
• Coughtrie, M. W., Sharp, S. (1991). Glucuronidation of imipramine in rabbit and human liver microsomes: assay conditions and interaction with other tertiary amine drugs. Biochem Pharmacol 42:1497–1501.
   PubMed Web of Science ®Google Scholar
• Elovaara, E., Mikkola, J., Stockmann-Juvala, H., Luukkanen, L., Keski-Hynnila, H., Kostiainen, R., et al. (2007). Polycyclic aromatic hydrocarbon (PAH) metabolizing enzyme activities in human lung, and their inducibility by exposure to naphthalene, phenanthrene, pyrene, chrysene, and benzo(a)pyrene as shown in the rat lung and liver. Arch Toxicol 81:169–182.
   PubMed Web of Science ®Google Scholar
• Erichsen, T. J., Ehmer, U., Kalthoff, S., Lankisch, T. O., Muller, T. M., Munzel, P. A., et al. (2008). Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP-glucuronosyltransferase (UGT) 1A4 gene. Toxicol Appl Pharmacol 230:252–260.
   PubMed Web of Science ®Google Scholar
• Falkner, K. C., Ritter, J. K., Prough, R. A. (2008). Regulation of the rat UGT1A6 by glucocorticoids involves a cryptic glucocorticoid response element. Drug Metab Dispos 36:409–417.
   PubMed Web of Science ®Google Scholar
• Gardner-Stephen, D., Heydel, J. M., Goyal, A., Lu, Y., Xie, W., Lindblom, T., et al. (2004). Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression. Drug Metab Dispos 32:340–347.
   PubMed Web of Science ®Google Scholar
• Gardner-Stephen, D. A., Gregory, P. A., Mackenzie, P. I. (2005). Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genes. Meth Enzymol 400:22–46.
   PubMed Web of Science ®Google Scholar
• Gardner-Stephen, D. A., Mackenzie, P. I. (2007a). Hepatocyte nuclear factor 1 transcription factors are essential for the UDP-glucuronosyltransferase 1A9 promoter response to hepatocyte nuclear factor 4 alpha. Pharmacogenet Genom 17:25–36.
   PubMed Web of Science ®Google Scholar
• Gardner-Stephen, D. A., Mackenzie, P. I. (2007b). Isolation of the UDP-glucuronosyltransferase 1A3 and 1A4 proximal promoters and characterization of their dependence on the transcription factor hepatocyte nuclear factor 1 alpha. Drug Metab Dispos 35:116–120.
   PubMed Web of Science ®Google Scholar
• Gardner-Stephen, D. A., Mackenzie, P. I. (2008). Liver-enriched transcription factors and their role in regulating UDP-glucuronosyltransferase gene expression. Curr Drug Metab 9:439–452.
   PubMed Web of Science ®Google Scholar
• Gestl, S. A., Green, M. D., Shearer, D. A., Frauenhoffer, E., Tephly, T. R., Weisz, J. (2002). Expression of UGT2B7, a UDP-glucuronosyltransferase implicated in the metabolism of 4-hydroxyestrone and all-trans retinoic acid, in normal human breast parenchyma and in invasive and in situ breast cancers. Am J Pathol 160:1467–1479.
   PubMed Web of Science ®Google Scholar
• Gregory, P. A., Gardner-Stephen, D. A., Lewinsky, R. H., Duncliffe, K. N., Mackenzie, P. I. (2003). Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: differential regulation through an interior-like region. J Biol Chem 278:36107–36114.
   PubMed Web of Science ®Google Scholar
• Gregory, P. A., Gardner-Stephen, D. A., Rogers, A., Michael, M. Z., Mackenzie, P. I. (2006). The caudal-related homeodomain protein, Cdx2, and hepatocyte nuclear factor 1 alpha cooperatively regulate the UDP-glucuronosyltransferase 2B7 gene promoter. Pharmacogenet Genom 16:527–536.
   PubMed Web of Science ®Google Scholar
• Gregory, P. A., Hansen, A.J., Mackenzie, P. I. (2000). Tissue-specific differences in the regulation of the UDP-glucuronosyltransferase 2B17 gene promoter. Pharmacogenetics 10:809–820.
   PubMedGoogle Scholar
• Gregory, P. A., Lewinsky, R. H., Gardner-Stephen, D. A., Mackenzie, P. I. (2004a). Coordinate regulation of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 genes by hepatocyte nuclear factor 1 alpha and the caudal-related homeodomain protein 2. Mol Pharmacol 65:953–963.
   PubMed Web of Science ®Google Scholar
• Gregory, P. A., Lewinsky, R. H., Gardner-Stephen, D. A., Mackenzie, P. I. (2004b). Regulation of UDP-glucuronosyltransferases in the gastrointestinal tract. Toxicol Appl Pharmacol 199:354–363.
   PubMed Web of Science ®Google Scholar
• Gregory, P.A., Mackenzie, P. I. (2002). The homeodomain Pbx2-Prep1 complex modulates hepatocyte nuclear factor 1-alpha-mediated activation of the UDP-glucuronosyltransferase 2B17 gene. Mol Pharmacol 62:154–161.
   PubMed Web of Science ®Google Scholar
• Guillemette, C., Belanger, A., Lepine, J. (2004). Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview. Breast Cancer Res 6:246–254.
   PubMed Web of Science ®Google Scholar
• Hansen, A. J., Lee, Y. H., Gonzalez, F. J., Mackenzie, P. I. (1997). HNF1 alpha activates the rat UDP-glucuronosyltransferase UGT2B1 gene promoter. DNA Cell Biol 16:207–214.
   PubMed Web of Science ®Google Scholar
• Hansen, A. J., Lee, Y. H., Sterneck, E., Gonzalez, F. J., Mackenzie, P. I. (1998). C/EBPalpha is a regulator of the UDP-glucuronosyltransferase UGT2B1 gene. Mol Pharmacol 53:1027–1033.
   PubMed Web of Science ®Google Scholar
• Haque, S. J., Petersen, D. D., Nebert, D. W., Mackenzie, P. I. (1991). Isolation, sequence, and developmental expression of rat UGT2B2: the gene encoding a constitutive UDP-glucuronosyltransferase that metabolizes etiocholanolone and androsterone. DNA Cell Biol 10:515–524.
   PubMed Web of Science ®Google Scholar
• Harrington, W. R., Sengupta, S., Katzenellenbogen, B. S. (2006). Estrogen regulation of the glucuronidation enzyme, UGT2B15, in estrogen receptor-positive breast cancer cells. Endocrinology 147:3843–3850.
   PubMed Web of Science ®Google Scholar
• Hu, D. G., Mackenzie, P. I. (2009). Estrogen receptor α, fos-related antigen-2 and c-Jun coordinately regulate human UDP-glucuronosyltransferase 2B15 and 2B17 expression in response to 17β-estradiol in MCF-7 cells. Mol Pharmacol 76:1–15.
   PubMedGoogle Scholar
• Ishii, T., Itoh, K., Takahashi, S., Sato, H., Yanagawa, T., Katoh, Y., et al. (2000a). Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275:16023–16029.
   PubMed Web of Science ®Google Scholar
• Ishii, Y., Hansen, A.J., Mackenzie, P. I. (2000b). Octamer transcription factor-1 enhances hepatic nuclear factor-1 alpha-mediated activation of the human UDP-glucuronosyltransferase 2B7 promoter. Mol Pharmacol 57:940–947.
   PubMed Web of Science ®Google Scholar
• Itaaho, K., Mackenzie, P., Ikushiro, S-I., Miners, J., Finel, M. (2008). The configuration of the 17-hydroxy group variably influences the glucuronidation of {beta}-estradiol and epiestradiol by human UDP-glucuronosyltransferases. Drug Metab Dispos 36:2307–2315.
   PubMed Web of Science ®Google Scholar
• Kaeding, J., Belanger, J., Caron, P., Verreault, M., Belanger, A., Barbier, O. (2008a). Calcitrol (1alpha,25-dihydroxyvitamin D3) inhibits androgen glucuronidation in prostate cancer cells. Mol Cancer Ther 7:380–390.
   PubMed Web of Science ®Google Scholar
• Kaeding, J., Bouchaert, E., Belanger, J., Caron, P., Chouinard, S., Verreault, M., et al. (2008b). Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells. Biochem J 410:245–253.
   PubMed Web of Science ®Google Scholar
• Kamiyama, Y., Matsubara, T., Yoshinari, K., Nagata, K., Kamimura, H., Yamazoe, Y. (2007). Role of human hepatocyte nuclear factor 4 alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA. Drug Metab Pharmacokinet 22:287–298.
   PubMed Web of Science ®Google Scholar
• Lankisch, T. O., Gillman, T. C., Erichsen, T. J., Ehmer, U., Kalthoff, S., Freiberg, N., et al. (2008). Aryl hydrocarbon receptor-mediated regulation of the human estrogen and bile acid UDP-glucuronosyltransferase 1A3 gene. Arch Toxicol 82:573–582.
   PubMed Web of Science ®Google Scholar
• Lee, J. H., Zhou, J., Xie, W. (2008). PXR and LXR in hepatic steatosis: a new dog and an old dog with new tricks. Mol Pharmaceut 5:60–66.
   PubMed Web of Science ®Google Scholar
• Lehmann, L., Wagner, J. (2008). Gene expression of 17beta-estradiol-metabolizing isozymes: comparison of normal human mammary gland to normal human liver and to cultured human breast adenocarcinoma cells. Adv Exp Med Biol 617:617–624.
   PubMed Web of Science ®Google Scholar
• Lu, Y., Heydel, J-M., Li, X., Bratton, S., Lindblom, T., Radominska-Pandya, A. (2005). Lithocholic acid decreases expression of UGT2B7 in Caco-2 cells: a potential role for a negative farnesoid X receptor response element. Drug Metab Dispos 33:937–946.
   PubMed Web of Science ®Google Scholar
• Mackenzie, P. I., Gregory, P. A., Gardner-Stephen, D. A., Lewinsky, R. H., Jorgensen, B. R., Nishiyama, T., et al. (2003). Regulation of UDP-glucuronosyltransferase genes. Curr Drug Metab 4:249–257.
   PubMed Web of Science ®Google Scholar
• Mackenzie, P. I., Gregory, P. A., Lewinsky, R. H., Yasmin, S. N., Height, T., McKinnon, R. A., et al. (2005). Polymorphic variations in the expression of the chemical detoxifying UDP-glucuronosyltransferases. Toxicol Appl Pharmacol 207:S77–S83.
   PubMedGoogle Scholar
• Mackenzie, P. I., Mojarrabi, B., Meech, R., Hansen, A. (1996). Steroid UDP-glucuronosyltransferases: characterization and regulation. J Endocrinol 150:S79–S86.
   Google Scholar
• Mackenzie, P.I., Rodbourn, L. (1990). Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene and characterization of its promoter. J Biol Chem 265:11328–11332.
   PubMed Web of Science ®Google Scholar
• Mendel, D.B., Crabtree, G. R. (1991). HNF-1, a member of a novel class of dimerizing homeodomain proteins. J Biol Chem 266:677–680.
   PubMed Web of Science ®Google Scholar
• Mendel, D. B., Hansen, L. P., Graves, M. K., Conley, P. B., Crabtree, G. R. (1991). HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro. Genes Dev 5:1042–1056.
   PubMed Web of Science ®Google Scholar
• Mojarrabi, B., Butler, R., Mackenzie, P. I. (1996). cDNA cloning and characterization of the human UDP-glucuronosyltransferase, UGT1A3. Biochem Biophys Res Commun 225:785–790.
   PubMed Web of Science ®Google Scholar
• Munzel, P. A., Bookjans, G., Mehner, G., Lehmkoster, T., Bock, K. W. (1996). Tissue-specific 2,3,7,8-tetrachlorodibenzo-p-;;dioxin-inducible expression of human UDP-glucuronosyltransferase UGT1A6. Arch Biochem Biophys 335:205–210.
   PubMed Web of Science ®Google Scholar
• Munzel, PA, Lehmkoster, T, Bruck, M, Ritter, JK and Bock, K.W. (1998). Aryl hydrocarbon receptor-inducible or constitutive expression of human UDP-glucuronosyltransferase Ugt1a6. Arch Biochem Biophys 350:72–78.
   PubMed Web of Science ®Google Scholar
• Munzel, P. A., Schmohl, S., Buckler, F., Jaehrling, J., Raschko, F. T., Kohle, C., et al. (2003). Contribution of the Ah receptor to the phenolic antioxidant-mediated expression of human and rat UDP-glucuronosyltransferase UGT1A6 in Caco-2 and rat hepatoma 5L cells. Biochem Pharmacol 66:841–847.
   PubMed Web of Science ®Google Scholar
• Nakamura, A., Nakajima, M., Yamanaka, H., Fujiwara, R., Yokoi, T. (2008). Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. Drug Metab Dispos 36:1461–1464.
   PubMed Web of Science ®Google Scholar
• Nguyen, T., Huang, H. C., Pickett, C. B. (2000). Transcriptional regulation of the antioxidant response element—activation by Nrf2 and repression by MafK. J Biol Chem 275:15466–15473.
   PubMed Web of Science ®Google Scholar
• Odom, D. T., Dowell, R. D., Jacobsen, E. S., Gordon, W., Danford, T. W., et al. (2007). Tissue-specific transcriptional regulation has diverged significantly between human and mouse. Nat Gen 39:730–732.
   PubMed Web of Science ®Google Scholar
• Odom, D. T., Zizlsperger, N., Gordon, D. B., Bell, G. W., Rinaldi, N. J., Murray, H. L., et al. (2004). Control of pancreas and liver gene expression by HNF transcription factors [see comment]. Science 303:1378–1381.
   PubMed Web of Science ®Google Scholar
• Ohno, S., Nakajin, S. (2009). Determination of mRNA expression of human UDP-glucuronosyltransferases and application for localization in various human tissues by real-time reverse transcriptase-polymerase chain reaction. Drug Metab Dispos 37:32–40.
   PubMed Web of Science ®Google Scholar
• Rae, J. M., Johnson, M. D., Lippman, M. E., Flockhart, D. A. (2001). Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays. J Pharmacol Exp Ther 299:849–857.
   PubMed Web of Science ®Google Scholar
• Ritter, J. K., Chen, F., Sheen, Y. Y., Tran, H. M., Kimura, S., Yeatman, M. T., et al. (1992). A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. J Biol Chem 267:3257–3261.
   PubMed Web of Science ®Google Scholar
• Senekeo-Effenberger, K., Chen, S., Brace-Sinnokrak, E., Bonzo, J. A., Yueh, M-F., Argikar, U., et al. (2007). Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos 35:419–427.
   PubMed Web of Science ®Google Scholar
• Starlard-Davenport, A., Lyn-Cook, B., Radominska-Pandya, A. (2008). Identification of UDP-glucuronosyltransferase 1A10 in nonmalignant and malignant human breast tissues. Steroids 73:611–620.
   PubMed Web of Science ®Google Scholar
• Starlard-Davenport, A., Xiong, Y., Bratton, S., Gallus-Zawada, A., Finel, M., Radominska-Pandya, A. (2007). Phenylalanine(90) and phenylalanine(93) are crucial amino acids within the estrogen-binding site of the human UDP-glucuronosyltransferase 1A10. Steroids 72:85–94.
   PubMed Web of Science ®Google Scholar
• Strassburg, C. P., Kneip, S., Topp, J., Obermayer-Straub, P., Barut, A., Tukey, R. H., et al. (2000). Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. J Biol Chem 275:36164–36171.
   PubMed Web of Science ®Google Scholar
• Sugatani, J., Kojima, H., Ueda, A., Kakizaki, S., Yoshinari, K., Gong, Q. H., et al. (2001). The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor, CAR. Hepatology 33:1232–1238.
   PubMed Web of Science ®Google Scholar
• Sugatani, J., Mizushima, K., Osabe, M., Yamakawa, K., Kakizaki, S., Takagi, H., et al. (2008). Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter. Naunyn-Schmiedebergs Arch Pharmacol 377:597–605.
   PubMed Web of Science ®Google Scholar
• Sugatani, J., Nishitani, S., Yamakawa, K., Yoshinari, K., Sueyoshi, T., Negishi, M., et al. (2005). Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1. Mol Pharmacol 67:845–855.
   PubMed Web of Science ®Google Scholar
• Sugatani, J., Yamakawa, K., Tonda, E., Nishitani, S., Yoshinari, K., Degawa, M., et al. (2004). The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics [erratum appears in Biochem Pharmacol 67:2991–2992]. Biochem Pharmacol 67:989–1000.
   PubMed Web of Science ®Google Scholar
• Timsit, Y. E., Negishi, M. (2007). CAR and PXR: the xenobiotic-sensing receptors. Steroids 72:231–246.
   PubMed Web of Science ®Google Scholar
• Tobin, J. F., Freedman, L. P. (2006). Nuclear receptors as drug targets in metabolic diseases: new approaches to therapy. Trends Endocrinol Metab 17:284–290.
   PubMed Web of Science ®Google Scholar
• Turgeon, D., Carrier, J. S., Levesque, E., Hum, D. W., Belanger, A. (2001). Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members. Endocrinology 142:778–787.
   PubMed Web of Science ®Google Scholar
• Verreault, M., Senekeo-Effenberger, K., Trottier, J., Bonzo, J. A., Belanger, J., Kaeding, J., et al. (2006). The liver X-receptor alpha controls hepatic expression of the human bile acid-;glucuronidating UGT1A3 enzyme in human cells and transgenic mice. Hepatology 44:368–378.
   PubMed Web of Science ®Google Scholar
• Xie, W., Yeuh, M-F., Radominska-Pandya, A., Saini, S. P. S., Negishi, Y., Bottroff, B. S., et al. (2003). Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor [see comment]. Proc Natl Acad Sci U S A 100:4150–4155.
   PubMed Web of Science ®Google Scholar
• Yueh, M-F., Tukey, R. H. (2007). Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem 282:8749–8758.
   PubMed Web of Science ®Google Scholar
• Yueh, M. F., Huang, Y. H., Hiller, A., Chen, S., Nguyen, N., Tukey, R. H. (2003). Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem 278:15001–15006.
   PubMed Web of Science ®Google Scholar