Increasing recognition of the importance of aldehyde oxidase in drug development and discovery

References

• Alfaro, J. F., Joswig-Jones, C. A., Ouyang, W., Nichols, J., Crouch, G. J., Jones, J. P. (2009). Purification and mechanism of human aldehyde oxidase expressed in Escherichia coli. Drug Metab Dispos 37:2393–2398.
   PubMed Web of Science ®Google Scholar
• Andersson, A., Ritz, C., Lindgren, D., Eden, P., Lassen, C., Heldrup, J., et al. (2007). Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status. Leukemia 21:1198–1203.
   PubMed Web of Science ®Google Scholar
• Badwey, J. A., Robinson, J. M., Karnovsky, M. J., Karnovsky, M. L. (1981). Superoxide production by an unusual aldehyde oxidase in guinea pig granulocytes. Characterization and cytochemical localization. J Biol Chem 256:3479–3486.
   PubMed Web of Science ®Google Scholar
• Barbier, G. G., Joshi, R. C., Campbell, E. R., Campbell, W. H. (2004). Purification and biochemical characterization of simplified eukaryotic nitrate reductase expressed in Pichia pastoris. Protein Expr Purif 37:61–71.
   PubMed Web of Science ®Google Scholar
• Beedham, C (1987). Molybdenum hydroxylases: biological distribution and substrate-inhibitor specificity. Prog Med Chem 24:85–127.
   PubMedGoogle Scholar
• Beedham, C. (1997). The role of non-P450 enzymes in drug oxidation. Pharm World Sci 19:255–263.
   PubMed Web of Science ®Google Scholar
• Beer, D. G., Kardia, S. L., Huang, C. C., Giordano, T. J., Levin, A. M., Misek, D. E., et al. (2002). Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat Med 8:816–824.
   PubMed Web of Science ®Google Scholar
• Beroukhim, R., Brunet, J. P., Di Napoli, A., Mertz, K. D., Seeley, A., Pires, M. M., et al. (2009). Patterns of gene expression and copy-number alterations in von-Hippel Lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Res 69:4674–4681.
   PubMed Web of Science ®Google Scholar
• Beroukhim, R., Getz, G., Nghiemphu, L., Barretina, J., Hsueh, T., Linhart, D., et al. (2007). Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc Natl Acad Sci U S A 104:20007–20012.
   PubMed Web of Science ®Google Scholar
• Blaveri, E., Simko, J. P., Korkola, J. E., Brewer, J. L., Baehner, F., Mehta, K., et al. (2005). Bladder cancer outcome and subtype classification by gene expression. Clin Cancer Res 11:4044–4055.
   PubMed Web of Science ®Google Scholar
• Bredel, M., Bredel, C., Juric, D., Harsh, G. R., Vogel, H., Recht, L. D., et al. (2005). High-resolution genome-wide mapping of genetic alterations in human glial brain tumors. Cancer Res 65:4088–4096.
   PubMed Web of Science ®Google Scholar
• Buchholz, M., Braun, M., Heidenblut, A., Kestler, H. A., Kloppel, G., Schmiegel, W., et al. (2005). Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions. Oncogene 24:6626–6636.
   PubMed Web of Science ®Google Scholar
• Cates, L. A., Jones, G. S., Jr., Good, D. J., Tsai, H. Y., Li, V. S., Caron, N., et al. (1980). Cyclophosphamide potentiation and aldehyde oxidase inhibition by phosphorylated aldehydes and acetals. J Med Chem 23:300–304.
   PubMed Web of Science ®Google Scholar
• Chang, C. N., Doong, S. L., Cheng, Y. C. (1992). Conversion of 5-iodo-2-pyrimidinone-2′-deoxyribose to 5-iodo-deoxyuridine by aldehyde oxidase. Implication in hepatotropic drug design. Biochem Pharmacol 43:2269–2273.
   PubMed Web of Science ®Google Scholar
• Chen, X., Leung, S. Y., Yuen, S. T., Chu, K. M., Ji, J., Li, R., et al. (2003). Variation in gene expression patterns in human gastric cancers. Mol Biol Cell 14:3208–3215.
   PubMed Web of Science ®Google Scholar
• Cheung, K. J., Tzameli, I., Pissios, P., Rovira, I., Gavrilova, O., Ohtsubo, T., et al. (2007). Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab 5:115–128.
   PubMed Web of Science ®Google Scholar
• Choi, Y. L., Tsukasaki, K., O’Neill, M. C., Yamada, Y., Onimaru, Y., Matsumoto, K., et al. (2007). A genomic analysis of adult T-cell leukemia. Oncogene 26:1245–1255.
   PubMed Web of Science ®Google Scholar
• Crnogorac-Jurcevic, T., Gangeswaran, R., Bhakta, V., Capurso, G., Lattimore, S., Akada, M., et al. (2005). Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma. Gastroenterology 129:1454–1463.
   PubMed Web of Science ®Google Scholar
• Das, P. K., Guha, S. R. (1985). In vitro pigment formation from tryptamine. Role of indole-3-acetaldehyde. Biochem Pharmacol 34:2663–2667.
   PubMed Web of Science ®Google Scholar
• Demontis, S., Kurosaki, M., Saccone, S., Motta, S., Garattini, E., Terao, M. (1999). The mouse aldehyde oxidase gene: molecular cloning, chromosomal mapping, and functional characterization of the 5′-flanking region. Biochim Biophys Acta 1489:207–222.
   PubMed Web of Science ®Google Scholar
• Detwiller, K. Y., Fernando, N. T., Segal, N. H., Ryeom, S. W., D’Amore, P. A., Yoon, S. S. (2005). Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A. Cancer Res 65:5881–5889.
   PubMed Web of Science ®Google Scholar
• Dyrskjot, L., Kruhoffer, M., Thykjaer, T., Marcussen, N., Jensen, J. L., Moller, K., et al. (2004). Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification. Cancer Res 64:4040–4048.
   PubMed Web of Science ®Google Scholar
• Eger, B. T., Okamoto, K., Enroth, C., Sato, M., Nishino, T., Pai, E. F. (2000). Purification, crystallization, and preliminary X-ray diffraction studies of xanthine dehydrogenase and xanthine oxidase isolated from bovine milk. Acta Crystallogr D Biol Crystallogr 56:1656–1658.
   PubMed Web of Science ®Google Scholar
• Enroth, C., Eger, B. T., Okamoto, K., Nishino, T., Pai, E. F. (2000). Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion. Proc Natl Acad Sci U S A 97:10723–10728.
   PubMed Web of Science ®Google Scholar
• Finak, G., Bertos, N., Pepin, F., Sadekova, S., Souleimanova, M., Zhao, H., et al. (2008). Stromal gene expression predicts clinical outcome in breast cancer. Nat Med 14:518–527.
   PubMed Web of Science ®Google Scholar
• Fischer, K., Barbier, G. G., Hecht, H. J., Mendel, R. R., Campbell, W. H., Schwarz, G. (2005). Structural basis of eukaryotic nitrate reduction: crystal structures of the nitrate reductase active site. Plant Cell 17:1167–1179.
   PubMed Web of Science ®Google Scholar
• Garattini, E., Fratelli, M., Terao, M. (2008). Mammalian aldehyde oxidases: genetics, evolution, and biochemistry. Cell Mol Life Sci 65:1019–1048.
   PubMed Web of Science ®Google Scholar
• Garattini, E., Fratelli, M., Terao, M. (2009). The mammalian aldehyde oxidase gene family. Hum Genomics 4:119–130.
   PubMedGoogle Scholar
• Garattini, E., Mendel, R., Romao, M. J., Wright, R., Terao, M. (2003). Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function, and pathophysiology. Biochem J 372:15–32.
   PubMed Web of Science ®Google Scholar
• Gok, F., Ichida, K., Topaloglu, R. (2003). Mutational analysis of the xanthine dehydrogenase gene in a Turkish family with autosomal recessive classical xanthinuria. Nephrol Dial Transpl 18:2278–2283.
   PubMed Web of Science ®Google Scholar
• Graessler, J., Fischer, S. (2007). The dual substrate specificity of aldehyde oxidase 1 for retinal and acetaldehyde and its role in ABCA1 mediated efflux. Horm Metab Res 39:775–776.
   PubMed Web of Science ®Google Scholar
• Gumz, M. L., Zou, H., Kreinest, P. A., Childs, A. C., Belmonte, L. S., LeGrand, S. N., et al. (2007). Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. Clin Cancer Res 13:4740–4749.
   PubMed Web of Science ®Google Scholar
• Guo, X., Lerner-Tung, M., Chen, H. X., Chang, C. N., Zhu, J. L., Chang, C. P., et al. (1995). 5-fluoro-2-pyrimidinone, a liver aldehyde oxidase-activated prodrug of 5-fluorouracil. Biochem Pharmacol 49:1111–1116.
   PubMed Web of Science ®Google Scholar
• Guo, Y., Lu, P., Farrell, E., Zhang, X., Weller, P., Monshouwer, M., et al. (2007). In silico and in vitro pharmacogenetic analysis in mice. Proc Natl Acad Sci U S A 104:17735–17740.
   PubMed Web of Science ®Google Scholar
• Hall, W. W., Krenitsky, T. A. (1986). Aldehyde oxidase from rabbit liver: specificity toward purines and their analogs. Arch Biochem Biophys 251:36–46.
   PubMed Web of Science ®Google Scholar
• Hao, Y., Triadafilopoulos, G., Sahbaie, P., Young, H. S., Omary, M. B., Lowe, A. W. (2006). Gene expression profiling reveals stromal genes expressed in common between Barrett’s esophagus and adenocarcinoma. Gastroenterology 131:925–933.
   PubMed Web of Science ®Google Scholar
• Hendrix, N. D., Wu, R., Kuick, R., Schwartz, D. R., Fearon, E. R., Cho, K. R. (2006). Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas. Cancer Res 66:1354–1362.
   PubMed Web of Science ®Google Scholar
• Hesberg, C., Hansch, R., Mendel, R. R., Bittner, F. (2004). Tandem orientation of duplicated xanthine dehydrogenase genes from Arabidopsis thaliana: differential gene expression and enzyme activities. J Biol Chem 279:13547–13554.
   PubMed Web of Science ®Google Scholar
• Hille, R., Nishino, T. (1995). Flavoprotein structure and mechanism. 4. Xanthine oxidase and xanthine dehydrogenase. FASEB J 9:995–1003.
   PubMed Web of Science ®Google Scholar
• Hodnett, C. N., McCormack, J. J., Sabean, J. A. (1976). Oxidation of selected pteridine derivatives by mamalian liver xanthine oxidase and aldehyde oxidase. J Pharm Sci 65:1150–1154.
   PubMed Web of Science ®Google Scholar
• Hoshino, K., Itoh, K., Masubuchi, A., Adachi, M., Asakawa, T., Watanabe, N., et al. (2007). Cloning, expression, and characterization of male cynomolgus monkey liver aldehyde oxidase. Biol Pharm Bull 30:1191–1198.
   PubMed Web of Science ®Google Scholar
• Hsiao, L. L., Dangond, F., Yoshida, T., Hong, R., Jensen, R. V., Misra, J., et al. (2001). A compendium of gene expression in normal human tissues. Physiol Genomics 7:97–104.
   PubMed Web of Science ®Google Scholar
• Hu, R., Xu, C., Shen, G., Jain, M. R., Khor, T. O., Gopalkrishnan, A., et al. (2006). Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray. Life Sci 79:1944–1955.
   PubMed Web of Science ®Google Scholar
• Huang, D. Y., Furukawa, A., Ichikawa, Y. (1999). Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli. Arch Biochem Biophys 364:264–272.
   PubMed Web of Science ®Google Scholar
• Iacobuzio-Donahue, C. A., Maitra, A., Olsen, M., Lowe, A. W., van Heek, N. T., Rosty, C., et al. (2003). Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. Am J Pathol 162:1151–1162.
   PubMed Web of Science ®Google Scholar
• Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., Chaudhuri, G. (1987). Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A 84:9265–9269.
   PubMed Web of Science ®Google Scholar
• Ishikawa, M., Yoshida, K., Yamashita, Y., Ota, J., Takada, S., Kisanuki, H., et al. (2005). Experimental trial for diagnosis of pancreatic ductal carcinoma based on gene expression profiles of pancreatic ductal cells. Cancer Sci 96:387–393.
   PubMed Web of Science ®Google Scholar
• Johns, D. G. (1967). Human liver aldehyde oxidase: differential inhibition of oxidation of charged and uncharged substrates. J Clin Invest 46:1492–1505.
   PubMed Web of Science ®Google Scholar
• Johns, D. G., Farquhar, D., Wolpert, M. K., Chabner, B. A., Loo, T. L. (1973). Dialkyl esters of methotrexate and 3′,5′-dichloromethotrexate: synthesis and interaction with aldehyde oxidase and dihydrofolate reductase. Drug Metab Dispos 1:580–589.
   PubMed Web of Science ®Google Scholar
• Kaiser, S., Park, Y. K., Franklin, J. L., Halberg, R. B., Yu, M., Jessen, W. J., et al. (2007). Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol 8:R131.
   PubMed Web of Science ®Google Scholar
• Karnoub, A. E., Dash, A. B., Vo, A. P., Sullivan, A., Brooks, M. W., Bell, G. W., et al. (2007). Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449:557–563.
   PubMed Web of Science ®Google Scholar
• Khor, T. O., Huang, M. T., Kwon, K. H., Chan, J. Y., Reddy, B. S., Kong, A. N. (2006). Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Res 66:11580–11584.
   PubMed Web of Science ®Google Scholar
• Ki, D. H., Jeung, H. C., Park, C. H., Kang, S. H., Lee, G. Y., Lee, W. S., et al. (2007). Whole genome analysis for liver metastasis gene signatures in colorectal cancer. Int J Cancer 121:2005–2012.
   PubMed Web of Science ®Google Scholar
• Kinsella, T. J., Kunugi, K. A., Vielhuber, K. A., McCulloch, W., Liu, S. H., Cheng, Y. C. (1994). An in vivo comparison of oral 5-iodo-2’-deoxyuridine and 5-iodo-2-pyrimidinone-2′-deoxyribose toxicity, pharmacokinetics, and DNA incorporation in athymic mouse tissues and the human colon cancer xenograft, HCT-116. Cancer Res 54:2695–2700.
   PubMed Web of Science ®Google Scholar
• Kinsella, T. J., Kunugi, K. A., Vielhuber, K. A., Potter, D. M., Fitzsimmons, M. E., Collins, J. M. (1998). Preclinical evaluation of 5-iodo-2-pyrimidinone-2′-deoxyribose as a prodrug for 5-iodo-2′-deoxyuridine-mediated radiosensitization in mouse and human tissues. Clin Cancer Res 4:99–109.
   PubMed Web of Science ®Google Scholar
• Kinsella, T. J., Schupp, J. E., Davis, T. W., Berry, S. E., Hwang, H. S., Warren, K., et al (2000). Preclinical study of the systemic toxicity and pharmacokinetics of 5-iodo-2-deoxypyrimidinone-2′;-deoxyribose as a radiosensitizing prodrug in two, non-rodent animal species: implications for phase I study design. Clin Cancer Res 6:3670–3679.
   PubMed Web of Science ®Google Scholar
• Kitamura, S., Nitta, K., Tayama, Y., Tanoue, C., Sugihara, K., Inoue, T., et al. (2008). Aldehyde oxidase-catalyzed metabolism of N1-methylnicotinamide in vivo and in vitro in chimeric mice with humanized liver. Drug Metab Dispos 36:1202–1205.
   PubMed Web of Science ®Google Scholar
• Kitamura, S., Sugihara, K., Nakatani, K., Ohta, S., Ohhara, T., Ninomiya, S., et al. (1999). Variation of hepatic methotrexate 7-hydroxylase activity in animals and humans. IUBMB Life 48:607–611.
   PubMed Web of Science ®Google Scholar
• Kundu, T. K., Hille, R., Velayutham, M., Zweier, J. L. (2007). Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues. Arch Biochem Biophys 460:113–121.
   PubMed Web of Science ®Google Scholar
• Kurosaki, M., Demontis, S., Barzago, M. M., Garattini, E., Terao, M. (1999). Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone. Biochem J 341(Pt 1):71–80.
   PubMedGoogle Scholar
• Kurosaki, M., Terao, M., Barzago, M. M., Bastone, A., Bernardinello, D., Salmona, M., et al. (2004). The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa. J Biol Chem 279:50482–50498.
   PubMed Web of Science ®Google Scholar
• Landi, M. T., Dracheva, T., Rotunno, M., Figueroa, J. D., Liu, H., Dasgupta, A., et al. (2008). Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival. PLoS One 3:e1651.
   PubMed Web of Science ®Google Scholar
• Lapointe, J., Li, C., Higgins, J. P., van de Rijn, M., Bair, E., Montgomery, K., et al. (2004). Gene expression profiling identifies clinically relevant subtypes of prostate cancer. Proc Natl Acad Sci U S A 101:811–816.
   PubMed Web of Science ®Google Scholar
• Lee, J., Kotliarova, S., Kotliarov, Y., Li, A., Su, Q., Donin, N. M., et al. (2006). Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9:391–403.
   PubMed Web of Science ®Google Scholar
• Lenburg, M. E., Liou, L. S., Gerry, N. P., Frampton, G. M., Cohen, H. T., Christman, M. F. (2003). Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data. BMC Cancer 3:31.
   PubMed Web of Science ®Google Scholar
• Li, H., Cui, H., Kundu, T. K., Alzawahra, W., Zweier, J. L. (2008). Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase. J Biol Chem 283:17855–17863.
   PubMed Web of Science ®Google Scholar
• Li, H., Kundu, T. K., Zweier, J. L. (2009). Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite. J Biol Chem 284:33850–33858.
   PubMed Web of Science ®Google Scholar
• Liu, P., Ramachandran, S., Ali Seyed, M., Scharer, C. D., Laycock, N., Dalton, W. B., et al (2006). Sex-determining region Y box 4 is a transforming oncogene in human prostate cancer cells. Cancer Res 66:4011–4019.
   PubMedGoogle Scholar
• Logsdon, C. D., Simeone, D. M., Binkley, C., Arumugam, T., Greenson, J. K., Giordano, T. J., et al. (2003). Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res 63:2649–2657.
   PubMed Web of Science ®Google Scholar
• Luo, J. H., Yu, Y. P., Cieply, K., Lin, F., Deflavia, P., Dhir, R., et al. (2002). Gene expression analysis of prostate cancers. Mol Carcinog 33:25–35.
   PubMed Web of Science ®Google Scholar
• Magee, J. A., Araki, T., Patil, S., Ehrig, T., True, L., Humphrey, P. A., et al. (2001). Expression profiling reveals hepsin overexpression in prostate cancer. Cancer Res 61:5692–5696.
   PubMed Web of Science ®Google Scholar
• Mendel, R. R., Bittner, F. (2006). Cell biology of molybdenum. Biochim Biophys Acta 1763:621–635.
   PubMed Web of Science ®Google Scholar
• Mertens, J. A., Shiraishi, N., Campbell, W. H. (2000). Recombinant expression of molybdenum reductase fragments of plant nitrate reductase at high levels in Pichia pastoris. Plant Physiol 123:743–756.
   PubMed Web of Science ®Google Scholar
• Mira, L., Maia, L., Barreira, L., Manso, C. F. (1995). Evidence for free radical generation due to NADH oxidation by aldehyde oxidase during ethanol metabolism. Arch Biochem Biophys 318:53–58.
   PubMed Web of Science ®Google Scholar
• Moncada, S., Palmer, R. M., Higgs, E. A. (1991). Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109–142.
   PubMed Web of Science ®Google Scholar
• Neumeier, M., Weigert, J., Schaffler, A., Weiss, T. S., Schmidl, C., Buttner, R., et al. (2006). Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro. Biochem Biophys Res Commun 350:731–735.
   PubMed Web of Science ®Google Scholar
• Nishimura, M., Naito, S. (2006). Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes. Drug Metab Pharmacokinet 21:357–374.
   PubMed Web of Science ®Google Scholar
• Nishino, T. (1994). The conversion of xanthine dehydrogenase to xanthine oxidase and the role of the enzyme in reperfusion injury. J Biochem 116:1–6.
   PubMed Web of Science ®Google Scholar
• Nishino, T., Amaya, Y., Kawamoto, S., Kashima, Y., Okamoto, K. (2002). Purification and characterization of multiple forms of rat liver xanthine oxidoreductase expressed in baculovirus-insect cell system. J Biochem 132:597–606.
   PubMed Web of Science ®Google Scholar
• Nishino, T., Okamoto, K., Eger, B. T., Pai, E. F. (2008). Mammalian xanthine oxidoreductase—mechanism of transition from xanthine dehydrogenase to xanthine oxidase. FEBS J 275:3278–3289.
   PubMed Web of Science ®Google Scholar
• Notterman, D. A., Alon, U., Sierk, A. J., Levine, A. J. (2001). Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays. Cancer Res 61:3124–3130.
   PubMed Web of Science ®Google Scholar
• Obach, R. S. (2004). Potent inhibition of human liver aldehyde oxidase by raloxifene. Drug Metab Dispos 32:89–97.
   PubMed Web of Science ®Google Scholar
• Obach, R. S., Huynh, P., Allen, M. C., Beedham, C. (2004). Human liver aldehyde oxidase: inhibition by 239 drugs. J Clin Pharmacol 44:7–19.
   PubMed Web of Science ®Google Scholar
• Ohkubo, M., Sakiyama, S., Fujimura, S. (1983). Increase of nicotinamide methyltransferase and N1-methyl-nicotinamide oxidase activities in the livers of the rats administered alkylating agents. Cancer Lett 21:175–181.
   PubMed Web of Science ®Google Scholar
• Okamoto, K., Matsumoto, K., Hille, R., Eger, B. T., Pai, E. F., Nishino, T. (2004). The crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition. Proc Natl Acad Sci U S A 101:7931–7936.
   PubMed Web of Science ®Google Scholar
• Palmer, R. M., Ferrige, A. G., Moncada, S. (1987). Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524–526.
   PubMed Web of Science ®Google Scholar
• Panchal, H. D., Vranizan, K., Lee, C. Y., Ho, J., Ngai, J., Timiras, P. S. (2008). Early anti-oxidative and anti-proliferative curcumin effects on neuroglioma cells suggest therapeutic targets. Neurochem Res 33:1701–1710.
   PubMed Web of Science ®Google Scholar
• Pilarsky, C., Wenzig, M., Specht, T., Saeger, H. D., Grutzmann, R (2004). Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data. Neoplasia 6:744–750.
   PubMed Web of Science ®Google Scholar
• Pyeon, D., Newton, M. A., Lambert, P. F., den Boon, J. A., Sengupta, S., Marsit, C. J., et al. (2007). Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers. Cancer Res 67:4605–4619.
   PubMed Web of Science ®Google Scholar
• Reiss, J., Bonin, M., Schwegler, H., Sass, J. O., Garattini, E., Wagner, S., et al. (2005). The pathogenesis of molybdenum cofactor deficiency, its delay by maternal clearance, and its expression pattern in microarray analysis. Mol Genet Metab 85:12–20.
   PubMed Web of Science ®Google Scholar
• Richardson, A. L., Wang, Z. C., De Nicolo, A., Lu, X., Brown, M., Miron, A., et al. (2006). X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell 9:121–132.
   PubMed Web of Science ®Google Scholar
• Rivera, S. P., Choi, H. H., Chapman, B., Whitekus, M. J., Terao, M., Garattini, E., et al. (2005). Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes. Toxicology 207:401–409.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Trelles, F., Tarrio, R., Ayala, F. J. (2003). Convergent neofunctionalization by positive Darwinian selection after ancient recurrent duplications of the xanthine dehydrogenase gene. Proc Natl Acad Sci U S A 100:13413–13417.
   PubMed Web of Science ®Google Scholar
• Rooseboom, M., Commandeur, J. N., Vermeulen, N. P. (2004). Enzyme-catalyzed activation of anticancer prodrugs. Pharmacol Rev 56:53–102.
   PubMed Web of Science ®Google Scholar
• Rosenwald, A., Alizadeh, A. A., Widhopf, G., Simon, R., Davis, R. E., Yu, X., et al. (2001). Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 194:1639–1647.
   PubMed Web of Science ®Google Scholar
• Rosowsky, A., Wright, J. E., Holden, S. A., Waxman, D. J. (1990). Influence of lipophilicity and carboxyl group content on the rate of hydroxylation of methotrexate derivatives by aldehyde oxidase. Biochem Pharmacol 40:851–857.
   PubMed Web of Science ®Google Scholar
• Roth, R. B., Hevezi, P., Lee, J., Willhite, D., Lechner, S. M., Foster, A. C., et al. (2006). Gene expression analyses reveal molecular relationships among 20 regions of the human CNS. Neurogenetics 7:67–80.
   PubMed Web of Science ®Google Scholar
• Sahi, J., Khan, K. K., Black, C. B. (2008). Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey, and human. Drug Metab Lett 2:176–183.
   PubMedGoogle Scholar
• Saif, M. W., Berk, G., Cheng, Y. C., Kinsella, T. J. (2007). IPdR: a novel oral radiosensitizer. Exp Opin Investig Drugs 16:1415–1424.
   PubMed Web of Science ®Google Scholar
• Sanchez-Carbayo, M., Socci, N. D., Lozano, J., Saint, F., Cordon-Cardo, C. (2006). Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. J Clin Oncol 24:778–789.
   PubMed Web of Science ®Google Scholar
• Schumann, S., Terao, M., Garattini, E., Saggu, M., Lendzian, F., Hildebrandt, P., et al. (2009). Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1. PLoS One 4:e5348.
   PubMed Web of Science ®Google Scholar
• Segara, D., Biankin, A. V., Kench, J. G., Langusch, C. C., Dawson, A. C., Skalicky, D. A., et al. (2005). Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia. Clin Cancer Res 11:3587–3596.
   PubMed Web of Science ®Google Scholar
• Shyamsundar, R., Kim, Y. H., Higgins, J. P., Montgomery, K., Jorden, M., Sethuraman, A., et al. (2005). A DNA microarray survey of gene expression in normal human tissues. Genome Biol 6:R22.
   PubMed Web of Science ®Google Scholar
• Sigruener, A., Buechler, C., Orso, E., Hartmann, A., Wild, P. J., Terracciano, L., et al. (2007). Human aldehyde oxidase 1 interacts with ATP-binding cassette transporter-1 and modulates its activity in hepatocytes. Horm Metab Res 39:781–789.
   PubMed Web of Science ®Google Scholar
• Stegmaier, K., Ross, K. N., Colavito, S. A., O’Malley, S., Stockwell, B. R., Golub, T. R. (2004). Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation. Nat Genet 36: 257–263.
   PubMed Web of Science ®Google Scholar
• Steinberg, K. K., Relling, M. V., Gallagher, M. L., Greene, C. N., Rubin, C. S., French, D., et al. (2007). Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada. Environ Health Perspect 115:158–164.
   PubMed Web of Science ®Google Scholar
• Su, L. J., Chang, C. W., Wu, Y. C., Chen, K. C., Lin, C. J., Liang, S. C., et al (2007). Selection of DDX5 as a novel internal control for Q-RT-PCR from microarray data using a block bootstrap re-sampling scheme. BMC Genomics 8:140.
   PubMed Web of Science ®Google Scholar
• Sugihara, K., Tayama, Y., Shimomiya, K., Yoshimoto, D., Ohta, S., Kitamura, S. (2006). Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats. Drug Metab Dispos 34:208–212.
   PubMed Web of Science ®Google Scholar
• Talantov, D., Mazumder, A., Yu, J. X., Briggs, T., Jiang, Y., Backus, J., et al. (2005). Novel genes associated with malignant melanoma but not benign melanocytic lesions. Clin Cancer Res 11:7234–7242.
   PubMed Web of Science ®Google Scholar
• Terao, M., Kurosaki, M., Barzago, M. M., Fratelli, M., Bagnati, R., Bastone, A., et al. (2009). Role of the molybdoflavoenzyme aldehyde oxidase homolog 2 in the biosynthesis of retinoic acid: generation and characterization of a knockout mouse. Mol Cell Biol 29:357–377.
   PubMed Web of Science ®Google Scholar
• Terao, M., Kurosaki, M., Barzago, M. M., Varasano, E., Boldetti, A., Bastone, A., et al. (2006). Avian and canine aldehyde oxidases. Novel insights into the biology and evolution of molybdo-flavoenzymes. J Biol Chem 281:19748–19761.
   PubMed Web of Science ®Google Scholar
• Terao, M., Kurosaki, M., Demontis, S., Zanotta, S., Garattini, E. (1998). Isolation and characterization of the human aldehyde oxidase gene: conservation of intron/exon boundaries with the xanthine oxidoreductase gene indicates a common origin. Biochem J 332(Pt 2):383–393.
   PubMed Web of Science ®Google Scholar
• Terao, M., Kurosaki, M., Marini, M., Vanoni, M. A., Saltini, G., Bonetto, V., et al. (2001). Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1. J Biol Chem 276:46347–46363.
   PubMed Web of Science ®Google Scholar
• Terao, M., Kurosaki, M., Saltini, G., Demontis, S., Marini, M., Salmona, M., et al. (2000). Cloning of the cDNAs coding for two novel molybdo-flavoproteins showing high similarity with aldehyde oxidase and xanthine oxidoreductase. J Biol Chem 275:30690–30700.
   PubMed Web of Science ®Google Scholar
• Valk, P. J., Verhaak, R. G., Beijen, M. A., Erpelinck, C. A., Barjesteh van Waalwijk van Doorn-Khosrovani S., Boer, J. M., et al. (2004). Prognostically useful gene-expression profiles in acute myeloid leukemia. NEJM 350:1617–1628.
   PubMed Web of Science ®Google Scholar
• Vanaja, D. K., Cheville, J. C., Iturria, S. J., Young, C. Y. (2003). Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression. Cancer Res 63:3877–3882.
   PubMed Web of Science ®Google Scholar
• Varambally, S., Yu, J., Laxman, B., Rhodes, D. R., Mehra, R., Tomlins, S. A., et al. (2005). Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell 8:393–406.
   PubMed Web of Science ®Google Scholar
• Ventura, S. M., Dachtler, S. L. (1980). Development and maturation of aldehyde oxidase levels in fetal hepatic tissue of C57BL/6J mice. Enzyme 25:213–219.
   PubMedGoogle Scholar
• Ventura, S. M., Dachtler, S. L. (1981). Effects of sex hormones on hepatic aldehyde oxidase activity in C57BL/6J mice. Horm Res 14:250–259.
   PubMed Web of Science ®Google Scholar
• Vila, R., Kurosaki, M., Barzago, M. M., Kolek, M., Bastone, A., Colombo, L., et al. (2004). Regulation and biochemistry of mouse molybdo-flavoenzymes. The DBA/2 mouse is selectively deficient in the expression of aldehyde oxidase homologues 1 and 2 and represents a unique source for the purification and characterization of aldehyde oxidase. J Biol Chem 279:8668–8683.
   PubMed Web of Science ®Google Scholar
• Wachi, S., Yoneda, K., Wu, R. (2005). Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues. Bioinformatics 21:4205–4208.
   PubMed Web of Science ®Google Scholar
• Wallace, T. A., Prueitt, R. L., Yi, M., Howe, T. M., Gillespie, J. W., Yfantis, H. G., et al. (2008). Tumor immunobiological differences in prostate cancer between African-American and European-American men. Cancer Res 68:927–936.
   PubMed Web of Science ®Google Scholar
• Wang, P., Zweier, J. L. (1996). Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury. J Biol Chem 271:29223–29230.
   PubMed Web of Science ®Google Scholar
• Weigert, J., Neumeier, M., Bauer, S., Mages, W., Schnitzbauer, A. A., Obed, A., et al. (2008). Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release. FEBS Lett 582:2965–2972.
   PubMed Web of Science ®Google Scholar
• Welsh, J. B., Zarrinkar, P. P., Sapinoso, L. M., Kern, S. G., Behling, C. A., Monk, B. J., et al. (2001). Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer. Proc Natl Acad Sci U S A 98:1176–1181.
   PubMed Web of Science ®Google Scholar
• Wootton, J. C., Nicolson, R. E., Cock, J. M., Walters, D. E., Burke, J. F., Doyle, W. A., et al. (1991). Enzymes depending on the pterin molybdenum cofactor: sequence families, spectroscopic properties of molybdenum, and possible cofactor-binding domains. Biochim Biophys Acta 1057:157–185.
   PubMed Web of Science ®Google Scholar
• Wright, J. E., Rosowsky, A., Waxman, D. J., Trites, D., Cucchi, C. A., Flatow, J., et al. (1987). Metabolism of methotrexate and gamma-tert-butyl methotrexate by human leukemic cells in culture and by hepatic aldehyde oxidase in vitro. Biochem Pharmacol 36:2209–2214.
   PubMed Web of Science ®Google Scholar
• Wright, R. M., McManaman, J. L., Repine, J. E. (1999). Alcohol-induced breast cancer: a proposed mechanism. Free Radic Biol Med 26:348–354.
   PubMed Web of Science ®Google Scholar
• Wright, R. M., Riley, M. G., Weigel, L. K., Ginger, L. A., Costantino, D. A., McManaman, J. L. (2000). Activation of the human aldehyde oxidase (hAOX1) promoter by tandem cooperative Sp1/Sp3 binding sites: identification of complex architecture in the hAOX upstream DNA that includes a proximal promoter, distal activation sites, and a silencer element. DNA Cell Biol 19:459–474.
   PubMed Web of Science ®Google Scholar
• Wurmbach, E., Chen, Y. B., Khitrov, G., Zhang, W., Roayaie, S., Schwartz, M., et al. (2007). Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology 45:938–947.
   PubMed Web of Science ®Google Scholar
• Yoo, C. B., Chuang, J. C., Byun, H. M., Egger, G., Yang, A. S., Dubeau, L., et al. (2008). Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice. Cancer Prev Res (Phila Pa) 1:233–240.
   PubMed Web of Science ®Google Scholar
• Yusenko, M. V., Kuiper, R. P., Boethe, T., Ljungberg, B., van Kessel, A. G., Kovacs, G. (2009). High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas. BMC Cancer 9:152.
   PubMed Web of Science ®Google Scholar
• Zannolli, R., Micheli, V., Mazzei, M. A., Sacco, P., Piomboni, P., Bruni, E., et al. (2003). Hereditary xanthinuria type II associated with mental delay, autism, cortical renal cysts, nephrocalcinosis, osteopenia, and hair and teeth defects. J Med Genet 40:e121.
   PubMedGoogle Scholar
• Zhang, X., Liu, H. H., Weller, P., Zheng, M., Tao, W., Wang, J., et al. (2011). In silico and in vitro pharmacogenetics: aldehyde oxidase rapidly metabolizes a p38 kinase inhibitor. Pharmacogenomics J 11:15–24.
   PubMed Web of Science ®Google Scholar