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Review Article

Xenobiotic-metabolizing enzymes in plants and their role in uptake and biotransformation of veterinary drugs in the environment

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Pages 374-387 | Received 24 Apr 2015, Accepted 22 Jul 2015, Published online: 14 Aug 2015

References

  • Alderete LGS, Talano MA, Ibanez SG, et al. (2009). Establishment of transgenic tobacco hairy roots expressing basic peroxidases and its application for phenol removal. J Biotechnol 139:273–279
  • Baetz U, Martinoia E. (2014). Root exudates: The hidden part of plant defense. Trends Plant Sci 19:90–98
  • Baguer AJ, Jensen J, Krogh PH. (2000). Effects of the antibiotics oxytetracycline and tylosin on soil fauna. Chemosphere 40:751–757
  • Bartha B, Huber C, Harpaintner R, Schroder P. (2010). Effects of acetaminophen in Brassica juncea L. Czern: Investigation of uptake, translocation, detoxification, and the induced defense pathways. Environ Sci Pollut Res 17:1553–1562
  • Bartha B, Huber C, Schroder P. (2014). Uptake and metabolism of diclofenac in Typha latifolia – How plants cope with human pharmaceutical pollution. Plant Sci 227:12–20
  • Bartikova H, Skalova L, Lamka J, et al. (2010). The effects of flubendazole and its metabolites on the larval development of Haemonchus contortus (Nematoda: Trichostrongylidae): An in vitro study. Helminthologia 47:269–272
  • Basantani M, Srivastava A. (2007). Plant glutathione transferases – A decade falls short. Can J Bot 85:443–456
  • Basantani M, Srivastava A, Sen S. (2011). Elevated antioxidant response and induction of tau-class glutathione S-transferase after glyphosate treatment in Vigna radiata (L.) Wilczek. Pesticide Biochem Physiol 99:111–117
  • Blackwell BR, Karnjanapiboonwong A, Anderson TA, Smith PN. (2012). Uptake of 17beta-trenbolone and subsequent metabolite trendione by the pinto bean plant (Phaseolus vulgaris). Ecotoxicol Environ Saf 85:110–114
  • Boonsaner M, Hawker DW. (2010). Accumulation of oxytetracycline and norfloxacin from saline soil by soybeans. Sci Total Environ 408:1731–1737
  • Boxall ABA, Fogg L, Blackwell PA, et al. (2002). Review of veterinary medicines in the environment R&D Technical Report P6-012/8/TR. Bristol: Environment Agency
  • Boxall ABA, Johnson P, Smith EJ, et al. (2006). Uptake of veterinary medicines from soils into plants. J Agric Food Chem 54:2288–2297
  • Boxall ABA, Kolpin B, Holling-Sorensen B, Tolls J. (2003). Are veterinary medicines causing environmental risks? USGS Staff – Published Research Paper 67
  • Brocker C, Vasiliou M, Carpenter S, et al. (2013). Aldehyde dehydrogenase (ALDH) superfamily in plants: Gene nomenclature and comparative genomics. Planta 237:189–210
  • Cascone A, Forni C, Migliore L. (2004). Flumequine uptake and the aquatic duckweed, Lemna minor L. Water Air Soil Pollut 156:241–249
  • Caverzan A, Passaia G, Rosa SB, et al. (2012). Plant responses to stresses: Role of ascorbate peroxidase in the antioxidant protection. Genet Mol Biol 35:1011–1019
  • Conte SS, Lloyd AM. (2011). Exploring multiple drug and herbicide resistance in plants-Spotlight on transporter proteins. Plant Sci 180:196–203
  • Cortes JM, Larsson E, Jonsson JA. (2013). Study of the uptake of non-steroid anti-inflammatory drugs in wheat and soybean after application of sewage sludge as a fertilizer. Sci Total Environ 449:385–389
  • Cummins I, Landrum M, Steel PG, Edwards R. (2007). Structure activity studies with xenobiotic substrates using carboxylesterases isolated from Arabidopsis thaliana. Phytochemistry 68:811–818
  • Dabrowska G, Katai A, Goc A, et al. (2007). Characteristics of the plant ascorbate peroxidase family. Acta Biol Cracow Ser Bot 49:7–17
  • Dolliver H, Kumar K, Gupta S. (2007). Sulfamethazine uptake by plants from manure-amended soil. J Environ Qual 36:1224–1230
  • Dordio AV, Belo M, Martins Teixeira D, et al. (2011). Evaluation of carbamazepine uptake and metabolization by Typha spp., a plant with potential use in phytotreatment. Bioresource Technol 102:7827–7834
  • Du LF, Liu WK. (2012). Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems. A review. Agron Sustain Dev 32:309–327
  • Dubrovskaya EV, Polikarpova IO, Muratova AY, et al. (2014). Changes in physiological, biochemical, and growth parameters of sorghum in the presence of phenanthrene. Russ J Plant Physiol 61:529–536
  • Eggen T, Asp TN, Grave K, Hormazabal V. (2011). Uptake and translocation of metformin, ciprofloxacin and narasin in forage and crop plants. Chemosphere 85:26–33
  • Eva C, Zelenyanszki H, Tomoskozi-Farkas R, Tamas L. (2014). Transgenic barley expressing the Arabidopsis AKR4C9 aldo-keto reductase enzyme exhibits enhanced freezing tolerance and regenerative capacity. South Afr J Bot 93:179–184
  • Farkas MH, Berry JO, Aga DS. (2007). Chlortetracycline detoxification in maize via induction of glutathione S-transferases after antibiotic exposure. Environ Sci Technol 41:1450–1456
  • Frova C. (2003). The plant glutathione transferase gene family: Genomic structure, functions, expression and evolution. Physiol Plant 119:469–479
  • Garcia-Rodriguez A, Matamoros V, Fontas C, Salvado V. (2014). The ability of biologically based wastewater treatment systems to remove emerging organic contaminants – A review. Environ Sci Pollut Res 21:11708–11728
  • Gershater M, Sharples K, Edwards R. (2006). Carboxylesterase activities toward pesticide esters in crops and weeds. Phytochemistry 67:2561–2567
  • Gershater MC, Edwards R. (2007). Regulating biological activity in plants with carboxylesterases. Plant Sci 173:579–588
  • Grote M, Schwake-Anduschus C, Michel R, et al. (2007). Incorporation of veterinary antibiotics into crops from manured soil. Landbauforschung Volkenrode 57:25–32
  • Halley BA, Vandenheuvel WJ, Wislocki PG. (1993). Environmental effects of the usage of avermectins in livestock. Vet Parasitol 48:109–125
  • Halling-Sorensen B. (2001). Inhibition of aerobic growth and nitrification of bacteria in sewage sludge by antibacterial agents. Arch Environ Contam Toxicol 40:451–460
  • Halling-Sorensen B, Nors Nielsen S, Lanzky PF, et al. (1998). Occurrence, fate and effects of pharmaceutical substances in the environment – A review. Chemosphere 36:357–393
  • Hamdane D, Zhang HM, Hollenberg P. (2008). Oxygen activation by cytochrome P450 monooxygenase. Photosynth Res 98:657–666
  • He DH, Lei ZP, Xing HY, Tang BS. (2014). Genome-wide identification and analysis of the aldehyde dehydrogenase (ALDH) gene superfamily of Gossypium raimondii. Gene 549:123–133
  • He XA, Szewczyk P, Karyakin A, et al. (2010). Structure of a cation-bound multidrug and toxic compound extrusion transporter. Nature 467:991–994
  • Hirschmann F, Krause F, Papenbrock J. (2014). The multi-protein family of sulfotransferases in plants: Composition, occurrence, substrate specificity, and functions. Front Plant Sci 5:556
  • Horvat AJM, Petrovic M, Babic S, et al. (2012). Analysis, occurrence and fate of anthelmintics and their transformation products in the environment. Trends Anal Chem 31:61–84
  • Huber C, Bartha B, Schroder P. (2012). Metabolism of diclofenac in plants – Hydroxylation is followed by glucose conjugation. J Hazard Mater 243:250–256
  • Husain Q, Ulber R. (2011). Immobilized peroxidase as a valuable tool in the remediation of aromatic pollutants and xenobiotic compounds: A review. Crit Rev Environ Sci Technol 41:770–804
  • Chasov AV, Alekseeva VY, Kolesnikov OP, Minibayeva FV. (2010). Activation of extracellular peroxidase of wheat roots under the action of xenobiotics. Appl Biochem Microbiol 46:431–437
  • Iori V, Zacchini M, Pietrini F. (2013). Growth, physiological response and phytoremoval capability of twowillow clones exposed to ibuprofen under hydroponic culture. J Hazard Mater 262:796–804
  • Jansen MAK, Hill LM, Thorneley RNF. (2004). A novel stress-acclimation response in Spirodela punctata (Lemnaceae): 2,4,6-Trichlorophenol triggers an increase in the level of an extracellular peroxidase, capable of the oxidative dechlorination of this xenobiotic pollutant. Plant Cell Environ 27:603–613
  • Jjemba PK. (2002). The potential impact of veterinary and human therapeutic agents in manure and biosolids on plants grown on arable land: A review. Agric Ecosyst Environ 93:267–278
  • Jouili H, Bouazizi H, El Ferjani E. (2011). Plant peroxidases: Biomarkers of metallic stress. Acta Physiol Plant 33:2075–2082
  • Karnjanapiboonwong A, Chase DA, Canas JE, et al. (2011). Uptake of 17alpha-ethynylestradiol and triclosan in pinto bean, Phaseolus vulgaris. Ecotoxicol Environ Saf 74:1336–1342
  • Kemper N. (2008). Veterinary antibiotics in the aquatic and terrestrial environment. Ecol Indic 8:1–13
  • Klein M, Papenbrock J. (2004). The multi-protein family of Arabidopsis sulphotransferases and their relatives in other plant species. J Exp Bot 55:1809–1820
  • Kolodziejska M, Maszkowska J, Bialk-Bielinska A, et al. (2013). Aquatic toxicity of four veterinary drugs commonly applied in fish farming and animal husbandry. Chemosphere 92:1253–1259
  • Kong WD, Zhu YG, Liang YC, et al. (2007). Uptake of oxytetracycline and its phytotoxicity to alfalfa (Medicago sativa L.). Environ Pollut 147:187–193
  • Kools SA, Moltmann JF, Knacker T. (2008). Estimating the use of veterinary medicines in the European union. Regul Toxicol Pharmacol 50:59–65
  • Kotchoni SO, Jimenez-Lopez JC, Kayode APP, et al. (2012). The soybean aldehyde dehydrogenase (ALDH) protein superfamily. Gene 495:128–133
  • Kumar K, Gupta SC, Baidoo SK, et al. (2005). Antibiotic uptake by plants from soil fertilized with animal manure. J Environ Qual 34:2082–2085
  • Kumar RR, Lee JT, Cho JY. (2012). Fate, occurrence, and toxicity of veterinary antibiotics in environment. J Korean Soc Appl Biol Chem 55:701–709
  • Kummerer K. (2010). Pharmaceuticals in the environment. Annu Rev Environ Resources 35:57–75
  • Laurent F, Canlet C, Debrauwer L, Pascal-Lorber S. (2007). Metabolic fate of C-14 -2,4-dichlorophenol in tobacco cell suspension cultures. Environ Toxicol Chem 26:2299–2307
  • Li XQ, Guo RR, Li J, et al. (2013). Genome-wide identification and analysis of the aldehyde dehydrogenase (ALDH) gene superfamily in apple (Malus x domestica Borkh.). Plant Physiol Biochem 71:268–282
  • Li Y, Baldauf S, Lim EK, Bowles DJ. (2001). Phylogenetic analysis of the UDP-glycosyltransferase multigene family of Arabidopsis thaliana. J Biol Chem 276:4338–4343
  • Lillenberg M, Herodes K, Kipper K, Nei L. (2010a). Plant uptake of some pharmaceuticals from fertilized soils. Proceedings of 2009 International Conference on Environmental Science and Technology, April 2010
  • Lillenberg M, Litvin SV, Nei L, et al. (2010b). Enrofloxacin and ciprofloxacin uptake by plants from soil. Agron Res 8:807–814
  • Liscombe DK, Louie GV, Noel JP. (2012). Architectures, mechanisms and molecular evolution of natural product methyltransferases. Nat Prod Rep 29:1238–1250
  • Liu L, Liu YH, Liu CX, et al. (2013). Potential effect and accumulation of veterinary antibiotics in Phragmites australis under hydroponic conditions. Ecol Eng 53:138–143
  • Ma LL, Shang Y, Cao AZ, et al. (2010). Molecular cloning and characterization of an up-regulated UDP-glucosyltransferase gene induced by DON from Triticum aestivum L. cv. Wangshuibai. Mol Biol Rep 37:785–795
  • Malchi T, Maor Y, Tadmor G, et al. (2014). Irrigation of root vegetables with treated wastewater: Evaluating uptake of pharmaceuticals and the associated human health risks. Environ Sci Technol 48:9325–9333
  • Manjasetty B, Yu XH, Panjikar S, et al. (2012). Structural basis for modification of flavonol and naphthol glucoconjugates by Nicotiana tabacum malonyltransferase (NtMaT1). Planta 236:781–793
  • Marsolais F, Boyd J, Paredes Y, et al. (2007). Molecular and biochemical characterization of two brassinosteroid sulfotransferases from Arabidopsis, AtST4a (At2g14920) and AtST1 (At2g03760). Planta 225:1233–1244
  • Martinoia E, Klein M, Geisler M, et al. (2002). Multifunctionality of plant ABC transporters – More than just detoxifiers. Planta 214:345–355
  • Meech R, Miners JO, Lewis BC, Mackenzie PI. (2012). The glycosidation of xenobiotics and endogenous compounds: Versatility and redundancy in the UDP glycosyltransferase superfamily. Pharmacol Ther 134:200–218
  • Migliore L, Brambilla G, Casoria P, et al. (1996). Effect of sulphadimethoxine contamination on barley (Hordeum distichum L., Poaceae, Liliposida). Agric Ecosyst Environ 60:121–128
  • Migliore L, Brambilla G, Cozzolino S, Gaudio L. (1995). Effect on plants of sulphadimethoxine used in intensive farming (Panicum miliaceum, Pisum sativum and Zea mays). Agric Ecosyst Environ 52:103–110
  • Migliore L, Cozzolino S, Fiori M. (2000). Phytotoxicity to and uptake of flumequine used in intensive aquaculture on the aquatic weed, Lythrum salicaria L. Chemosphere 40:741–750
  • Migliore L, Cozzolino S, Fiori M. (2003). Phytotoxicity to and uptake of enrofloxacin in crop plants. Chemosphere 52:1233–1244
  • Michelini L, Gallina G, Capolongo F, Ghisi R. (2014). Accumulation and response of willow plants exposed to environmental relevant sulfonamide concentrations. Int J Phytoremediation 16:947–961
  • Michelini L, Reichel R, Werner W, et al. (2012). Sulfadiazine uptake and effects on Salix fragilis L. and Zea mays L. plants. Water Air Soil Pollut 223:5243–5257
  • Mizuno T, Kamo T, Sasaki N, et al. (2015). Novel C-xylosylflavones from the leaves and flowers of Iris gracilipes. Nat Prod Commun 10:441–444
  • Mohsenzadeh S, Esmaeili M, Moosavi F, et al. (2011). Plant glutathione S-transferase classification, structure and evolution. Afr J Biotechnol 10:8160–8165
  • Moore MT, Kroger R. (2010). Effect of three insecticides and two herbicides on rice (Oryza sativa) seedling germination and growth. Arch Environ Contam Toxicol 59:574–581
  • Morant M, Bak S, Moller BL, Werck-Reichhart D. (2003). Plant cytochromes P450: tools for pharmacology, plant protection and phytoremediation. Curr Opin Biotechnol 14:151–162
  • Moriyama Y, Hiasa M, Matsumoto T, Omote H. (2008). Multidrug and toxic compound extrusion (MATE)-type proteins as anchor transporters for the excretion of metabolic waste products and xenobiotics. Xenobiotica 38:1107–1118
  • Moummou H, Kallberg Y, Tonfack LB, et al. (2012). The plant short-chain dehydrogenase (SDR) superfamily: Genome-wide inventory and diversification patterns. BMC Plant Biol 12:219
  • Narawongsanont R, Kabinpong S, Auiyawong B, Tantitadapitak C. (2012). Cloning and characterization of AKR4C14, a rice aldo-keto reductase, from Thai jasmine rice. Protein J 31:35–42
  • Nelson D, Werck-Reichhart D. (2011). A P450-centric view of plant evolution. Plant J 66:194–211
  • Nuruzzaman M, Zhang R, Cao HZ, Luo ZY. (2014). Plant pleiotropic drug resistance transporters: Transport mechanism, gene expression, and function. J Integr Plant Biol 56:729–740
  • Oztetik E. (2008). A tale of plant glutathione S-transferases: Since 1970. Bot Rev 74:419–437
  • Park H, Choung YK. (2007). Degradation of antibiotics (tetracycline, sulfathiazole, ampicillin) using enzymes of glutathion S-transferase. Hum Ecol Assess 13:1147–1155
  • Pinot F, Bosch H, Salaun JP, et al. (1997). Epoxide hydrolase activities in the microsomes and the soluble fraction from Vicia sativa seedlings. Plant Physiol Biochem 35:103–110
  • Piotrowicz-Cieslak AI, Adomas B, Nalecz-Jawecki G. (2012). Phytotoxicity of sulfonamide soil pollutants to legume plant species. Fresenius Environ Bull 21:1310–1314
  • Podlipna R, Skalova L, Seidlova H, et al. (2013). Biotransformation of benzimidazole anthelmintics in reed (Phragmites australis) as a potential tool for their detoxification in environment. Bioresource Technol 144:216–224
  • Powles SB, Yu Q. (2010). Evolution in action: Plants resistant to herbicides. Annu Rev Plant Biol 61:317–347
  • Puglisi I, Lo Cicero L, Lo Piero AR. (2013). The glutathione S-transferase gene superfamily: An in silico approach to study the post translational regulation. Biodegradation 24:471–485
  • Rea PA. (2007). Plant ATP-Binding cassette transporters. Annu Rev Plant Biol 58:347–375
  • Ross J, Li Y, Lim EK, Bowles DJ. (2001). Higher plant glycosyltransferases. Genome Biol 2:1–6
  • Rowland A, Miners JO, Mackenzie PI. (2013). The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification. Int J Biochem Cell Biol 45:1121–1132
  • Samy MN, Sugimoto S, Matsunami K, et al. (2014). One new flavonoid xyloside and one new natural triterpene rhamnoside from the leaves of Syzygium grande. Phytochem Lett 10:86–90
  • San Miguel A, Schroder P, Harpaintner R, et al. (2013). Response of phase II detoxification enzymes in Phragmites australis plants exposed to organochlorines. Environ Sci Pollut Res 20:3464–3471
  • Sarmah AK, Meyer MT, Boxall AB. (2006). A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere 65:725–759
  • Saxena A, Singh P, Yadav DK, et al. (2013). Identification of cytochrome P450 heme motif in plants proteome. Plant Omics 6:1–12
  • Seki H, Sawai S, Ohyama K, et al. (2011). Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin. Plant Cell 23:4112–4123
  • Seo Y-H, Cho B-O, Kang A-S, et al. (2010). Antibiotic uptake by plants from soil applied with antibiotic-treated animal manure. Korean J Soil Sci Fertil 43:466–470
  • Sharma R, Rawat V, Suresh CG. (2014). Genome-wide identification and tissue-specific expression analysis of UDP-glycosyltransferases genes confirm their abundance in Cicer arietinum (Chickpea) genome. PLoS One 9:e109715
  • Shin S, Torres-Acosta JA, Heinen SJ, et al. (2012). Transgenic Arabidopsis thaliana expressing a barley UDP-glucosyltransferase exhibit resistance to the mycotoxin deoxynivalenol. J Exp Bot 63:4731–4740
  • Schmidt B, Rivero C, Thiede B. (1995). 3,4-Dichloroaniline N-glucosyltransferase and N-malonyltransferase activities in cell-cultures and plants of soybean and wheat. Phytochemistry 39:81–84
  • Simon C, Langlois-Meurinne M, Didierlaurent L, et al. (2014). The secondary metabolism glycosyltransferases UGT73B3 and UGT73B5 are components of redox status in resistance of Arabidopsis to Pseudomonas syringae pv. tomato. Plant Cell Environ 37:1114–1129
  • Sosa-Ferrera Z, Mahugo-Santana C, Santana-Rodriguez JJ. (2013). Analytical methodologies for the determination of endocrine disrupting compounds in biological and environmental samples. BioMed Res Int 2013:674838
  • Strommer J. (2011). The plant ADH gene family. Plant J 66:128–142
  • Taguchi G, Shitchi Y, Shirasawa S, et al. (2005). Molecular cloning, characterization, and downregulation of an acyltransferase that catalyzes the malonylation of flavonoid and naphthol glucosides in tobacco cells. Plant J 42:481–491
  • Taguchi G, Ubukata T, Nozue H, et al. (2010). Malonylation is a key reaction in the metabolism of xenobiotic phenolic glucosides in Arabidopsis and tobacco. Plant J 63:1031–1041
  • Tanoue R, Sato Y, Motoyama M, et al. (2012). Plant uptake of pharmaceutical chemicals detected in recycled organic manure and reclaimed wastewater. J Agric Food Chem 60:10203–10211
  • Thuy TTH, Loan TCT, Le NP, Dao QP. (2013). A preliminary study on the phytoremediation of antibiotic contaminated sediment. Int J Phytoremediation 15:65–76
  • Tisler T, Erzen NK. (2006). Abamectin in the aquatic environment. Ecotoxicology 15:495–502
  • Tiwari M, Sharma D, Singh M, et al. (2014). Expression of OsMATE1 and OsMATE2 alters development, stress responses and pathogen susceptibility in Arabidopsis. Sci Rep 4:3964
  • Van Peteghem C, Van Poucke C, Broekaert N, et al. (2012). Experimental study: uptake of coccidiostats. CFP/EFSA/CONTAM/2010/02. Ghent University, Department of Bioanalysis, Laboratory of Food Analysis and the Institute for Agricultural and Fisheries Research and it’s Own Capital (ILVO/EV ILVO)
  • Varin L, Marsolais F, Richard M, Rouleau M. (1997). Biochemistry and molecular biology of plant sulfotransferases. FASEB J 11:517–525
  • Vymazal J. (2011). Plants used in constructed wetlands with horizontal subsurface flow: A review. Hydrobiologia 674:133–156
  • Wagil M, Bialk-Bielinska A, Puckowski A, et al. (2015). Toxicity of anthelmintic drugs (fenbendazole and flubendazole) to aquatic organisms. Environ Sci Pollut Res 22:2566–2573
  • Wanke D, Kolukisaoglu HU. (2010). An update on the ABCC transporter family in plants: Many genes, many proteins, but how many functions? Plant Biol 12:15–25
  • Wollenberger L, Halling-Sorensen B, Kusk KO. (2000). Acute and chronic toxicity of veterinary antibiotics to Daphnia magna. Chemosphere 40:723–730
  • Wu C, Spongberg AL, Witter JD. (2011). The uptake of pharmaceuticals and personal care products by agriculturally relevant plant species. Chim Oggi-Chem Today 29:54–56
  • Yoshimura H, Endoh YS. (2005). Acute toxicity to freshwater organisms of antiparasitic drugs for veterinary use. Environ Toxicol 20:60–66
  • Zhang D, Gersberg RM, Ng WJ, Tan SK. (2014). Removal of pharmaceuticals and personal care products in aquatic plant-based systems: A review. Environ Pollut 184:620–639
  • Zhang DQ, Hua T, Gersberg RM, et al. (2012). Fate of diclofenac in wetland mesocosms planted with Scirpus validus. Ecol Eng 49:59–64
  • Zhang DQ, Hua T, Gersberg RM, et al. (2013). Carbamazepine and naproxen: Fate in wetland mesocosms planted with Scirpus validus. Chemosphere 91:14–21
  • Zhao J, Huhman D, Shadle G, et al. (2011). MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. Plant Cell 23:1536–1555
  • Zhao N, Ferrer JL, Moon HS, et al. (2012). A SABATH Methyltransferase from the moss Physcomitrella patens catalyzes S-methylation of thiols and has a role in detoxification. Phytochemistry 81:31–41
  • Zhou ML, Zhang Q, Zhou M, et al. (2012). Aldehyde dehydrogenase protein superfamily in maize. Funct Integr Genomics 12:683–691

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