MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors

References

• Aakula A, Leivonen SK, Hintsanen P, et al. (2015). MicroRNA-135b regulates ERalpha, AR and HIF1AN and affects breast and prostate cancer cell growth. Mol Oncol 9:1287–1300
   PubMed Web of Science ®Google Scholar
• Adams BD, Furneaux H, White BA. (2007). The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol 21:1132–1147
   PubMed Web of Science ®Google Scholar
• Allred DC, Brown P, Medina D. (2004). The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer. Breast Cancer Res 6:240–245
   PubMed Web of Science ®Google Scholar
• Baek D, Villen J, Shin C, et al. (2008). The impact of microRNAs on protein output. Nature 455:64–71
   PubMed Web of Science ®Google Scholar
• Barbier O, Duran-Sandoval D, Pineda-Torra I, et al. (2003a). FXR induces the UGT2B4 enzyme in hepatocytes: A potential mechanism of negative feedback control of FXR activity. Gastroenterology 124:1926–1940
   PubMed Web of Science ®Google Scholar
• Barbier O, Torra IP, Sirvent A, et al. (2003b). Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme. J Biol Chem 278:32852–32860
   PubMed Web of Science ®Google Scholar
• Barbier O, Villeneuve L, Bocher V, et al. (2003c). The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene. J Biol Chem 278:13975–13983
   PubMed Web of Science ®Google Scholar
• Bartel DP. (2009). MicroRNAs: Target recognition and regulatory functions. Cell 136:215–233
   PubMed Web of Science ®Google Scholar
• Belanger AS, Tojcic J, Harvey M, Guillemette C. (2010). Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells. BMC Mol Biol 11:9
   PubMed Web of Science ®Google Scholar
• Betel D, Wilson M, Gabow A, et al. (2008). The microRNA.org resource: Targets and expression. Nucleic Acids Res 36:D149–D153
   PubMed Web of Science ®Google Scholar
• Blanchard RL, Freimuth RR, Buck J, et al. (2004). A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily. Pharmacogenetics 14:199–211
   PubMedGoogle Scholar
• Bleck B, Grunig G, Chiu A, et al. (2013). MicroRNA-375 regulation of thymic stromal lymphopoietin by diesel exhaust particles and ambient particulate matter in human bronchial epithelial cells. J Immunol 190:3757–3763
   PubMed Web of Science ®Google Scholar
• Bock KW. (2012). Human UDP-glucuronosyltransferases: Feedback loops between substrates and ligands of their transcription factors. Biochem Pharmacol 84:1000–1006
   PubMed Web of Science ®Google Scholar
• Boon RA, Iekushi K, Lechner S, et al. (2013). MicroRNA-34a regulates cardiac ageing and function. Nature 495:107–110
   PubMed Web of Science ®Google Scholar
• Bort R, Gomez-Lechon MJ, Castell JV, Jover R. (2004). Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes. Arch Biochem Biophys 426:63–72
   PubMed Web of Science ®Google Scholar
• Bosio A, Binczek E, Le Beau MM, et al. (1996). The human gene CGT encoding the UDP-galactose ceramide galactosyl transferase (cerebroside synthase): Cloning, characterization, and assignment to human chromosome 4, band q26. Genomics 34:69–75
   PubMed Web of Science ®Google Scholar
• Braun JE, Huntzinger E, Izaurralde E. (2013). The role of GW182 proteins in miRNA-mediated gene silencing. Adv Exp Med Biol 768:147–163
   PubMed Web of Science ®Google Scholar
• Brennecke J, Stark A, Russell RB, Cohen SM. (2005). Principles of microRNA-target recognition. PLoS Biol 3:e85
   PubMed Web of Science ®Google Scholar
• Brodersen P, Voinnet O. (2009). Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol 10:141–148
   PubMed Web of Science ®Google Scholar
• Calin GA, Cimmino A, Fabbri M, et al. (2008). MiR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci USA 105:5166–5171
   PubMed Web of Science ®Google Scholar
• Carthew RW, Sontheimer EJ. (2009). Origins and mechanisms of miRNAs and siRNAs. Cell 136:642–655
   PubMed Web of Science ®Google Scholar
• Chen K, Song F, Calin GA, et al. (2008). Polymorphisms in microRNA targets: A gold mine for molecular epidemiology. Carcinogenesis 29:1306–1311
   PubMed Web of Science ®Google Scholar
• Chen H, Yang K, Choi S, et al. (2009). Up-regulation of UDP-glucuronosyltransferase (UGT) 1A4 by 17beta-estradiol: A potential mechanism of increased lamotrigine elimination in pregnancy. Drug Metab Dispos 37:1841–1847
   PubMed Web of Science ®Google Scholar
• Chen F, Chen C, Yang S, et al. (2012). Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2. PLoS One 7:e39197
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhang S, Zhou T, et al. (2013). Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells. Toxicol Appl Pharmacol 268:106–112
   PubMed Web of Science ®Google Scholar
• Chen S, He N, Yu J, et al. (2014). Post-transcriptional regulation by miR-137 underlies the low abundance of CAR and low rate of bilirubin clearance in neonatal mice. Life Sci 107:8–13
   PubMed Web of Science ®Google Scholar
• Chivukula RR, Mendell JT. (2009). Abate and switch: miR-145 in stem cell differentiation. Cell 137:606–608
   PubMed Web of Science ®Google Scholar
• Choi YM, An S, Lee EM, et al. (2012). CYP1A1 is a target of miR-892a-mediated post-transcriptional repression. Int J Oncol 41:331–336
   PubMed Web of Science ®Google Scholar
• Cook I, Wang T, Almo SC, et al. (2013). Testing the sulfotransferase molecular pore hypothesis. J Biol Chem 288:8619–8626
   PubMed Web of Science ®Google Scholar
• Crettol S, Petrovic N, Murray M. (2010). Pharmacogenetics of phase I and phase II drug metabolism. Curr Pharm Des 16:204–219
   PubMed Web of Science ®Google Scholar
• Dai X, Zhang W, Zhang H, et al. (2014). Modulation of HBV replication by microRNA-15b through targeting hepatocyte nuclear factor 1alpha. Nucleic Acids Res 42:6578–6590
   PubMed Web of Science ®Google Scholar
• Deenen MJ, Cats A, Beijnen JH, Schellens JH. (2011a). Part 2: Pharmacogenetic variability in drug transport and phase I anticancer drug metabolism. Oncologist 16:820–834
   PubMed Web of Science ®Google Scholar
• Deenen MJ, Cats A, Beijnen JH, Schellens JH. (2011b). Part 3: Pharmacogenetic variability in phase II anticancer drug metabolism. Oncologist 16:992–1005
   PubMed Web of Science ®Google Scholar
• Deuschle U, Schuler J, Schulz A, et al. (2012). FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS One 7:e43044
   PubMed Web of Science ®Google Scholar
• Dluzen DF, Sun D, Salzberg AC, et al. (2014). Regulation of UDP-glucuronosyltransferase 1A1 expression and activity by microRNA 491-3p. J Pharmacol Exp Ther 348:465–477
   PubMed Web of Science ®Google Scholar
• Drocourt L, Ourlin JC, Pascussi JM, et al. (2002). Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J Biol Chem 277:25125–25132
   PubMed Web of Science ®Google Scholar
• Dvorak Z, Pavek P. (2010). Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev 42:621–635
   PubMed Web of Science ®Google Scholar
• Echchgadda I, Song CS, Roy AK, Chatterjee B. (2004). Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor. Mol Pharmacol 65:720–729
   PubMed Web of Science ®Google Scholar
• Edvardsson K, Nguyen-Vu T, Kalasekar SM, et al. (2013). Estrogen receptor beta expression induces changes in the microRNA pool in human colon cancer cells. Carcinogenesis 34:1431–1441
   PubMed Web of Science ®Google Scholar
• Eichhorn SW, Guo H, McGeary SE, et al. (2014). mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues. Mol Cell 56:104–115
   PubMed Web of Science ®Google Scholar
• Enright AJ, John B, Gaul U, et al. (2003). MicroRNA targets in Drosophila. Genome Biol 5:R1
   PubMed Web of Science ®Google Scholar
• Eulalio A, Huntzinger E, Nishihara T, et al. (2009). Deadenylation is a widespread effect of miRNA regulation. RNA 15:21–32
   PubMed Web of Science ®Google Scholar
• Eulalio A, Mano M, Dal Ferro M, et al. (2012). Functional screening identifies miRNAs inducing cardiac regeneration. Nature 492:376–381
   PubMed Web of Science ®Google Scholar
• Fang HL, Strom SC, Cai H, et al. (2005). Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor. Mol Pharmacol 67:1257–1267
   PubMed Web of Science ®Google Scholar
• Gagnon JF, Bernard O, Villeneuve L, et al. (2006). Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer. Clin Cancer Res 12:1850–1858
   PubMed Web of Science ®Google Scholar
• Gao J, Xie W. (2010). Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism. Drug Metab Dispos 38:2091–2095
   PubMed Web of Science ®Google Scholar
• Gardner-Stephen D, Heydel JM, Goyal A, et al. (2004). Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression. Drug Metab Dispos 32:340–347
   PubMed Web of Science ®Google Scholar
• Garzon R, Marcucci G, Croce CM. (2010). Targeting microRNAs in cancer: Rationale, strategies and challenges. Nat Rev Drug Discov 9:775–789
   PubMed Web of Science ®Google Scholar
• Glimelius B, Garmo H, Berglund A, et al. (2011). Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer. Pharmacogenomics J 11:61–71
   Web of Science ®Google Scholar
• Gnerre C, Blattler S, Kaufmann MR, et al. (2004). Regulation of CYP3A4 by the bile acid receptor FXR: Evidence for functional binding sites in the CYP3A4 gene. Pharmacogenetics 14:635–645
   PubMedGoogle Scholar
• Guengerich FP. (2008). Cytochrome p450 and chemical toxicology. Chem Res Toxicol 21:70–83
   PubMed Web of Science ®Google Scholar
• Guerit D, Philipot D, Chuchana P, et al. (2013). Sox9-regulated miRNA-574-3p inhibits chondrogenic differentiation of mesenchymal stem cells. PLoS One 8:e62582
   PubMed Web of Science ®Google Scholar
• Guillemette C. (2003). Pharmacogenomics of human UDP-glucuronosyltransferase enzymes. Pharmacogenomics J 3:136–158
   PubMed Web of Science ®Google Scholar
• Guo H, Ingolia NT, Weissman JS, Bartel DP. (2010). Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466:835–840
   PubMed Web of Science ®Google Scholar
• Haas U, Sczakiel G, Laufer SD. (2012). MicroRNA-mediated regulation of gene expression is affected by disease-associated SNPs within the 3′-UTR via altered RNA structure. RNA Biol 9:924–937
   PubMed Web of Science ®Google Scholar
• Habano W, Gamo T, Terashima J, et al. (2011). Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells. BMC Cancer 11:81
   PubMed Web of Science ®Google Scholar
• Hao J, Zhang S, Zhou Y, et al. (2011). MicroRNA 421 suppresses DPC4/Smad4 in pancreatic cancer. Biochem Biophys Res Commun 406:552–557
   PubMed Web of Science ®Google Scholar
• Helguero LA, Faulds MH, Gustafsson JA, Haldosen LA. (2005). Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene 24:6605–6616
   PubMed Web of Science ®Google Scholar
• Hino K, Fukao T, Watanabe M. (2007). Regulatory interaction of HNF1-alpha to microRNA-194 gene during intestinal epithelial cell differentiation. Nucleic Acids Symp Ser (Oxf) 15:415–416
   Google Scholar
• Holley SL, Fryer AA, Haycock JW, et al. (2007). Differential effects of glutathione S-transferase pi (GSTP1) haplotypes on cell proliferation and apoptosis. Carcinogenesis 28:2268–2273
   PubMed Web of Science ®Google Scholar
• Honkakoski P, Zelko I, Sueyoshi T, Negishi M. (1998). The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol 18:5652–5658
   PubMed Web of Science ®Google Scholar
• Hu W, Wang X, Ding X, et al. (2012). MicroRNA-141 represses HBV replication by targeting PPARA. PLoS One 7:e34165
   PubMed Web of Science ®Google Scholar
• Huang JY, Chou SF, Lee JW, et al. (2015). MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1alpha and PPARgamma. RNA 21:385–400
   PubMed Web of Science ®Google Scholar
• Huang TC, Chang HY, Chen CY, et al. (2012). Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR. FEBS Lett 585:3582–3586
   Web of Science ®Google Scholar
• Ikediobi ON. (2008). Somatic pharmacogenomics in cancer. Pharmacogenomics J 8:305–314
   PubMed Web of Science ®Google Scholar
• Iliopoulos D, Rotem A, Struhl K. (2011). Inhibition of miR-193a expression by Max and RXRalpha activates K-Ras and PLAU to mediate distinct aspects of cellular transformation. Cancer Res 71:5144–5153
   PubMed Web of Science ®Google Scholar
• Ingelman-Sundberg M, Sim SC, Gomez A, Rodriguez-Antona C. (2007). Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol Ther 116:496–526
   PubMed Web of Science ®Google Scholar
• Inui M, Martello G, Piccolo S. (2010). MicroRNA control of signal transduction. Nat Rev Mol Cell Biol 11:252–263
   PubMed Web of Science ®Google Scholar
• Ivanov M, Kacevska M, Ingelman-Sundberg M. (2012). Epigenomics and interindividual differences in drug response. Clin Pharmacol Ther 92:727–736
   PubMed Web of Science ®Google Scholar
• Jancova P, Anzenbacher P, Anzenbacherova E. (2010). Phase II drug metabolizing enzymes. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 154:103–116
   PubMed Web of Science ®Google Scholar
• Janssen HL, Reesink HW, Lawitz EJ, et al. (2013). Treatment of HCV infection by targeting microRNA. N Engl J Med 368:1685–1694
   PubMed Web of Science ®Google Scholar
• Jennewein C, von Knethen A, Schmid T, Brune B. (2010). MicroRNA-27b contributes to lipopolysaccharide-mediated peroxisome proliferator-activated receptor gamma (PPARgamma) mRNA destabilization. J Biol Chem 285:11846–11853
   PubMed Web of Science ®Google Scholar
• Ji J, Zhang J, Huang G, et al. (2009). Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Lett 583:759–766
   PubMed Web of Science ®Google Scholar
• Jiang Z, Guo J, Xiao B, et al. (2010). Increased expression of miR-421 in human gastric carcinoma and its clinical association. J Gastroenterol 45:17–23
   PubMed Web of Science ®Google Scholar
• Jinek M, Doudna JA. (2009). A three-dimensional view of the molecular machinery of RNA interference. Nature 457:405–412
   PubMed Web of Science ®Google Scholar
• John B, Enright AJ, Aravin A, et al. (2004). Human MicroRNA targets. PLoS Biol 2:e363
   PubMed Web of Science ®Google Scholar
• Kacevska M, Ivanov M, Wyss A, et al. (2012). DNA methylation dynamics in the hepatic CYP3A4 gene promoter. Biochimie 94:2338–2344
   PubMed Web of Science ®Google Scholar
• Kasinski AL, Slack FJ. (2011). Epigenetics and genetics. MicroRNAs en route to the clinic: Progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer 11:849–864
   PubMed Web of Science ®Google Scholar
• Kida K, Nakajima M, Mohri T, et al. (2011). PPARalpha is regulated by miR-21 and miR-27b in human liver. Pharm Res 28:2467–2476
   PubMed Web of Science ®Google Scholar
• Kim SY, Kim AY, Lee HW, et al. (2010). miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARgamma expression. Biochem Biophys Res Commun 392:323–328
   PubMed Web of Science ®Google Scholar
• Kim VN. (2005). MicroRNA biogenesis: Coordinated cropping and dicing. Nat Rev Mol Cell Biol 6:376–385
   PubMed Web of Science ®Google Scholar
• Klaassen CD, Lu H, Cui JY. (2011). Epigenetic regulation of drug processing genes. Toxicol Mech Methods 21:312–324
   PubMed Web of Science ®Google Scholar
• Kliewer SA, Goodwin B, Willson TM. (2002). The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism. Endocr Rev 23:687–702
   PubMed Web of Science ®Google Scholar
• Kliewer SA. (2003). The nuclear pregnane X receptor regulates xenobiotic detoxification. J Nutr 133(7 Suppl):2444S–2447S
   PubMed Web of Science ®Google Scholar
• Kohle C, Bock KW. (2007). Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochem Pharmacol 73:1853–1862
   PubMed Web of Science ®Google Scholar
• Komagata S, Nakajima M, Takagi S, et al. (2009). Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125b. Mol Pharmacol 76:702–709
   PubMed Web of Science ®Google Scholar
• Krek A, Grun D, Poy MN, et al. (2005). Combinatorial microRNA target predictions. Nat Genet 37:495–500
   PubMed Web of Science ®Google Scholar
• Krueger SK, Williams DE. (2005). Mammalian flavin-containing monooxygenases: Structure/function, genetic polymorphisms and role in drug metabolism. Pharmacol Ther 106:357–387
   PubMed Web of Science ®Google Scholar
• Kruger J, Rehmsmeier M. (2006). RNAhybrid: microRNA target prediction easy, fast and flexible. Nucleic Acids Res 34:W451–W454
   PubMed Web of Science ®Google Scholar
• Krutzfeldt J, Rosch N, Hausser J, et al. (2012). MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1alpha) in adult liver and controls expression of frizzled-6. Hepatology 55:98–107
   PubMed Web of Science ®Google Scholar
• Lazarus P, Sun D. (2010). Potential role of UGT pharmacogenetics in cancer treatment and prevention: Focus on tamoxifen and aromatase inhibitors. Drug Metab Rev 42:182–194
   PubMed Web of Science ®Google Scholar
• Lee EK, Lee MJ, Abdelmohsen K, et al. (2011). miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol 31:626–638
   PubMed Web of Science ®Google Scholar
• Lee FY, Lee H, Hubbert ML, et al. (2006). FXR, a multipurpose nuclear receptor. Trends Biochem Sci 31:572–580
   PubMed Web of Science ®Google Scholar
• Lee IS, Kim D. (2011). Polymorphic metabolism by functional alterations of human cytochrome P450 enzymes. Arch Pharm Res 34:1799–1816
   PubMed Web of Science ®Google Scholar
• Lee JJ, Drakaki A, Iliopoulos D, Struhl K. (2012). MiR-27b targets PPARgamma to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells. Oncogene 31:3818–3825
   PubMed Web of Science ®Google Scholar
• Lee RC, Feinbaum RL, Ambros V. (1993). The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843–854
   PubMed Web of Science ®Google Scholar
• Lee Y, Jeon K, Lee JT, et al. (2002). MicroRNA maturation: Stepwise processing and subcellular localization. Embo J 21:4663–4670
   PubMed Web of Science ®Google Scholar
• Leivonen SK, Makela R, Ostling P, et al. (2009). Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines. Oncogene 28:3926–3936
   PubMed Web of Science ®Google Scholar
• Leivonen SK, Rokka A, Ostling P, et al. (2011). Identification of miR-193b targets in breast cancer cells and systems biological analysis of their functional impact. Mol Cell Proteomics 10:M110 005322
   PubMed Web of Science ®Google Scholar
• Lewis BP, Burge CB, Bartel DP. (2005). Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15–20
   PubMed Web of Science ®Google Scholar
• Lewis BP, Shih IH, Jones-Rhoades MW, et al. (2003). Prediction of mammalian microRNA targets. Cell 115:787–798
   PubMed Web of Science ®Google Scholar
• Li CH, To KF, Tong JH, et al. (2013). Enhancer of zeste homolog 2 silences microRNA-218 in human pancreatic ductal adenocarcinoma cells by inducing formation of heterochromatin. Gastroenterology 144:1086–1097 e9
   PubMed Web of Science ®Google Scholar
• Li M, Yang Y, He ZX, et al. (2014). MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through downregulation of the nuclear receptor corepressor dosage-sensitive sex-reversal adrenal hypoplasia congenital critical region on the X chromosome, gene 1 (DAX-1). Drug Metab Dispos 42:44–61
   PubMed Web of Science ®Google Scholar
• Listing H, Mardin WA, Wohlfromm S, et al. (2015). MiR-23a/-24-induced gene silencing results in mesothelial cell integration of pancreatic cancer. Br J Cancer 112:131–139
   PubMed Web of Science ®Google Scholar
• Long MD, Sucheston-Campbell LE, Campbell MJ. (2015). Vitamin D receptor and RXR in the post-genomic era. J Cell Physiol 230:758–766
   PubMed Web of Science ®Google Scholar
• Lu TT, Repa JJ, Mangelsdorf DJ. (2001). Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J Biol Chem 276:37735–37738
   PubMed Web of Science ®Google Scholar
• Mackenzie PI, Bock KW, Burchell B, et al. (2005). Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet Genomics 15:677–685
   PubMed Web of Science ®Google Scholar
• Mackenzie PI, Hu DG, Gardner-Stephen DA. (2010). The regulation of UDP-glucuronosyltransferase genes by tissue-specific and ligand-activated transcription factors. Drug Metab Rev 42:99–109
   PubMed Web of Science ®Google Scholar
• Martinez-Jimenez CP, Jover R, Donato MT, et al. (2007). Transcriptional regulation and expression of CYP3A4 in hepatocytes. Curr Drug Metab 8:185–194
   PubMed Web of Science ®Google Scholar
• Masui S, Nakatake Y, Toyooka Y, et al. (2007). Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol 9:625–635
   PubMed Web of Science ®Google Scholar
• Matsubara H, Takeuchi T, Nishikawa E, et al. (2007). Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene 26:6099–6105
   PubMed Web of Science ®Google Scholar
• McIlwain CC, Townsend DM, Tew KD. (2006). Glutathione S-transferase polymorphisms: cancer incidence and therapy. Oncogene 25:1639–1648
   PubMed Web of Science ®Google Scholar
• Mimori K, Tanaka Y, Yoshinaga K, et al. (2004). Clinical significance of the overexpression of the candidate oncogene CYP24 in esophageal cancer. Ann Oncol 15:236–241
   PubMed Web of Science ®Google Scholar
• Mohri T, Nakajima M, Takagi S, et al. (2009). MicroRNA regulates human vitamin D receptor. Int J Cancer 125:1328–1333
   PubMed Web of Science ®Google Scholar
• Mohri T, Nakajima M, Fukami T, et al. (2010). Human CYP2E1 is regulated by miR-378. Biochem Pharmacol 79:1045–1052
   PubMed Web of Science ®Google Scholar
• Molina-Pinelo S, Carnero A, Rivera F, et al. (2014). MiR-107 and miR-99a-3p predict chemotherapy response in patients with advanced colorectal cancer. BMC Cancer 14:656
   PubMed Web of Science ®Google Scholar
• Monostory K, Dvorak Z. (2012). Steroid regulation of drug-metabolizing cytochromes P450. Curr Drug Metab 12:154–172
   Web of Science ®Google Scholar
• Moraes LA, Piqueras L, Bishop-Bailey D. (2006). Peroxisome proliferator-activated receptors and inflammation. Pharmacol Ther 110:371–385
   PubMed Web of Science ®Google Scholar
• Moriya Y, Nohata N, Kinoshita T, et al. (2012). Tumor suppressive microRNA-133a regulates novel molecular networks in lung squamous cell carcinoma. J Hum Genet 57:38–45
   Google Scholar
• Morozova N, Zinovyev A, Nonne N, et al. (2012). Kinetic signatures of microRNA modes of action. RNA 18:1635–1655
   PubMed Web of Science ®Google Scholar
• Mu W, Hu C, Zhang H, et al. (2015). miR-27b synergizes with anticancer drugs via p53 activation and CYP1B1 suppression. Cell Res 25:477–495
   PubMed Web of Science ®Google Scholar
• Mukherji S, Ebert MS, Zheng GX, et al. (2011). MicroRNAs can generate thresholds in target gene expression. Nat Genet 43:854–859
   PubMed Web of Science ®Google Scholar
• Mutallip M, Nohata N, Hanazawa T, et al. (2011). Glutathione S-transferase P1 (GSTP1) suppresses cell apoptosis and its regulation by miR-133alpha in head and neck squamous cell carcinoma (HNSCC). Int J Mol Med 27:345–352
   PubMed Web of Science ®Google Scholar
• Narasimhan M, Patel D, Vedpathak D, et al. (2012). Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells. PLoS One 7:e51111
   PubMed Web of Science ®Google Scholar
• Nguyen T, Nioi P, Pickett CB. (2009). The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 284:13291–13295
   PubMed Web of Science ®Google Scholar
• Oda Y, Nakajima M, Mohri T, et al. (2012). Aryl hydrocarbon receptor nuclear translocator in human liver is regulated by miR-24. Toxicol Appl Pharmacol 260:222–231
   PubMed Web of Science ®Google Scholar
• Olive V, Jiang I, He L. (2010). mir-17-92, a cluster of miRNAs in the midst of the cancer network. Int J Biochem Cell Biol 42:1348–1354
   PubMed Web of Science ®Google Scholar
• Pan YZ, Gao W, Yu AM. (2009). MicroRNAs regulate CYP3A4 expression via direct and indirect targeting. Drug Metab Dispos 37:2112–2117
   PubMed Web of Science ®Google Scholar
• Panda H, Chuang TD, Luo X, Chegini N. (2012). Endometrial miR-181a and miR-98 expression is altered during transition from normal into cancerous state and target PGR, PGRMC1, CYP19A1, DDX3X, and TIMP3. J Clin Endocrinol Metab 97:E1316–E1326
   PubMed Web of Science ®Google Scholar
• Pandey DP, Picard D. (2009). miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNA. Mol Cell Biol 29:3783–3790
   PubMed Web of Science ®Google Scholar
• Paraskevopoulou MD, Georgakilas G, Kostoulas N, et al. (2013). DIANA-microT web server v5.0: Service integration into miRNA functional analysis workflows. Nucleic Acids Res 41:W169–W173
   PubMed Web of Science ®Google Scholar
• Pascussi JM, Gerbal-Chaloin S, Drocourt L, et al. (2003). The expression of CYP2B6, CYP2C9 and CYP3A4 genes: A tangle of networks of nuclear and steroid receptors. Biochim Biophys Acta 1619:243–253
   PubMed Web of Science ®Google Scholar
• Patron JP, Fendler A, Bild M, et al. (2012). MiR-133b targets antiapoptotic genes and enhances death receptor-induced apoptosis. PLoS One 7:e35345
   PubMed Web of Science ®Google Scholar
• Peterkin VC, Bauman JN, Goosen TC, et al. (2007). Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes. Br J Clin Pharmacol 64:458–468
   PubMed Web of Science ®Google Scholar
• Petersen CP, Bordeleau ME, Pelletier J, Sharp PA. (2006). Short RNAs repress translation after initiation in mammalian cells. Mol Cell 21:533–542
   PubMed Web of Science ®Google Scholar
• Pillai RS, Bhattacharyya SN, Artus CG, et al. (2005). Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science 309:1573–1576
   PubMed Web of Science ®Google Scholar
• Pratt AJ, MacRae IJ. (2009). The RNA-induced silencing complex: A versatile gene-silencing machine. J Biol Chem 284:17897–17901
   PubMed Web of Science ®Google Scholar
• Radominska-Pandya A, Czernik PJ, Little JM, et al. (1999). Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev 31:817–899
   PubMed Web of Science ®Google Scholar
• Ramamoorthy A, Li L, Gaedigk A, et al. (2012). In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4alpha expression. Drug Metab Dispos 40:726–733
   PubMed Web of Science ®Google Scholar
• Rehmsmeier M, Steffen P, Hochsmann M, Giegerich R. (2004). Fast and effective prediction of microRNA/target duplexes. RNA 10:1507–1517
   PubMed Web of Science ®Google Scholar
• Renoir JM, Marsaud V, Lazennec G. (2013). Estrogen receptor signaling as a target for novel breast cancer therapeutics. Biochem Pharmacol 85:449–465
   PubMed Web of Science ®Google Scholar
• Rieger JK, Klein K, Winter S, Zanger UM. (2013). Expression variability of absorption, distribution, metabolism, excretion-related microRNAs in human liver: Influence of nongenetic factors and association with gene expression. Drug Metab Dispos 41:1752–1762
   PubMed Web of Science ®Google Scholar
• Rieger JK, Reutter S, Hofmann U, et al. (2015). Inflammation-associated MicroRNA-130b down-regulates cytochrome P450 activities and directly targets CYP2C9. Drug Metab Dispos 43:884–888
   PubMed Web of Science ®Google Scholar
• Rodriguez-Antona C, Bort R, Jover R, et al. (2003). Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. Mol Pharmacol 63:1180–1189
   PubMed Web of Science ®Google Scholar
• Runge-Morris M, Kocarek TA. (2009). Regulation of sulfotransferase and UDP-glucuronosyltransferase gene expression by the PPARs. PPAR Res 2009:728941
   PubMed Web of Science ®Google Scholar
• Rusinov V, Baev V, Minkov IN, Tabler M, et al. (2005). MicroInspector: A web tool for detection of miRNA binding sites in an RNA sequence. Nucleic Acids Res 33:W696–W700
   PubMed Web of Science ®Google Scholar
• Saito T, Saetrom P. (2010). MicroRNAs – Targeting and target prediction. N Biotechnol 27:243–249
   PubMed Web of Science ®Google Scholar
• Sau A, Pellizzari Tregno F, Valentino F, et al. (2010). Glutathione transferases and development of new principles to overcome drug resistance. Arch Biochem Biophys 500:116–122
   PubMed Web of Science ®Google Scholar
• Selbach M, Schwanhausser B, Thierfelder N, et al. (2008). Widespread changes in protein synthesis induced by microRNAs. Nature 455:58–63
   PubMed Web of Science ®Google Scholar
• Sen GL, Blau HM. (2005). Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. Nat Cell Biol 7:633–636
   PubMed Web of Science ®Google Scholar
• Sheweita SA, Tilmisany AK. (2003). Cancer and phase II drug-metabolizing enzymes. Curr Drug Metab 4:45–58
   PubMed Web of Science ®Google Scholar
• Shibahara Y, Miki Y, Onodera Y, et al. (2012). Aromatase inhibitor treatment of breast cancer cells increases the expression of let-7f, a microRNA targeting CYP19A1. J Pathol 227:357–366
   PubMed Web of Science ®Google Scholar
• Shimada T, Fujii-Kuriyama Y. (2004). Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1. Cancer Sci 95:1–6
   PubMed Web of Science ®Google Scholar
• Sun C, Southard C, Olopade OI, Di Rienzo A. (2011). Differential allelic expression of c.1568C>A at UGT2B15 is due to variation in a novel cis-regulatory element in the 3′UTR. Gene 481:24–28
   PubMed Web of Science ®Google Scholar
• Sundaram GM, Common JE, Gopal FE, et al. (2013). ‘See-saw’ expression of microRNA-198 and FSTL1 from a single transcript in wound healing. Nature 495:103–106
   PubMed Web of Science ®Google Scholar
• Swart M, Dandara C. (2014). Genetic variation in the 3′-UTR of CYP1A2, CYP2B6, CYP2D6, CYP3A4, NR1I2, and UGT2B7: Potential effects on regulation by microRNA and pharmacogenomics relevance. Front Genet 5:167
   PubMed Web of Science ®Google Scholar
• Takagi S, Nakajima M, Mohri T, Yokoi T, et al. (2008). Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4. J Biol Chem 283:9674–9680
   PubMed Web of Science ®Google Scholar
• Takagi S, Nakajima M, Kida K, et al. (2010). MicroRNAs regulate human hepatocyte nuclear factor 4alpha, modulating the expression of metabolic enzymes and cell cycle. J Biol Chem 285:4415–4422
   PubMed Web of Science ®Google Scholar
• Takahashi K, Oda Y, Toyoda Y, et al. (2014). Regulation of cytochrome b5 expression by miR-223 in human liver: Effects on cytochrome P450 activities. Pharm Res 31:780–794
   PubMed Web of Science ®Google Scholar
• Takwi AA, Wang YM, Wu J, et al. (2014). miR-137 regulates the constitutive androstane receptor and modulates doxorubicin sensitivity in parental and doxorubicin-resistant neuroblastoma cells. Oncogene 33:3717–3729
   PubMed Web of Science ®Google Scholar
• Thomas M, Burk O, Klumpp B, et al. (2013). Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARalpha). Mol Pharmacol 83:709–718
   PubMed Web of Science ®Google Scholar
• Thulin P, Wei T, Werngren O, et al. (2013). MicroRNA-9 regulates the expression of peroxisome proliferator-activated receptor delta in human monocytes during the inflammatory response. Int J Mol Med 31:1003–1010
   PubMed Web of Science ®Google Scholar
• Tojo M, Matsuzaki K, Minami T, et al. (2002). The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system. J Biol Chem 277:46576–46585
   PubMed Web of Science ®Google Scholar
• Tombolan L, Zampini M, Casara S, et al. (2015). MicroRNA-27a contributes to rhabdomyosarcoma cell proliferation by suppressing RARA and RXRA. PLoS One 10:e0125171
   Web of Science ®Google Scholar
• Tong JL, Zhang CP, Nie F, et al. (2011). MicroRNA 506 regulates expression of PPAR alpha in hydroxycamptothecin-resistant human colon cancer cells. FEBS Lett 585:3560–3568
   PubMed Web of Science ®Google Scholar
• Trottier J, Verreault M, Grepper S, et al. (2006). Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver. Hepatology 44:1158–1170
   PubMed Web of Science ®Google Scholar
• Tsai NP, Lin YL, Wei LN. (2009). MicroRNA mir-346 targets the 5′-untranslated region of receptor-interacting protein 140 (RIP140) mRNA and up-regulates its protein expression. Biochem J 424:411–418
   Google Scholar
• Tsuchiya Y, Nakajima M, Takagi S, et al. (2006). MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Res 66:9090–9098
   PubMed Web of Science ®Google Scholar
• Uchida Y, Chiyomaru T, Enokida H, et al. (2011). MiR-133a induces apoptosis through direct regulation of GSTP1 in bladder cancer cell lines. Urol Oncol 31:115–123
   PubMed Web of Science ®Google Scholar
• Valadi H, Ekstrom K, Bossios A, et al. (2007). Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9:654–659
   PubMed Web of Science ®Google Scholar
• Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. (2006). Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 20:515–524
   PubMed Web of Science ®Google Scholar
• Vermeulen A, Behlen L, Reynolds A, et al. (2005). The contributions of dsRNA structure to Dicer specificity and efficiency. RNA 11:674–682
   PubMed Web of Science ®Google Scholar
• Verreault M, Senekeo-Effenberger K, Trottier J, et al. (2006). The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice. Hepatology 44:368–378
   PubMed Web of Science ®Google Scholar
• Wang YD, Chen WD, Moore DD, Huang W. (2008). FXR: a metabolic regulator and cell protector. Cell Res 18:1087–1095
   PubMed Web of Science ®Google Scholar
• Wang YM, Ong SS, Chai SC, Chen T. (2012). Role of CAR and PXR in xenobiotic sensing and metabolism. Expert Opin Drug Metab Toxicol 8:803–817
   PubMed Web of Science ®Google Scholar
• Watanabe K, Sakurai K, Tsuchiya Y, et al. (2013). Dual roles of nuclear receptor liver X receptor alpha (LXRalpha) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator. Biochem Pharmacol 86:428–436
   PubMed Web of Science ®Google Scholar
• Wei Z, Chen M, Zhang Y, et al. (2013). No correlation of hsa-miR-148a with expression of PXR or CYP3A4 in human livers from Chinese Han population. PLoS One 8:e59141
   PubMed Web of Science ®Google Scholar
• Wei Z, Jiang S, Zhang Y, et al. (2014). The effect of microRNAs in the regulation of human CYP3A4: A systematic study using a mathematical model. Sci Rep 4:4283
   PubMed Web of Science ®Google Scholar
• Wells PG, Mackenzie PI, Chowdhury JR, et al. (2004). Glucuronidation and the UDP-glucuronosyltransferases in health and disease. Drug Metab Dispos 32:281–290
   PubMed Web of Science ®Google Scholar
• Wheeler HE, Maitland ML, Dolan ME, et al. (2013). Cancer pharmacogenomics: Strategies and challenges. Nat Rev Genet 14:23–34
   PubMed Web of Science ®Google Scholar
• Wilkinson GR. (2005). Drug metabolism and variability among patients in drug response. N Engl J Med 352:2211–2221
   PubMed Web of Science ®Google Scholar
• Winter J, Jung S, Keller S, et al. (2009). Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 11:228–234
   PubMed Web of Science ®Google Scholar
• Xiao F, Zuo Z, Cai G, et al. (2009). miRecords: An integrated resource for microRNA-target interactions. Nucleic Acids Res 37:D105–D110
   PubMed Web of Science ®Google Scholar
• Xu N, Papagiannakopoulos T, Pan G, et al. (2009). MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 137:647–658
   PubMed Web of Science ®Google Scholar
• Yang M, Yao Y, Eades G, et al. (2011). MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism. Breast Cancer Res Treat 129:983–991
   PubMed Web of Science ®Google Scholar
• Yekta S, Shih IH, Bartel DP. (2004). MicroRNA-directed cleavage of HOXB8 mRNA. Science 304:594–596
   PubMed Web of Science ®Google Scholar
• Yoshimoto N, Toyama T, Takahashi S, et al. (2011). Distinct expressions of microRNAs that directly target estrogen receptor alpha in human breast cancer. Breast Cancer Res Treat 130:331–339
   PubMed Web of Science ®Google Scholar
• Yu X, Dhakal IB, Beggs M, et al. (2010). Functional genetic variants in the 3′-untranslated region of sulfotransferase isoform 1A1 (SULT1A1) and their effect on enzymatic activity. Toxicol Sci 118:391–403
   PubMed Web of Science ®Google Scholar
• Yuan Q, Loya K, Rani B, et al. (2013). MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration. Hepatology 57:299–310
   PubMed Web of Science ®Google Scholar
• Yueh MF, Tukey RH. (2007). Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem 282:8749–8758
   PubMed Web of Science ®Google Scholar
• Zhang SY, Surapureddi S, Coulter S, et al. (2012a). Human CYP2C8 is post-transcriptionally regulated by microRNAs 103 and 107 in human liver. Mol Pharmacol 82:529–540
   PubMed Web of Science ®Google Scholar
• Zhang X, Zhu J, Xing R, et al. (2012b). miR-513a-3p sensitizes human lung adenocarcinoma cells to chemotherapy by targeting GSTP1. Lung Cancer 77:488–494
   PubMed Web of Science ®Google Scholar
• Zhang Y, Gong W, Dai S, et al. (2012c). Downregulation of human farnesoid X receptor by miR-421 promotes proliferation and migration of hepatocellular carcinoma cells. Mol Cancer Res 10:516–522
   Google Scholar
• Zhao JJ, Lin J, Yang H, et al. (2008). MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer. J Biol Chem 283:31079–31086
   PubMed Web of Science ®Google Scholar
• Zhao Y, Deng C, Wang W, et al. (2011a). Let-7 family miRNAs regulate estrogen receptor alpha signaling in estrogen receptor positive breast cancer. Breast Cancer Res Treat 127:69–80
   PubMed Web of Science ®Google Scholar
• Zhao Y, Deng C, Lu W, et al. (2011b). let-7 microRNAs induce tamoxifen sensitivity by downregulation of estrogen receptor alpha signaling in breast cancer. Mol Med 17:1233–1241
   PubMed Web of Science ®Google Scholar
• Zhong D, Huang G, Zhang Y, et al. (2013a). MicroRNA-1 and microRNA-206 suppress LXRalpha-induced lipogenesis in hepatocytes. Cell Signal 25:1429–1437
   PubMed Web of Science ®Google Scholar
• Zhong D, Zhang Y, Zeng YJ, et al. (2013b). MicroRNA-613 represses lipogenesis in HepG2 cells by downregulating LXRalpha. Lipids Health Dis 12:32
   PubMed Web of Science ®Google Scholar
• Zhong XY, Yu JH, Zhang WG, et al. (2012). MicroRNA-421 functions as an oncogenic miRNA in biliary tract cancer through down-regulating farnesoid X receptor expression. Gene 493:44–51
   PubMed Web of Science ®Google Scholar
• Zhou C, Assem M, Tay JC, et al. (2006). Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J Clin Invest 116:1703–1712
   PubMed Web of Science ®Google Scholar
• Zhou J, Wang KC, Wu W, et al. (2011). MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci USA 108:10355–10360
   PubMed Web of Science ®Google Scholar
• Zhou SF, Liu JP, Chowbay B. (2009). Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab Rev 41:89–295
   PubMed Web of Science ®Google Scholar