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Research Article

Disulfiram (Tetraethylthioperoxydicarbonic Diamide): A Reappraisal of Its Toxicity and Therapeutic Application

Pages 319-335 | Published online: 22 Sep 2008

References

  • Hald J., Jacobsen E. “A Drug Sensitizing the Organism to Ethyl Alcohol”. Lancet 1948; 2: 1001–1004
  • Hald J., Jacobsen E., Larsen V. “The Sensitizing Effect of Tetraethylthiuram Disulfide (Antabuse) to Ethyl Alcohol”. Acta Pharmacol. Toxicol 1948; 4: 285–296
  • Elenbaas R. M. “Management of the Disulflram-Alcohol Reaction”. J. Maine Med. Assoc 1977; 68: 236–240
  • Amador E., Gazdar A. “Sudden Death during Disulfiram-Alcohol Reaction”. Q. J. Stud. Alcohol 1967; 28: 649–654
  • Althoff H. “Multiple Haemorrhagic Necrosis of the Brain as a Complication of Disulflram (Antabuse) Therapy”. Ger. Med. Mon. 1968; 13: 180–183
  • Guornaschelll J. J., Zapanta E., Pitts F. W. “Intracranial Hemorrhage Associated with the Disulflram-Alcohol Reaction”. Bull. Los Angeles Neurol. Soc 1972; 37: 19–23
  • Becker M. D., Sugarman G. “Death Following 'Test Drink' of Alcohol in Patients Receiving Antabuse”. J. Am. Med. Assoc 1951; 149: 568–571
  • Ritchie J. M. “The Aliphatic Alcohols”. The Pharmacological Basis of Therapeutics, 5th ed., L. S. Goodman, A. Gilman. Macmlllan, New York 1975; 148
  • Lundwall L., Baekeland F. “Disulfiram Treatment of Alcoholism”. J. Nerv. Ment. Pis. 1971; 153: 381, 394
  • Keeffe E. B., Smith F. W. “Disulfiram Hypersensitivity Hepatitis”. J. Am. Med. Assoc 1974; 230: 435–436
  • Fisher A. A. “Disulfiram Hypersensitivity Hepatitis”. J. Am. Med. Assoc 1965; 231: 464
  • Ranekand L., Andreasen P. B. “Disulfiram Hepatotoxicity”. Br. Med. J. 1977; 2: 94–96
  • Knee S. T., Razani J. “Acute Organic Brain Syndrome: A Complication of Disulfiram Therapy”. Am. J. Psychiatry 1974; 113: 1281–1282
  • Kingler D., Sehmidbauer H. “EEG Changes in Patients with Antabuse Incompatability”. Soc. Proc. Austrian and Swiss EEG Soc 1976; 9: 193
  • Schwartz R. B. “EEG-Veranderungen unter Antabus (Disulfiram) und Antabus-Alkohol-Expositlon. Eln Beitrag zur Pathogenese von Antabus-Behandlungs-Kompllkatlon”. Neruenarzt 1974; 45: 436–440
  • Prigatano G. P. “Neuropsychological Functioning in Recidivist Alcoholics Treated with Dlsulfiram”. Alcoholism: Clin. Exp. Res. 1977; 1: 81–86
  • Rainey J. M., Jr. “Disulfiram Toxicity and Carbon Disulfide Poisoning”. Am. J. Psychiatry 1977; 134: 371–378
  • Price T. R. P., Silberfarb P. M. “Disulfiram-Induced Convulsions without Challenge by Alcohol”. J. Stud. Alcohol 1976; 37: 980–982
  • Liddon S. C., Satran R. “Disulfiram (Antabuse) Psychosis”. Am. J. Psychiatry 1967; 123: 1284–1289
  • Hotson J. R., Langston J. W. “Disulfiram-Induced Encephalopathy”. A. ch. Jeurol 1976; 33: 141–142
  • Moddel G., Bilbao J. M., Payne D., Ashby P. “Pathological Findings in Disulfiram (Antabuse) Neuropathy”. Can. J. Neurol. Sci. 1977; 4: 222
  • Hosobuchi Y., Wemmer J. “Disulfiram Inhibition of Development of Tolerance to Analgesia Induced by Central Gray Stimulation in Humans”. Eur. J. Pharmacol 1977; 43: 385–387
  • Maugery J., Magnard P., Villon J. C. “Nevrites optiques au cours d'un traitement au disulfirame”. Ann. Ocul 1974; 209: 695
  • Serebro B. “The Suppression of Noradrenaline and 3-Hydroxy-tyramine (Dopamine) Excretion by Disulfiram in Alcohol Dependent Patients”. Br. J. Addict 1974; 69: 305–309
  • Major L. F., Ballenger J. C., Goodwin F. K., Brown G. L. “Cerebrospinal Fluid Homovanillic Acid in Male Alcoholics: Effects of Disulfiram”. Biol. Psychiatry 1977; 12: 635–642
  • Ewing J. A., Rouse B. A., Mueller R. A., Silver D. “Can Dopamine beta-Hydroxylase Levels Predict Adverse Reactions to Disulfiram?”. Alcoholism: Clin. Exp. Res. 1978; 2: 93–94
  • Lake C. R., Major L. F., Ziegler M. G., Kopin I. J. “Increased Sympathetic Nervous System Activity in Alcoholic Patients Treated with Disulfiram”. Am. J. Psychiatry 1977; 134: 1411–1414
  • Kraml M. “A Rapid Test for Antabuse Ingestion”. CMA J 1973; 109: 578
  • Fried R., Masoud A. N., Klein F. M. “Colorimetric Assay of Disulfiram”. J. Pharm. Sci. 1973; 62: 1368–1369
  • Sauter A. M., Wiegrebe W., von Wartburg J. P. “Determination of Disulfiram and Its Metabolites in Human Blood”. Arzeim. -Forsch 1976; 26: 173–177
  • Wells J., Koves E. “Detection of Carbon Disulphiade (A Disulfiram Metabolite) in Expired Air by Gas Chromatography”. J. Chromatogr 1974; 92: 442–444
  • Sauter A. M., von Wartburg J. P. “Quantitative Analysis of Disulfiram and Its Metabolites In Human Blood by Gas-Liquid Chromatography”. J. Chromatogr 1977; 133: 167–172
  • Cobby J., Mayerson M., Selllah S. “The Rapid Reduction of Disulfiram in Blood and Plasma”. J. Pharmacol. Exp. Ther 1977; 202: 724–731
  • Shelnln E. B., Benson W. R. “Proton Magnetic Resonance Spectroscopic Determination of Disulfiram: Collaborative Study”. J. Assoc. Off. Anal. Chem 1978; 61: 55–59
  • Brown M. W., Porter G. S., Williams A. E. “The Determination of Disulfiram in Blood, and of Exhaled Carbon Disulphide Using Cathode Ray Polarography”. J. Pharm. Pharmacol. Suppl 1974; 26: 95P
  • Martens F., Heyndrickx A. “Detection of NaDEDC (Sodium Diethyldithioearbamate): A Metabolite of Antabuse in Post-Mortem Blood Samples”. Bull. TIAFT 1975; 11: 18–19
  • Faiman M. D., Dodd D. E., Nolan R. J., Artman L., Hanzlik R. E. “A Rapid and Simple Method for the Determination of Disulfiram and Its Metabolites from a Single Sample of Biological Fluid or Tissue”. Res. Commun. Chem. Pathol. Pharmacol 1977; 17: 481–496
  • Shamszad M., Dutta S. K., Krause S., Iber F. L. “Metabolism of 35S-Disulfiram in Normals and in Patients with Liver Disease”. Gastroenterology 1975; 68: A-126
  • de Saint-Blanquat G., Derache R. “Mecanisme d'action des substances anti-alcool dependantes (Disulfirame)”. J. Pharmacol. (Paris) 1976; 7: 393–408
  • Cobby J., Mayersohn M., Selliah S. “Methyl Diethyldithioearbamate, A Metabolite of Disulfiram in Man”. Life Sci 1977; 21: 937–941
  • Easier H., Merlevede E. “On the Mechanism of the Di-sulfiram-Ethanol Intoxication Symptoms. Arch. Int. Phar-macodyn 1962; 138: 343–344; 139, 165–176, 1962 332
  • Kitson T. M. “Reinvestigation of the Chemical Reaction between Disulfiram and Ethanol”. J. Stud. Alcohol 1977; 38: 1771–1772
  • Iber F. L., Dutta S., Shams zad M., Krause S. “Excretion of Radioactivity Following Administration of -Sulfur-Labeled Disulfiram in Man”. Alcoholism: Clin. Exp. Res. 1977; 1: 359–364
  • Djuric D., Postic-Grujin A., Graovac-Leposavic L., Delic V. “Disulfiram as an Indicator of Human Susceptibility to Carbon Disulfide”. Arch. Environ. Health 1973; 26: 287–289
  • Vessell E. S., Passananti G. T., Glenwright P. A. “Anomalous Result of Studies on Drug Interaction in Man. III. Disulfiram and Antipyrine”. Pharmacology 1975; 13: 481–491
  • Zemaitis M. A., Greenes F. E. “Impairment of Hepatic Microsomal Drug Metabolism in the Rat during Daily Disulfiram Administration”. Biochem. Pharmacol 1976; 25: 1355–1360
  • Lang M., Marselos M., Torronen R. “Modification of Drug Metabolism by Disulfiram and Diethyldithiocarbamate. I. Mixed-Function Oxidase”. Chem. Biol. Interact 1976; 15: 267–276
  • Marselos M., Lang M., Torronen R. “Modification of Drug Metabolism by Disulfiram and Diethyldithiocarbamate. II. D-Glucuronic Acid Pathway”. Chem. Biol. Interact 1976; 15: 277–287
  • DeMaster E. G., Nagasawa H. T. “Disulfiram-Induced Acetonemia in the Rat and Man”. Res. Commun. Chem. Pathol. Pharmacol 1977; 18: 361–364
  • Sellers E. M., MacLeod S. M., Greenblatt D. J., Giles H. G. “Influence of Disulfiram and Disease on Benzodiazepine Disposition”. Clin. Pharmacol 1977; 21: 117
  • O'Reilly R. A., Motley C. H. “Breath Odor after Disulfiram”. J. Am. Med. Assoc 1977; 238: 2600
  • Loiseau P., Brachet A., Henry P., Cenraud P. “Intoxication par la diphenyl hydantoine lors d'une cure de di-sulfirame”. Presse Med 1975; 4: 504
  • Dry J., Pradalier A. “Intoxication par la phenytoine au cours d'une association therapeutique avec le disulfirame”. Therapie 1973; 28: 799–802
  • Svendsen T. L., Kristensen M. B., Hansen J. M., Skovsted L. “The Influence of Disulfiram on the Half-Life and Metabolic Clearance Rate of Diphenylhydantoin and Tolbutamide in Man”. Eur. J. Clin. Pharmacol 1976; 9: 439–441
  • Sharkawi M., Cianflone D., El-Hawari A. M. “Toxic Interactions between Disulfiram, and Some Centrally Acting Drugs in Rats”. J. Pharm. Pharmacol 1978; 30: 63
  • Tong T. G., Benowitz N. L., Kreck M. J. “Methadone Disulfiram Interaction during Methadone Maintenance”. Clin. Pharmacol 1978; 23: 132
  • Pugliese A., Martinez M., Maselli A., Zalick D. H. “Treatment of Alcoholic Methadone-Maintenanee Patients with Disulfiram”. J. Stud. Alcohol 1975; 36: 1584–1588
  • Charuvastra C. V., Panell J., Hopper M., Erhmann M., Blakis M., Ling W. “The Medical Safety of the Combined Usage of Disulfiram and Methadone”. Arch. Gen. Psychiatry 1976; 33: 391–393
  • Tottmar O., Marchner H. “Disulfiram as a Tool in the Studies on the Metabolism of Acetylaldehyde in the Rat”. Acta Pharmacol. Toxicol 1976; 38: 366–375
  • Berger D., Weiner H. “Effect of Disulfiram and Chloral Hydrate on the Metabolism of Catecholamines in Rat Liver and Brain”. Biochem. Pharmacol 1977; 26: 741–747
  • Fiala E. S., Bobotas G., Kulakis C., Weisberger J. H. “Inhibition of 1,2-Dimethylhydrazine Metabolism by Disulfiram”. Xenobiotica 1977; 7: 5–9
  • Fiala E. S., Bobotas G., Kulakis C., Wattenberg L. W., Weisberger J. H. “Effects of Disulfiram and Related Compounds on the Metabolism in vivo of the Colon Carcinogen, 1,2-Dimethylhydrazine”. Biochem. Pharmacol 1977; 26: 1763–1768
  • Fiala S., Fiala A. E., Keller R. W. “Activation of y-Glutamyl Transferase in Rat Liver by Disulfiram and Its Effect on the First Stage of Azo-Dye Induced Carcinogenesis”. Fed. Proc 1977; 36: 349
  • Plotnick H. B. “Carcinogenesis in Rats of Combined Ethylene Dibromide and Disulfiram”. J. Am. Med. Assoc 1978; 239: 1609
  • Benowitz N., Rogers W., Wilson M. “Disulfiram Induced Hypertension in Normal Man”. Clin. Res. 1978; 26: 99A
  • Rainey J. M., Jr., Neal R. A. “Disulfiram, Carbon Di-sulphide, and Athersclerosis”. Lancet 1975; I: 284–285
  • Ekvarn S., Jonsson M., Lindquist N. G., Holmberg B., Kronevi T. “Disulflram-Induced Myocardial and Skeletal-Muscle Degeneration in Rats. Lancet 1977; II: 770–771
  • Nora A. H., Nora J. J., Blu J. “Limb-Reduction Anomalies in Infants Born to Disulfiram-Treated Alcoholic Mothers”. Lancet 1977; II: 664
  • Whyteand C. R., O'Brien P. M. J. “Disulfiram Implant; A Controlled Trial”. Br. J. Psychiatry 1974; 124: 44–44
  • Wilson A., Davidson W. J., White J. “Disulfiram Implantation: Placebo, Psychological Deterrent, and Pharmacological Deterrent Effects”. Lancet 1976; 129: 277–280
  • Wilson A., Davidson W. J., White J. “Disulfiram-Ethanol Reaction to Implanted Disulfiram”. Can. Psychiat. Assoc. J. 1976; 21: 217–220
  • Boss D., Sauter A., Cornu F. “Abslinenzverhalten und Disulfiram-Plasmakonzentration bei Alkoholikern nach Esperal-Implantation”. Schweiz. Med. Wochenschr 1976; 106: 1074–1077
  • Mann R., Vogel-Sprott M. “Antabuse Implants: Placebo Treatment for Alcoholism;'”. CMAJ 1977; 116: 134–138
  • Kline S. A., Kingstone E. “Disulfiram Implants: The Right Treatment but the Wrong Drug?. CMAJ 1977; 116: 1382–1383
  • Wilson A., Davidson W. J. “Implantation de disulfiram: Effects inhibiteur, pharmacologique, et placebo”. Rev. Alcool 1977; 23: 22–30
  • Mieniewski Z. “Wyniki wszczepiania Esperalu” (“Results of Treatment with Esperal Implantation”). Probl. Alk zmu, Wars 1967; 15: 6–7
  • Fructuose P. A. “La implantacion subcutanea de disulfiram en el tratamiento del alcoholismo cronico”. Folia Clin. Int. 1976; 26: 272–277
  • Telerman-Toppet N., Vanaise A., Six R., Vanherweghem J. L., Sternon J., Coers C. “A propos d'um cas de periarterite noueuse apres implantation de disulfiram”. Acta Clin. Belg 1975; 30: 101–107
  • Lewis M. J., Bland R. C., Baile W. “Disulfiram Implantation for Alcoholism”. Can. Psychiatr. Assoc. J. 1975; 20: 283–286
  • Lachapelle J. M., Tennstedt D. “Les complications cutanees consecutives aux implants de disulfirame”. Rev. Alcool 1977; 23: 13–21
  • Lachapelle J. M. “Allergic‘Contact’ Dermatitis from Disulfiram Implants”. Contact Dermatitis 1975; 1: 218–220
  • Kingstone E., Line S. A. “Disulfiram Implants in the Treatment of Alcoholism Some Mechanisms of Action”. Int. Pharmacopsychiatry 1975; 10: 183–191

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