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Research Article

Structure-Metabolism Relationships SMR) for the Prediction of Health Hazards)y the Environmental Protection Agency. I. Background for the Practice of Predictive Toxicology

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Pages 171-184 | Published online: 22 Sep 2008

References

  • Di Carlo F. J. Metabolism, pharmacokinetics, and toxicokinetics defined. Drug Metab. Rev. 1982; 13: 1–4
  • Konemann H. Quantitative structure-activity relationships (QSARs) in fish toxicity studies. Part 1: Relationship for industrial pollutants. Toxicology 1981; 19: 209–221
  • Veith G. D., De Foe D. L., Bergstedt B. V. Measuring and estimating the bioconcentration factor of chemicals in fish. J. Fish Res. Board (Canada) 1979; 36: 1040–1049
  • Wester R. C., Maibach H. I. Cutaneous pharmacokinetics: 10 steps to percutaneous absorption. Drug Metab. Rev. 1983; 14: 169–205
  • Scheuplein R. J., Blank I. H. Permeability of the skin. Physiol. Rev. 1971; 51: 702–747
  • Sollmann T. A Manual of Pharmacology and Its Applications to Therapeutics and Toxicology. W. B. Saunders, Philadelphia 1957; 27–28
  • Lien E. J. Structure-activity relationships and drug disposition. Ann. Rev. Pharmacol. Toxicol. 1981; 21: 31–61
  • Tichy M. Prediction of adverse activities from physical and chemical properties of vapors and gases (QSAR analysis). Modeling of Inhalation Exposure to Vapors: Uptake, Distribution, and Elimination, V. Fiserova-Bergerova. CRC Press, Boca Raton, FL 1983; vol. 2: 3–35
  • Fiserova-Bergerova V., Tichy M., Di Carlo F. J. Effects of biosolubility on pulmonary uptake and disposition of gases and vapors of lipophilic chemicals. Drug Metab. Rev. 1984; 15: 1033–1070
  • Tichy M., Fiserova-Bergerova V., Di Carlo F. J. Estimation of biosolubility of hydrophilic compounds -QSAR study. QSAR in Toxicology and Xenobiochem-istry, M. Tichy. Elsevier, Amsterdam 1985; 225–231
  • Smith D. A., Brown K., Neale M. G. Chromone-2-carboxylic acids: Roles of acidity and lipophilicity in drug disposition. Drug Metab. Rev. 1985; 16: 365–388
  • Scheline R. R. Metabolism of foreign compounds by gastrointestinal microorganisms. Pharmacol. Rev. 1973; 25: 451–523
  • Renwick A. G. Microbial metabolism of drugs. Drug Metabolism from Microbe to Man, D. V. Parke, R. L. Smith. Taylor and Francis, London 1977; 169–189
  • Silva J., Jr. Clinical summary of conference. Anaerobic Bacteria: Selected Topics, D. W. Be Lam, Jr., R. J. Genco, K. J. Mayberry-Carson. Plenum Press, New York 1980; 297
  • Holdeman L. V., Cato E. P., Moore W. E. C. Recent changes in identification and classification of some anaerobes. Anaerobic Bacteria: Selected Topics, D. W. Lambe, Jr., R. J. Genco, K. J. Mayberry-Carson. Plenum Press, New York 1980; 25–38
  • Matthews H. B., Kato S., Morales N. M., Tuey D. B. Distribution and excretion of 2,4,5,2′,4 5′-hexabromobi-phenyl, the major component of Firemaster BP-6. J. Toxicol. Environ. Health 1977; 3: 599–605
  • Sherwin C. P. The fate of foreign organic compounds in the animal body. PhysioZ. Rev. 1922; 2: 238–276
  • Ambrose A. M., Sherwin C. P. Detoxication mechanisms. Ann. Rev. Biochem. 1933; 2: 377–396
  • Harrow B., Sherwin C. P. Detoxication mechanisms. Ann. Rev. Biochem. 1935; 4: 263–278
  • Williams R. T. Detoxication Mechanisms. Chapman and Hall, London 1947
  • Williams R. T. Detoxication Mechanisms, 2nd ed. Wiley, New York 1959; 97, 727–730
  • Peters R. A., Stocken L. A., Thompson R. H. S. British anti-lewisite (BAL). Nature 1945; 156: 616–619
  • Peters R. A. Biochemical Lesions and Lethal Synthesis. Pergamon Press, London 1963
  • Boyland E. The biological significance of metabolism of polycyclic compounds. Biochem. Soc. Symp. 1950; 5: 40–54
  • Jerina D. M., Daley J. W., Witkop B., Zaltzman-Niren-berg P., Udenfriend S. The role of arene oxide - oxepin systems in the metabolism of aromatic substrates. III. Formation of 1,2-naphthalene oxide from naphthalene by liver microsomes. J. Am. Chem. Soc 1968; 90: 6525–6527
  • Gillette J. R. The problem of chemically reactive metabolites. Drug Metab. Rev. 1982; 13: 941–961
  • Guengerich F. P., Liebler D. C. Enzymatic activation of chemicals to toxic metabolites. CRC Crit. Rev. Toxicol. 1985; 14: 259–307
  • Quick A. J. The relationship between chemical structure and physiological response: II. The conjugation of hydroxy- and methoxybenzoic acids. J. Biol. Chem. 1932; 97: 403–419
  • Weiner I. M., Mudge G. H. Renal tubular mechanisms for excretion of organic acids and bases. Am. J. Med. 1964; 36: 743–762
  • Di Carlo F. J., Bickart P., Auer C. M. Role of structure-activity team (SAT) in the premanufacture notification (PMN) process. QSAR in Toxicology and Xenobiochem-istry, M. Tichy. Elsevier, Amsterdam 1985; 433–449
  • Di Carlo F. J., Bickart P., Auer C. M. Structure-metabolism relationships (SMR) for the prediction of health hazards by the Environmental Protection Agency. II. Application to teratogenicity and other toxic effects caused by aliphatic acids. Drug Metab. Rev., 17(3&4), (in press)

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