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Research Article

Human Exposure Monitoring, Dosimetry, and Cancer Risk Assessment: The Use of Antisera Specific for Carcinogen-DNA Adducts and Carcinogen-Modified DNA

Pages 87-109 | Published online: 22 Sep 2008

References

  • Poirier M. C. The use of carcinogen-DNA adduct antisera for quantitation and localization of genomic damage in animal models and the human population. Environ. Mol. Mutagen. 1984; 6: 879–887
  • Poirier M. C. Development of Immunoassays for the Detection of Carcinogen-DNA Adducts. Molecular Dosimetry and Human Cancer, P. L. Skipper, J. D. Groopman. CRC Press, Boca Raton, FL 1991; 211–229
  • Phillips D. H. Modern Methods of DNA Adduct Determination. Handbook of Experimental Pharmacology, C. S. Cooper, P. L. Grover. Springer-Verlag, Berlin 1990; Vol. 94/1: 503–546
  • Santella R. M., Yang X. Y., Hsieh L. L., Young T. L. Immunologic methods for the detection of carcinogen adducts in humans. Prog. Clin. Biol. Res. 1990; 340C: 247–257
  • Weston A., Manchester D. K., Povey A., Harris C. C. Detection of carcinogen-macromolecular adducts in humans. J. Am. Coll. Toxicol. 1989; 8: 913–932
  • Poirier M. C., Weston A. DNA adduct determination in humans. Prog. Clin. Biol. Res. 1991; 372: 205–218
  • Huitfeldt H. S., Brandtzaeg P., Poirier M. C. Reduced DNA adduct formation in replicating liver cells during continuous feeding of a chemical carcinogen. Proc. Natl. Acad. Sci. USA 1990; 87: 5955–5958
  • Olivero O. A., Huitfeldt H., Poirier M. C. Chromosome site-specific immunohistochemical detection of DNA adducts in N-acetoxy-2-acetylaminofluorene-exposed Chinese hamster ovary cells. Mol. Carcinog. 1990; 3: 37–43
  • Groopman J. D., Zhu J. Q., Donahue P. R., Pikul A., Zhang L. S., Chen J. S., Wogan G. N. Molecular dosimetry of urinary afla-toxin-DNA adducts in people living in Guangxi Autonomous Region, People's Republic of China. Cancer Res. 1992; 52: 45–52
  • Groopman J. D., Hall A. J., Whittle H., Hudson G. J., Wogan G. N., Ruggero M., Wild C. P. Molecular dosimetry of aflatoxin-yv7-guanine in human urine obtained in the Gambia, West Africa. Cancer Epidemiol. Biom. Prev. 1992; 1: 221–227
  • Harrison J. C., Garner R. C. Immunological and HPLC detection of aflatoxin adducts in human tissues after an acute poisoning incident in S.E. Asia. Carcinogenesis 1991; 12: 741–743
  • Lee H. S., Sarosi I., Vyas G. N. Aflatoxin Bl formamidopyri-midine adducts in human hepatocarcinogenesis: A preliminary report. Gastroenterology 1989; 97: 1281–1287
  • Hsieh L. L., Hsu S. W., Chen D. S., Santella R. M. Immunological detection of aflatoxin Bl-DNA adducts formed in vivo. Cancer Res. 1988; 48: 6328–6331
  • Kadlubar F. F., Talaska G., Lang N. P., Benson R. W., Roberts D. W. Assessment of exposure and susceptibility to aromatic amine carcinogens. 1ARC Sci. Publ. 1988; 89: 166–174
  • Wilson V. L., Weston A., Manchester D. K., Trivers G. E., Roberts D. W., Kadlubar F. F., Wild C. P., Montesano R., Willey J. C., Mann D. L., Harris C. C. Alkyl and aryl carcinogen adducts detected in human peripheral lung. Carcinogenesis 1989; 10: 2149–2153
  • Cuzick J., Routledge M. N., Jenkins D., Garner R. C. DNA adducts in different tissues of smokers and non-smokers. Int. J. Cancer 1990; 45: 673–678
  • Haugen A., Becher G., Benestad C., Vahakangas K., Trivers G. E., Newman M. J., Harris C. C. Determination of polycyclic aromatic hydrocarbons in the urine, benzo(a)pyrene diol epoxide-DNA adducts in lymphocyte DNA, and antibodies to the adducts in sera from coke oven workers exposed to measured amounts of polycyclic aromatic hydrocarbons in the work atmosphere. Cancer Res. 1986; 46: 4178–4183
  • van Schooten F. J., Hillebrand M. J., van Leeuwen F. E., Lutger-ink J. T., van Zandwijk N., Jansen H. M., Kriek E. Polycyclic aromatic hydrocarbon-DNA adducts in lung tissue from lung cancer patients. Carcinogenesis 1990; 11: 1677–1681
  • van Schooten F. J., van Leeuwen F. E., Hillebrand M. J., de Rijke M. E., Hart A. A., van Veen H. G., Oosterink S., Kriek E. Determination of benzo[a]pyrene diol epoxide-DNA adducts in white blood cell DNA from coke-oven workers: The impact of smoking. J. Natl. Cancer Inst. 1990; 82: 927–933
  • van Schooten F. J., Hillebrand M. J., van Leeuwen F. E., van Zandwijk N., Jansen H. M., den Engelse L., Kriek E. Polycyclic aromatic hydrocarbon-DNA adducts in white blood cells from lung cancer patients: No correlation with adduct levels in lung. Carcinogenesis 1992; 13: 987–993
  • øvrebø S., Haugen A., Phillips D. H., Hewer A. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells from coke oven workers: Correlation with job categories. Cancer Res. 1992; 52: 1510–1514
  • Hemminki K., Grzybowska E., Chorazy M., Twardowska-Saucha K., Sroczynski J. W., Putman K. L., Randerath K., Phillips D. H., Hewer A., Santella R. M., Young T. L., Perera F. P. DNA adducts in human environmentally exposed to aromatic compounds in an industrial area of Poland. Carcinogenesis 1990; 11: 1229–1231
  • Santella R. M., Grinberg-Funes R. A., Young T. L., Dickey C., Singh V. N., Wang L. W., Perera F. P. Cigarette smoking related polycyclic aromatic hydrocarbon-DNA adducts in peripheral mononuclear cells. Carcinogenesis 1992; 13: 2041–2045
  • Santella R. M., Hemminki K., Tang D. L., Paik M., Ottman R., Young T. L., Savela K., Vodickova L., Dickey C., Whyatt R., Perera F. P. Polycyclic aromatic hydrocarbon-DNA adducts in white blood cells and urinary 1-hyroxypyrene in foundry workers. Cancer Epidemiol. Biom. Prev. 1993; 2: 59–62
  • Perera F. P., Poirier M. C., Yuspa S. H., Nakayama J., Jaretzki A., Curnen M. M., Knowles D. M., Weinstein I. B. A pilot project in molecular cancer epidemiology: Determination of benzo[a]pyrene-DNA adducts in animal and human tissues by immunoassays. Carcinogenesis 1982; 3: 1405–1410
  • Perera F. P., Santella R. M., Brenner D., Poirier M. C., Munshi A. A., Fischman H. K., VanRyzin J. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. J. Natl. Cancer Inst. 1987; 79: 449–456
  • Perera F., Mayer J., Jaretzki A., Hearne S., Brenner D., Young T. L., Fischman H. K., Grimes M., Grantham S., Tang M. X., Tsai W. Y., Santella R. M. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. Cancer Res. 1989; 49: 4446–4451
  • Hatch M. C., Warburton D., Santella R. M. Polycyclic aromatic hydrocarbon-DNA adducts in spontaneously aborted fetal tissue. Carcinogenesis 1990; 11: 1673–1675
  • Paleologo M., van Schooten F. J., Pavanello S., Kriek E., Zordan M., Clonfero E., Bezze C., Levis A. G. Detection of benzo[a]pyrene-diol-epoxide-DNA adducts in white blood cells of psoriatic patients treated with coal tar. Mutat. Res. 1992; 281: 11–16
  • Liou S. H., Jacobson-Kram D., Poirier M. C., Nguyen D., Strickland P. T., Tockman M. S. Biological monitoring of fire fighters: Sister chromatid exchange and polycyclic aromatic hydrocarbon-DNA adducts in peripheral blood cells. Cancer Res. 1989; 49: 4929–4935
  • Rothman N., Poirier M. C., Baser M. E., Hansen J. A., Gentile C., Bowman E. D., Strickland P. T. Formation of polycyclic aromatic hydrocarbon-DNA adducts in peripheral white blood cells during consumption of charcoal-broiled beef. Carcinogenesis 1990; 11: 1241–1243
  • Harris C. C., Vahakangas K., Newman M. J., Trivers G. E., Shamsuddin A., Sinopoli N., Mann D. L., Wright W. E. Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers. Proc. Natl. Acad. Sci. USA 1985; 82: 6672–6676
  • Montesano R., Hall J., Hollstein M., Mironov N., Wild C. P. Alkylation repair in human tissues. Basic Life Sci. 1990; 53: 437–452
  • Rang H. I., Konishi C., Eberle G., Rajewsky M. F., Kuroki T., Huh N. H. Highly sensitive, specific detection of O6-methylguanine, O4-methylthymine, and 04-ethylthymine by the combination of high-performance liquid chromatography prefractionation, 32P-postlabeling, and immunoprecipitation. Cancer Res. 1992; 52: 5307–5312
  • Cooper D. P., Griffin K. A., Povey A. C. Immunoaffinity purification combined with 32P-postlabelling for the detection of O6-methylguanine in DNA from human tissues. Carcinogenesis 1992; 13: 469–475
  • Bruze M., Emmett E. A., Creasey J., Strickland P. T. Cyclobuta-dithymidine induction by solar-simulating UV radiation in human skin: II. Individual responses. J. Invest. Dermatol. 1989; 93: 341–344
  • Yang X. Y., Gasparro F. P., DeLeo V. A., Santella R. M. 8-Methoxypsoralen-DNA adducts in patients treated with 8- methoxypsoralen and ultraviolet A light. J. Invest. Dermatol. 1989; 92: 59–63
  • Yang X. Y., DeLeo V., Santella R. M. Immunological detection and visualization of 8-methoxypsoralen-DNA photoadducts. Cancer Res. 1987; 47: 2451–2455
  • van Delft J. H., van den Ende A. M., Keizer H. J., Ouwerkerk J., Baan R. A. Determination of N7-methylguanine in DNA of white blood cells from cancer patients treated with dacarbazine. Carcinogenesis 1992; 13: 1257–1259
  • Poirier M. C., Egorin M. J., Fichtinger-Schepman A. M., Yuspa S. H., Reed E. DNA adducts of cisplatin and carboplatin in tissues of cancer patients. IARC Sci. Publ. 1988; 313–320
  • Poirier M. C., Reed E., Litterst C. L., Katz D., Gupta-Burt S. Persistence of platinum-ammine-DNA adducts in gonads and kidneys of rats and multiple tissues from cancer patients. Cancer Res. 1992; 52: 149–153
  • Gupta-Burt S., Shamkhani H., Reed E., Tarone R. E., Allegra C. J., Pai L. H., Poirier M. C. Relationship between patient response in ovarian and breast cancer and platinum drug-DNA adduct formation. Cancer Epidemiol. Biom. Prev. 1993; 2: 229–234
  • Terheggen R M.A. B., Begg A. C., Emondt J. Y., Dubbelman R., Floot B. G. J., den Engelse L. Formation of interaction products of carboplatin with DNA in vitro and in cancer patients. Brit. J. Cancer 1991; 63: 195–200
  • Parker R. J., Gill I., Tarone R., Vionnet J. A., Grunberg S., Muggia F. M., Reed E. Platinum-DNA damage in leukocyte DNA of patients receiving carboplatin and cisplatin chemotherapy, measured by atomic absorption spectrometry. Carcinogenesis 1991; 12: 1253–1258
  • Fichtinger A. M. J., Schepman S. D., van der Velde-Visser H. C. M., van Dijk-Knijnenburg van Oosterom A. T., Baan R. A., Berends F. Kinetics of the formation and removal of cisplatin-DNA adducts in blood cells and tumor tissue of cancer patients receiving chemotherapy: Comparison with in vitro adduct formation. Cancer Res. 1990; 50: 7887–7894
  • Fichtinger A. M., Schepman A. -T., van OosteromLohman P. H., Berends F. ris-Diamminedichloroplatinum(II)-induced DNA adducts in peripheral leukocytes from seven cancer patients: Quantitative immunochemical detection of the adduct induction and removal after a single dose of m-diamminedichloroplatinum(II). Cancer Res. 1987; 47: 3000–3004
  • Olivero O. A., Semino C., Poirier M. C. Localization of DNA-adducts induced by A/r-acetoxy-A'-2-acetylaminofluorene in Chinese hamster ovary cells using electron microscopy and colloidal gold. Genes Chromosomes Cancer 1990; 2: 130–136
  • Poirier M. C., Connor R. J. A radioimmunoassay for 2-acetyl-aminofluorene-DNA adducts. Methods in Enzymology, 84
  • Immunochemical Techniques, H. VanVunakis, J. Langone. Academic Press, New York 1982; 607–618
  • Schoket B., Doty W. A., Vincze I., Strickland P. T., Assennato G., Poirier M. C. Increased sensitivity for determination of polycy-clic aromatic hydrocarbon-DNA adducts in human DNA samples by dissociation-enhanced lanthanide fluoroimmunoassay (DELFIA). Cancer Epidemiol. Biom. Prev. 1993; 2: 349–353
  • Santella R. M., Weston A., Perera F. P., Trivers G. T., Harris C. C., Young T. L., Nguyen D., Lee B. M., Poirier M. C. Interlaboratory comparison of antisera and immunoassays for benzo[a]pyrene-diol-epoxide-I-modified DNA. Carcinogenesis 1988; 9: 1265–1269
  • van Schooten F. J., Kriek E., Steenwinkel M. J., Noteborn H. P., Hillebrand M. J., van Leeuwen F. E. The binding efficiency of polyclonal and monoclonal antibodies to DNA modified with ben-zo[a]pyrene diol epoxide is dependent on the level of modification. Implications for quantitation of benzo[a]pyrene-DNA adducts in vivo. Carcinogenesis 1987; 8: 1263–1269
  • Friesen M. D., Garren L., Prevost V., Shuker D. E. Isolation of urinary 3-methyladenine using immunoaffinity columns prior to determination by low-resolution gas chromatography-mass spectrometry. Chem. Res. Toxicol. 1991; 4: 102–106
  • Harrison J. C., Carvajal M., Garner R. C. Immunological detection of aflatoxin B,-DNA and AFB,-serum albumin adducts in rat and human tissues. Human Carcinogen Exposure, R. C. Garner, P. B. Farmer, G. T. Steel, A. S. Wright. Oxford Univ. Press, New York 1991; 255–265
  • Sun T. T., Wu S. M., Wu Y. Y., Chu Y. R. Measurement of Individual Aflatoxin Exposure Among People Having Different Risk to Primary Hepatocellular Carcinoma, Y. Hyaishi, M. Nagao, T. Sug-imura, S. Takayama, L. Tomatis, L. W. Wattenberg, G. N. Wogan. Japan. Sci. Soc. Press, Tokyo 1986; 225–235
  • Manchester D. K., Wilson V. L., Hsu I. C., Choi J. S., Parker N. B., Mann D. L., Weston A., Harris C. C. Synchronous fluorescence spectroscopic, immunoaffinity chromatographic and 32P-postlabeling analysis of human placental DNA known to contain benzo[a]pyrene diol epoxide adducts. Carcinogenesis 1990; II: 553–559
  • Weston A., Bowman E. D. Fluorescence detection of benzo[a]py-rene-DNA adducts in human lung. Carcinogenesis 1991; 12: 1445–1449
  • Groopman J. D., Hasler J. A., Trudel L. J., Pikul A., Donahue P. R., Wogan G. N. Molecular dosimetry in rat urine of aflatoxin-N7-guanine and other aflatoxin metabolites by multiple monoclonal antibody affinity chromatography and immunoaffinity/high performance liquid chromatography. Cancer Res. 1992; 52: 261–21A
  • Groopman J. D., Skipper P. L., Donahue P. R., Trudel L. J., Wild-schutte M., Kadlubar F. F, Tannenbaum S. R. Monoclonal antibodies and rabbit antisera recognizing 4-aminobiphenyl-DNA adducts and application to immunoaffinity chromatography. Carcinogenesis 1992; 13: 917–922
  • Weston A., Beland F. A., Manchester D. K., Parker N. B., Harris C. C., Poirier M. C. Development of preparative immunoaffinity chromatography for the isolation of aromatic amine-DNA adducts from humans,. Proc. Am. Assoc. Cancer Res. 1989; 30: 134
  • Rubin A. L., Parenteau N. L., Rice R. H. Coordination of kera-tinocyte programming in human SCC-13 squamous carcinoma and normal epidermal cells. J. Cell Physiol. 1989; 138: 208–214
  • Engelse L. D., Benthem J. V., Scherer E. Immunocytochemical analysis of in vivo DNA modification. Mutat. Res. 1990; 233: 265–287
  • Terheggen P. M., Dijkman R., Begg A. C., Dubbelman R., Floot B. G., Hart A. A., den Engelse L. Monitoring of interaction products of m-diamminedichloroplatinum(II) and cw-diammine(1,1-cyclobutanedicarboxylato) platinum(II) with DNA in cells from platinum-treated cancer patients. Cancer Res. 1988; 48: 5597–5603
  • Roza L., DeGruijl F. R., Bergen J. B., Henegouwen K., Guikers Van H., Van Weelden Der Schans G. P., Baan R. A. Detection of photorepair of UV-induced thymine dimers in human epidermis by immunofluorescence microscopy. J. Invest. Dermatol. 1991; 96: 903–907
  • Schulte P. A., Perera F. P. Molecular Epidemiology: Principles and Practices. CRC Press, Boca Raton, FL 1993
  • Perera F. P., Weinstein I. B. Molecular epidemiology and carcin-ogen-DNA adduct detection: New approaches to studies of human cancer causation. J. Chronic. Dis. 1982; 35: 581–600
  • Reed E., Ozols R. F., Tarone R., Yuspa S. H., Poirier M. C. Platinum-DNA adducts in leukocyte DNA correlate with disease response in ovarian cancer patients receiving platinum-based chemotherapy. Proc. Natl. Acad. Sci. USA 1987; 84: 5024–5028
  • Reed E., Ozols R. F., Tarone R., Yuspa S. H., Poirier M. C. The measurement of cisplatin-DNA adduct levels in testicular cancer patients. Carcinogenesis 1988; 9: 1909–1911
  • Ross R. K., Yuan J. M., Yu M. C., Wogan G. N., Qian G. S., Tu J. T., Groopman J. D., Gao Y. T., Henderson B. E. Urinary afla-toxin biomarkers and risk of hepatocellular carcinoma. Lancet 1992; 339: 943–946
  • Perera F. P., Hemminki K., Young T. L., Brenner D., Kelly G., Santella R. M. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. Cancer Res. 1988; 48: 2288–2291
  • Hemminki K., Randerath K., Reddy M. V., Putman K. L., Santella R. M., Perera F. P., Young T. L., Phillips D. H., Hewer A., Savela K. Postlabeling and immunoassay analysis of polycyclic aromatic hydrocarbons-adducts of deoxyribonucleic acid in white blood cells of foundry workers. Scand. J. Work. Environ. Health 1990; 16: 158–162
  • DiGiovanni J., Prichett W. P., Decina P. C., Diamond L. DBA/2 mice are as sensitive as SENCAR mice to skin tumor promotion by 12–0-tetradecanoylphorbol-13-acetate. Carcinogenesis 1984; 5: 1493–1498
  • Rothman N., Correa A., Villasenor D., Ford P, Poirier M. C., Haas R., Hansen J. A., O'Toole T., Strickland P. T. Contribution of occupation and diet to white blood cell polycyclic aromatic hydrocarbon-DNA adducts in wildland firefighters. Cancer Epidemiol. Biom. Prev. 1993; 2: 341–348
  • Poirier M. C., Beland F. A. DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: implications for DNA adduct-based human cancer risk assessment. Chem. Res. Toxicol. 1992; 5: 749–755
  • Qian G. S., Yu M. C., Ross R., Yuan J. M., Gao Y. T., Henderson B., Wogan G. N., Groopman J. D. Urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China. Cancer Epidemiol. Biom. Prev. 1994, in press
  • Huh N. H., Satoh M. S., Shiga J., Rajewsky M. R., Kuroki T. Immunoanalytical detection of 04-ethylthymine in liver DNA of individuals with or without malignant tumors. Cancer Res. 1989; 49: 93–97

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