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Original Article

Covalent Binding of Xenobiotics to Specific Proteins in the Liver

, &
Pages 39-57 | Published online: 15 Feb 2010

References

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  • Halmes N. C., Perkins E. J., Mc Millan D. C., Pumford N. R. Detection of trichloroethylene-protein adducts in rat liver and plasma 1996, submitted for publication
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  • Satoh H., Martin B. M., Schulick A. H., Christ D. D., Kenna J. G., Pohl L. R. ldquo;Human anti-endoplasmic reticulum antibodies in sera of patients with halothane-induced hepatitis are directed against a trifluoroacetylated carboxylesterase”. Proc. Natl. Acad. Sci. USA 1989; 86: 322–326
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  • Pumford N. R., Martin B. M., Thomassen D., Burris J. A., Kenna J. G., Martin J. L., Pohl L. R. ldquo;Serum antibodies from halothane hepatitis patients react with the rat endoplasmic reticulum protein ERp72”. Chem. Res. Toxicol. 1993; 6: 609–615
  • Davila J. C., Pumford N. R., Martin B. M., Thomassen D., Martin J. L., Pohl L. R. A trifluoroacetylated 82 kDa stress protein appears to be a neoantigen associated with halothane hepatitis. Toxicologist 1991; 11: 268
  • Thomassen D., Martin B. M., Martin J. L., Pumford N. R., Pohl L. R. Characterization of a halothane induced trifluoroacetylated 100 kDa neoantigen that is related to a glucose-regulated protein, FASEB J. 1999; 4
  • Amouzadeh H. R., Bourdi M., Martin J. L., Martin B. M., Pohl L. R. ldquo;UDP-glucose:gylcoprotein glucosyltransferase associates with endoplasmic reticulum chaperons and its activity is decreased in vivo by the inhalation anesthetic halothane”. Chem. Res. Toxicol. 1997; 10: 59–63
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  • Bourdi M., Chen W., Peter R. M., Martin J. L., Buters J. T. M., Nelson S. D., Pohl L. R. ldquo;Human P4502E1 is a major auto-antigen associated with halothane hepatitis and the epitopes are conformational”. Chem. Res. Toxicol. 1996; 9: 1159–1166
  • Brown A. P., Hastings K. L., Gandolfi A. J., Liebler D. C., Brendel K. ldquo;Formation and identification of protein adducts to cytosolic proteins in guinea pig liver slices exposed to halothane”. Toxicology 1992; 73: 281–295

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