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Drug Metabolism Reviews Volume 29, 1997 - Issue 1-2
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Original Article

Characterization of the Humoral Immune Response and Hepatotoxicity After Multiple Halothane Exposures in Guinea Pigs

Mingli Chen Department of Anesthesiology, College of Medicine University of Arizona, Tucson, Arizona, 85724-5114
&
A. Jay Gandolfi Department of Anesthesiology, College of Medicine University of Arizona, Tucson, Arizona, 85724-5114Correspondence[email protected]
Pages 103-122 | Published online: 15 Feb 2010

References

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  • Wright R., Eade O. E. ldquo;A controlled prospective study of the effect on liver function of multiple exposures to halothane”. Lance 1979; 1: 817–820
  • Martin J. L. Halothane hepatitis: A possible immune-mediated hepatitis. Human Immunotoxicology Mechanisms and Controversies, D. S. Newcombe, D. R. Rose, J. C. Bloom. Raven Press, New York 1992; 155–175
  • Ray D. C., Drummond G. B. ldquo;Halothane hepatitis”. Br. J. Anaesth. 1991; 67: 84–89
  • Stock J. G. L., Strunin L. ldquo;Unexplained hepatitis following halothane”. Anesthesiology 1985; 63: 424–439
  • Clarke J. B., Lind R. C., Gandolfi A. J. Mechanisms of anesthetic hepatotoxicity. Advances in Anesthesia, R. K. Stoelting, P. G. Barash, T. J. Gallagher. Mosby Year Book. 1993; Vol. 10: 219–246
  • Neuberger J., Williams R. ldquo;Halothane anesthesia and liver damage”. Br. Med. J. 1984; 289: 1136–1139
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  • Kenna J. G., Satoh H., Christ D. D., Pohl L. R. Metabolic basis for a drug hypersensitivity: Antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane. J. Pharmacol. Exp. Ther. 1988; 245: 1103
  • Clarke J. B., Gandolfi A. J. Volatile anesthetic mechanisms of potential hepatotoxicity. Clinical Anesthesia Updates, P. G. Barash, B. F. Cullen, R. K. Stoelting. Lippincott, Philadelphia 1992; Vol. 3: 1–10
  • Siadat-Pajouh M., Hubbard A. K., Roth T. P., Gandolfi A. J. ldquo;Generation of halothane induced immune response in a guinea pig model of halothane hepatitis”. Anesth. Analg. 1987; 66: 1209–1214
  • Clarke J. B., Thomas C. T., Chen M. L., Gandolfi A. J. ldquo;Halogenated anesthetics form liver adducts and antigens that cross-react with halothane-induced antibodies”. Int. Arch. Allergy Immunol. 1995; 108: 24–32
  • Lunam C. A., Hall P. M., Cousins M. J. ldquo;The pathology of halothane hepatotoxicity in a guinea pig model: A comparison with human halothane hepatitis”. Br. J. Exp. Pathol. 1989; 70: 533–541
  • Clarke J. B., Chen M. L., Gandolfi A. J. Characterization of the antibody response to halothane, Implication for animal models. Toxicologist 1994; 14: 406
  • Callis A. H., Brooks S. D., Roth R. P., Gandolfi A. J., Brown B. R. ldquo;Characterization of a halothane-induced humoral immune response in rabbits”. Clin. Exp. Immunol. 1987; 67: 343–351
  • Lind R. C., Gandolfi A. J., Hall P. M. ldquo;Age and gender influence halothane-associated hepatotoxicity in strain 13 guinea pigs”. Anesthesiology 1989; 71: 878–884
  • Lind R. C., Gandolfi A. J., Brown B. R., Hall P. M. ldquo;Halothane hepatotoxicity in guinea pigs”. Anesth. Analg. 1987; 66: 222–228
  • Furst S. M., Chen M. L., Gandolfi A. J. ldquo;Use of halothane as a model for investigating chemical-induced autoimmune hepatotoxicity”. Drug Inform. J. 1996; 30: 301–307
  • Benjamin S. B., Goodman Z. D., Ishak K. G. The morphologic spectrum of halothane-induced hepatic injury: Analysis of 77 cases. Hepatology 1985; 5: 11163
  • Clarke J. B., Lind R. C., Gandolfi A. J. Biotransformation and hepatotoxicity of inhalation anesthetics. General Anesthesia, 6th ed., B. R. Brown, C. Prys-Roberts. Butterworth Heinemann, Oxford 1995
  • Hubbard A. K., Roth T. P., Gandolfi A. J., Bown B. R., Webster N. R., Nunn J. F. ldquo;Halothane hepatitis patients generate an antibody response toward a covalently bound metabolite of halothane”. Anesthesiology 1988; 68: 791–796
  • Gunaratnam N. T., Benson J., Gandolfi A. J., Chen M. L. ldquo;Isoflurane hepatitis in an obese patient with a history of halothane hepatitis”. Anesthesiology 1995; 83: 1361–1364
  • Gut J., Christen U., Huwyler J. ldquo;Mechanisms of halothane toxicity: Novel insights”. Pharmacol. Ther. 1993; 58: 133–155
  • Luedke D., Furst S. M., Gandolfi A. J. Trifluoroacetylated (TFA) proteins and Kupffer cells sensitize the immune system in halothane exposed guinea pigs. Toxicologist 1995; 15: 102
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