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Original Article

Metallothionein in Physiological and Physiopathological Processes

&
Pages 261-307 | Published online: 15 Feb 2010

References

  • Abel J., De Ruiter N. ldquo;Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein”. Toxicol. Lett. 1989; 47: 191–196
  • Andersen R. D., Taplitz S. J., Oberbauer A. M., Calame K. L., Herschman H. R. ldquo;Metal-dependent binding of a nuclear factor to the rat metallothionein-I promoter”. Nucleic Acids Res. 1990; 18: 6049–6055
  • Andersen R. D., Taplitz S. J., Wong S., Bristol G., Larkin B., Herschman H. R. ldquo;Metal-dependent binding of a factor in vivo to the metal-responsive elements of the metallothionein 1 gene promoter”. Mol. Cell. Biol. 1987; 7: 3574–3581
  • Andersen R. D., Winter W. P., Maher J. J., Bernstein I. A. ldquo;Turnover of metallothioneins in rat liver”. Biochem. J. 1978; 174: 327–338
  • Angel P., Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1991; 1072: 129–157
  • Bahnson R. R., Banner B. F., Ernstoff M. S., Lazo J. S., Cherian M. G., Banerjee D., Chin J. L. ldquo;Immunohistochemical localization of metallothionein in transitional cell carcinoma of the bladder”. J. Urol. 1991; 146: 1518–1520
  • Bakaa A., Endresen L., Johnsen A. B. S., Edminson P. D., Rugstad H. E. Resistance against cis-dichlorodiammineplatinum in cultured cells with high content of metallothionein. Toxicol. Appl. Pharmacol. 1981; 61: 215–226
  • Bakka A., Johnsen A. S., Endresen L., Rugstad H. E. ldquo;Radio-resistance in cells with high content of metallothionein”. Experientia 1982; 38: 381–383
  • Banerjee D., Onosaka S., Cherian M. G. ldquo;Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of rat liver and kidney”. Toxicology 1982; 24: 95–105
  • Basu A., Lazo J. S. Suppression of dexamethasone-induced metallothionein expression and cis-diamminedichloroplatinum(II) resistance by v-mos. Cancer Res. 1991; 51: 893–896
  • Bauknecht T., Angel P., Kohler M., Kommoss F., Birmelin G., Pfleiderer A., Wagner E. Gene structure and expression analysis of the epidermal growth factor receptor, transforming growth factor-alpa, myc, jun, and metallothionein in human ovarian carcinomas. Cancer 1993; 71: 419–429
  • Bauman J. W., Liu J., Liu Y. P., Klaassen C. D. ldquo;Increase in metallothionein produced by chemicals that induce oxidative stress”. Toxicol. Appl. Pharmacol. 1991; 110: 347–354
  • Beattie J. H., Marion M., Denizeau F. ldquo;The modulation by metallothionein of cadmium-induced cytotoxicity in primary hepatocyte cultures”. Toxicology 1987; 44: 329–339
  • Beltramini M., Lerch K. ldquo;Copper transfer betwen neurospora copper metallothionein and type 3 copper apoproteins”. FEBS Lett. 1982; 142: 219–222
  • Bettger W. J., O'Dell B. L. ldquo;A critical physiological role of zinc in the structure and function of biomembranes”. Life Sci. 1981; 28: 1425–1438
  • Birkenmeier E. H., Gordon J. I. ldquo;Developmental regulation of a gene that encodes a cysteine-rich intestinal protein and maps near the murine immunoglobulin heavy chain locus”. Proc. Natl. Acad. Sci. USA 1986; 83: 2516–2520
  • Blalock T. L., Dunn M. A., Cousins R. J. ldquo;Metallothionein gene expression in rats: Tissue-specific regulation by dietary copper and zinc”. J. Nutr. 1988; 118: 222–228
  • Bray T. M., Bettger W. J. ldquo;The physiological role of zinc as an antioxidant”. Free Bad. Biol. Med. 1990; 8: 281–291
  • Bremner I. Involvement of metallothionein in the regulation of mineral metabolism. Metallothionein III, Biological Roles and Medical Implications, K. T. Suzuki, N. Imura, M. Kimura. Birkhauser Verlag, Basel 1993; 111–124
  • Bremner I., Mehra R. K. ldquo;Metallothionein: Some aspects of its structure and function with special regard to its involvement in copper and zinc metabolism”. Chem. Scr. 1983; 21: 117–121
  • Brewer G. J. ldquo;Practical recommendations and new therapies for Wilson's disease”. Drugs 1995; 50: 240–249
  • Brewer G. J., Yuzbasiyan V., Gurkan D., Lee Y., Appel-Man H. ldquo;Treatment of Wilson's disease with zinc. VI. Initial treatment studies”. J. Lab. Clin. Med. 1989; 114: 633–638
  • Briggs R. W., Armitage I. M. ldquo;Evidence for site-selective metal binding in calf liver metallothionein”. J. Biol. Chem. 1982; 257: 1259–1262
  • Brouwer M., Brouwer-Hoexum T. Interaction of coppermetallothionein from the American lobster, Homarus americanus, with glutathione. Arch. Biochem. Biophys. 1991; 290: 207–213
  • Brouwer M., Hoexum-Brouwer T., Cashon R. E. ldquo;A putative glutathione-binding site in CdZn-metallothionein identified by equilibrium binding and molecular-modelling studies”. Biochem. J. 1993; 294: 219–225
  • Brugnera E., Georgiev O., Radtke F., Heuchel R., Baker E., Sutherland G. R., Schaffner W. Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1. Nucleic Acids Res. 1994; 22: 3167–3173
  • Cagen S. Z., Klaassen C. D. ldquo;Binding of gluatathione-depleting agents to metallothionein”. Toxicol. Appl. Pharmacol. 1980; 54: 229–237
  • Cain K., Griffiths B. L. ldquo;A comparison of isometallothionein synthesis in rat liver after partial hepatectomy and parenteral zinc injection”. Biochem. J. 1984; 217: 85–92
  • Cain K., Holt D. E. ldquo;Metallothionein degradation: Metal composition as a controlling factor”. Chem.-Biol. Interact. 1979; 28: 91–106
  • Carr B. I., Hayashi I., Branum E. L., Moses H. L. ldquo;Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type β transforming growth factor”. Cancer Res. 1986; 46: 2330–2334
  • Carter A. D., Felber B. K., Walling M.-J., Jubier M.-F., Schmidt C. J., Hamer D. H. ldquo;Duplicated heavy metal control sequences of the mouse metallothionein-I gene”. Proc. Natl. Acad. Sci. USA 1984; 81: 7392–7396
  • Chan H. M., Cherian M. G., Bremner I. ldquo;Quantification of metallothionein isoforms using an enzyme-linked immunosorbent assay (ELISA) with two specific antisera”. Toxicol. Appl. Pharmacol. 1992; 116: 267–270
  • Chan H. M., Cherian M. G. ldquo;Ontogenic changes in hepatic metallothionein isoforms in prenatal and newborn rats”. Biochem. Cell. Biol. 1993; 71: 133–140
  • Chen M. L., Failla M. L. ldquo;Degradation of zinc-metallothionein in monolayer cultures of rat hepatocytes”. Proc. Soc. Exp. Biol. Med. 1989; 191: 130–138
  • Cherian M. G., Goyer R. A., Delaquerriere-Richardson L. ldquo;Relationship between plasma cadmium-thionein and cadmium-induced nephropathy”. Toxicol. Appl. Pharmacol. 1977; 41: 145–146
  • Cherian M. G., Howell S. B., Imura N., Klaassen C. D., Koropatnick J., Lazo J. S., Waalkes M. P. ldquo;Role of metallothionein in carcinogenesis”. Toxicol. Appl. Pharmacol. 1994; 126: 1–5
  • Chesters J. K., Petrie L., Lipson K. E. ldquo;Two zinc-dependent steps during G1 to S phase transition”. J. Cell. Physiol. 1993; 155: 445–451
  • Chin J. L., Banerjee D., Kadhim S. A., Kontozoglou T. E., Chauvin P. J., Cherian M. G. ldquo;Metallothionein in testicular germ cell tumors and drug resistance. Clinical correlation”. Cancer 1993; 72: 3029–3035
  • Choudhuri S., Mc Kim J. M., Klaassen C. D. ldquo;Role of hepatic lysosomes in the degradation of metallothionein”. Toxicol. Appl. Pharmacol. 1992; 115: 64–71
  • Chubatsu L. S., Gennari M., Meneghini R. ldquo;Glutathione is the antioxidant responsible for resistance to oxidative strses in V79 Chinese hamster fibroblasts rendered resistant to cadmium”. Chem.-Biol. Interact. 1992; 82: 99–110
  • Chubatsu L. S., Meneghini R. Metallothionein protects DNA from oxidative damage. Biochem. J. 1993; 291: 193–198
  • Clarkson J. P., Elmes M. E., Jasani B., Webb M. ldquo;Histological demonstration of immunoreactive zinc metallothionein in liver and ileum of rat and man”. Histochem. J. 1985; 17: 343–352
  • Compere S. J., Palmiter R. D. ldquo;DNA methylation controls the inducibility of the mouse metallothionein-I gene in lymphoid cells”. Cell 1981; 25: 233–240
  • Coogan T. P., Bare R. M., Waalkes M. P. ldquo;Cadmium-induced DNA strand damage in cultured liver cells: Reduction in cadmium genotoxicity following zinc pretreatment”. Toxicol. Appl. Pharmacol. 1992; 113: 227–233
  • Cousins R. J. Absorption, transport, and hepatic metabolism of copper and zinc: Special reference to metallothionein and ceruloplasmin. Physiol. Rev. 1985; 65: 238–309
  • Cousins R. J., Lee-Ambrose L. M. ldquo;Nuclear zinc uptake and interactions and metallothionein gene expression are influenced by dietary zinc in rats”. J. Nutr. 1992; 122: 56–64
  • Cox D. W. ldquo;Genes of the copper pathway”. Am. J. Hum. Genet. 1995; 56: 828–834
  • Coyle P., Philcox J. C., Rofe A. M. ldquo;Hepatic zinc in metallothionein-null mice following zinc challenge: In vivo and in vitro studies”. Biochem. J. 1995; 309: 25–31
  • Czupryn M., Brown W. E., Vallee B. L. ldquo;Zinc rapidly induces a metal response element-binding factor”. Proc. Natl. Acad. Sci. USA 1992; 89: 10395–10399
  • Da Costa A. M., Ciriolo Ferreira M. R., Marcocci L., Rotilio G. ldquo;Copper(I) transfer into metallothionein mediated by glutathione”. Biochem. J. 1993; 292: 673–676
  • Dalton T., Palmiter R. D., Andrews G. K. ldquo;Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor antioxidant response element and metal response promoter elements”. Nucleic Acids Res. 1994; 22: 5016–5023
  • Danielson K. G., Ohi S., Huang P. C. ldquo;Immunochemical localization of metallothionein in rat liver and kidney”. J. Histochem. Cytochem 1982; 30: 1033–1039
  • De S. K., Enders G. C., Andrews G. K. ldquo;Metallothionein mRNA stability in chicken and mouse cells”. Biochim. Biophys. Acta 1991; 1090: 223–229
  • De S. K., Mc Masters M. T., Andrews G. K. ldquo;Endotoxin induction of murine metallothionein gene expression”. J. Biol. Chem 1990; 265: 15267–15274
  • Denizeau F., Marion M. ldquo;Genotoxic effects of heavy metals in rat hepatocytes”. Cell Biol. Toxicol. 1989; 5: 15–25
  • Denizeau F., Marion M., Chtaib J.-M., Schmit P. ldquo;Toxicity of heavy metals in cultured hepatocytes”. Environ. Toxicol. Chem. 1990; 9: 737–743
  • Din W. S., Frazier J. M. ldquo;Protective effect of metallothionein on cadmium toxicity in isolated rat hepatocytes”. Biochem. J. 1985; 230: 395–402
  • Dumam D. M., Palmiter R. D. ldquo;Transcriptional regulation of the mouse metallothionein-I gene by heavy metals”. J. Biol. Chem. 1981; 256: 5712–5716
  • Endresen L., Bakka A., Rugstad H. E. ldquo;Increased resistance to chlorambucil in cultured cells with high concentration of cytoplasmic metallothionein”. Cancer Res. 1983; 43: 2918–2926
  • Endresen L. ldquo;Comparison of the cytotoxic effect of prednimustine in cultured cells with high or low levels of metallothionein”. Acta. Pharmacol. Toxicol. 1984; 54: 49–57
  • Endresen L., Schjerven L., Rugstad H. E. Tumors from a cell strain with a high content of metallothionein show enhanced resistance against cis-dichlorodiammineplatinum. Acta Pharmacol. Toxicol. 1984; 55: 183–187
  • Felix K., Weser U. Release of copper from yeast copperthionein after S-alkylation of copper-thiolate clusters. Biochem. J. 1988; 252: 577–581
  • Fliss H., Menard M. ldquo;Oxidant-induced mobilization of zinc from metallothionein”. Arch. Biochem. Biophys. 1992; 293: 195–199
  • Freedman J. H., Ciriolo M. R., Peisach J. ldquo;The role of glutathione in copper metabolism and toxicity”. J. Biol. Chem. 1989; 264: 5598–5605
  • Freedman J. H., Peisach J. ldquo;Intracellular copper transport in cultured hepatoma cells”. Biochem. Biophys. Res. Commun. 1989; 164: 134–140
  • Fresno M., Wu W., Rodriguez J. M., Nadji M. ldquo;Localization of metallothionein in breast carcinomas. An immunohistochemical study”. Virchows Arch. A 1993; 423: 215–219
  • Furst P., Hu S., Hackett R., Hamer D. ldquo;Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein”. Cell 1988; 55: 705–717
  • Gagne F., Marion M., Denizeau F. ldquo;Metal homeostasis and metallothionein induction in rainbow trout hepatocytes exposed to cadmium”. Fundam. Appl. Toxicol. 1990; 14: 429–437
  • Gehring U. The structure of the glucocorticoid receptors. J. Steroid Biochem. Molec. Biol. 1993; 45: 183–190
  • Geller B. L., Winge D. R. ldquo;Metal binding sites of rat liver Cuthionein”. Arch. Biochem. Biophys. 1982; 213: 109–117
  • Goering P. L., Klaassen C. D. ldquo;Altered subcellular distribution of cadmium following cadmium pretreatment: Possible mechanism of tolerance of cadmium-induced lethality”. Toxicol. Appl. Pharmcol. 1983; 70: 195–203
  • Goering P. L., Klaassen C. D. ldquo;Resistance to cadmium-induced hepatotoxicity in immature rats”. Toxicol. Appl. Pharmacol. 1984; 74: 321–329
  • Goering P. L., Klaassen C. D. ldquo;Zinc-induced tolerance to cadmium hepatotoxicity”. Toxicol. Appl. Pharmacol. 1984; 74: 299–307
  • Goncharova E. I., Rossman T. G. ldquo;A role for metallothionein and zinc in spontaneous mutagenesis”. Cancer Res. 1994; 54: 5318–5323
  • Haber B. A., Mohn K. L., Diamond R. H., Taub R. ldquo;Induction patterns of 70 genes during nine days after hepatectomy define the temporal course of liver regeneration”. J. Clin. Invest. 1993; 91: 1319–1326
  • Hager L. J., Palmiter R. D. ldquo;Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids”. Nature 1981; 291: 340–342
  • Haile Meskel H., Cherian M. G., Martinez V. J., Veinot L. A., Frei J. V. ldquo;Metallothionein as an epithelial proliferative compartment marker for DNA flow cytometry”. Modern Pathol. 1993; 6: 755–760
  • Hamer D. H. ldquo;Metallothionein”. Annu. Rev. Biochem. 1986; 55: 913–951
  • Hankinson O. ldquo;The aryl hydrocarbon receptor complex”. Annu. Rev. Pharmacol. Toxicol. 1995; 35: 307–340
  • Hart B. A., Voss G. W., Vacek P. M. ldquo;Metallothionein in human lung carcinoma”. Cancer Lett. 1993; 75: 121–128
  • Hempe J. M., Cousins R. J. ldquo;Cysteine-rich intestinal protein and intestinal metallothionein: An inverse relationship as a conceptual model for zinc absorption in rats”. J. Nutr. 1992; 122: 89–95
  • Hempe J. M., Cousins R. J. ldquo;Cysteine-rich intestinal protein binds zinc during transmucosal zinc transport”. Proc. Natl. Acad. Sci. USA 1991; 88: 9671–9674
  • Hempe J. M., Cousins R. J. ldquo;Effect of EDTA and zinc-methionine complex on zinc absorption by rat intestine”. J. Nutr. 1989; 119: 1179–1187
  • Hernandez J., Zarnegar R., Michalopoulos G. K. ldquo;Characterization of the effects of human placental HGF on rat hepatocytes”. J. Cell. Physiol. 1992; 150: 116–121
  • Heuchel R., Radtke F., Georgiev O., Stark G., Aguet M., Schaffner W. The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J. 1994; 13: 2870–2875
  • Hidalgo J., Campmany L., Borras M., Garvey J. S., Armario A. Metallothionein response to stress in rats: Role in free radical scavenging. Am. J. Physiol. 1988; 255: E518–E524
  • Imagawa M., Chiu R., Karin M. ldquo;Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP”. Cell 1987; 51: 251–260
  • Imbra R. J., Karin M. ldquo;Metallothionein gene expression is regulated by serum factors and activators of protein kinase C”. Mol. Cell. Biol. 1987; 7: 1358–1363
  • Inouye C., Remondelli P., Karin M., Elledge S. ldquo;Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: The one hybrid system”. DNA Cell Biol. 1994; 13: 731–742
  • Itoh N., Okamoto H., Ohta M., Hori T., Min K.-S., Onosaka S., Nakanishi H., Okabe M., Muto N., Tanaka K. N-Hexane-induced synthesis of hepatic metallothionein is mediated by IL-6 in mouse. Toxicol. Appl. Pharmacol. 1994; 124: 257–261
  • Jaiswal A. K. ldquo;Antioxidant response element”. Biochem. Pharmacol. 1994; 48: 439–444
  • Jensen D. E. ldquo;Denitrosation as a determinant of nitrosocimetidine in vivo activity”. Cancer Res. 1983; 43: 5258–5267
  • Jensen D. E., Mackay R. L. Rat, mouse and hamster isozyme specificity in glutathione transferase-mediated denitrosation of nitrosoguanidinium compounds. Cancer Res. 1990; 50: 1440–1448
  • Kagi J. H. R., Vallee B. L. ldquo;Metallothionein: A cadmium- and zinc-containing protein from equine renal cortex. H. Physicochemical properties”. J. Biol. Chem 1961; 235: 3460–3465
  • Kagi J. H. R., Vallee B. L. ldquo;Metallothionein: A cadmium- and zinc-containing protein from equine renal cortex”. J. Biol. Chem. 1960; 235: 3460–3465
  • Kagi J. H. R. Evolution, structure and chemical activity of class I metallothioneins: An overview. Metallothionein III, Biological Roles and Medical Implications, K. T. Suzuki, N. Imura, M. Kimura. Birkhauser Verlag, Basel 1993; 29–55
  • Kaina B., Lohrer H., Karin M., Herrlich P. ldquo;Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents”. Proc. Natl. Acad. Sci. USA 1990; 87: 2710–2714
  • Karin M., Andersen R. D., Slater E., Smith K., Herschman H. R. ldquo;Metallothionein mRNA induction in HeLa cells in response to zinc or dexamethasone is a primary induction response”. Nature 1980; 286: 295–297
  • Karin M., Haslinger A., Holtgreve H., Richards R. I., Krauter P., Westphal H. M., Beato M. Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene. Nature 1984; 308: 513–519
  • Kawashima I., Kennedy T. D., Chino M., Lane B. G. Wheat Ec metallothionein genes. Like mammalian Zn2+ metallothionein genes, wheat Zn2+ metallothionein genes are conspicuously expressed during embryogenesis. Eur. J. Biochem. 1992; 209: 971–976
  • Kelley S. L., Basu A., Teicher B. A., Hacker M. P., Hamer D. H., Lazo J. S. Overexpression of metallothionein confers resistance to anticancer drugs. Science 1988; 241: 1813–1815
  • Kern S. R., Smith H. A., Fontaine D., Bryan S. E. ldquo;Partitioning of zinc and copper in fetal liver subfraction: Appearance of metallothionein-like proteins during development”. Toxicol. Appl. Pharmacol. 1981; 59: 346–354
  • Kerr D., Miller D. B., Matrisian L. M. TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence. Cell, 61: 267–278
  • Kershaw W. C., Klaassen C. D. ldquo;Degradation and metal composition of hepatic isometallothioneins in rats”. Toxicol. Appl. Pharmacol. 1992; 112: 24–31
  • Kershaw W. C., Lehman-McKeeman L. D., Klaassen C. D. ldquo;Hepatic isometallothioneins in mice: Induction in adults and postnatal ontogeny”. Toxicol. Appl. Pharmacol. 1990; 104: 267–275
  • Khoo C., Cousins R. J. ldquo;Purification and properties of rat cysteine-rich intestinal protein”. Biochem. J. 1993; 299: 445–450
  • Kimura M., Otaki N., Yoshiki S., Suzuki M., Horiuchi N., Suda T. The isolation of metallothionein and its protective role in cadmium poisoning. Arch. Biochem. Biophys. 1974; 165: 340–348
  • Koizumi S., Suzuki K., Otsuka F. ldquo;A nuclear factor that recognizes the metal-responsive elements of human metallothionein IIA gene”. J. Biol. Chem. 1992; 267: 18659–18664
  • Kondo Y., Kuo S.-M., Lazo J. S. Interleukin-1β-mediated metallothionein induction and cytoprotection against cadmium and cis-diamminedichloroplatinum. J. Pharmacol. Exp. Ther. 1994; 270: 1313–1318
  • Kontozoglou T. E., Banerjee D., Cherian M. G. ldquo;Immunohistochemical localization of metallothionein in human testicular embryonal carcinoma cells”. Virchows Arch. A Pathol. Anat. 1989; 415: 545–549
  • Koropatnick J., Pearson J. ldquo;Altered cisplatin and cadmium resistance and cell survival in Chinese hamster ovary cells expressing mouse metallothionein”. Mol. Pharmacol. 1993; 44: 44–50
  • Koropatnick J., Pearson J. Zinc treatment, metallothionein expression, and resistance to cisplatin in mouse melanoma cells. Som. Cell. Mol. Gen. 1990; 16: 529–537
  • Kotsonis F. N., Klaassen C. D. ldquo;Increase in hepatic metallothionein in rats treated with alkylating agents”. Toxicol. Appl. Pharmacol. 1979; 51: 19–27
  • Krezoski S. K., Villalobos J. F., Shaw I II, Petering D. H. ldquo;Kinetic lability of zinc bound to metallothionein in Ehrlich cells”. Biochem. J. 1988; 255: 483–491
  • Kr K.-D., öncke Fehsel K., Sommer M.-A., Rodriguez L., Kolb-Bachofen V. Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage. Biol. Chem. Hoppe-Seyler 1995; 376: 179–185
  • Labb S., é Larouche L., Mailhot D., Seguin C. Purification of mouse MEP-1, a nuclear protein which binds to the metal regulatory elements of genes encoding metallothionein. Nucleic Acids Res. 1993; 21: 1549–1554
  • Laurin D. E., Klasing K. C. ldquo;Roles of synthesis and degradation in the regulation of metallothionein accretion in a chicken macrophage-cell line”. Biochem. J. 1990; 268: 459–463
  • Lazo J. S., Pitt B. R. ldquo;Metallothioneins and cell death by anti-cancer drugs”. Annu. Rev. Pharmacol. Toxicol. 1995; 35: 635–653
  • Leber A. P., Miya T. S. ldquo;A mechanism for cadmium- and zinc-induced tolerance to cadmium toxicity: Involvement of metallothionein”. Toxicol. Appl. Pharmacol. 1976; 37: 403–414
  • Lee D.-Y., Brewer G. J., Wang Y. ldquo;Treatment of Wilson's disease with zinc. VII. Protection of the liver from copper toxicity by zinc-induced metallothionein in a rat model”. J. Lab. Clin. Med. 1989; 114: 639–646
  • Lee W., Haslinger A., Karin M., Tjian R. ldquo;Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40”. Nature 1987; 325: 368–372
  • Lehman-McKeeman L. D., Andrews G. K., Klaassen C. D. ldquo;Mechanisms of regulation of rat hepatic metallothionein-I and -II levels following administration of zinc”. Toxicol. Appl. Pharmacol. 1988; 92: 1–9
  • Lehman-McKeeman L. D., Kershaw K. C., Klaassen C. D. Species differences in metallothionein regulation: A comparison of the induction of isometallothioneins in rats and mice. Metallothionein in Biology and Medicine, C. D. Klaassen, K. T. Suzuki. CRC Press, Boca Raton, FL 1991; 121–131
  • Lehman-McKeeman L. D., Klaassen C. D. ldquo;Induction of metallothionein-I and -II in rats by cadmium and zinc”. Toxicol. Appl. Pharmacol. 1987; 88: 195–202
  • Levenson C. W., Shay N. F., Lee-Ambrose L. M., Cousins R. J. ldquo;Regulation of cysteine-rich intestinal protein by dexamethasone in the neonatal rat”. Proc. Natl. Acad. Sci. USA 1993; 90: 712–715
  • Leyshon-Sorland K., Morkrid L., Rugstad H. E. ldquo;Metallothionein: A protein conferring resistance in vitro to tumor necrosis factor”. Cancer Res. 1993; 53: 4874–4880
  • Li T.-Y., Kraker A. J.C. F., Shaw I II, Petering D. H. ldquo;Ligand substitution reactions of metallothioneins with EDTA and apo-carbonic anhydrase”. Proc. Natl. Acad. Sci. USA 1980; 77: 6334–6338
  • Lieberman M. W., Beach L. R., Palmiter R. D. ldquo;Ultraviolet radiation-induced metallothionein-I gene activation is associated with extensive DNA demethylation”. Cell 1983; 35: 207–214
  • Liu J., Liu Y. P., Sendelbach L. E., Klaassen C. D. ldquo;Endotoxin induction of hepatic metallothionein is mediated through cytokines”. Toxicol. Appl. Pharmacol. 1991; 109: 235–240
  • Lohrer H., Robson T., Grindley H., Foster S., Hall A. ldquo;Differential effects on cell killing in metallothionein overexpressing CHO mutant cell lines”. Carcinogenesis 1990; 11: 1937–1941
  • Maret W. ldquo;Oxidative metal release from metallothionein via zincthiol/disulfide interchange”. Proc. Natl. Acad. Sci. USA 1994; 91: 237–241
  • Margoshes M., Vallee B. L. ldquo;A cadmium protein from equine kidney cortex”. J. Am. Chem. Soc. 1957; 79: 4813–4814
  • Martel J., Marion M., Denizeau F. ldquo;Effect of cadmium on membrane potential in isolated rat hepatocytes”. Toxicology 1990; 60: 161–172
  • Masters B. A., Kelly E. J., Quaife C. J., Brinster R. L., Palmiter R. D. ldquo;Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium”. Proc. Natl. Acad. Sci. USA 1994; 91: 584–588
  • Mc Cormick C. C., Salati L. M., Goodridge A. G. ldquo;Abundance of hepatic metallothionein mRNA is increased by protein-synthesis inhibitors”. Biochem. J. 1991; 273: 185–188
  • Mc Kim J. M., Jr., Choudhuri S., Klaassen C. D. In vitro degradation of apo-, zinc-, and cadmium-metallothionein by cathepsins B, C, and D. Toxicol. Appl. Pharmacol. 1992; 116: 117–124
  • Mc Kim J. M., Jr., Liu J., Liu Y. P., Klaassen C. D. Distribution of cadmium chloride and cadmium-metallothionein to liver parenchymal, Kupffer, and endothelial cells: Their relative ability to express metallothionein. Toxicol. Appl. Pharmacol. 1992; 112: 324–330
  • Mead J. E., Fausto N. ldquo;Transforming growth factor a may be a physiological regulator of liver regeneration by means of an autocrine mechanism”. Proc. Natl. Acad. Sci. USA 1989; 86: 1558–1562
  • Mehra R. K., Mulchandani P. ldquo;Glutathione-mediated transfer of Cu(I) into phytochelatins”. Biochem. J. 1995; 307: 697–705
  • Mercer J. F. B., Grimes A. Variation in the amounts of hepatic copper, zinc and metallothionein mRNA during development in the rat. Biochem. J. 1986; 238: 23–27
  • Michalopoulos G. K., Appasamy R. Metabolism of HGF-SF and its role in liver regeneration. Hepatocyte Growth Factor-Scatter Factor (HGF-SF) and the c-Met Receptor, I. D. Goldberg, E. M. Rosen. Birkhauser Verlag, Basel 1993; 275–283
  • Michalopoulos G. K. ldquo;Liver regeneration: Molecular mechanisms of growth control”. FASEB J. 1990; 4: 176–187
  • Michalska A. E., Choo K. H. A. ldquo;Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse”. Proc. Natl. Acad. Sci. USA 1993; 90: 8088–8092
  • Min K.-S., Mukai S., Ohta M., Onosaka S., Tanaka K. ldquo;Glucocorticoid inhibition of inflammation-induced metallothionein synthesis in mouse liver”. Toxicol. Appl. Pharmacol. 1992; 113: 293–298
  • Min K.-S., Nakatsubo T., Fujita Y., Onosaka S., Tanaka K. ldquo;Degradation of cadmium metallothionein in vitro by lysosomal proteases”. Toxicol. Appl. Pharmacol. 1992; 113: 299–305
  • Min K.-S., Terano Y., Onosaka S., Tanaka K. ldquo;Induction of hepatic metallothionein by nonmetallic compounds associated with acute-phase response in inflammation”. Toxicol. Appl. Pharmacol. 1991; 111: 152–162
  • Min K.-S., Terano Y., Onosaka S., Tanaka K. ldquo;Induction of metallothionein synthesis by menadione or carbon tetrachloride is independent of free radical production”. Toxicol. Appl. Pharmacol. 1992; 113: 74–79
  • Moffatt P., Lachapelle M., Plaa G. L., Denizeau F. Induction and localization of metallothionein in isolated rat hepatocytes exposed to zinc and epidermal growth factor. Proceedings of the Third International Symposium on Metal Ions in Biology and Medicine, P. Collery, L. A. Poirier, N. A. Littlefield, J.-C. Etienne. John Libbey Eurotext, Montrouge 1994; 577–582
  • Moffatt P., Marion M., Denizeau F. ldquo;Cadmium-2-acetylaminofluorene interaction in isolated rat hepatocytes”. Cell Biol. Toxicol. 1992; 8: 277–290
  • Moffatt P., Plaa G. L., Denizeau F. Rat hepatocytes with elevated metallothionein expression are resistant to N-methyl-N-nitro-N-nitrosoguanidine cytotoxicity. Toxicol. Appl. Pharmacol. 1996; 136: 200–207
  • Moffatt P., Plaa G. L., Denizeau F. ldquo;Induction of metallothionein gene expression by epidermal growth factor and its inhibition by transforming growth factor-β and dexamethasone in rat hepatocytes”. Hepatology 1995; 21: 1038–1044
  • Monia B. P., Butt T. R., Ecker D. J., Mirabelli C. K., Crooke S. T. ldquo;Metallothionein turnover in mammalian cells”. J. Biol. Chem. 1986; 261: 10957–10959
  • Morton K. A., Jones B. M.-J., Sohn H., Datz F. L., Lynch R. E. ldquo;Enrichment for metallothionein does not confer resistance to cisplatin in transfected NIH/3T3 cells”. J. Pharmacol. Exp. Ther. 1993; 267: 697–702
  • Mueller P. R., Salser S. J., Wold B. Constitutive and metal-inducible protein:DNA interactions at the mouse metallothionein I promoter examined by in vivo and in vitro footprinting. Genes Develop 1988; 2: 412–427
  • Mulder T. P. J., Janssens A. R., Verspaget H. W., van Hattum J. C., Lamers B. H. W. Metallothionein concentration in the liver of patients with Wilson's disease, primary biliary cirrhosis, and liver metastasis of colorectal cancer. J. Hepatol. 1992; 16: 346–350
  • Muller R., Mumberg D., Lucibello F. C. ldquo;Signals and genes in the control of cell-cycle progression”. Biochim. Biophys. Acta 1993; 1155: 151–179
  • Murphy D., Mc Gown A. T., Crowther D., Mander A., Fox B. W. ldquo;Metallothionein levels in ovarian tumours before and after chemotherapy”. Br. J. Cancer 1991; 63: 711–714
  • Nagel W. W., Vallee B. L. ldquo;Cell cycle regulation of metallothionein in human colonic cancer cells”. Proc. Natl. Acad. Sci. USA 1995; 92: 579–583
  • Nartey N., Cherian M. G., Banerjee D. ldquo;Immunohistochemical localization of metallothionein in human thyroid tumors”. Am. J. Pathol. 1987; 129: 177–182
  • Nebes V. L., De Franco D., Morris S. M. ldquo;Cyclic AMP induces metallothionein gene expression in rat hepatocytes but not in rat kidney”. Biochem. J. 1988; 255: 741–743
  • Nemer M., Travaglini E. C., Rondinelli E., D'Alonzo J. Developmental regulation, induction and embryonic tissue specificity of sea urchin metallothionein gene expression. Dev. Biol. 1984; 102: 471–482
  • Nettesheim D. G., Engeseth H. R., Otvos J. D. ldquo;Products of metal exchange reactions of metallothionein”. Biochemistry 1985; 24: 6744–6751
  • Nielson K. B., Atkin C. L., Winge D. R. ldquo;Distinct metal-binding configurations in metallothionein”. J. Biol. Chem. 1985; 260: 5342–5350
  • Nielson K. B., Winge D. R. ldquo;Order of metal binding in metallothionein”. J. Biol. Chem. 1983; 258: 13063–13069
  • Nielson K. B., Winge D. R. ldquo;Preferential binding of copper to the a domain of metallothionein”. J. Biol. Chem. 1984; 259: 4941–4946
  • Niknahad H., O'Brien P. J. Cytotoxicity induced by N-methyl-N-nitro-N-nitrosoguanidine may involve S-nitrosyl glutathione and nitric oxide. Xenobiotica 1995; 25: 91–101
  • Nishimura H., Nishimura N., Tohyama C. ldquo;Immunohistochemical localization of metallothionein in developing rat tissues”. J. Histochem. Cytochem. 1989; 37: 715–722
  • Oestreicher P., Cousins R. J. ldquo;Copper and zinc absorption in the rat: mechanism of mutual antagonism”. J. Nutr. 1985; 115: 159–166
  • Oh S. H., Deagen J. T., Whanger P. D., Weswig P. H. Biological function of metallothionein. V. Its induction in rats by various stresses. Am. J. Physiol. 1978; 234: E282–E285
  • Ohtake H., Hasegawa K., Koga M. Zinc-binding protein in the livers of neonatal, normal and partially hepatectomized rats. Biochem. J. 1978; 174: 999–1005
  • Olsson P.-E., Kling P., Erkell L. J., Kille P. ldquo;Structural and functional anlaysis of the rainbow trout (Oncorhyncus mykiss) metallothionein-A gene”. Eur. J. Biochem. 1995; 230: 344–349
  • Onosaka S., Cherian M. G. ldquo;The induced synthesis of metallothionein in various tissues of rat in response to metals. I. Effect of repeated injection of cadmium salts”. Toxicology 1981; 22: 91–101
  • Onosaka S., Cherian M. G. The induced synthesis of metallothionein in various tissues of rats in response to metals. II. Influence of zinc status and specific effect on pancreatic metallothionein. Toxicology 1982; 23: 11–20
  • Onosaka K.-S., Min S., Fukuhara C., Tanaka S.-K., Tashiro I., Shimizu I., Furuta M., Yasutomi T., Kobashi K., Yamamoto K. I. ldquo;Concentrations of metallothionein and metals in malignant and non-malignant tissues in human liver”. Toxicology 1986; 38: 261–268
  • Otsuka F., Iwamatsu A., Suzuki K., Ohsawa M., Hamer D. H., Koizumi S. ldquo;Purification and characterization of a protein that binds to metal responsive elements of the human metallothionein IIA gene”. J. Biol. Chem. 1994; 269: 23700–23707
  • Otvos J. D., Engeseth H. R., Wehrli S. Preparation and 113Cd NMR studies of homogeneous reconstituted metallothionein: reaffirmation of the two-cluster arrangement of metals. Biochemistry 1985; 24: 6735–6740
  • Otvos J. D., Liu X., Li H., Shen G., Basti M. Dynamic aspects of metallothionein structure. Metallothioein III, Biological Roles and Medical Implications, K. T. Suzuki, N. Imura, M. Kimura. Birkhauser Verlag, Basel 1993; 57–74
  • Palmiter R. D., Findley S. D., Whitmore T. E., Durnam D. M. MT-III, a brain-specific member of the metallothionein gene family. Proc. Natl. Acad. Sci. USA 1992; 89: 6333–6337
  • Palmiter R. D. Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-1. Proc. Natl. Acad. Sci. USA 1994; 91: 1219–1223
  • Palumaa P., Mackay E. A., Vasak M. ldquo;Nonoxidative cadmium-dependent dimerization of Cdr MT from rabbit liver”. Biochemistry 1992; 31: 2181–2186
  • Pande J., Vasak M., Kagi J. H. R. ldquo;Interaction of lysine residues with the metal thiolate clusters in metallothionein”. Biochemistry 1985; 24: 6717–6722
  • Panemangalore M., Banerjee D., Onosaka S., Cherian M. G. ldquo;Changes in the intracellular accumulation and distribution of metallothionein in rat liver and kidney during postnatal development”. Dev. Biol. 1983; 97: 95–102
  • Philcox J. C., Coyle P., Michalska A., Choo K. H. A., Rofe A. M. ldquo;Endotoxin-induced inflammation does not cause hepatic zinc accumulation in mice lacking metallothionein gene expression”. Biochem. J. 1995; 308: 543–546
  • Piletz J. E., Andersen R. D., Birren B. W., Herschman H. R. Metallothionein synthesis in foetal, neonatal and maternal rat liver. Eur. J. Biochem. 1983; 131: 489–495
  • Piscator M. ldquo;On cadmium in normal human kidneys together with a report on the isolation of metallothionein from livers of cadmium-exposed rabbits”. Nord. Hyg. Tikskr. 1964; 45: 76–82
  • Presta A., Green A. R., Zelazowski A., Stillman M. J. Copper binding to rabbit liver metallothionein. Formation of a continuum of copper(I)-thiolate stoichiometric species. Eur. J. Biochem. 1995; 227: 226–240
  • Pryor W. A.G. L. Squadrito, The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am. J. Physiol. 1995; 268: L699–L722
  • Quaife C., Hammer R. E., Mottet N. K., Palmiter R. D. ldquo;Glucocorticoid regulation of metallothionein during murine development”. Dev. Biol. 1986; 118: 549–555
  • Quaife C. J., Findley S. D., Erickson J. C., Froelick G. J., Kelly E. J., Zambrowicz B. P., Palmiter R. D. ldquo;Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia”. Biochemistry 1994; 33: 7250–7259
  • Radtke F., Heuchel R., Georgiev O., Hergersberg M., Gariglio M., Dembic Z., Schaffner W. ldquo;Cloned transcription factor MTF-1 activates the mouse metallothionein-I promoter”. EMBO J. 1993; 12: 1355–1362
  • Rhodes D., Klug A. ldquo;Zinc fingers”. Sci. Am. 1993; 268: 56–65
  • Robbins A. H., Mc Ree D. E., Williamson M., Collett S. A., Xuong N. H., Furey W. F., Wang B. C., Stout C. D. Refined crystal structure of Cd, Zn metallothionein at 2.0 Å resolution. J. Mol. Biol. 1991; 221: 1269–1293
  • Roberts S. A., Schnell R. C. ldquo;Cadmium-induced inhibition of hepatic drug oxidation in the rat: Time dependency of tolerance development and metallothionein synthesis”. Toxicol. Appl. Pharmacol. 1982; 64: 42–51
  • Robson T., Hall A., Lohrer H. ldquo;Increased sensitivity of a Chinese hamster ovary cell line to alkylating agents after over-expression of the human metallothionein II-A gene”. Mutat. Res. 1992; 274: 177–185
  • Samson L.-S. A., Gedamu L. ldquo;Metal-responsive elements of the rainbow trout metallothionein-B gene function for basal and metal-induced activity”. J. Biol. Chem. 1995; 270: 6864–6871
  • Schilder R. J., Hall L., Monks A., Handel L. M., Fornace A. J., Jr, Ozols R. F., Fojo A. T., Hamilton T. C. ldquo;Metallothionein gene expression and resistance to cisplatin in human ovarian cancer”. Mt. J. Cancer 1990; 45: 416–422
  • Schmidt C. J., Hamer D. H. ldquo;Cell specificity and an effect of ras on human metallothionein gene expression”. Proc. Natl. Acad. Sci. USA 1986; 83: 3346–3350
  • Schroeder J. J., Cousins R. J. ldquo;Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte mono-layer cultures”. Proc. Natl. Acad. Sci. USA 1990; 87: 3137–3141
  • Schwarz M. A., Lazo J. S., Yalowich J. C., Allen W. P., Whitmore M., Bergonia H. A., Tzeng E., Billiar T. R., Robbins P. D., Lancaster J. R., Jr, Pitt B. R. ldquo;Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide”. Proc. Natl. Acad. Sci. USA 1995; 92: 4452–4456
  • Schwarz M. A., Lazo J. S., Yalowich J. C., Reynolds I., Kagan V. E., Tyurin Y.-V., Kim M., Watkins S. C., Pitt B. R. ldquo;Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity”. J. Biol. Chem. 1994; 269: 15238–15243
  • Seagrave J. C., Tobey R. A., Hildebrand C. E. ldquo;Zinc effects on glutathione metabolism relationship to zinc-induced protection from alkylating agents”. Biochem. Pharmacol. 1983; 32: 3017–3021
  • Searle P. F. ldquo;Zinc dependent binding of a liver nuclear factor to metal response element MRE-a of the mouse metallothionein-I gene and variant sequences”. Nucleic Acids Res. 1990; 18: 4683–4690
  • Seguin C., Felber B. K., Carter A. D., Hamer D. H. ldquo;Competition for cellular factors that activate metallothionein gene transcription”. Nature 1984; 312: 781–785
  • Stennard F. A., Holloway A. F., Hamilton J., West A. K. ldquo;Characterisation of six additional human metallothionein genes”. Biochim. Biophys. Acta 1994; 1218: 357–365
  • Sternlieb I. ldquo;Perspectives on Wilson's disease”. Hepatology 1990; 12: 1234–1239
  • Stuart G. W., Searle P. F., Chen H. Y., Brinster R. L., Palmiter R. D. ldquo;A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene”. Proc. Natl. Acad. Sci. USA 1984; 81: 7318–7322
  • Stuart G. W., Searle P. F., Palmiter R. D. ldquo;Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences”. Nature 1985; 317: 828–831
  • Suzuki K. T., Kuroda T. Transfer of copper and zinc from ionic and metallothionein-bound forms to Cu,Zn-superoxide dismutase. Res. Commun. Mol. Pathol. Pharmacol. 1995; 87: 287–296
  • Tam Y. C., Chopra A., Hassan M. J.-P. Thirion, Cloning, nucleotide sequence and characterization of a New Zealand rabbit metallothionein-I gene. Biochem. Biophys. Res. Commun. 1988; 153: 209–216
  • Tamai K. T., Gralla E. B., Ellerby L. M., Valentine J. S., Thiele D. J. ldquo;Yeast and mammalian metallothioneins functionally substitute for years copper-zinc superoxide dismutase”. Proc. Natl. Acad. Sci. USA 1993; 90: 8013–8017
  • Taplitz S. J., Calame K. L., Herschman H. R. ldquo;Alternative inducers of the rat metallothionein I gene cause distinct changes in chromatin structure in the 5 region of the gene”. Mol. Cell. Biol. 1986; 6: 2576–2581
  • Templeton D. M., Banerjee D., Cherian M. G. ldquo;Metallothionein synthesis and localization in relation to metal storage in rat liver during gestation”. Can. J. Biochem. Cell Biol. 1985; 63: 16–22
  • Thiele D. J. ldquo;Metal-regulated transcription in eukaryotes”. Nucleic Acids Res. 1992; 20: 1183–1191
  • Thomas J. P., Bachowski G. J., Girotti A. W. ldquo;Inhibition of cell membrane lipid peroxidation by cadmum- and zinc-metallothioneins”. Biochim. Biophys. Acta 1986; 884: 448–461
  • Thornalley P. J., Vasak M. ldquo;Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals”. Biochim. Biophys. Acta 1985; 827: 36–44
  • Tohyama C., Suzuki J. S., Hemelraad J., Nishimura N., Nishimura H. ldquo;Induction of metallothionein and its localization in the nucleus of rat hepatocytes after partial hepatectomy”. Hepatology 1993; 18: 1193–1201
  • Tsujikawa K., Imai T., Kakutani M., Kayamori Y., Mimura T., Otaki N., Kimura M., Fukuyama R., Shimizu N. ldquo;Localization of metallothionein in nuclei of growing primary cultured adult rat hepatocytes”. FEBS Lett. 1991; 283: 239–242
  • Tsujikawa K., Suzuki N., Sagawa K., Itoh M., Sugiyama T., Kohama Y., Otaki N., Kimura M., Mimura T. ldquo;Induction and subcellular localization of metallothionein in regenerating rat liver”. Eur. J. Cell Biol. 1994; 63: 240–246
  • Uchida Y., Takio K., Titani K., Ihara Y., Tomanaga M. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. Neuron 1991; 7: 337–347
  • Udom A. O., Brady F. O. ldquo;Reactivation in vitro of zinc-requiring apo-enzymes by rat liver zinc-thionein”. Biocheim. J. 1980; 187: 329–335
  • Vallee B. L., Falchuk K. H. ldquo;The biochemical basis of zinc physiology”. Physiol. Rev. 1993; 73: 79–118
  • Vander Mallie R. J., Garvey J. S. Production and study of antibody produced against rat cadmium thionein. Immunochemistry 1978; 15: 857–868
  • Waalkes M. P., Diwan B. A., Weghorst C. M., Ward J. M., Rice J. M., Cherian M. G., Goyer R. A. ldquo;Further evidence of the tumor-suppressive effects of cadmium in the B6C3F1 mouse liver and lung: Late stage vulnerability of tumors to cadmium and the role of metallothionein”. J. Pharmacol. Exp. Ther. 1993; 266: 1656–1663
  • Waalkes M. P., Klaassen C. D. ldquo;Concentration of metallothionein in major organs of rats after administration of various metals”. Fundam. Appl. Toxicol. 1985; 5: 473–477
  • Waalkes M. P., Klaassen C. D. ldquo;Postnatal ontogeny of metallothionein in various organs of the rat”. Toxicol. Appl. Pharmcaol. 1984; 74: 314–320
  • Wan X., Lachapelle M., Marion M., Fournier M., Denizeau F. ldquo;Recovery potential of hepatocytes from inhibition of albumin secretion by cadmium”. J. Toxicol. Environ. Health 1993; 38: 381–392
  • Wang X., Lee G., Liebhaber S. A., Cooke N. E. ldquo;Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc”. J. Biol. Chem. 1992; 267: 9176–9184
  • Watanabe K., Hasegawa K., Ohtake H., Tohyama C., Koga M. ldquo;Inhibition of DNA synthesis by EDTA and its cancellation by zinc in primary cultures of adult rat hepatocytes”. Biomed. Res. 1993; 14: 99–110
  • Webb M. ldquo;Binding of cadmium ions by rat liver and kidney”. Biochem. Pharmacol. 1972; 21: 2751–2765
  • Webb M. Metallothionein in regeneration, reproduction and development. Experientia 1987, Suppl. 52: 483–498
  • Webb M. ldquo;Protection by zinc against cadmium toxicity”. Biochem. Pharmacol. 1972; 21: 2767–2771
  • Webber M. M., Maseehur Rehman S. M., James G. T. ldquo;Metallothionein induction and deinduction in human prostatic carninoma cells: Relationship with resistance and sensitivity to Adriamycin”. Cancer Res. 1988; 48: 4503–4508
  • West A. K., Stallings R., Hildebrand C. E., Chiu R., Karin M., Richards R. I. ldquo;Human metallothionein genes: Structure of the functional locus at 16q13”. Genomics 1990; 8: 513–518
  • Westin G., Schaffner W. ldquo;A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene”. EMBO J. 1988; 7: 3763–3770
  • Williams L. M., Cunningham H., Ghaffar A., Riddoch G. I., Bremner I. ldquo;Metallothionein immunoreactivity in the liver and kidney of copper injected rats”. Toxicology 1989; 55: 307–316
  • Williams T., Tjian R. ldquo;Analysis of the DNA-binding and activation properties of the human transcription factor AP-2”. Genes Develop. 1991; 5: 670–682
  • Winge D. R., Miklossy K.-A. ldquo;Differences in the polymorphic forms of metallothionein”. Arch. Biochem. Biophys. 1982; 214: 80–88
  • Yagle M. K., Palmiter R. D. ldquo;Coordinate regulation of mouse metallothionein I and II genes by heavy metals and glucocorticoids”. Mol. Cell. Biol. 1985; 5: 291–294
  • Yang J., Cherian M. G. ldquo;Protective effects of metallothionein on streptozotocin-induced diabetes in rats”. Life Sci. 1994; 55: 43–51
  • Yasuda H., Mine T., Shibata H., Eto Y., Hasegawa Y., Takeuchi T., Asano S., Kojima I. ldquo;Activin-A: An autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes”. J. Clin. Invest. 1993; 92: 1491–1496
  • Zelger B., Hittmair A., Schir M., Ofner C., Ofner D., Fritsch P. O., Bocker W., Jasani B., Schmid K. W. ldquo;Immunohistochemically demonstrated metallothionein expression in malignant melanoma”. Histopathology 1993; 23: 257–264
  • Zeng J., Heuchel R., Schaffner W., Kagi J. H. R. ldquo;Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Sp 1”. FEBS Lett. 1991; 279: 310–312
  • Zeng J., Vallee B. L., Kagi J. H. R. ldquo;Zinc transfer from transcription factor IIIA fingers to thionein clusters”. Proc. Natl. Acad. Sci. USA 1991; 88: 9984–9988

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