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Review Article

Olestra, a Nonabsorbed, Noncaloric Replacement for Dietary Fat: A Review

, &
Pages 651-703 | Published online: 15 Feb 2010

References

  • Schneeman B. Fats in the diet: Why and where?. Fd. Tech. 1986; 40: 115–120
  • Cooper H. R. Texture in diary products and its sensory evaluation. Food Texture, H. R. Moskowitz. Marcel Dekker, New York 1987; 217–250
  • Committee on Diet and Health. Food and Nutrition Board, Commission on Life Sciences, Diet and Health, Implications for Reducing Chronic Disease Risk. National Academy Press, Washington, DC 1989
  • American Heart Association. Position statement. Dietary guidelines for healthy American adults. A statement for physicians and health professionals by the nutrition community. Circulation 1986; 74: 1465A–1468A
  • Butrum R. T., Clifford C. K., Lanza E. MCI dietary guidelines: rationale. Am. J. Clin. Nutr. 1988; 48: 888–895
  • Department of Health and Human Services. The Surgeon General's Report on Nutrition and Health. Public Health Service, Washington, DC 1988, Pub. PHS 88–50210
  • American Dietetic Association. Position of the American Dietetic Association: Fat replacements. J. Am. Diet. Assoc. 1991; 91: 1285–1288
  • Editorial, Dietary fat intake down, but still above goal. Milling & Baking News. March 8, 1994; 10
  • Block G., Dresser C. M., Hartman A. M., Carroll M. D. Nutrient sources in the American diet: Quantitative data from the NHANES II study. Am. J. Epidemiol. 1985; 122: 27–40
  • Lenfant C., Erast N. Daily dietary fat and total food-energy intakes—Third National Health and Nutrition Examination Survey, Phase 1, 1988–91. Morb. Mortal. Wkly. Rep. 1994; 43: 116–117; 123–125
  • Kuczmarski R. J., Flegal K. M., Campbell S. M., Johnson C. L. Increasing prevalence of overweight among US adults, the National Health and Nutrition Examinations Surveys, 1960 to 1991. JAMA 1994; 272: 205–211
  • Mela D. J. The basis of dietary fat preferences. Trends Fd. Sci. Tech. 1990; 1: 71–73
  • Dolecek T. A., Milas N. C., Horn L. V., Farrand M. E., Gorder D. D., Duchene A. G., Dyer J. R., Stone P. A., Randall B. L. A long-term nutrition intervention experience: lipid responses and dietary adherence patterns in the Multiple Risk Factor Intervention Trial. J. Am. Diet. Assoc. 1986; 86: 752–758
  • Dunbar J. Practical aspects of dietary management of hypertension: compliance. Can. J. Phys. Pharmacol. 1986; 64: 831–835
  • Thuesen L., Henriksen L. B., Engby B. One-year experience with a low-fat, low-cholesterol diet in patients with coronary heart disease. Am. J. Clin. Nutr. 1986; 44: 212–219
  • Bernhardt C. A. Olestra—A non-caloric fat replacement. Food Tech. Intl. (Eur.) 1988; 1988: 176–178
  • Haumann B. F. Fat replacers: Here's a list of who's producing what. INFORM 1992; 3: 1284–1287
  • Rizzi G. P., Taylor H. M. A solvent-free synthesis of sucrose polyester. JAOCS 1978; 55: 398–401
  • Kester J. J. Food product development using olestra as a fat substitute, in Science for the Food Industry of the 21st Century. Biotechnology, Supercritical Fluids, Membrane and Other Advanced Technologies for Low Calorie, Healthy Food Alternatives, M. Yalpani. ATL Press, Mount Prospect, IL 1993; 37–50
  • Formo M. W., Jungermann E., Norris F. A., Sonntag N. O. Physical properties of fats and fatty acids. Bailey's Industrial Oil and Fat Products, D. Swern. Wiley, New York 1979; 177–232
  • Rios J. J., Perez-Camino M. C., Marquez-Ruis G., Dobarganes M. C. Comparison of oxidation of sucrose octaesters and triacylglycerols derived from olive oil. Food Chem. 1992; 44: 357–362
  • Gardner D. R., Sanders R. A. Isolation and characterization of polymers in heated olestra and an olestra/triglyercide blend. JAOCS 1990; 67: 788–796
  • Gardner D. R., Sanders R. A., Henry D. E., Tallmadge D. H., Wharton H. W. Characterization of used frying oils. I. Isolation and identification of compound classes. JAOCS 1992; 69: 499–508
  • Henry D. E., Tallmadge D. H., Sanders R. A., Gardner D. R. Characterization of used frying oils. Part 2: Comparison of olestra and triglyceride. JAOCS 1992; 69: 509–519
  • Jandacek R. J., Webb M. R. Physical properties of pure sucrose octaesters. Chem. Phys. Lipids 1978; 22: 163–176
  • Glueck C. J., Mattson F. H., Jandacek R. J. The lowering of plasma cholesterol by sucrose polyester in subjects consuming diets with 800, 300, or less than 50 mg of cholesterol per day. Am. J. Clin. Nutr. 1979; 32: 1636–1644
  • Fallat R. W., Glueck C. J., Lutmer R., Mattson F. H. Short term study of sucrose polyester, a nonabsorbable fat-like material, as a dietary agent for lowering plasma cholesterol. Am. J. Clin. Nutr. 1976; 29: 1204–1215
  • Halmos A. L., Tiu C. Liquid foodstuffs exhibiting yield stress and shear-degradability. J. Texture Stud. 1981; 12: 39–46
  • , Food Additive Petition 7A 3997, Submitted to the U.S. Food and Drug Administration, The Procter & Gamble Company, Cincinnati, OH.
  • Webb D. R. The Procter & Gamble Co., Cincinnati, OH 1995, private communication
  • National Research Council, Committee on GRAS List Survey-Phase III. The 1977 Survey of Industry on the Use of Food Additives. Vol 3. Estimates of Daily Intake. National Academy of Sciences, Washington, DC 1979; 1755–2135
  • Cardell R. R., Badenhausen S., Porter K. R. Intestinal triglyceride absorption in the rat. An electron microscopical study. J. Cell. Biol. 1967; 54: 123–155
  • Mattson F. H., Volpenhein R. A. Hydrolysis of fully esterified alcohols containing from one to eight hydroxyl groups by the lipolytic enzymes of rat pancreatic juice. J. Lipid. Res. 1972; 13: 325–328
  • Mattson F. H., Nolen G. A. Absorbability by rats of compounds containing from one to eight ester groups. J. Nutr. 1972; 102: 1171–1176
  • Mattson F. H., Volpenhein R. A. Rate and extent of absorption of the fatty acids of fully esterified glycerol, erythriol, and sucrose as measured in thoracic duct cannulated rats. J. Nutr. 1972; 102: 1177–1180
  • Jandacek R. J., Holcombe B. N. The excretion and characterization of intravenously administered olestra. Lipids 1991; 26: 754–758
  • Mattson F. H., Jandacek R. J. Distribution among tissues of intravenously administered sucrose octaoleate. Lipids 1991; 26: 750–753
  • Wood F. E., DeMark B. R., Hollenbach E. J., Sargent M. C., Triebwasser K. C. Analysis of liver tissue for olestra following long-term feeding to rats and monkeys. Fd. Chem. Toxic. 1991; 29: 231–236
  • Miller K. W., Lawson K. D., Tallmadge D. H., Madison B. L., Okenfuss J. R., Hudson P., Wilson S., Thorstenson J., Vanderploeg B. P. Disposition of ingested olestra in the Fischer 344 rat. Fund. Appl. Toxicol. 1995; 24: 229–237
  • Miller K., Lawson K., Madison B., Tallmadge D., Hudson P., Okenfuss J., Blair M., Thorstenson J., Vanderploeg P. Absorption, distribution and elimination of olestra after oral administration in rats. Toxicologist 1992; 12: 145
  • Dahlqvist A., Thomson D. L. The digestion and absorption of sucrose by the intact rat. J. Physiol. (Lund.) 1963; 167: 193–209
  • Weser E., Sleisenger M. H. Metabolism of circulating disaccharides in man and the rat. J. Clin. Invest. 1967; 46: 499–505
  • Daher G. C., Lawson K. D., Tallmadge D. H., Blair M. M., Thorstenson J., Vanderploeg P., Miller K. W. Absorption, distribution and elimination of olestra after oral administration in weanling mini-pigs. 13th Annual Meeting of the American College of Toxicology, Dallas, TX, October, 28–301992
  • Miller E. R., Ullrey D. E. The pig as a model for human nutrition. Annu. Rev. Nutr. 1987; 7: 361–382
  • Moughan P. J., Mirtles M. J., Cranwell P. D., Smith W. C., Pedraza M. The piglet as a model animal for studying aspects of disgestion and absorption in milk-fed human infants. World Rev. Nutr. Diet. 1992; 67: 40–113
  • Leary H. L., Lecce J. G. Uptake of macromolecules by enterocytes on transposed and isolated small intestine. J. Nutr. 1976; 106: 419–427
  • Grand R. J., Watkins J. B., Torti F. M. Development of the human intestinal tract. Gastroenterology 1976; 70: 790–810
  • Hamosh M. Lipid metabolism in premature infants. Biol. Neonate 1979; 52(Suppl. 1)50–64
  • Daher G., Lawson K., Tallmadge D., Blair M., Miller K. Comparison of the absorption, distribution, and elimination of olestra in guinea pigs with normal and compromised gastrointestinal tracts. FASEB J. 1992; 6: A1679
  • Marcus A. J., Marcus S. N., Marcus R., Watt J. Rapid production of ulcerative disease of the colon in newly-weaned guinea pigs by degraded carrageenan. J. Pharm. Pharmacol. 1988; 41: 423–426
  • Watt J., Marcus R. Carrageenan-induced ulceration of the large intestine in the guinea pig. Gut 1971; 12: 164–171
  • U. S. Food and Drug Administration. Toxicological Principles for the Safety Assessment of Direct Food Additives and Color Additives Used in Foods. National Information Service, Springfield, VA 1982
  • Borzelleca J. F. Macronutrient substitutes: safety evaluation. Regul. Toxicol. Pharmacol. 1992; 16: 253–264
  • Munro I. Issues to be considered in the safety evaluation of fat substitutes. Fd. Chem. Toxicol. 1990; 28: 751–753
  • Bergholz C. M. Safety evaluation of olestra, a nonabsorbable fat replacement derived from fat. Food Safety Assessment, J. W. Finley, S. F. Robinson, D. J. Armstrong. American Chemical Society, Washington, DC 1992; 391–399
  • Bergholz C. M. Safety evaluation of olestra, a nonabsorbed, fatlike fat replacement. Crit. Rev. Food Sci. Nutr. 1992; 32: 141–146
  • Bergholz C. M., Jandacek R. J., Thomson A. B. R. Review of laboratory and clinical studies of olestra, a nonabsorbable lipid. Can. J. Gastroenterol. 1991; 5: 137–146
  • Miller K. W., Long P. H. A 91-day feeding study in rats with heated olestra/vegetable oil blends. Fd. Chem. Toxicol. 1990; 28: 307–315
  • Wood F. E., Tierney W. J., Knezevich A. L., Bolte H. F., Maurer J. K., Bruce R. D. Chronic toxicity and carcinogenicity studies of olestra in Fischer 344 rats. J. Chem. Toxic. 1991; 29: 223–230
  • Miller K. W., Wood F. E., Staurd S. B., Alden C. L. A 20-month olestra feeding study in dogs. Fd. Chem. Toxicol. 1991; 29: 427–435
  • Lafranconi W. M. Ninety-one day feeding study of olestra in the mouse. 30th Annual Meeting of the Society of Toxicology, New Orleans, LA, February, 12–131991
  • Lafranconi W. M., Long P. H., Atkinson J. E., Knezevich A. L., Wooding W. L. Lack of chronic toxicity and carcinogenicity of olestra in Swiss CD-1 mice. J. Chem. Toxicol. 1994; 32: 789–798
  • Adams M., McMahan M. R., Mattson F. H., Clarkson T. B. The long-term effects of dietary sucrose polyesters on African Green monkeys. Proc. Soc. Exp. Biol. Med. 1981; 167: 346–353
  • Nolen G. A., Wood F. W., Dierckman T. A. A two-generation reproductive and developmental study of sucrose polyester. Fd. Chem. Toxicol. 1987; 25: 1–8
  • Denine E. P., Schroeder R. E. A segment II teratology study in rabbits dosed with olestra which had been used for deep frying potatoes. Toxicologist 1993; 13: 80
  • Skare K. L., Skare J. A., Thompson E. D. Evaluation of olestra in short-term genotoxicity assays. Fd. Chem. Toxicol. 1990; 28: 69–73
  • Jones D. Y., Miller K. W., Koonsvitsky B. P., Ebert M. L., Lin P. Y. T., Jones M. B., DeLuca H. F. Serum 25-hydroxyvitamin D concentrations of free-living subjects consuming olestra. Am. J. Clin. Nutr. 1991; 53: 1281–1287
  • Jones D. Y., Koonsvitsky B. P., Ebert M. L., Jones M. B., Lin P. Y. T., Will B. H., Suttie. Vitamin K status of free-living subjects consuming olestra. Am. J. Clin. Nutr. 1991; 53: 943–946
  • Grundy S. M., Anastasia J. V., Kesaniemi A., Abrams J. Influence of sucrose polyester on plasma lipoproteins and cholesterol metabolism in obese patients with and without diabetes mellitus. Am. J. Clin. Nutr. 1986; 44: 620–629
  • Geil P. B., Lawrence S. R., Anderson J. W. Effects of sucrose polyester (SPE) in patients with Type II diabetes mellitus. Annual Meeting of the American Dietetic Association, Kansas City, MO, October, 23–271989
  • Mellies M. J., Jandacek R. J., Taube J. D., Tewksbury M. B., Lamkin G., Baehler L., King P., Boggs D., Goldman S., Gouge A., Tsang R., Glueck C. J. A double-blind placebo-controlled study of sucrose polyester in hypercholesterolemic outpatients. Am. J. Clin. Nutr. 1983; 37: 339–346
  • Miller K. W., Williams D. S., Carter S. B., Jones M. G., Mishell D. R. The effect of olestra on systemic levels of oral contraceptives. Clin. Pharmacol. Ther. 1990; 48: 34–40
  • Koonsvitsky B. P., Jones D. Y., Berry D. A., Jones M. B. Status of vitamins E, D, and K in free-living subjects consuming olestra. Am. J. Clin. Nutr. 1991; 53: P21
  • Schlagheck T., McEdwards J., Riccardi K., Zorich N., Jones M., King D., Peters J., Dugan L., Torri S., Davidson M. Effect of olestra on nutritional status in man. FASEB J. 1994; 8: A933
  • Daher G., Cooper D., Riccardi K., Zorich N., King D., Marks P., Peters J. The effect of olestra on retinyl palmitate absorption in man. FASEB J. 1994; 8: A443
  • Zorich N., Daher G., Cooper D., Riccardi K., King D., Marks P., Peters J. The effect of olestra on triglyceride absorption. FASEB J. 1994; 8: A735
  • Zorich N. L., Carter S. B., McEdwards J. M., Bayless T. M. Safety of olestra in patients with inflammatory bowel disease. Gastroenterology 1994; 106: A796
  • Curry C. E. J. Handbook of Nonprescription Drugs. American Pharmaceutical Association, Washington, DC 1986; 75–97
  • Federation of American Societies of Experimental Biologists. Physiological Effects and Health Consequences of Dietary Fiber. Life Sciences Research Office, Bethesda, MD 1987; 1–236
  • Lipsky H., Gloger M., Frishman W. H. Dietary fiber for reducing blood cholesterol. J. Clin. Pharmacol. 1990; 30: 699–703
  • Becker D. J., Sinclair J., Castell D. O., Wu W. C. A comparison of high and low fat meals on postprandial esophageal acid expo-sure. Am. J. Gastroenterol. 1989; 84: 782–786
  • Nebel O., Castell D. Inhibition of the lower oesophageal sphincter by fat: A mechanism for fatty food intolerance. Gut 1973; 14: 270–274
  • Just R., Katz L., Verhille M., Schlagheck T., Castell D. A comparison of the effect of olestra and triglyceride on postprandial esophageal acid exposure. Am. J. Gastroenterol. 1993; 88: 1734–1737
  • Cortot A., Phillips S. F., Malagelda J. R. Gastric emptying of liquid after ingestion of a solid-lipid meal in humans. Gastroenterology 1981; 80: 922–927
  • Cortot A., Phillips S. F., Malagelada J. Parallel gastric emptying of nonhydrolysable fat and water after a solid-liquid meal in humans. Gastroenterology 1982; 82: 877–881
  • Aggarwal A. M., Camilleri M., Phillips S. F., Schlagheck T. G., Brown M. L., Thomforde G. M. Olestra, a nondigestible, nonabsorbable fat. Effects on gastrointestinal and colonic transit. Dig. Dis. Sci. 1993; 38: 1009–1014
  • Hager M. H., Schneeman B. O. Pancreatic enzyme and plasma cholesterol response to chronic ingestion of a nonabsorbable lipid in rats. J. Nutr. 1986; 116: 2372–2377
  • Jandacek R. J. The effect of nonabsorbable lipids on the intestinal absorption of lipophiles. Drug Metab. Rev. 1982; 13: 695–714
  • Jandacek R. J., Mattson F. H., McNeely S., Gallon L., Yunker R., Glueck C. J. Effect of sucrose polyester on fecal steroid excretion by 24 normal men. Am. J. Clin. Nutr. 1980; 33: 251–259
  • Mattson F. H., Hollenbach E. J., Kuehlthau C. M. The effect of a non-absorbable fat, sucrose polyester, on the metabolism of vitamin A by the rat. J. Nutr. 1979; 109: 1688–1693
  • Glueck C. J., Jandacek R. J., Subbiah M. T. R., Gallon L., Yunker R., Allen C., Hogg E., Laskarzewski P. M. Effect of sucrose polyester on fecal bile acid excretion and composition in normal men. Am. J. Clin. Nutr. 2980; 33: 2177–2181
  • Crouse J. R., Grundy S. M. Effects of sucrose polyester on cholesterol metabolism in man. Metabolism 1979; 28: 994–1000
  • Eastwood M. A., Allgood G. S. The effect of olestra on breath gas production and faecal microbial counts. Eur. J. Clin. Nutr. 1995; 49: 627–639
  • Siigur U., Norin K. E., Allgood G., Schlagheck T., Midvedt T. Effect of olestra on faecal water and short-chain fatty acids. Micro. Eco. Health Dis. 1996; 9: 9–17
  • Nuck B. A., Schlagheck T. G., Federle T. W. Inability of the human colonic microflora to metabolize the nonabsorbable fat substitute, olestra. J. Must. Microbiol. 1994; 13: 328–334
  • McAvoy D. C., Shimp R. J., Namkung E., Hand V. C. Fate and effects of olestra, a fat substitute, during conventional wastewater treatment. Water Environ. Res. 1996; 68: 169–177
  • Logan T. J., Harrison B. J., McAvoy D. C., Greff J. A. Effects of olestra in sewage sludge on soil physical properties. J. Environ. Qual. 1996; 24: 153–161
  • Allgood G. S., Shimp R. J., Federle T. W. Biodegradation of olestra in activated sludge and soil. 1994 Annual Meeting of the Society of Environmental Toxicology and Chemistry, Denver, CO, Oct.-Nov, 30–41994
  • Greff J. A., McAvoy D. C., Webb D. R., Allgood G. S. Fate and effects of olestra in septic tanks. 1994 Annual Meeting of the Society of Environmental Toxicology and Chemistry, Denver, CO, Oct.-Nov., 30–41994
  • Allgood G. S. Aquatic toxicity studies of olestra in bacteria, algae, zooplankton, and fish. 1994 Annual Meeting of the Society of Environmental Toxicology and Chemistry, Denver, CO, Oct.-Nov., 30–41994
  • Allgood G. S. Terrestrial toxicity studies of olestra: Effects on plan seedling growth and on earthworms. 1994 Annual Meeting of the Society of Environmental Toxicology and Chemistry, Denver, CO, Oct.-Nov., 30–41994
  • Overcash M. R., Versteeg D. J., Koewer J., Li Y., Li P. Plant growth response to olestra as related to beneficial use of municipal sludge. Arch. Environ. Contam. Tox. 1994; 26: 408–414
  • Hofmann A. F., Borgrstrom B. Physico-chemical state of lipids in intestinal content during digestion and absorption. Fed. Proc. 1966; 21: 43–50
  • Kuksis A. Absorption of fat-soluble vitamins. Fat Absorption, A. Kuksis. CRC Press, Boca Raton, FL 1987; Vol. II: 65–86
  • Chou J. T., Jurs P. C. Computation of partition coefficients from molecular structures by a fragment addition method. Physical Chemical Properties of Drugs, S. H. Yalkowsky, A. A. Sinkula, S. C. Valvani. Marcel Dekker, New York 1980; 163–199
  • Roberts R. J., Leff R. D. Influence of absorbable and nonabsorbable lipids and lipidlike substances on drug bioavailability. Clin. Pharmacol., Ther. 1989; 45: 299–304
  • Cooper D., Berry D., Jones M., Spendel V., Peters J., King D., Aldridge D., Kiorpes A. An assessment of the nutritional effects of olestra in the domestic pig. FASEB J. 1994; 8: A191
  • St Clair R. W., Wood L. L., Clarkson T. B. Effect of sucrose polyester on plasma lipids and cholesterol absorption in African Green monkeys with variable hypercholesterolemic response to dietary cholesterol. Metabolism 1981; 30: 176–183
  • Mattson F. H., Jandacek R. J., Webb M. R. The effect of a nonabsorbable lipid, sucrose polyester, on the absorption of dietary cholesterol by the rat. J. Nutr. 1976; 106: 747–752
  • Jandacek R. J., Ramirez M. M., Crouse J. R. Effects of partial replacement of dietary fat by olestra on dietary cholesterol absorption in man. Metabolism 1990; 39: 848–852
  • Mellies M. J., Vitale C., Jandacek R. J., Lamkin G., Glueck C. J. The substitution of sucrose polyester for dietary fat in obese, hypercholesterolemic outpatients. Am. J. Clin. Nutr. 1985; 41: 1–12
  • Glueck C. J., Hastings M. M., Allen C., Hogg R. D., Baehler B. A., Gartside P. S., Phillips D., Jones M., Hollenbach E. J., Braun B., Anastasia J. V. Sucrose polyester and covert caloric dilution. Am. J. Clin. Nutr. 1982; 35: 1352–1359
  • National Research Council. Nutrient Requirements of Swine. National Academy Press, Washington, DC 1988
  • Weststrate J. A., van het Hof K. H. Sucrose polyester and plasma carotenoid concentrations in healthy humans. Am. J. Clin. Nutr. 1995; 62: 591–596
  • Cooper D. A. The Procter & Gamble Co. 1996, private communication
  • Olson J. A. Recommended dietary intakes (RDI) of vitamin A in humans. Am. J. Clin. Nutr. 1987; 45: 704–716
  • Block G., Petterson B., Subar A. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence. Ntr. Cancer 1992; 18: 1–29
  • Burton G. W., Ingold K. U. β-Carotene: An unusual type of lipid antioxidant. Science 1984; 224: 569–573
  • Linscheer W. G., Vergrosen A. J. Lipids. Modern Nutrition in Health and Disease, 17th ed., M. E. Shils, V. R. Young. Lea & Febiger, Philadelphia 1988; 74–85
  • Sies H., Krinsky N. I. The present status of antioxidant vitamins and β-carotene. Am. J. Clin. Nutr. 1995; 62(Suppl.)1299S–1300S
  • Department of Health, London 1993; 88–89, Committee on Medical Aspects of Food Policy. Dietary reference values for food endergy and nutrients for the United Kingdom. Report of the Panel on Dietary Reference Values of the Committee on Medical Aspects of Food Policy
  • Halliwell B. Free radicals antioxidants, and human disease: curiosity, cause, or consequence?. Lancet 1994; 334: 721–724
  • Hennekens C. H., Buring J. E., Manson J. E., Stampfer M., Rosner B., Cook N. R., Belanger C., LaMotte F., Gaziano J. M., Ridker P. M., Willett W., Peto R. Lack of effect of long-term supplementation with β-carotene on the incidence of malignant neoplasms and cardiovascular disease. N. Engl. J. Med. 1996; 334: 1145–1149
  • Omenn G. S., Goodman G. E., Thronquist M. D., Balmes J., Cullen M. R., Glass A., Keogh J. P., Meyskens F. L., Valanis B., Williams J. H., Barnhart S., Hammar S. Effects of a combination of β-carotene and vitamin A on lung cancer and cardiovascular disease. N. Engl. J. Med. 1996; 334: 1150–1155
  • The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group, The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 1994; 330: 1029–1035
  • Greenburg E. R., Baron J. A., Tosteson T. D., Freeman D. H., Beck G. J., Bond J. H., Colacchio T. A., Coller J. A., Frankl H. D., Haile R. W., Mandel J. S., Nierenberg D. W., Rothstein R., Snover D. C., Stevens M. M., Summers R. W., van Stolk R. V. A clinical trial of antioxidant vitamins to prevent coloreectal adenoma. N. Engl. J. Med. 1994; 331: 141–147
  • Greenburg E. R., Baron J. A., Stukel T. A., Stevens M. M., Mandel J. S., Spencer S. J., Elias P. M., Lowe N., Nierenberg D. W., Bayrd G., Vance J. C., Freeman D. H., Clendenning W. E., Kwan T. A clinical trial of β-carotene to prevent basal-cell and squamous-cell cancers of the skin. N. Engl. J. Med. 1990; 323: 789–795
  • Ziegler R. G., Mayne S. T., Swanson C. A. Nutrition and lung cancer. Cancer Causes and Control 1996; 7: 157–177
  • van Poppel G., Goldbohm R. A. Epidemiologic evidence for β-carotene and cancer prevention. Am. J. Clin. Nutr. 1995; 62: 1393S–14025S
  • Rolls B. J., Pirraglia P. A., Jones M. B., Peters J. C. Effects of olestra, a noncaloric fat substitute, on daily energy and fat intakes in lean men. Am. J. Clin. Nutr 1992; 56: 84–92
  • Blundell J. E., Burley J. C., Peters J. C. Dietary fat and human appetite: effects of non-absorbable fat on energy and nutrients intakes. Obesity: Dietary Factors and Control, D. R. Romsos, J. Himms-Hagen, M. Suzuki. Japan Scientific Societies Press, Tokyo 1991; 3–13
  • Birch L. L., Johnson S. L., Jones M. B., Peters J. C. Effects of a nonenergy fat substitute on children's energy and macronutrient intake. Am. J. Clin. Nutr. 1993; 58: 326–333
  • Bray G. A., Sparti A., Windhauser M. M., York D. A. Effect of two weeks fat replacement by olestra on food intake and energy metabolism. FASEB J. 1995; 9: A439
  • Johnson S. L., Cooper D. A., Stone M., Seagle H., Smith S., Wyatt F., Riddardi K., Tran S., Peters J. C., Hill J. O. Effects of covert substitution of olestra on self-selected food intake. FASEB J. 1996; 10: A550
  • Sparti A., Windhauser M., Lovejoy J., Bray G. Subjects eat for carbohydrate not calories after dietary fat replacement with olestra. Am. J. Clin. Nutr. 1995; 61: 902
  • Miller D. L., Hammer V. A., Shide D. J., Peters J. C., Rolls B. J. Consumption of fat-free potato chips by obese and restrained males and females. FASEB J. 1995; 9: 3
  • Kendall A., Levitsky D. A., Strupp B. J., Lissner L. Weight loss on a low-fat diet: Consequence of the imprecision of the control of food intake in humans. Am. J. Clin. Nutr. 1991; 53: 1124–1129
  • Lissner L., Levitsky D. A., Strupp B. J., Kalkwarf H. J., Roe D. A. Dietary fat and the regulation of energy intake in human subjects. Am. J. Clin. Nutr. 1987; 46: 886–892
  • Hulshof T. Fat and non-absorbable fat and the regulation of food intake. Ph.D. theseis, Wageningen Agricultural University, The Netherlands 1994
  • Birch L. L., Deysher M. Caloric compensation and sensory specific satiety: evidence for self-regulation of food intake by young children. Appetite 1986; 7: 323–331
  • Miller D. L., Hammer V. A., Peters J. C., Rolls B. J. Influence of the fat content of a food on sensory-specific satiety. FASEB J. 1996; 10: A824
  • Birch L. L., Johnson S. L., Andresen G., Peters J. C., Schulte M. The variability of young children's energy and macronutrient intake. N. Engl. J. Med. 1991; 324: 232–235
  • Peters J. C. The Procter & Gamble Co. 1996, private communication
  • Bolton M. P., Pace P. W., Reeves R. S. Use of olestra products in a nutrition education program to reduce fat intake. J. Am. Diet. Assoc. 1991; 295(Suppl.)A16

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