Iron Overload, Cardiac and Other Factors Affecting Pregnancy in Thalassemia Major

REFERENCES

• Borgna-Pignatti C, Rugolotto S, De Stefano P, Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica. 2004;89(10):1187–1193.
   PubMed Web of Science ®Google Scholar
• Nassar AH, Usta IM, Rechdan JB, Pregnancy in patients with β-thalassemia intermedia: outcome of mothers and newborns. Am J Hematol. 2006;81(7):499–502.
   PubMed Web of Science ®Google Scholar
• Skordis N, Christou S, Koliou M, Fertility in female patients with thalassemia. J Pediatr Endocrinol Metab. 1998;11(suppl 3):935–943.
   PubMed Web of Science ®Google Scholar
• Origa R, Piga A, Quarta G, Pregnancy and β-thalassemia: an Italian multicenter experience. Haematologica. ( in press).
   Google Scholar
• Toumba M, Kanaris C, Simamonian K, Outcome and management of pregnancy in women with thalassaemia in Cyprus. East Mediterr Health J. 2008;14(3):628–635.
   PubMedGoogle Scholar
• Tuck SM. Fertility and pregnancy in thalassemia major. Ann NY Acad Sci. 2005;1054:300–307.
   PubMed Web of Science ®Google Scholar
• Aessopos A, Karabatsos F, Farmakis D, Pregnancy in patients with well-treated β-thalassemia: outcome for mothers and newborn infants. Am J Obstet Gynecol. 1999;180(2, Pt 1):360–365.
   PubMed Web of Science ®Google Scholar
• Daskalakis GJ, Papageorgiou IS, Antsaklis AJ, Pregnancy and homozygous β thalassaemia major. Br J Obstet Gynaecol. 1998;105(9):1028–1032.
   PubMedGoogle Scholar
• Kumar RM, Rizk DEE, Khuranna A. β-Thalassemia major and successful pregnancy. Reprod Med. 1997;42(5):294–298.
   PubMedGoogle Scholar
• Tampakoudis P, Tsatalas C, Mamopoulos M, Transfusion-dependent homozygous β-thalassaemia major: successful pregnancy in five cases. Eur J Obstet Gynecol Reprod Biol. 1997;74(2):127–131.
   PubMedGoogle Scholar
• Lupton M, Oteng-Ntim E, Ayida G, Cardiac disease in pregnancy. Curr Opin Obstet Gynecol. 2002;14(2):137–143.
   PubMedGoogle Scholar
• Avila WS, Rossi EG, Ramires JA, Pregnancy in patients with heart disease: experience with 1,000 cases Clin Cardiol. 2003;26(3):135–142.
   PubMed Web of Science ®Google Scholar
• Gardenghi S, Marongiu MF, Ramos P, Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. Blood. 2007;109(11):5027–5035.
   PubMed Web of Science ®Google Scholar
• Esposito BP, Breuer W, Sirankapracha P, Labile plasma iron in iron overload: redox activity and susceptibility to chelation. Blood. 2003;102(7):2670–2677.
   PubMed Web of Science ®Google Scholar
• Aessopos A, Fragodimitri C, Karabatsos F, Cardiac magnetic resonance imaging R2* assessments and analysis of historical parameters in patients with transfusion-dependent thalassemia. Haematologica. 2007;92(1):131–132.
   PubMed Web of Science ®Google Scholar
• Tanner MA, Galanello R, Dessi C, Myocardial iron loading in patients with thalassemia major on desferrioxamine chelation. J Cardiovasc Magn Reson. 2006;8(3):543–547.
   PubMed Web of Science ®Google Scholar
• Aessopos A, Berdoukas V, Tsironi M. The heart in transfusion dependent homozygous thalassaemia today–prediction, prevention and management. Eur J Haematol. 2008;80(2):93–106.
   PubMedGoogle Scholar
• Aessopos A, Farmakis D. Pulmonary hypertension in β-thalassemia. Ann NY Acad Sci. 2005;1054:342–349.
   PubMed Web of Science ®Google Scholar
• Tanner MA, Galanello R, Dessi C, A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with desferrioxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance. Circulation. 2007;115(14):1876–1884.
   PubMed Web of Science ®Google Scholar
• Casanueva E, Viteri FE. Iron and oxidative stress in pregnancy. J Nutr. 2003;133(5, Suppl 2):1700S–1708S.
   PubMed Web of Science ®Google Scholar
• Gaenzer H, Marschang P, Sturm W, Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis. J Am Coll Cardiol. 2002;40(12):2189–2194.
   PubMedGoogle Scholar
• Brenner B. Haemostatic changes in pregnancy. Thromb Res. 2004;114(5-6):409–414.
   PubMed Web of Science ®Google Scholar
• James AH, Jamison MG, Brancazio LR, Venous thromboembolism during pregnancy and the postpartum period incidence, risk factors, and mortality. Am J Obstet Gynecol. 2006;194(5):1311–1315.
   PubMed Web of Science ®Google Scholar
• Borgna Pignatti C, Carnelli V, Caruso V, Thromboembolic events in β thalassemia major: an Italian multicenter study. Acta Haematol. 1998;99(2):76–79.
   PubMed Web of Science ®Google Scholar
• Veille J-C, Hanson R, Sivakoff M, Effects of maternal ingestion of low-dose aspirin on the fetal cardiovascular system. Am J Obstet Gynecol. 1993;168(5):1430–1437.
   PubMed Web of Science ®Google Scholar
• Romero R. Intrauterine infection, premature birth and the fetal inflammatory response syndrome. J Nutr. 2003;133(5, Suppl. 2):1668S–1673S.
   PubMedGoogle Scholar
• Walker EM, Walker SM. Effects of iron overload on the immune system. Ann Clin Lab Sci. 2000;30(4):354–365.
   PubMed Web of Science ®Google Scholar
• Pinero D J, Hu J, Cook BM, Interleukin-1β increases binding of the iron regulatory protein and the synthesis of ferritin by increasing the labile iron pool. Biochim. Biophys Acta. 2000;1497(3):279–288.
   PubMed Web of Science ®Google Scholar
• Eleftheriou A, Kalakoutis G, Pavlides N. Transfusional transmitted viruses in pregnancy. J Pediatr Endocrinol Metab. 1998;11(Suppl. 3):901–914.
   PubMedGoogle Scholar
• Levy A, Fraser D, Katz M, Maternal anemia during pregnancy is an independent risk factor for low birthweight and preterm delivery. Eur J Obstet Gynecol Reprod Biol. 2005;122(2):182–186.
   PubMed Web of Science ®Google Scholar
• Savona-Ventura C, Grech ES. Pregnancy complications in homozygous thalassaemia patients. J Obstet Gynaecol 1991;11(3):175–176.
   Google Scholar
• Nassar AH, Naja M, Cesaretti C, Pregnancy outcome in patients with β-thalassemia intermedia at two tertiary care centers, in Beirut and Milan. Haematologica. 2008;93(10):1586–1587.
   PubMed Web of Science ®Google Scholar
• Steingrub J. Pregnancy-associated severe liver dysfunction. Crit Care Clin. 2004;20(4):763–776.
   PubMedGoogle Scholar
• Tsironi M, Ladis V, Margellis Z, Impairment of cardiac function in a successful full-term pregnancy in a homozygous β-thalassemia major: does chelation have a positive role?. Eur J Obstet Gynecol Reprod Biol. 2005;120(1):117–118.
   PubMed Web of Science ®Google Scholar
• Yamada T, Grisham MB. Roll of neutrophil-derived oxidants in the pathogenesis of intestinal inflammation. Klin Wochenschr. 1991;69(21-23):988–994.
   PubMedGoogle Scholar
• Karagiorga-Lagana M. Fertility in thalassemia–The Greek experience. J Pediatr Endocrinol Metab. 1998;11(Suppl. 3):945–951.
   PubMedGoogle Scholar
• Tuck SM, Jensen CE, Wonke B, A pregnancy management and outcomes in women with thalassaemia major. J Pediatr Endocrino Metab. 1998;11(Suppl. 3):923–928.
   PubMed Web of Science ®Google Scholar
• Singer ST, Vichinsky EP. Deferoxamine treatment during pregnancy: is it harmful?. Am J Hematol. 1999;60(1):24–26.
   PubMed Web of Science ®Google Scholar
• Curry SC, Bond GR, Raschke R, An ovine model of maternal iron poisoning in pregnancy. Ann Emerg Med. 1990;19(6):632–638.
   PubMedGoogle Scholar