Advanced search
Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 36, 2012 - Issue 4
Submit an article Journal homepage
422
Views
24
CrossRef citations to date
0
Altmetric
Original Article

Low Fixed-Dose Hydroxyurea in Severely Affected Indian Children with Sickle Cell Disease

Dipty L. Jain Department of Paediatrics, Government Medical College, Nagpur, Maharsashtra-440009, IndiaCorrespondence[email protected]
,
Vijaya Sarathi Department of Paediatrics, Government Medical College, Nagpur, Maharsashtra-440009, India
,
Saumil Desai Department of Paediatrics, Government Medical College, Nagpur, Maharsashtra-440009, India
,
Manoj Bhatnagar Department of Paediatrics, Government Medical College, Nagpur, Maharsashtra-440009, India
&
Abhijit Lodha Department of Paediatrics, Government Medical College, Nagpur, Maharsashtra-440009, India
Pages 323-332 | Received 28 Dec 2011, Accepted 12 Apr 2012, Published online: 26 Jun 2012

REFERENCES

  • Weatherall DJ. The inherited disorders of haemoglobin: an increasingly neglected global health burden. Indian J Med Res. 2011;134(4):493–497.
  • Mohanty D, Mukherjee MB. Sickle cell disease in India. Curr Opin Hematol. 2002;9(2):117–122.
  • Mukherjee MB, Lu CY, Ducrocq R, . R. Effect of α-thalassemia on sickle-cell anemia linked to the Arab-Indian haplotype in India. Am J Hematol. 1997;55(2):104–109.
  • Singh H, Dulhani N, Kumar BN, Singh P, Tiwari P. Effective control of sickle cell disease with hydroxyurea therapy. Indian J Pharmacol. 2010;42(1):32–35.
  • Italia K, Jain D, Gattani S, . Hydroxyurea in sickle cell disease–a study of clinico-pharmacological efficacy in the Indian haplotype. Blood Cells Mol Dis. 2009;42(1):25–31.
  • Segal JB, Strouse JJ, Beach MC, . Hydroxyurea for the treatment of sickle cell disease. Evid Rep Technol Assess (Full Rep). 2008;(165):1–95.
  • Olivieri NF, Vichinsky EP. Hydroxyurea in children with sickle cell disease: impact on splenic function and compliance with therapy. J Pediatr Hematol Oncol. 1998;20(1):26–31.
  • Kinney TR, Helms RW, O’Branski EE, . Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group. Blood. 1999;94(5):1550–1554.
  • Steinberg MH, McCarthy WF, Castro O, . Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia and MSH Patients’ Follow-Up. Am J Hematol. 2010;85(6):403–408.
  • Hankins JS, Ware RE, Rogers ZR, . Long term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study. Blood. 2005;106(7):2269–2275.
  • Santos A, Pinheiro V, Anjos C, . Scintigraphic follow-up of the effects of therapy with hydroxyurea on splenic function in patients with sickle cell disease. Eur J Nucl Med Mol Imaging. 2002;29(4):536–541.
  • Svarch E, Machín S, Nieves RM, Mancia de Reyes AG, Navarrete M, Rodríguez H. Hydroxyurea treatment in children with sickle cell anemia in Central America and the Caribbean countries. Pediatr Blood Cancer. 2006;47(1):111–112.
  • Strouse JJ, Lanzkron S, Beach MC, . Hydroxyurea for sickle cell disease: a systematic review for efficacy and toxicity in children. Pediatrics. 2008;122(6):1332–1342.
  • Elford HL. Effect of hydroxyurea on ribonucleotide reductase. Biochem Biophys Res Commun. 1968;33(1):129–135.
  • Snyder RD. The role of deoxynucleoside triphosphate pools in the inhibition of DNA-excision repair and replication in human cells by hydroxyurea. Mutat Res. 1984;131(3–4):163–172.
  • Zhou B, Mo X, Liu X, Qiu W, Yen Y. Human ribonucleotide reductase M2 subunit gene amplification and transcriptional regulation in a homogeneous staining chromosome region responsible for the mechanisms of drug resistance. Cytogenet Cell Genet. 2001;95(1–2):34–42.
  • Mabaera R, West RJ, Conine SJ, . A cell stress signaling model of fetal hemoglobin induction: what doesn’t kill red blood cells may make them stronger. Exp Hematol. 2008;36(9):1057–1072.
  • Alcaín FJ, Löw H, Crane FL, Navas P. Iron chelators hydroxyurea and bathophenanthroline disulfonate inhibit DNA synthesis by different pathways. Biochem Mol Biol Int. 1994;34(2):273–279.
  • Cokic VP, Smith RD, Beleslin-Cokic BB, . Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase. J Clin Invest. 2003;111(2):231–239.
  • Huang J, Yakubu M, Kim-Shapiro DB, King SB. Rat liver-mediated metabolism of hydroxyurea to nitric oxide. Free Radic Biol Med. 2006;40(9):1675–1681.
  • Zimmerman SA, Schultz WH, Davis JS, . Sustained long-term hematologic efficacy of hydroxyurea at maximum tolerated dose in children with sickle cell disease. Blood. 2004;103(6):2039–2045.
  • Ware RE, Eggleston B, Redding-Lallinger R, . Predictors of fetal hemoglobin response in children with sickle cell anemia receiving hydroxyurea therapy. Blood. 2002;99(1):10–14.
  • Ware RE, Despotovic JM, Mortier NA, . Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia. Blood. 2011;118(18):4985–4991.
  • Ware RE. How I use hydroxyurea to treat young patients with sickle cell anemia. Blood. 2010;115(26):5300–5311.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.