Effect of Antioxidant Therapy on Hepatic Fibrosis and Liver Iron Concentrations in β-Thalassemia Major Patients

REFERENCES

• Omar A, Abdel-Karim E, Gendy WE, Marzouk I, Wagdy M. Molecular basis of β-thalassemia in Alexandria. Egypt J Immunol. 2005;12(1):15–24.
   PubMedGoogle Scholar
• Scott MD. H2O2 injury in β thalassemic erythrocytes: protective role of catalase and the prooxidant effects of GSH. Free Radic Biol Med. 2006;40(7):1264–1272.
   PubMed Web of Science ®Google Scholar
• Waseem F, Khemomal KA, Sajid R. Antioxidant status in β thalassemia major: a single-center study. Indian J Pathol Microbiol. 2011;54(4):761–763.
   PubMed Web of Science ®Google Scholar
• Cighetti G, Duca L, Bortone L, Oxidative status and malondialdehyde in β-thalassemia patients. Eur J Clin Invest. 2002;32(Suppl 1):55–60.
   PubMedGoogle Scholar
• Şimşek F, Öztürk G, Kemahlı S, Erbaş D, Hasanoğlu A. Oxidant and antioxidant status in β thalassaemia major patients. J Ankara Univ Faculty Med. 2005;58(1):34–38.
   Google Scholar
• Naithani R, Chandra J, Bhattacharjee J, Verma P, Narayan S. Peroxidative stress and antioxidant enzymes in children with β-thalassemia major. Pediatr Blood Cancer. 2006;46(7):780–785.
   PubMed Web of Science ®Google Scholar
• Pfeifer WP, Degasperi GR, Almeida MT, Vercesi AE, Costa FF, Saad STO. Vitamin E supplementation reduces oxidative stress in β thalassaemia intermedia. Acta Haematol. 2008;120(4):225–231.
   PubMed Web of Science ®Google Scholar
• Abdulla MY, Fawzi M, Al-Maloul SR, El-Banna N, Tayyem RF, Ahmad IM. Increased oxidative stress and iron overload in Jordanian β-thalassemic children. Hemoglobin. 2011;35(1):67–79.
   PubMed Web of Science ®Google Scholar
• Walter PB, Fung E, Killilea DW, Oxidative stress and inflammation in iron-overloaded patients with β-thalassaemia or sickle cell disease. Br J Haematol. 2006;135(2):254–263.
   PubMed Web of Science ®Google Scholar
• Giardina PJV, Forget BG. Thalassemia syndromes. In: Hoffman R, Benz EJ, Shattil SS, Eds. Hematology: Basic Principles and Practice, 5th ed. Philadelphia: Churchill Livingstone/Elsevier. 2008: chapter 41.
   Google Scholar
• ElAlfy MS, Sari TT, Lee CL, Tricta F, El-Beshlawy A. The safety, tolerability, and efficacy of a liquid formulation of deferiprone in young children with transfusional iron overload. Pediatr Hematol Oncol. 2010;32(8):601–605.
   Google Scholar
• Cappellini MD, Robbiolo L, Bottasso BM, Coppola R, Fiorelli G, Mannucci AP. Venous thromboembolism and hypercoagulability in splenectomized patients with thalassemia intermedia. Br J Haematol. 2000;111(2):467–473.
   PubMed Web of Science ®Google Scholar
• Boucher B, Cotterchio M, Kreiger N, Nadalin V, Block T, Block G. Validity and reliability of the Block 98 food-frequency questionnaire in a sample of Canadian women. Public Health Nutr. 2006;9(1):84–93.
   PubMed Web of Science ®Google Scholar
• Van Kampen EJ, Zijlstra WG. Determination of hemoglobin and its derivatives. Adv Clin Chem. 1965;8(2):140–187.
   Google Scholar
• Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 1957;28(1):56–63.
   PubMed Web of Science ®Google Scholar
• Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med. 1963;61(5):882–888.
   PubMed Web of Science ®Google Scholar
• Satoh K. Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clin Chim Acta. 1978;90(1):37–43.
   PubMed Web of Science ®Google Scholar
• Nishikimi M, Appaji N, Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun. 1972;46(2):849–854.
   PubMed Web of Science ®Google Scholar
• Goldberg DM, Spooner RJ. Glutathione reductase. In: Bergmeyer HU, Bergmeyer J, Grassl M, Eds. Methods of Enzymatic Analysis, 3rd ed. Deerfield Beach: Weinheim/Verlag Chemie. 1983:256–258.
   Google Scholar
• Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967;70(1):158–169.
   PubMed Web of Science ®Google Scholar
• Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121–126.
   PubMed Web of Science ®Google Scholar
• Harris LJ, Ray SN. Diagnosis of vitamin-C subnutrition by urine analysis: with a note on the antiscorbutic value of human milk. Lancet. 1953;225(5811):71–77.
   Google Scholar
• Kenneth WM, Nancy AL, Chung SY. (1984) Simultaneous determination of plasma retinal, α-tocopherol, lycopene, α-carotene and β-carotene by high-performance liquid chromatography. Anal Biochem. 1984;138(2):340–344.
   PubMed Web of Science ®Google Scholar
• Ley JT, Yazer MH, Waters JH. Hemolysis and red blood cell mechanical fragility in shed blood after total knee arthroplasty. Transfusion. 2012;52(1):34–38.
   PubMed Web of Science ®Google Scholar
• Attia AMM, El-Hefnawy AMM. Conformational stability against auto-oxidation for mice and human oxyhemoglobins. Romanian J Biophys. 2009;19(3):187–189.
   Google Scholar
• Ishak K, Baptista A, Bianchi L, Histological grading and staging of chronic hepatitis. J Hepatol. 1995;22(6):696–699.
   PubMed Web of Science ®Google Scholar
• Sandrin L, Fourquet B, Hasquenoph JM, Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol. 2003;29(12):1705–1713.
   PubMed Web of Science ®Google Scholar
• Walter PB, Macklin EA, Porter J, Thalassemia Clinical Research Network. Inflammation and oxidant-stress in β-thalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: an ancillary study of the Novartis CICL670A0107 trial. Haematologica. 2008;93(6):817–825.
   PubMed Web of Science ®Google Scholar
• Chakraborty I, Mitra S, Gachhui R, Kar M. Non-haem iron-mediated oxidative stress in Haemoglobin E β-thalassaemia. Ann Acad Med Singapore. 2010;39(1):13–16.
   PubMed Web of Science ®Google Scholar
• Veena D, Ratan K, Marwaha RK, Ganguly NK. Antioxidant status in children with homozygous β-thalassaemia. Indian Pediatr. 2005;42(1):195–200.
   Google Scholar
• Rashidi M, Aboomardani M, Rafraf M, Arefhossein SR, Keshtkar A, Joshaghani H. Effects of vitamin E and zinc supplementation on antioxidants in β thalassemia major patients. Iranian J Pediatr. 2011;21(1):8–14.
   PubMed Web of Science ®Google Scholar
• Ray SN, Marwaha RK, Sethuraan G, Trehan A. Scurvy in transfusion dependent β-thalassaemia. Indian Pediatr. 1999;36(5):504–506.
   PubMedGoogle Scholar
• Dissayabutra T, Tosukhowong P, Seksan P. The benefits of vitamin C and vitamin E in children with β-thalassemia with high oxidative stress. J Med Assoc Thai. 2005;88(Suppl 4):S317–S321.
   PubMedGoogle Scholar
• Lang KS, Roll B, Myssina S, Enhanced erythrocyte apoptosis in sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency. Cell Physiol Biochem. 2002;12(4):365–372.
   PubMedGoogle Scholar
• Perez VI, Bokov A, Van Remmen H, Is the oxidative stress theory of aging dead? Biochim Biophys Acta. 2009;1790(10):1005–1014.
   PubMed Web of Science ®Google Scholar
• Judge S, Jang YM, Smith A, Hagen T, Leeuwenburgh C. Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging. FASEB J. 2005;19(3):419–421.
   PubMedGoogle Scholar
• Dröge W, Breitkreutz R. Glutathione and immune function. Proc Nutr Soc. 2000;59(4):595–600.
   PubMed Web of Science ®Google Scholar
• Eldor A, Rachmilewitz EA.The hypercoagulable state in thalassemia. Blood. 2002;99(1):36–43.
   PubMed Web of Science ®Google Scholar
• Roseff SD. Sickle cell disease: a review. Immunohematology. 2009;25(2):67–74.
   PubMedGoogle Scholar
• Crary SE, Buchanan GR. Vascular complications after splenectomy for hematologic disorders. Blood. 2009;114(14):2861–2868.
   PubMed Web of Science ®Google Scholar
• Rebulla P, Model B. Transfusion requirement and effects in patients with thalassemia major. Lancet. 1991;337(8736):277–280.
   PubMed Web of Science ®Google Scholar
• Casaril M, Stanzial AM, Tognella P, (2000). Role of iron load on fibrogenesis in chronic hepatitis C. Hepatogastroenterology. 2000;47(31):220–225.
   PubMedGoogle Scholar
• Souza RM, Freitas LAR, Lyra AC, Moraes CF, Braga EL, Lyra LGC. Effect of iron overload on the severity of liver histologic alterations and on the response to interferon and ribavirin therapy of patients with hepatitis C infection. Braz J Med Biol Res. 2006;39(1):79–83.
   PubMed Web of Science ®Google Scholar
• Thursz M. Iron, haemochromatosis and thalassaemia as risk factors for fibrosis in hepatitis C virus infection. Gut. 2007;56(5):613–614.
   PubMed Web of Science ®Google Scholar
• Galli A, Svegliati-Baroni G, Ceni E, Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism. Hepatology. 2005;41(5)1074–1084.
   PubMed Web of Science ®Google Scholar
• Origa R, Galanello R. Pathophysiology of β thalassaemia. Pediatr Endocrinol Rev. 2011;8(Suppl 2):263–270.
   PubMedGoogle Scholar
• Almeida AM, Bertoncini CR, Borecký J, Souza-Pinto NC, Vercesi AE. Mitochondrial DNA damage associated with lipid peroxidation of the mitochondrial embrane induced by Fe2+-citrate. An Acad Bras Cienc. 2006;78(3):505–514.
   PubMed Web of Science ®Google Scholar
• Hermes-Lima M, Castilho RF, Meinicke AR,Vercesi AE. Characteristics of Fe(II)ATP complex-induced damage to the rat liver mitochondria. Mol Cell Biochem. 1995;145(1):53–60.
   PubMed Web of Science ®Google Scholar
• Kowaltowski AJ, Castilho RF, Vercesi AE. Mitochondrial permeability transition and oxidative stress. FEBS Lett. 2001;495(1-2):12–15.
   PubMed Web of Science ®Google Scholar
• Ismail MH, Pinzani M. Reversal of liver fibrosis. Saudi J Gastroenterol. 2009;15(1):72–79.
   PubMedGoogle Scholar
• Prakash S, Joshi YK. Assessment of micronutrient antioxidants, total antioxidant capacity and lipid peroxidation levels in liver cirrhosis. Asia Pac J Clin Nutr. 2004;13(Suppl):S110–S155.
   Google Scholar
• Leonis MA, Balistreri WF. Neonatal hemochromatosis: It’s OK to say “NO” to antioxidant-chelator therapy. Liver Transpl. 2005;11(11):1323–1325.
   PubMed Web of Science ®Google Scholar
• Thasinas D, Piyaratana T, Panya S. The benefits of vitamin C and vitamin E in children with β-thalassemia with high oxidative stress. J Med Assoc Thai. 2005;88(Suppl 4):4–8.
   Google Scholar
• Das N, Das CT, Chattopadhyay A, Datta AG. Attenuation of oxidative stress-induced changes in thalassemic erythrocytes by vitamin E. Pol J Pharmacol. 2004;56(1):85–96.
   PubMedGoogle Scholar
• Cappellini MD, Tavazzi D, Duca L. Non-transferrin-bound iron, iron related oxidative stress and lipid peroxidation in β-thalassemia intermedia. Transfus Sci. 2000;23(3):245–246.
   PubMedGoogle Scholar
• Chakraborty D, Bhattacharyya M. Antioxidant defense status of red blood cells of patients with β-thalassemia and E/β-thalassemia. Clin Chem Acta. 2001;305(1-2):123–129.
   PubMed Web of Science ®Google Scholar
• Ruchaneekorn WK, Noppadol S, Praphaipit I, Improvement in oxidative stress and antioxidant parameters in β-thalassemia/Hb E patients treated with curcuminoids. Clin Biochem. 2010;43(4):424–429.
   PubMed Web of Science ®Google Scholar
• Michelle H. Serum ferritin: different assays mean different results, study reports. Nephrol Times. 2009;2(2)1–15.
   Google Scholar
• Ho PJ, Tay L, Lindeman R, Catley L, Bowden DK. Australian guidelines for the assessment of iron overload and iron chelation in transfusion-dependent thalassaemia major, sickle cell disease and other congenital anaemias. Intern Med J. 2011;41(7):516–524.
   PubMed Web of Science ®Google Scholar
• Barber T, Borras E, Torres L, Vitamin A deficiency causes oxidative damage to liver mitochondria in rats. Free Radic Biol Med. 2000.29(1):1–7.
   PubMed Web of Science ®Google Scholar
• Halliwell B. How to characterize a biological antioxidant. Free Radic Res Commun. 1990;9(1):1–32.
   PubMed Web of Science ®Google Scholar
• Ingold KU, Webb AC, Witter D, Burton GW, Metcalfe TA, Muller DP. Vitamin E remains the major lipid-soluble, chain-breaking antioxidant in human plasma even in individuals suffering severe vitamin E deficiency. Arch Biochem Biophys. 1987;259(1):224–225.
   PubMed Web of Science ®Google Scholar
• Buettner GR. The pecking order of free radicals and antioxidants: lipid peroxidation, α-tocopherol and ascorbate. Arch Biochem Biophys. 1993;300(2):535–543.
   PubMed Web of Science ®Google Scholar
• McCay PB. Vitamin E: interactions with free radicals and ascorbate. Annu Rev Nutr. 1985;5(1):323–340.
   PubMedGoogle Scholar
• Desouky OS, Selim NS, El-Barawy EM, El-Marakby SM. Biophysical characterization of β-thalassemic red blood cells. Cell Biochem Biophys. 2009;55(1):45–53.
   PubMed Web of Science ®Google Scholar
• Hardison RC. A brief history of hemoglobins: plant, animal, protest, and bacteria. Proc Natl Acad Sci USA. 1996;93(3):5675–5679.
   PubMedGoogle Scholar
• Mwanti L, Worsley A, Ryan P, Masika J. Supplemental vitamin A improves anemia and growth in anemic school children in Tanzania. J Nutr. 2000;130(11):2691–2696.
   PubMed Web of Science ®Google Scholar
• Zimmermann MB, Biebinger R, Rohner F, Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron. Am J Clin Nutr. 2006;84(3):580–586.
   PubMed Web of Science ®Google Scholar