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Hemoglobin
international journal for hemoglobin research
Volume 37, 2013 - Issue 4
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Original Article

Leg Ulcers in Sickle Cell Disease: Current Patterns and Practices

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Pages 325-332 | Received 18 Oct 2012, Accepted 16 Jan 2013, Published online: 19 Apr 2013

REFERENCES

  • Herrick JB. Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia. 1910. Yale J Biol Med. 2001;74(3):179–184.
  • Eckman JR. Leg ulcers in sickle cell disease. Hematol Oncol Clin North Am. 1996;10(6):1333–1344.
  • Koshy M, Entsuah R, Koranda A, Leg ulcers in patients with sickle cell disease. Blood. 1989;74(4):1403–1408.
  • Serjeant GR. Leg ulceration in sickle cell anemia. Arch Intern Med. 1974;133(4):690–694.
  • Minniti CP, Eckman J, Sebastiani P, Steinberg MH, Ballas SK. Leg ulcers in sickle cell disease. Am J Hematol. 2010;85(10):831–833.
  • Parent F, Bachir D, Inamo J, A hemodynamic study of pulmonary hypertension in sickle cell disease. N Engl J Med. 2011;365(1):44–53.
  • Kato GJ, McGowan V, Machado RF, Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood. 2006;107(6):2279-2285.
  • Nolan VG, Adewoye A, Baldwin C, Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway. Br J Haematol. 2006;133(5):570–578.
  • Halabi-Tawil M, Lionnet F, Girot R, Bachmeyer C, Levy PP, Aractingi S. Sickle cell leg ulcers: a frequently disabling complication and a marker of severity. Br J Dermatol. 2008;158(2):339–344.
  • Borgna-Pignatti C, Marsella M, Zanforlin N. The natural history of thalassemia intermedia. Ann NY Acad Sci. 2010;1202:214–220.
  • Giraldi S, Abbage KT, Marinoni LP, Leg ulcer in hereditary spherocytosis. Pediatr Dermatol. 2003;20(5):427–428.
  • Muller-Soyano A, Tovar de Roura E, Duke PR, Pyruvate kinase deficiency and leg ulcers. Blood. 1976;47(5):807–813.
  • Powars DR. Sickle cell anemia and major organ failure. Hemoglobin. 1990;14(6):573–598.
  • Minniti CP, Taylor JG 6th, Hildesheim M, Laboratory and echocardiography markers in sickle cell patients with leg ulcers. Am J Hematol. 2011;86(8):705–708.
  • Marti-Carvajal AJ, Knight-Madden JM, Martinez-Zapata MJ. Interventions for treating leg ulcers in people with sickle cell disease. Cochrane Database Syst Rev. 2012;11:CD008394.
  • Nguyen TV, Margolis DJ. Hydroxyurea and lower leg ulcers. Cutis. 1993;52(4):217–219.
  • Charache S, Terrin ML, Moore RD, Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N Engl J Med. 1995;332(20):1317–1322.
  • Lansdown AB. Zinc in the healing wound. Lancet. 1996;347(9003):706–707.
  • Serjeant GR, Galloway RE, Gueri MC. Oral zinc sulphate in sickle-cell ulcers. Lancet. 1970;2(7679):891–892.
  • O’Meara S, Cullum NA, Nelson EA. Compression for venous leg ulcers. Cochrane Database Syst Rev. 2009(1):CD000265.
  • Abisi S, Tan J, Burnand KG. Excision and meshed skin grafting for leg ulcers resistant to compression therapy. Br J Surg. 2007;94(2):194–197.
  • Dumville JC, Worthy G, Bland JM, Larval therapy for leg ulcers (VenUS II): randomised controlled trial. BMJ. 2009;338:b773.
  • Paul AG, Ahmad NW, Lee HL, Maggot debridement therapy with Lucilia cuprina: a comparison with conventional debridement in diabetic foot ulcers. Int Wound J. 2009;6(1):39–46.
  • Kranke P, Bennett M, Roeckl-Wiedmann I, Debus S. Hyperbaric oxygen therapy for chronic wounds. Cochrane Database Syst Rev. 2004(2):CD004123.
  • Londahl M, Katzman P, Nilsson A, Hammarlund C. Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes. Diabetes Care. 2010;33(5):998–1003.
  • Mery L, Girot R, Aractingi S. Topical effectiveness of molgramostim (GM-CSF) in sickle cell leg ulcers. Dermatology. 2004;208(2):135–137.
  • Wethers DL, Ramirez GM, Koshy M, Accelerated healing of chronic sickle-cell leg ulcers treated with RGD peptide matrix. RGD Study Group. Blood. 1994;84(6):1775–1779.
  • McMahon L, Tamary H, Askin M, A randomized phase II trial of Arginine Butyrate with standard local therapy in refractory sickle cell leg ulcers. Br J Haematol. 2010;151(5):516–524.
  • Perrine RP, Pembrey ME, John P, Perrine S, Shoup F. Natural history of sickle cell anemia in Saudi Arabs. A study of 270 subjects. Ann Intern Med. 1978;88(1):1–6.
  • Kersgard C, Osswald MB. Hydroxyurea and sickle cell leg ulcers. Am J Hematol. 2001;68(3):215–216.
  • Sirieix ME, Debure C, Baudot N, Leg ulcers and hydroxyurea: forty-one cases. Arch Dermatol. 1999;135(7):818–820.
  • Trent JT, Kirsner RS. Leg ulcers in sickle cell disease. Adv Skin Wound Care. 2004;17(8):410–416.

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