References
- Jensen CE, Tuck SM, Agnew JE, et al. High prevalence of low bone mass in thalassaemia major. Br J Haematol. 1998;103(4):911–915
- Pollak RD, Rachmilewitz E, Blumenfeld A, et al. Bone mineral metabolism in adults with β-thalassaemia major and intermedia. Br J Haematol. 2000;111(3):902–907
- Sambrook P, Cooper C. Osteoporosis. Lancet. 2006;367(9527):2010–2018
- Voskaridou E, Terpos E. New insights into the pathophysiology and management of osteoporosis in patients with β thalassaemia. Br J Haematol. 2004;127(2):127–139
- Anapliotou M, Kastanias I, Psara P, et al. The contribution of hypogonadism to the development of osteoporosis in thalassemia major: New therapeutic approaches. Clin Endocrinol. 1995;42(3):279–287
- Chatterjee R, Katz M. Reversible hypogonadotrophic hypogonadism in sexually infantile male thalassemic patients with transfusion iron overload. Clin Endocrinol. 2000;53(1):33–42
- Scacchi M, Danes L, Cattaneio A, et al. Bone demineralization in adult thalassemic patients: contribution of GH and IGF-1 at different skeletal sites. Clin Endocrinol. 2008;69(2):202–207
- Lasco A, Morabito N, Gaudio A, et al. Osteoporosis and β-thalassemia major: Role of the IGF-I/IGFBP-III axis. J Endocrinol Invest. 2002;25(4):338–344
- Toumba M, Skordis N. Osteoporosis syndrome in thalassemia major: An overview. J Osteoporos. 2010;2010:537673
- Voskaridou E, Terpos E. Pathogenesis and management of osteoporosis in thalassemia. Pediatr Endocrinol Rev. 2008;6(1):86–93
- Skordis N, Efstathiou E, Kyriakou A, Toumba M. Hormonal dysregulation and bones in thalassemia—an overview. Pediatr Endocrinol Rev. 2008;6(Suppl 1):107–115
- De Sanctis V, Pinamonti A, Di Palma A, et al. Growth and development in thalassaemia major patients with severe bone lesions due to desferrioxamine. Eur J Paediatr. 1996;155(5):368–372
- Borgna-Pignatti C, Rugolotto S, De Stefan P, et al. Survival and complications in patients with thalasaaemia major treated with transfusion and deferoxamine. Haematologica. 2004;89(10):1187–1193
- Terpos E, Voskaridou E. Treatment options for thalassemia patients with osteoporosis. Ann N Y Acad Sci. 2010;1202:237–243
- Johanson NA. Musculoskeletal problems in hemoglobinopathy. Orthop Clin North Am. 1990;21(1):191–198
- Origa R, Fiumana E, Gamberini MR, et al. Osteoporosis in β-thalassemia: Clinical and genetic aspects. Ann N Y Acad Sci. 2005;1054:451–456
- Wonke B. Bone disease in β-thalassaemia major. Br J Haematol. 1998;103(4):897–901
- Tsitura S, Amarilio N, Lapatsanis P, et al. Serum 25-hydroxyvitamin D levels in thalassaemia. Arch Dis Child. 1978;53(4):347–348
- Napoli N, Carmina E, Bucchieri S, et al. Low serum levels of 25-hydroxy vitamin D in adults affected by thalassemia major or intermedia. Bone. 2006;38(6):888–892
- Soliman A, Adel A, Wagdy M, et al. Calcium homeostasis in 40 adolescents with β-thalassemia major: A case-control study of the effects of intramuscular injection of a megadose of cholecalciferol. Pediatr Endocrinol Rev. 2008;6(Suppl 1):149–154
- Singh K, Kumar R, Shukla A, et al. Status of 25-hydroxyvitamin D deficiency and effect of vitamin D receptor gene polymorphisms on bone mineral density in thalassemia patients of North India. Hematology. 2012;17(5):291–296
- Vogiatzi MG, Macklin EA, Trachtenberg FL, et al. Thalassemia Clinical Research Network. Differences in the prevalence of growth, endocrine and vitamin D abnormalities among the various thalassaemia syndromes in North America. Br J Haematol. 2009;146(5):546–556
- Dandona P, Menon RK, Houlder S, et al. Serum 1,25 dihydroxyvitamin D and osteocalcin concentrations in thalassaemia major. Arch Dis Child. 1987;62(5):474–477
- Zaino EC, Yeh JK, Aloia J. Defective vitamin D metabolism in thalassemia major. Ann N Y Acad Sci. 1985;445:127–134
- Voskaridou E, Kyrtsonis MC, Terpos E, et al. Bone resorption is increased in young adults with thalassaemia major. Br J Haematol. 2001;112(1):36–41
- Moulas A, Challa A, Chaliasos N, Lapatsanis PD. Vitamin D metabolites (25-hydroxyvitamin D, 24,25-dihydroxyvitamin D and 1,25-dihydroxyvitamin D) and osteocalcin in β-thalassaemia. Acta Paediatr. 1997;86(6):594–599
- St. Pierre TG, Clark PR, Chua-Anusorn W, et al. Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood. 2005;105(2):855–861
- Genuth S, Alberti KG, Bennett P, et al. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care. 2003;26(11):3160–3167
- World Health Organization Scientific Group on the Prevention and Management of Osteoporosis (2000: Geneva, Switzerland) (2003). “Prevention and management of osteoporosis: Report of a WHO scientific group.” Accessed September 20 2013
- The International Society for Clinical Densitometry. ISCD 2007 official positions-adult. Available at http://www.iscd.org/official-positions/2007-iscd-official-positions-adult/. Accessed September 20 2013
- Guidelines for the clinical management of thalassaemia. Thalassaemia International Federation, 2nd ed. 2008:1–202. Available at http://www.thalassaemia.org.cy. Accessed September 20 2013
- Standards for the clinical care of children and adults with thalassaemia in the United Kingdom. Thalassaemia Society, 2nd ed. 2008:1–120. Available at http://www.ukts.org. Accessed September 20 2013
- Mirhosseini NZ, Shahar S, Ghayour-Mobarhan M, et al. Bone-related complications of transfusion-dependent β thalassemia among children and adolescents. J Bone Miner Metab. 2013;31(4):468–476
- Wong P, Fuller PJ, Gillespie MT, et al. Thalassemia bone disease: the association between nephrolithiasis, bone mineral density and fractures. Osteoporos Int. 2013;24(7):1965–1971
- Vogiatzi MG, Macklin EA, Fung EB, et al. Thalassemia Clinical Research Network. Bone disease in thalassemia: a frequent and still unresolved problem. J Bone Miner Res. 2009;24(3):543–557
- Skordis N, Michaelidou M, Savva SC, et al. The impact of genotype on endocrine complications in thalassaemia major. Eur J Haematol. 2006;77(2):150–156
- Bielinski BK, Darbyshire PJ, Mathers L, et al. Impact of disordered puberty on bone density in β-thalassaemia major. Br J Haematol. 2003;120(2):353–358
- Rioja L, Girot R, Garabédian M, Cournot-Witmer G. Bone disease in children with homozygous β-thalassemia. Bone Miner. 1990;8(1):69–86
- Kyriakou A, Savva SC, Savvides I, et al. Gender differences in the prevalence and severity of bone disease in thalassemia. Pediatr Endocrinol Rev. 2008; 6(Suppl 1):116–122
- Garofalo F, Piga A, Lala R, et al. Bone metabolism in thalassemia. Ann N Y Acad Sci. 1998;850:475–478
- Hyppönen E, Power C. Hypovitaminosis D in British adults at age 45 y: Nationwide cohort study of dietary and lifestyle predictors. Am J Clin Nutr. 2007;85(3):860–868