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Hemoglobin
international journal for hemoglobin research
Volume 39, 2015 - Issue 3
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Original Article

Molecular Basis of β-Thalassemia Intermedia in Erbil Province of Iraqi Kurdistan

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Pages 178-183 | Received 10 Nov 2014, Accepted 26 Dec 2014, Published online: 22 Apr 2015

References

  • Weatherall DJ, Clegg JB. The Thalassaemia Syndromes, 4th ed. Oxford, UK: Blackwell Science, 2001
  • Camaschella C, Cappellini MD. Thalassemia intermedia. Haematologica. 1995;80(1):58–68
  • Thein SL. Genetic modifiers of β-thalassemia. Haematologica. 2005;90(5):649–660
  • Kanavakis E, Traeger-Synodinos J, Tzetis M, et al. Molecular characterization of homozygous (high Hb A2) β-thalassemia intermedia in Greece. Pediatr Hematol-Oncol. 1995;12(1):37–45
  • Thein SL, Menzel S, Lathrop M, Garner C. Control of fetal hemoglobin: New insights emerging from genomics and clinical implications. Hum Mol Genet. 2009;18(R2):R216–R23
  • Taher AT, Musallam KM, Cappellini MD. Thalassaemia intermedia: An update. Mediterr J Hematol Infect Dis. 2009;1(1):e2009004. doi: 10.4084/MJHID.2009.004
  • Giordano PC, Bakker-Verwij M, Harteveld CL. Frequency of α-globin gene triplications and their interaction with β-thalassemia mutations. Hemoglobin. 2009;33(2):124–131
  • Al-Allawi N, Al-Dousky A. Frequency of haemoglobinopathies at premarital health screening in Dohuk, Iraq: Implications for a regional prevention programme. East Mediterr Health J. 2010;16(4):8–20
  • Jalal S, Al-Allawi N, Faraj A, Ahmed N. Prevalence of hemoglobinopathies in Sulaimani-Iraq. Dohuk Med J. 2008;2(1):71–79
  • Al-Allawi NAS, Hassan KMA, Sheikha AK, et al. β-Thalassemia mutations among transfusion-dependent thalassemia major patients in Northern Iraq. Molec Biol Int. 2010;2010:479282. doi:10.4061/2010/479282
  • Jalal SD, Al-Allawi NA, Bayat N, et al. β-Thalassemia mutations in the Kurdish population of Northeastern Iraq. Hemoglobin. 2010;34(5):469–476
  • Al-Allawi NA, Jubrael JM, Hughson M. Molecular characterization of β-thalassemia in the Dohuk region of Iraq. Hemoglobin. 2006;30(4):479–486
  • Al-Allawi NA, Jalal SD, Mohammad AM, et al. β-Thalassemia intermedia in Northern Iraq: A single center experience. BioMed Res Int. 2014;2014:262853. doi:10.1155/2014/262853
  • Harteveld C, Refaldi C, Cassinerio E, et al. Segmental duplications involving the α-globin gene cluster are causing β-thalassemia intermedia phenotypes in β-thalassemia heterozygous patients. Blood Cells Mol Dis. 2008;40(3):312–316
  • Giardine B, Borg J, Viennas E, et al. Updates of the HbVar database of human hemoglobin variants and thalassemia mutations. Nucleic Acids Res. 2014;42(Database issue):D1063–D1069. (http://globin.cse.psu.edu)
  • Öner R, Agarwal S, Dimovski A, et al. The G→A mutation at position+ 22 3′ to the Cap site of the β-globin gene as a possible cause for a β-thalassemia. Hemoglobin. 1991;15(1–2):67–76
  • Cai S, Eng B, Francombe W, et al. Two novel β-thalassemia mutations in the 5′ and 3′ noncoding regions of the β-globin gene [see comments]. Blood. 1992;79(5):1342–1346
  • Akbari MT, Izadi P, Izadyar M, et al. Molecular basis of thalassemia intermedia in Iran. Hemoglobin. 2008;32(5):462–470
  • Altay Ç, Gürgey A. β-Thalassemia intermedia in Turkey. Ann N Y Acad Sci. 1990;612:81–89
  • Qatanani M, Taher A, Koussa S, et al. β Thalassaemia intermedia in Lebanon. Eur J Haematol. 2000;64(4):237–244
  • Rund D, Oron-Karni V, Filon D, et al. Genetic analysis of β thalassemia intermedia in Israel: Diversity of mechanisms and unpredictability of phenotype. Am J Hematol. 1997;54(1):16–22
  • Verma IC, Kleanthous M, Saxena R, et al. Multicenter study of the molecular basis of thalassemia intermedia in different ethnic populations. Hemoglobin. 2007;31(4):439–452
  • Thein SL, Wainscoat JS, Sampietro M, et al. Association of thalassaemia intermedia with a β-globin gene haplotype. Br J Haematol. 1987;65(3):367–373
  • Labie D, Dunda-Belkhodja O, Rouabhi F, et al. The −158 site 5′ to the Gγ gene and Gγ expression. Blood. 1985;66(6):1463–1465
  • Arab A, Karimipoor M, Rajabi A, et al. Molecular characterization of β-thalassemia intermedia: A report from Iran. Mol Biol Rep. 2011;38(7):4321–4326
  • Neishabury M, Azarkeivan A, Oberkanins C, et al. Molecular mechanisms underlying thalassemia intermedia in Iran. Genet Test. 2008;12(4):549–556
  • Karimi M, Yarmohammadi H, Farjadian S, et al. β-Thalassemia intermedia from southern Iran: IVS-II-1 (G→A) is the prevalent thalassemia intermedia allele. Hemoglobin. 2002;26(2):147–154
  • Fischel Ghodsian N, Vickers M, Seip M, et al. Characterization of two deletions that remove the entire human ζα globin gene complex (– –THAI and – –FIL). Br J Haematol. 1988;70(2):233–238
  • Al-Allawi NA, Badi AI, Imanian H, et al. Molecular characterization of α-thalassemia in the Dohuk region of Iraq. Hemoglobin. 2009;33(1):37–44
  • Guvenc B, Yildiz SM, Tekinturhan F, et al. Molecular characterization of α-thalassemia in Adana, Turkey: A single center study. Acta Haematol. 2010;123(4):197–200
  • Öner C, Gürgey A, Öner R, et al. The molecular basis of Hb H disease in Turkey. Hemoglobin. 1997;21(1):41–51
  • Hadavi V, Taromchi AH, Malekpour M, et al. Elucidating the spectrum of α-thalassemia mutations in Iran. Haematologica. 2007;92(7):992–993

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