Publication Cover
Hemoglobin
international journal for hemoglobin research
Volume 39, 2015 - Issue 6
123
Views
0
CrossRef citations to date
0
Altmetric
Short Communication

A Novel Heme Pocket Hemoglobin Variant Associated with Normal Hematology: Hb Zara or α91(FG3)Leu→Ile (α2) (HBA2: c.274C > A)

, , , , , & show all
Pages 427-429 | Received 24 Mar 2015, Accepted 23 Apr 2015, Published online: 13 Aug 2015

References

  • Giordano PC. Prospective and retrospective primary prevention of hemoglobinopathies in multiethnic societies. Clin Biochem. 2009;42(18):1757–1766
  • Masala B, Manca L. Detection of the common Hb F Sardinia [Aγ(E19)Ile→Thr] variant by isoelectric focusing in normal newborns and in adults affected by elevated fetal hemoglobin syndromes. Clin Chim Acta. 1991;198(3):195–202
  • Manca L, Formato M, Demuro P, et al. The γ globin chain heterogeneity of the Sardinian newborn baby. Hemoglobin. 1986;10(5):519–528
  • Masala B, Manca L. Detection of globin chains by reversed-phase high-performance liquid chromatography. Methods Enzymol. 1994;231:21–44
  • Brennan SO, Tauro GP, Melrose W. Haemoglobin Port Phillip α91(FG3)Leu→Pro, a new unstable haemoglobin. FEBS Lett. 1977;81(1):115–117
  • Brennan SO, Chan T, Sheen C. Novel hemoglobin (Hb Grey Lynn) substitution (α91Leu→Phe) affects heme interactions and α1β2 contacts. Clin Chem. 2007;53(5):990–991
  • Barberio G, Leone D, Ivaldi G, Giordano PC. Hb Treviso [α91(FG3)Leu→Phe (α2)]: A new slightly unstable hemoglobin variant with moderately decreased oxygen affinity. Hemoglobin. 2013;37(2):107–111
  • De La Fuente-Gonzalo F. Hb La Mancha [α91(FG3)Leu→Arg (α2); HBA2: c.275T > G]. HbVar ID 2965 [http://globin.cse.psu.edu/hbvar/menu.html (accessed 2015)]
  • Henderson S. Hb Kalavasos [α91(FG3)Leu→His (α2); HBA2: c.275T > A]. HbVar ID 2969 [http://globin.cse.psu.edu/hbvar/menu.html (accessed February 2015)]
  • Sack JS, Andrews LC, Magnus KA, et al. Location of amino acid residues in human deoxy hemoglobin. Hemoglobin. 1978;2(2):153–169
  • Gelin BR, Karplus M. Mechanism of tertiary structural change in hemoglobin. Proc Natl Acad Sci USA. 1977;74(3):801–805
  • Molchanova TP, Pobedimskaya DD, Huisman THJ. The differences in quantities of α2- and α1-globin gene variants in heterozygotes. Br J Haematol. 1994;88(2):300–306
  • Vestri R, Pieragostini E, Manca L, Masala B. Detection by reversed-phase HPLC of trace amounts of the α113His globin chain in a sheep homozygous for a quadruple α-globin gene chromosome. Int J Biochem. 1993;25(12):1939–1941
  • Jorge SE, Kimura EM, Oliveira DM, et al. Three new α-globin variants: Hb Itapira [α30(B11)Glu→Val (α1)], Hb Bom Jesus Da Lapa [α30(B11)Glu→Ala (α1)] and Hb Boa Esperança [α16(A14)Lys→Thr (α2)]. Hemoglobin. 2007;31(2):151–157

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.